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Conserved domains on  [gi|296080712|ref|NP_001171658|]
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GPI transamidase component PIG-T isoform 3 precursor [Homo sapiens]

Protein Classification

PIG-T family GPI transamidase component( domain architecture ID 10513789)

PIG-T family GPI transamidase component is part of the GPI transamidase complex that is essential for transfer of GPI (glycosylphosphatidylinositol) to proteins, particularly for formation of carbonyl intermediates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gpi16 pfam04113
Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase ...
32-484 3.31e-140

Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.


:

Pssm-ID: 461180  Cd Length: 524  Bit Score: 414.33  E-value: 3.31e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712   32 EELVITPLPSGDVAATFQFRTrwDSELQREGVSHYRLFPKALGQLISKYSLRELHLSFTQGFWRTRYWG----PPFLQAP 107
Cdd:pfam04113  19 EELLLRPLPDGKLLASFNFRS--NTSPASFEQQHFRLFPRSLGQILQHAGTRELHLRFTQGRWDAESWGarpwNGLKEGG 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  108 SGAELWVWFQ-DTVTDVDKSWKELSNVLSGIFCASLNFIDSTNTVTPTASFKPLGLANDTDHYFLRYAVLPREVVCTENL 186
Cdd:pfam04113  97 TGVELWAWFEaPSDEEADAKWLTLTNALSGLFCASLNFIDSTRTTRPVLSFQPEGGHSASNNLHLLHGTLPREVVCTENL 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  187 TPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVCrNARCTSISWELRQTLSVVFDafitgqgkKDWSLFRMFSR 266
Cdd:pfam04113 177 TPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPVC-DPDEGECGLELEQTIDMVTE--------QSWSLESLFGR 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  267 TLTEPCPL------------ASESRVYVDITTYN------------------------------QDNETLEVHPPPTTTY 304
Cdd:pfam04113 248 PIKGACPLtdssvppvclivPDSRNVYVQGASGGareaknpdgsssvlrcydldsdaefdlklpWQESTKEVPPEPPPLY 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  305 ---------QD-----VIL----GTRKTYAIY-DLLD----------TAMINNSRNLNIQLKWKRppengyIHYQPAQDR 355
Cdd:pfam04113 328 aersltghgQErggirIILtnpsPDEPVEFIYfESLPwfmrvylhtlKVTIDGQDPGSPSDFIKE------IYYRPAIDR 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  356 LQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALvpsmvaakpvdweesplfnslfpvSDGS 435
Cdd:pfam04113 402 KRPTQLELLLRLPPRSTVTLTYDFEKAILRYTEYPPDANRGFDVPPAVITVL------------------------DESS 457
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 296080712  436 NYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTF 484
Cdd:pfam04113 458 SEDYSIRTTSLLLPLPTPDFSMPYNVIILTSTVMALAFGSLFNLLTRRF 506
 
Name Accession Description Interval E-value
Gpi16 pfam04113
Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase ...
32-484 3.31e-140

Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.


