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Conserved domains on  [gi|299473781|ref|NP_001177398|]
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glial cell line-derived neurotrophic factor isoform 4 precursor [Homo sapiens]

Protein Classification

TGF-beta family protein( domain architecture ID 14443712)

transforming growth factor-beta (TGF-beta) family protein may control proliferation, differentiation, and other functions in many cell types

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 106-201 6.09e-59

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


:

Pssm-ID: 381650  Cd Length: 96  Bit Score: 180.04  E-value: 6.09e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 106 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDN 185
Cdd:cd19380    1 NRGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTRNKKLVSDKVGQACCRPIAFDDDLSFLDDN 80

                         90
                 ....*....|....*.
gi 299473781 186 LVYHILRKHSAKRCGC 201
Cdd:cd19380   81 LVYHTLKKHSAKKCGC 96
 
Name Accession Description Interval E-value
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 106-201 6.09e-59

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 180.04  E-value: 6.09e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 106 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDN 185
Cdd:cd19380    1 NRGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTRNKKLVSDKVGQACCRPIAFDDDLSFLDDN 80

                         90
                 ....*....|....*.
gi 299473781 186 LVYHILRKHSAKRCGC 201
Cdd:cd19380   81 LVYHTLKKHSAKKCGC 96
TGF_beta pfam00019
Transforming growth factor beta like domain;
108-201 7.21e-10

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 53.87  E-value: 7.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781  108 GCVLTAIHLNVTDLGLG--YETKEELIFRYCSGSC------DAAETTYDKIlknLSRNRRLVSDKVGQACCRPIAFDDDL 179
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCpshlnpQLSATNHAIL---QSLLHSLKPANVPKPCCVPTKLSPLS 77

                          90       100
                  ....*....|....*....|....*
gi 299473781  180 ---SFLDDNLVYHILRKHSAKRCGC 201
Cdd:pfam00019  78 vlyYDDEGNVVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 106-201 6.09e-59

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 180.04  E-value: 6.09e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 106 NRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDN 185
Cdd:cd19380    1 NRGCVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLTRNKKLVSDKVGQACCRPIAFDDDLSFLDDN 80

                         90
                 ....*....|....*.
gi 299473781 186 LVYHILRKHSAKRCGC 201
Cdd:cd19380   81 LVYHTLKKHSAKKCGC 96
TGF_beta_GDNF_like cd13750
transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived ...
 108-201 2.53e-43

transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived neurotrophic factor (GDNF) family of ligands; GDNF family of ligands includes GDNF, Artemin, Neurturin, and Persephin. They plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.


Pssm-ID: 381628  Cd Length: 95  Bit Score: 140.28  E-value: 2.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 108 GCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSD-KVGQACCRPIAFDDDLSFLDDNL 186
Cdd:cd13750    1 GCVLRELHLRVTDLGLGYASEEEVIFRYCAGSCEAARTNYDLILANLRGWRRLRSDrKVGQPCCRPTAYDDDVSFLDDNS 80

                         90
                 ....*....|....*
gi 299473781 187 VYHILRKHSAKRCGC 201
Cdd:cd13750   81 RYHILRKLSAKACGC 95
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 107-202 8.76e-25

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 93.22  E-value: 8.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 107 RGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQA----CCRPIAFDDDLSFL 182
Cdd:cd19383    5 KPCSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGKKSLKKGRKDKVrarpCCRPTAYEDDVSFL 84

                         90       100
                 ....*....|....*....|
gi 299473781 183 DDNLVYHILRKHSAKRCGCI 202
Cdd:cd19383   85 DNNNRYHTIQELSAKECGCV 104
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 108-202 2.67e-20

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 81.25  E-value: 2.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 108 GCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDK----VGQACCRPIAFDDDLSFLD 183
Cdd:cd19381    1 GCRLRSLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSLLKQGAIPPGPhervSSQPCCRPTRYENVSFMDV 80

                         90
                 ....*....|....*....
gi 299473781 184 DNlVYHILRKHSAKRCGCI 202
Cdd:cd19381   81 QN-VWQTVEKLSAAECSCV 98
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 107-202 1.46e-16

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 71.73  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 107 RGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNL---SRNRRLVSDKVGQACCRPiAFDDDLSFLD 183
Cdd:cd19382    1 RPCRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPRARTNHDLTLSRLlqkGDLPSLGEKIFGGPCCRP-THYEDVAFLD 79

                         90
                 ....*....|....*....
gi 299473781 184 DNLVYHILRKHSAKRCGCI 202
Cdd:cd19382   80 DNHRWHTVEKLSAAACACV 98
TGF_beta pfam00019
Transforming growth factor beta like domain;
108-201 7.21e-10

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 53.87  E-value: 7.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781  108 GCVLTAIHLNVTDLGLG--YETKEELIFRYCSGSC------DAAETTYDKIlknLSRNRRLVSDKVGQACCRPIAFDDDL 179
Cdd:pfam00019   1 ECRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCpshlnpQLSATNHAIL---QSLLHSLKPANVPKPCCVPTKLSPLS 77

                          90       100
                  ....*....|....*....|....*
gi 299473781  180 ---SFLDDNLVYHILRKHSAKRCGC 201
Cdd:pfam00019  78 vlyYDDEGNVVLKTYPDMVVESCGC 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 109-201 2.68e-09

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 52.48  E-value: 2.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299473781 109 CVLTAIHLNVTDLGLGYETK--EELIFRYCSGSCDAAETTYDKILKNL--SRNRRLVSDKVGQACCRPIAFDDDL--SFL 182
Cdd:cd08698    1 CCKQPLYVNFKDLGGLNWIIapSGFTANYCRGSCNSESSATTNHTKLLqwSRTRRHTPREELKPCCVPTSYEPLSilYYD 80

                         90       100
                 ....*....|....*....|
gi 299473781 183 DDNLVYH-ILRKHSAKRCGC 201
Cdd:cd08698   81 NNGTVVEtLLPNLIVTECGC 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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