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Conserved domains on  [gi|329755343|ref|NP_001178379|]
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slit homolog 3 protein precursor [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1140-1266 5.31e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.37  E-value: 5.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  1140 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKL 1217
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 329755343  1218 QKQPAVSINSPLYLGGIPTSTGLSALRQGMdrplgGFHGCIHEVRINNE 1266
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRA-----GFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
487-852 1.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  487 TDLRLNDNEISVLEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQletahgrAFRGLSGLKTLMLRS 566
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  567 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 646
Cdd:COG4886   123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  647 fLKEIPiqdvaiqdftcdgndesscqlgprcpeqctcvetvvrcsnRGLRALPKgipkdVTELYLEGNHLTAVPKELSSF 726
Cdd:COG4886   171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  727 RHLTLIDLSNNSIGMLTNyTFSNMSHLSTLILSYNRLRCIPvhSFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 806
Cdd:COG4886   205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 329755343  807 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 852
Cdd:COG4886   280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-324 8.83e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 8.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   66 LRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGiprkafrGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNI 145
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  146 SRIlVTSFNHMPKIRTLRLHSNHLYCdchlawLSDWLrqrrtvGPFTlcmapvHLRGFNVadvqkkeyvcsgphseppac 225
Cdd:COG4886   149 TDL-PEPLGNLTNLKSLDLSNNQLTD------LPEEL------GNLT------NLKELDL-------------------- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  226 nansiscpsactcSNNivdcrgkGLTEIPANL--PEGIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIApdAF 303
Cdd:COG4886   190 -------------SNN-------QITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--EL 246

                         250       260
                  ....*....|....*....|.
gi 329755343  304 QGLKSLTSLVLYGNKITEIPK 324
Cdd:COG4886   247 GNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-411 1.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  242 IVDCRGKGLTEIPANLPE--GIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 319
Cdd:COG4886   117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  320 TEIPKGLFDglvslqllLLNANKINClrvntfqdlqslsllslYDNKLQTISKGLfAPLQAIQTLHLAQN-----PFVCD 394
Cdd:COG4886   195 TDLPEPLGN--------LTNLEELDL-----------------SGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                         170
                  ....*....|....*...
gi 329755343  395 C-HLRWLadYLQDNPIET 411
Cdd:COG4886   249 LtNLEEL--DLSNNQLTD 264
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1062 1.49e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 329755343 1026 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFSGLHCE 1062
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 950-983 5.60e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.60e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 329755343  950 DDCED-NDCENNATCVDGVNNYVCVCPPNYTGELC 983
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1024 5.72e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 329755343  987 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYSGKLCE 1024
Cdd:cd00054     2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 914-946 4.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.32e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 329755343  914 NPCLHGGTCHLSEthkGGFSCSCPLGFEGQRCE 946
Cdd:cd00054     9 NPCQNGGTCVNTV---GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1075-1105 4.65e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.65e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 329755343  1075 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1105
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 9.37e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 9.37e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 329755343     33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 677-703 9.89e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 9.89e-05
                           10        20
                   ....*....|....*....|....*..
