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Conserved domains on  [gi|296080714|ref|NP_001171659|]
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GPI transamidase component PIG-T isoform 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gpi16 super family cl04404
Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase ...
63-449 2.87e-110

Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.


The actual alignment was detected with superfamily member pfam04113:

Pssm-ID: 461180  Cd Length: 524  Bit Score: 336.13  E-value: 2.87e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714   63 DTDHYFLRYAVLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVC--RNARCtsiSWELRQTL 140
Cdd:pfam04113 155 ASNNLHLLHGTLPREVVCTENLTPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPVCdpDEGEC---GLELEQTI 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  141 SVVFDafitgqgkKDWSLFRMFSRTLTEPCPLASESRVYVDIttynQDNETLEVHpPPTTTYQDVILGTRKTYAiyDLLD 220
Cdd:pfam04113 232 DMVTE--------QSWSLESLFGRPIKGACPLTDSSVPPVCL----IVPDSRNVY-VQGASGGAREAKNPDGSS--SVLR 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  221 TAMINNSRNLNIQLKWKRPPENEAPPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPVLLLDTVPWYLRLYVHTLTI 300
Cdd:pfam04113 297 CYDLDSDAEFDLKLPWQESTKEVPPEPPPLYAERSLTGHGQERGGIRIILTNPSPDEPVEFIYFESLPWFMRVYLHTLKV 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  301 TSKGKENKPSY-----IHYQPAQDRLQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALvps 375
Cdd:pfam04113 377 TIDGQDPGSPSdfikeIYYRPAIDRKRPTQLELLLRLPPRSTVTLTYDFEKAILRYTEYPPDANRGFDVPPAVITVL--- 453
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296080714  376 mvaakpvdweesplfnslfpvSDGSNYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTF 449
Cdd:pfam04113 454 ---------------------DESSSEDYSIRTTSLLLPLPTPDFSMPYNVIILTSTVMALAFGSLFNLLTRRF 506
 
Name Accession Description Interval E-value
Gpi16 pfam04113
Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase ...
63-449 2.87e-110

Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.


Pssm-ID: 461180  Cd Length: 524  Bit Score: 336.13  E-value: 2.87e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714   63 DTDHYFLRYAVLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVC--RNARCtsiSWELRQTL 140
Cdd:pfam04113 155 ASNNLHLLHGTLPREVVCTENLTPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPVCdpDEGEC---GLELEQTI 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  141 SVVFDafitgqgkKDWSLFRMFSRTLTEPCPLASESRVYVDIttynQDNETLEVHpPPTTTYQDVILGTRKTYAiyDLLD 220
Cdd:pfam04113 232 DMVTE--------QSWSLESLFGRPIKGACPLTDSSVPPVCL----IVPDSRNVY-VQGASGGAREAKNPDGSS--SVLR 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  221 TAMINNSRNLNIQLKWKRPPENEAPPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPVLLLDTVPWYLRLYVHTLTI 300
Cdd:pfam04113 297 CYDLDSDAEFDLKLPWQESTKEVPPEPPPLYAERSLTGHGQERGGIRIILTNPSPDEPVEFIYFESLPWFMRVYLHTLKV 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  301 TSKGKENKPSY-----IHYQPAQDRLQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALvps 375
Cdd:pfam04113 377 TIDGQDPGSPSdfikeIYYRPAIDRKRPTQLELLLRLPPRSTVTLTYDFEKAILRYTEYPPDANRGFDVPPAVITVL--- 453
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296080714  376 mvaakpvdweesplfnslfpvSDGSNYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTF 449
Cdd:pfam04113 454 ---------------------DESSSEDYSIRTTSLLLPLPTPDFSMPYNVIILTSTVMALAFGSLFNLLTRRF 506
 
Name Accession Description Interval E-value
Gpi16 pfam04113
Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase ...
63-449 2.87e-110

Gpi16 subunit, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.


Pssm-ID: 461180  Cd Length: 524  Bit Score: 336.13  E-value: 2.87e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714   63 DTDHYFLRYAVLPREVVCTENLTPWKKLLPCSSKAGLSVLLKADRLFHTSYHSQAVHIRPVC--RNARCtsiSWELRQTL 140
Cdd:pfam04113 155 ASNNLHLLHGTLPREVVCTENLTPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPVCdpDEGEC---GLELEQTI 231
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  141 SVVFDafitgqgkKDWSLFRMFSRTLTEPCPLASESRVYVDIttynQDNETLEVHpPPTTTYQDVILGTRKTYAiyDLLD 220
Cdd:pfam04113 232 DMVTE--------QSWSLESLFGRPIKGACPLTDSSVPPVCL----IVPDSRNVY-VQGASGGAREAKNPDGSS--SVLR 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  221 TAMINNSRNLNIQLKWKRPPENEAPPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPVLLLDTVPWYLRLYVHTLTI 300
Cdd:pfam04113 297 CYDLDSDAEFDLKLPWQESTKEVPPEPPPLYAERSLTGHGQERGGIRIILTNPSPDEPVEFIYFESLPWFMRVYLHTLKV 376
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 296080714  301 TSKGKENKPSY-----IHYQPAQDRLQPHLLEMLIQLPANSVTKVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALvps 375
Cdd:pfam04113 377 TIDGQDPGSPSdfikeIYYRPAIDRKRPTQLELLLRLPPRSTVTLTYDFEKAILRYTEYPPDANRGFDVPPAVITVL--- 453
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 296080714  376 mvaakpvdweesplfnslfpvSDGSNYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTF 449
Cdd:pfam04113 454 ---------------------DESSSEDYSIRTTSLLLPLPTPDFSMPYNVIILTSTVMALAFGSLFNLLTRRF 506
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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