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Conserved domains on  [gi|297206823|ref|NP_001171908|]
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NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [Homo sapiens]

Protein Classification

Ndufs5 domain-containing protein( domain architecture ID 10562886)

Ndufs5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndufs5 pfam10200
NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 ...
 1-96 7.75e-66

NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.


:

Pssm-ID: 431131  Cd Length: 96  Bit Score: 193.13  E-value: 7.75e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297206823    1 MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIR 80
Cdd:pfam10200   1 MPFLDLQKRLGINLDRWLLIQSGEQPHKRAARCHAFEKEWIECAHGIGKTRAKKECKIEFEDFYECLLRQKTMKRLHAIR 80

                          90
                  ....*....|....*.
gi 297206823   81 KQRDKLIKEGKYTPPP 96
Cdd:pfam10200  81 KQREKLIKEGKYTPPP 96
 
Name Accession Description Interval E-value
Ndufs5 pfam10200
NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 ...
 1-96 7.75e-66

NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.


Pssm-ID: 431131  Cd Length: 96  Bit Score: 193.13  E-value: 7.75e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297206823    1 MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIR 80
Cdd:pfam10200   1 MPFLDLQKRLGINLDRWLLIQSGEQPHKRAARCHAFEKEWIECAHGIGKTRAKKECKIEFEDFYECLLRQKTMKRLHAIR 80

                          90
                  ....*....|....*.
gi 297206823   81 KQRDKLIKEGKYTPPP 96
Cdd:pfam10200  81 KQREKLIKEGKYTPPP 96
NDUFS5-like cd24141
mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase ...
 20-87 7.80e-24

mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I is a 45-subunit complex that functions in the transfer of electrons from NADH to the respiratory chain. It plays a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. Ndufs5 is a component of the iron-sulfur (IP) subcomplex and does not seem to be involved in catalysis.


Pssm-ID: 467941  Cd Length: 66  Bit Score: 86.18  E-value: 7.80e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 297206823  20 IQSGEQPYKMAGRCHAFEKEWIECAHGIGytRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLI 87
Cdd:cd24141    1 MASGFGPRGGPGRCFPFWQDFSECMSEAD--RAPKECKPEREDYLECLHHRKELARLKAIKKEREKQE 66
 
Name Accession Description Interval E-value
Ndufs5 pfam10200
NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 ...
 1-96 7.75e-66

NADH:ubiquinone oxidoreductase, NDUFS5-15kDa; This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain.


Pssm-ID: 431131  Cd Length: 96  Bit Score: 193.13  E-value: 7.75e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 297206823    1 MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEYDDFVECLLRQKTMRRAGTIR 80
Cdd:pfam10200   1 MPFLDLQKRLGINLDRWLLIQSGEQPHKRAARCHAFEKEWIECAHGIGKTRAKKECKIEFEDFYECLLRQKTMKRLHAIR 80

                          90
                  ....*....|....*.
gi 297206823   81 KQRDKLIKEGKYTPPP 96
Cdd:pfam10200  81 KQREKLIKEGKYTPPP 96
NDUFS5-like cd24141
mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase ...
 20-87 7.80e-24

mitochondrial complex I subunit NDUFS5 and similar proteins; Ndufs5 (NADH dehydrogenase [ubiquinone] iron-sulfur protein 5) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Complex I is a 45-subunit complex that functions in the transfer of electrons from NADH to the respiratory chain. It plays a key role in cellular energy metabolism, generating a major portion of the proton motive force that drives aerobic ATP synthesis. Ndufs5 is a component of the iron-sulfur (IP) subcomplex and does not seem to be involved in catalysis.


Pssm-ID: 467941  Cd Length: 66  Bit Score: 86.18  E-value: 7.80e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 297206823  20 IQSGEQPYKMAGRCHAFEKEWIECAHGIGytRAEKECKIEYDDFVECLLRQKTMRRAGTIRKQRDKLI 87
Cdd:cd24141    1 MASGFGPRGGPGRCFPFWQDFSECMSEAD--RAPKECKPEREDYLECLHHRKELARLKAIKKEREKQE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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