gi 329755343   677 CPEQCTCVETVVRCSNRGLRALPKGIP 703
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
457-487 1.18e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 329755343    457 CPDRCRCEGTIVDCSNQKLARIPSHLPEYVT 487
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1418-1471 5.27e-03

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 37.38  E-value: 5.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 329755343   1418 SCATASKIPVMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEELERHLECGC 1471
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGC 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-905 6.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 329755343  870 DPCLS-SPCKNNGTCsQDPVEGHRCACSHGYKGRDCT 905
Cdd:cd00054     3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1140-1266 5.31e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.37  E-value: 5.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  1140 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKL 1217
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 329755343  1218 QKQPAVSINSPLYLGGIPTSTGLSALRQGMdrplgGFHGCIHEVRINNE 1266
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRA-----GFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1111-1264 4.01e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 4.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343 1111 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1186
Cdd:cd00110     1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 329755343 1187 DGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVSINSPLYLGGIPTStglsaLRQGMDRPLGGFHGCIHEVRIN 1264
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPED-----LKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1133-1266 4.83e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.98  E-value: 4.83e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   1133 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKG 1209
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 329755343   1210 APKSLGKLQKQPAVSINSPLYLGGIPTSTGLSALRQGmdrplGGFHGCIHEVRINNE 1266
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
487-852 1.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  487 TDLRLNDNEISVLEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQletahgrAFRGLSGLKTLMLRS 566
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  567 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 646
Cdd:COG4886   123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  647 fLKEIPiqdvaiqdftcdgndesscqlgprcpeqctcvetvvrcsnRGLRALPKgipkdVTELYLEGNHLTAVPKELSSF 726
Cdd:COG4886   171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  727 RHLTLIDLSNNSIGMLTNyTFSNMSHLSTLILSYNRLRCIPvhSFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 806
Cdd:COG4886   205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 329755343  807 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 852
Cdd:COG4886   280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-324 8.83e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 8.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   66 LRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGiprkafrGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNI 145
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  146 SRIlVTSFNHMPKIRTLRLHSNHLYCdchlawLSDWLrqrrtvGPFTlcmapvHLRGFNVadvqkkeyvcsgphseppac 225
Cdd:COG4886   149 TDL-PEPLGNLTNLKSLDLSNNQLTD------LPEEL------GNLT------NLKELDL-------------------- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  226 nansiscpsactcSNNivdcrgkGLTEIPANL--PEGIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIApdAF 303
Cdd:COG4886   190 -------------SNN-------QITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--EL 246

                         250       260
                  ....*....|....*....|.
gi 329755343  304 QGLKSLTSLVLYGNKITEIPK 324
Cdd:COG4886   247 GNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
278-618 1.18e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  278 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIPKGLFdglvslqllllNANKINCLRVntfqdlqsl 357
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-----------NLTNLKSLDL--------- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  358 sllslYDNKLQTISKGLfAPLQaiqtlhlaqnpfvcdcHLRWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 437
Cdd:COG4886   167 -----SNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  438 sgsedyrsrfssecfmdlvcpdrcrcegTIVDCSNQKLARIPSHLPEY--VTDLRLNDNEISVLEAtgiFKKLPNLRKIN 515
Cdd:COG4886   208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  516 LSNNRIKEVKEGAfdGAASVQELVLTGNQLETAHGRAFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITT 595
Cdd:COG4886   257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         330       340
                  ....*....|....*....|...
gi 329755343  596 ITPGAFTTLVSLSTINLLSNPFN 618
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-411 1.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  242 IVDCRGKGLTEIPANLPE--GIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 319
Cdd:COG4886   117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  320 TEIPKGLFDglvslqllLLNANKINClrvntfqdlqslsllslYDNKLQTISKGLfAPLQAIQTLHLAQN-----PFVCD 394
Cdd:COG4886   195 TDLPEPLGN--------LTNLEELDL-----------------SGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                         170
                  ....*....|....*...