Pssm-ID: 461180  Cd Length: 524  Bit Score: 414.33  E-value: 3.31e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712   32 EELVITPLPSGDVAATFQFRTrwDSELQREGVSHYRLFPKALGQLISKYSLRELHLSFTQGFWRTRYWG----PPFLQAP 107
Cdd:pfam04113  19 EELLLRPLPDGKLLASFNFRS--NTSPASFEQQHFRLFPRSLGQILQHAGTRELHLRFTQGRWDAESWGarpwNGLKEGG 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  108 SGAELWVWFQ-DTVTDVDKSWKELSNVLSGIFCASLNFIDSTNTVTPTASFKPLGLANDTDHYFLRYAVLPREVVCTENL 186
Cdd:pfam04113  97 TGVELWAWFEaPSDEEADAKWLTLTNALSGLFCASLNFIDSTRTTRPVLSFQPEGGHSASNNLHLLHGTLPREVVCTENL 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  187 TPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVCrNARCTSISWELRQTLSVVFDafitgqgkKDWSLFRMFSR 266
Cdd:pfam04113 177 TPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPVC-DPDEGECGLELEQTIDMVTE--------QSWSLESLFGR 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  267 TLTEPCPL------------ASESRVYVDITTYN------------------------------QDNETLEVHPPPTTTY 304
Cdd:pfam04113 248 PIKGACPLtdssvppvclivPDSRNVYVQGASGGareaknpdgsssvlrcydldsdaefdlklpWQESTKEVPPEPPPLY 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  305 ---------QD-----VIL----GTRKTYAIY-DLLD----------TAMINNSRNLNIQLKWKRppengyIHYQPAQDR 355
Cdd:pfam04113 328 aersltghgQErggirIILtnpsPDEPVEFIYfESLPwfmrvylhtlKVTIDGQDPGSPSDFIKE------IYYRPAIDR 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  356 LQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALvpsmvaakpvdweesplfnslfpvSDGS 435
Cdd:pfam04113 402 KRPTQLELLLRLPPRSTVTLTYDFEKAILRYTEYPPDANRGFDVPPAVITVL------------------------DESS 457
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 296080712  436 NYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTF 484
Cdd:pfam04113 458 SEDYSIRTTSLLLPLPTPDFSMPYNVIILTSTVMALAFGSLFNLLTRRF 506
 
Name Accession Description Interval E-value
Gpi16 pfam04113
Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase ...
32-484 3.31e-140

Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.


Pssm-ID: 461180  Cd Length: 524  Bit Score: 414.33  E-value: 3.31e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712   32 EELVITPLPSGDVAATFQFRTrwDSELQREGVSHYRLFPKALGQLISKYSLRELHLSFTQGFWRTRYWG----PPFLQAP 107
Cdd:pfam04113  19 EELLLRPLPDGKLLASFNFRS--NTSPASFEQQHFRLFPRSLGQILQHAGTRELHLRFTQGRWDAESWGarpwNGLKEGG 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  108 SGAELWVWFQ-DTVTDVDKSWKELSNVLSGIFCASLNFIDSTNTVTPTASFKPLGLANDTDHYFLRYAVLPREVVCTENL 186
Cdd:pfam04113  97 TGVELWAWFEaPSDEEADAKWLTLTNALSGLFCASLNFIDSTRTTRPVLSFQPEGGHSASNNLHLLHGTLPREVVCTENL 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  187 TPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVCrNARCTSISWELRQTLSVVFDafitgqgkKDWSLFRMFSR 266
Cdd:pfam04113 177 TPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPVC-DPDEGECGLELEQTIDMVTE--------QSWSLESLFGR 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  267 TLTEPCPL------------ASESRVYVDITTYN------------------------------QDNETLEVHPPPTTTY 304
Cdd:pfam04113 248 PIKGACPLtdssvppvclivPDSRNVYVQGASGGareaknpdgsssvlrcydldsdaefdlklpWQESTKEVPPEPPPLY 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  305 ---------QD-----VIL----GTRKTYAIY-DLLD----------TAMINNSRNLNIQLKWKRppengyIHYQPAQDR 355
Cdd:pfam04113 328 aersltghgQErggirIILtnpsPDEPVEFIYfESLPwfmrvylhtlKVTIDGQDPGSPSDFIKE------IYYRPAIDR 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080712  356 LQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALvpsmvaakpvdweesplfnslfpvSDGS 435
Cdd:pfam04113 402 KRPTQLELLLRLPPRSTVTLTYDFEKAILRYTEYPPDANRGFDVPPAVITVL------------------------DESS 457
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 296080712  436 NYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTF 484
Cdd:pfam04113 458 SEDYSIRTTSLLLPLPTPDFSMPYNVIILTSTVMALAFGSLFNLLTRRF 506
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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