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Conserved domains on  [gi|298231518|ref|NP_001177231|]
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novel KRAB box and zinc finger, C2H2 type domain containing protein isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 9.90e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 9.90e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 298231518    3 LVTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-543 8.37e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 8.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 129 KPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKRTHTGEKPYECNQCGKAFVSSGDLQKHK 206
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 207 RTHTGEkPYECKQCGKAFSQSSHLRIHK----RTHTGEKPYEWNQcGKAFARSGDLQKHKRTHTGEKPyeckqcgKAFAH 282
Cdd:COG5048  112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSLS-------KDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 283 SSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCG- 361
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 362 -----KAFSQSRHLRIHKRTHTG-EKPYECNQCGKAFARSGDQQEHKRT--HTGE--KPYEC--NQCGKAFIRRRVLQIH 429
Cdd:COG5048  263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 430 KRTHTGEKSYECKQC------GKAFAGSSHLRIHKR-THTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKSYECK-- 498
Cdd:COG5048  343 ILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 298231518 499 QCGKAFASSSDLQKHKRTHSGEKPYECKQCGKAFAQSSHLRIHKQ 543
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 9.90e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 9.90e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 298231518    3 LVTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 7.37e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.55  E-value: 7.37e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 298231518     4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-543 8.37e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 8.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 129 KPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKRTHTGEKPYECNQCGKAFVSSGDLQKHK 206
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 207 RTHTGEkPYECKQCGKAFSQSSHLRIHK----RTHTGEKPYEWNQcGKAFARSGDLQKHKRTHTGEKPyeckqcgKAFAH 282
Cdd:COG5048  112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSLS-------KDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 283 SSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCG- 361
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 362 -----KAFSQSRHLRIHKRTHTG-EKPYECNQCGKAFARSGDQQEHKRT--HTGE--KPYEC--NQCGKAFIRRRVLQIH 429
Cdd:COG5048  263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 430 KRTHTGEKSYECKQC------GKAFAGSSHLRIHKR-THTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKSYECK-- 498
Cdd:COG5048  343 ILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 298231518 499 QCGKAFASSSDLQKHKRTHSGEKPYECKQCGKAFAQSSHLRIHKQ 543
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.26e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.96  E-value: 1.26e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 298231518   4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 2.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 298231518  257 DLQKHKRTHTGEKPYECKQCGKAFAH 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 9.90e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 9.90e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 298231518    3 LVTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 7.37e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.55  E-value: 7.37e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 298231518     4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-543 8.37e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 8.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 129 KPYDCKQCGKAFARSCHLRIHNRTHAGEKQYECNQ--CGKAFKRRSDLQIHKRTHTGEKPYECNQCGKAFVSSGDLQKHK 206
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 207 RTHTGEkPYECKQCGKAFSQSSHLRIHK----RTHTGEKPYEWNQcGKAFARSGDLQKHKRTHTGEKPyeckqcgKAFAH 282
Cdd:COG5048  112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSLS-------KDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 283 SSHLHIHERRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCG- 361
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPr 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 362 -----KAFSQSRHLRIHKRTHTG-EKPYECNQCGKAFARSGDQQEHKRT--HTGE--KPYEC--NQCGKAFIRRRVLQIH 429
Cdd:COG5048  263 sslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 430 KRTHTGEKSYECKQC------GKAFAGSSHLRIHKR-THTGEKPYEC--NQCGKAFITRRVLQIHKRTHTGEKSYECK-- 498
Cdd:COG5048  343 ILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYkDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 298231518 499 QCGKAFASSSDLQKHKRTHSGEKPYECKQCGKAFAQSSHLRIHKQ 543
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.26e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 67.96  E-value: 1.26e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 298231518   4 VTYDDVQVNFTRDEWALLDPSQKSLYKGVMLETYRNLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-554 1.28e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 197 VSSGDLQKHKRTHTGE----KPYECKQCGKAFSQSSHLRIHKRTHTGEKPYEWNQ--CGKAFARSGDLQKHKRTHTGEKP 270
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 271 YECKQCGK--AFAHSSHLHIHErRHTGDKPYECKQCGKAFAVFYTLQMHKRTHTGDKPYECKQCGKAF------------ 336
Cdd:COG5048   92 DLNSKSLPlsNSKASSSSLSSS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpp 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 337 ----------TVIYTLQMHKQTHTGEKPYECKQCGKAFSQSRHLRIHKRTHTGEKPYECNQCGKAFARSGDQQEHKRT-- 404
Cdd:COG5048  171 lpanslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLss 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 405 ----HTGEKPYECNQCGKAFIRRRVLQIHKRTHTG-EKSYECKQCGKAFAGSSHLRIHKRT--HTGE--KPYEC--NQCG 473
Cdd:COG5048  251 sdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCG 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 474 KAFITRRVLQIHKRTHTGEKSYECK--QCGKAFASSSDLQKHKRTH-----SGEKPYEC--KQCGKAFAQSSHLRIHKQT 544
Cdd:COG5048  331 KLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIIT 410

                        410
                 ....*....|
gi 298231518 545 HTGERPYECN 554
Cdd:COG5048  411 HLSFRPYNCK 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 2.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 298231518  257 DLQKHKRTHTGEKPYECKQCGKAFAH 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 2.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 298231518  201 DLQKHKRTHTGEKPYECKQCGKAFSQ 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-394 5.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.54e-04
                          10        20
                  ....*....|....*....|....*.
gi 298231518  369 HLRIHKRTHTGEKPYECNQCGKAFAR 394
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-534 5.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 298231518  509 DLQKHKRTHSGEKPYECKQCGKAFAQ 534
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-478 9.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 298231518  453 HLRIHKRTHTGEKPYECNQCGKAFIT 478
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-337 1.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....
gi 298231518  314 LQMHKRTHTGDKPYECKQCGKAFT 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 1.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 298231518  173 DLQIHKRTHTGEKPYECNQCGKAFVS 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-366 1.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|....*
gi 298231518  342 LQMHKQTHTGEKPYECKQCGKAFSQ 366
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-234 2.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518  79 QCGKAFAYESGRQRHQ--IKHNGE--KHHDC--NQCGKDFRTWNVLQIHKRTHTGEKPYDCKQC------GKAFARSCHL 146
Cdd:COG5048  294 QCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQ 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298231518 147 RIHNRTHA-GEKQYEC--NQCGKAFKRRSDLQIHKRTHTGEKPYECN--QCGKAFVSSGDLQKHKRTHTGEKPYECKQCG 221
Cdd:COG5048  374 SLQQYKDLkNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK 453

                        170
                 ....*....|...
gi 298231518 222 KAFSQSSHLRIHK 234
Cdd:COG5048  454 SFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-142 2.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.67e-03
                          10        20
                  ....*....|....*....|....*
gi 298231518  118 LQIHKRTHTGEKPYDCKQCGKAFAR 142
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
399-422 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....
gi 298231518  399 QEHKRTHTGEKPYECNQCGKAFIR 422
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-506 3.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.99e-03
                          10        20
                  ....*....|....*....|....*
gi 298231518  482 LQIHKRTHTGEKSYECKQCGKAFAS 506
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-449 6.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.72e-03
                          10        20
                  ....*....|....*....|....
gi 298231518  426 LQIHKRTHTGEKSYECKQCGKAFA 449
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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