gi 329755343  395 C-HLRWLadYLQDNPIET 411
Cdd:COG4886   249 LtNLEEL--DLSNNQLTD 264
LRR_8 pfam13855
Leucine rich repeat;
727-787 1.54e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.54e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329755343   727 RHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDI 787
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
263-319 2.05e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.05e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 329755343   263 EIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 319
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 588-666 2.81e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 2.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   588 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 664
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 329755343   665 GN 666
Cdd:TIGR00864   82 EE 83
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
474-742 6.69e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 6.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  474 KLARIPSHLPEYVTDLRLNDNEIsvleatgifKKLP-----NLRKINLSNNRIKEVKEGAFDgaaSVQELVLTGNQLETA 548
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  549 HGRAfrgLSGLKTLMLRSNLISCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 628
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  629 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgndesscqlgprCPEQCTCVETVVRCSNRGLRALPKGIPKDVTE 708
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 329755343  709 LYLEGNHLTAVPKELSSfrHLTLIDLSNNSIGML 742
Cdd:PRK15370  372 LDVSRNALTNLPENLPA--ALQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 686-812 1.40e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  686 TVVRCSNRGLRALPK-GIPKDVTELYLEGNHLTAVPKeLSSFRHLTLIDLSNNSIGMLTNytFSNMSHLSTLILSYNRLR 764
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 329755343  765 CI-------------------P--------VHSFNGL-RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPLH 812
Cdd:cd21340    82 VVeglenltnleelhienqrlPpgekltfdPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-315 1.94e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   50 LGLRAVPRGIPRNAERLRLNKNKLQVLPELLfQSNLK--------LTRL-----------DLSENQILGIPRkafRGIAD 110
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPENL-QGNIKtlyansnqLTSIpatlpdtiqemELSINRITELPE---RLPSA 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  111 VKNLQLDNNHISCIEDGAFRALRDLEILtlnNNNISrilvTSFNHMPK-IRTLRLHSNHLycdchlawlsdwlrqrrTVG 189
Cdd:PRK15370  264 LQSLDLFHNKISCLPENLPEELRYLSVY---DNSIR----TLPAHLPSgITHLNVQSNSL-----------------TAL 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  190 PFTLcmaPVHLRGFNVADvqkkEYVCSGPHSEPPACNANSIS------CPSACTCSNNIVDCRGKGLTEIPANLPEGIVE 263
Cdd:PRK15370  320 PETL---PPGLKTLEAGE----NALTSLPASLPPELQVLDVSknqitvLPETLPPTITTLDVSRNALTNLPENLPAALQI 392

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 329755343  264 IRLEQNSIKSIPAGA---FTQYKKLKRIDISKNQISDiapDAFQGLKSLTSLVLY 315
Cdd:PRK15370  393 MQASRNNLVRLPESLphfRGEGPQPTRIIVEYNPFSE---RTIQNMQRLMSSVGY 444
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1062 1.49e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 329755343 1026 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFSGLHCE 1062
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
809-858 4.32e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 4.32e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 329755343    809 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 858
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
EGF_CA smart00179
Calcium-binding EGF-like domain;
1026-1062 2.98e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.98e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 329755343   1026 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFS-GLHCE 1062
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 950-983 5.60e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.60e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 329755343  950 DDCED-NDCENNATCVDGVNNYVCVCPPNYTGELC 983
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1024 5.72e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 329755343  987 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYSGKLCE 1024
Cdd:cd00054     2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 140-202 2.07e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 2.07e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 329755343   140 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGP-FTLCMAPVHLRG 202
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQPeAALCAGPGALAG 67
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-172 2.42e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   49 GLGLRAVPRGIPRNAERLR---LNKNKLQVLP----ELLFQSNLKLTRLDLSENQIL--GIPRKAfRGIADVKNLQ---L 116
Cdd:cd00116   122 DRGLRLLAKGLKDLPPALEklvLGRNRLEGAScealAKALRANRDLKELNLANNGIGdaGIRALA-EGLKANCNLEvldL 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 329755343  117 DNNHISCIED----GAFRALRDLEILTLNNNNIS----RILVTSFNHM-PKIRTLRLHSNHLYCD 172
Cdd:cd00116   201 NNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTdagaAALASALLSPnISLLTLSLSCNDITDD 265
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 914-946 4.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.32e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 329755343  914 NPCLHGGTCHLSEthkGGFSCSCPLGFEGQRCE 946
Cdd:cd00054     9 NPCQNGGTCVNTV---GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1030-1060 4.43e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.43e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 329755343  1030 CAAHRCRHGAQCVDAVNGYTCICPQGFSGLH 1060
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1075-1105 4.65e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.65e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 329755343  1075 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1105
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 364-425 7.80e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.77  E-value: 7.80e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 329755343   364 DNKLQTISKGLFAPLQAIQTLHLAQNPFVCDCHLRWLADYLQDNPIET---SGARCSSPRRLANK 425
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 9.37e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 9.37e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 329755343     33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 952-981 9.81e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 9.81e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 329755343   952 CEDNDCENNATCVDGVNNYVCVCPPNYTGE 981
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 677-703 9.89e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 9.89e-05
                           10        20
                   ....*....|....*....|....*..
gi 329755343   677 CPEQCTCVETVVRCSNRGLRALPKGIP 703
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.06e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 1.06e-04
                           10        20
                   ....*....|....*....|....*...
gi 329755343    33 ACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
987-1024 1.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 329755343    987 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYS-GKLCE 1024
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
950-979 1.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.65e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 329755343    950 DDCE-DNDCENNATCVDGVNNYVCVCPPNYT 979
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-618 3.91e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   86 KLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHISC-IEDGAFRALRDLEILTLNNNNISRILVTSFnhMPKIRTLRL 164
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  165 HSNHLYCDCHLawlsdwlrqrrTVGPFTlcmapvhlrGFNVADVQKKEYVcsgphSEPPACNANSISCPSACTCSNNIVD 244
Cdd:PLN00113  148 SNNMLSGEIPN-----------DIGSFS---------SLKVLDLGGNVLV-----GKIPNSLTNLTSLEFLTLASNQLVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  245 crgkgltEIPANLPE--GIVEIRLEQNSIK-SIPAgAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT- 320
Cdd:PLN00113  203 -------QIPRELGQmkSLKWIYLGYNNLSgEIPY-EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSg 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  321 EIPKGLFdglvslqllllNANKINCLRVNtfqdlqslsllslyDNKLQTISKGLFAPLQAIQTLHLAQNPFVCdchlrwl 400
Cdd:PLN00113  275 PIPPSIF-----------SLQKLISLDLS--------------DNSLSGEIPELVIQLQNLEILHLFSNNFTG------- 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  401 adylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRfSSECFMDLVC-------PDRCRCEGTIVDC--- 470
Cdd:PLN00113  323 ---------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH-NNLTVLDLSTnnltgeiPEGLCSSGNLFKLilf 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  471 SNQKLARIPSHLP--EYVTDLRLNDNEISVlEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQLETA 548
Cdd:PLN00113  389 SNSLEGEIPKSLGacRSLRRVRLQDNSFSG-ELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG 467

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  549 HGRAFRGlSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 618
Cdd:PLN00113  468 LPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
LRRCT smart00082
Leucine rich repeat C-terminal domain;
389-419 4.66e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 4.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 329755343    389 NPFVCDCHLRWLADYLQDNPI--ETSGARCSSP 419
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
232-263 7.16e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 7.16e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 329755343    232 CPSACTCSNNIVDCRGKGLTEIPANLPEGIVE 263
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
457-487 1.18e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 329755343    457 CPDRCRCEGTIVDCSNQKLARIPSHLPEYVT 487
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 911-944 3.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.47e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 329755343   911 CIQNPCLHGGTCHlseTHKGGFSCSCPLGFEGQR 944
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 997-1021 3.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.47e-03
                           10        20
                   ....*....|....*....|....*
gi 329755343   997 CQHEAKCISLDRGFRCECPPGYSGK 1021
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGK 30
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1418-1471 5.27e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 37.38  E-value: 5.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 329755343   1418 SCATASKIPVMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEELERHLECGC 1471
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGC 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-905 6.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 329755343  870 DPCLS-SPCKNNGTCsQDPVEGHRCACSHGYKGRDCT 905
Cdd:cd00054     3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 872-903 7.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 329755343   872 CLSSPCKNNGTCSQDPvEGHRCACSHGYKGRD 903
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
914-946 8.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 8.47e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 329755343    914 NPCLHGGTCHLSEthkGGFSCSCPLGFE-GQRCE 946
Cdd:smart00179    9 NPCQNGGTCVNTV---GSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1140-1266 5.31e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.37  E-value: 5.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  1140 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKL 1217
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 329755343  1218 QKQPAVSINSPLYLGGIPTSTGLSALRQGMdrplgGFHGCIHEVRINNE 1266
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRA-----GFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1111-1264 4.01e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 4.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343 1111 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1186
Cdd:cd00110     1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 329755343 1187 DGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVSINSPLYLGGIPTStglsaLRQGMDRPLGGFHGCIHEVRIN 1264
Cdd:cd00110    79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPED-----LKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1133-1266 4.83e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.98  E-value: 4.83e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   1133 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKG 1209
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 329755343   1210 APKSLGKLQKQPAVSINSPLYLGGIPTSTGLSALRQGmdrplGGFHGCIHEVRINNE 1266
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
487-852 1.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  487 TDLRLNDNEISVLEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQletahgrAFRGLSGLKTLMLRS 566
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  567 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 646
Cdd:COG4886   123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  647 fLKEIPiqdvaiqdftcdgndesscqlgprcpeqctcvetvvrcsnRGLRALPKgipkdVTELYLEGNHLTAVPKELSSF 726
Cdd:COG4886   171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  727 RHLTLIDLSNNSIGMLTNyTFSNMSHLSTLILSYNRLRCIPvhSFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 806
Cdd:COG4886   205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 329755343  807 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 852
Cdd:COG4886   280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
585-811 9.90e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 9.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  585 LLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQkpfFLKEIPIQDVAIQDFTCD 664
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDL---LLSSLLLLLSLLLLLLLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  665 GNDESSCQLGPRCPEQCTCVETVVRCSNRGLRALpkgipKDVTELYLEGNHLTAVPKELSSFRHLTLIDLSNNSIGMLTN 744
Cdd:COG4886    79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 329755343  745 yTFSNMSHLSTLILSYNRLRCIPvHSFNGLRSLRVLTLHGNDISSVPEgSFNDLTSLSHLALGTNPL 811
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
466-617 1.48e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  466 TIVDCSNQKLARIPSHLPE--YVTDLRLNDNEISVLEATgiFKKLPNLRKINLSNNRIKEVKEgAFDGAASVQELVLTGN 543
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 329755343  544 QLETAHGrAFRGLSGLKTLMLRSNLISCVSnDTFAGLSSVRLLSLYDNRITTITpgAFTTLVSLSTINLLSNPF 617
Cdd:COG4886   193 QITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
Laminin_G_1 pfam00054
Laminin G domain;
1138-1269 8.83e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 8.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  1138 VATDKDNGILLYKGDNDP---LALELYQGHVRLVYDsLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAP--- 1211
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARptg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 329755343  1212 -KSLGKLQKqpaVSINSPLYLGGIPtSTGLSALRQGMDRplgGFHGCIHEVRINNELQD 1269
Cdd:pfam00054   80 eSPLGATTD---LDVDGPLYVGGLP-SLGVKKRRLAISP---SFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-324 8.83e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 8.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   66 LRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGiprkafrGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNI 145
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  146 SRIlVTSFNHMPKIRTLRLHSNHLYCdchlawLSDWLrqrrtvGPFTlcmapvHLRGFNVadvqkkeyvcsgphseppac 225
Cdd:COG4886   149 TDL-PEPLGNLTNLKSLDLSNNQLTD------LPEEL------GNLT------NLKELDL-------------------- 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  226 nansiscpsactcSNNivdcrgkGLTEIPANL--PEGIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIApdAF 303
Cdd:COG4886   190 -------------SNN-------QITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--EL 246

                         250       260
                  ....*....|....*....|.
gi 329755343  304 QGLKSLTSLVLYGNKITEIPK 324
Cdd:COG4886   247 GNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
278-618 1.18e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  278 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIPKGLFdglvslqllllNANKINCLRVntfqdlqsl 357
Cdd:COG4886   108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-----------NLTNLKSLDL--------- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  358 sllslYDNKLQTISKGLfAPLQaiqtlhlaqnpfvcdcHLRWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 437
Cdd:COG4886   167 -----SNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  438 sgsedyrsrfssecfmdlvcpdrcrcegTIVDCSNQKLARIPSHLPEY--VTDLRLNDNEISVLEAtgiFKKLPNLRKIN 515
Cdd:COG4886   208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  516 LSNNRIKEVKEGAfdGAASVQELVLTGNQLETAHGRAFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITT 595
Cdd:COG4886   257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         330       340
                  ....*....|....*....|...
gi 329755343  596 ITPGAFTTLVSLSTINLLSNPFN 618
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-411 1.20e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  242 IVDCRGKGLTEIPANLPE--GIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 319
Cdd:COG4886   117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  320 TEIPKGLFDglvslqllLLNANKINClrvntfqdlqslsllslYDNKLQTISKGLfAPLQAIQTLHLAQN-----PFVCD 394
Cdd:COG4886   195 TDLPEPLGN--------LTNLEELDL-----------------SGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                         170
                  ....*....|....*...
gi 329755343  395 C-HLRWLadYLQDNPIET 411
Cdd:COG4886   249 LtNLEEL--DLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-402 1.61e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   62 NAERLRLNKNKLQVLPELLfqSNLK-LTRLDLSENQILGIPRkafrGIADVKNLQ---LDNNHISCIeDGAFRALRDLEI 137
Cdd:COG4886   114 NLESLDLSGNQLTDLPEEL--ANLTnLKELDLSNNQLTDLPE----PLGNLTNLKsldLSNNQLTDL-PEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  138 LTLNNNNISRILvTSFNHMPKIRTLRLHSNHLycdchlawlsdwlrqrrtvgpftlcmapvhlrgfnvadvqkkeyvcsg 217
Cdd:COG4886   187 LDLSNNQITDLP-EPLGNLTNLEELDLSGNQL------------------------------------------------ 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  218 phseppacnaNSISCPSAcTCSN-NIVDCRGKGLTEIP--ANLPEgIVEIRLEQNSIKSIPAGAftQYKKLKRIDISKNQ 294
Cdd:COG4886   218 ----------TDLPEPLA-NLTNlETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQ 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  295 ISDIAPDAFQGLKSLTSLVLYGNKITEIPkgLFDGLVSLQLLLLNANKINCLRVNTFQDLQSLSLLSLYDNKLQTISKGL 374
Cdd:COG4886   284 LTDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                         330       340
                  ....*....|....*....|....*...
gi 329755343  375 FAPLQAIQTLHLAQNPFVCDCHLRWLAD 402
Cdd:COG4886   362 LLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
253-617 3.39e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.59  E-value: 3.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  253 IPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNqisdiapDAFQGLKSLTSLVLYGNKITEIPKGLfdglvs 332
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL------ 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  333 lqllllnankinclrvntfqdlqslsllslydnklqtiskglfAPLQAIQTLHLAQNpfvcdchlrwladylqdnpiets 412
Cdd:COG4886   133 -------------------------------------------ANLTNLKELDLSNN----------------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  413 garcssprrlankRISQIKSkkfrcsgsedyrsrfssecfmdlvcpdrcrcegTIVDCSNqklaripshlpeyVTDLRLN 492
Cdd:COG4886   147 -------------QLTDLPE---------------------------------PLGNLTN-------------LKSLDLS 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  493 DNEISVLEATgiFKKLPNLRKINLSNNRIKEVKEgAFDGAASVQELVLTGNQLETAhGRAFRGLSGLKTLMLRSNLISCV 572
Cdd:COG4886   168 NNQLTDLPEE--LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL 243

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 329755343  573 SNdtFAGLSSVRLLSLYDNRITTITPGAftTLVSLSTINLLSNPF 617
Cdd:COG4886   244 PE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-169 7.05e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 7.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   44 SVDCHGLGLRAVPRGIPR--NAERLRLNKNKLQVLPELLfqSNLK-LTRLDLSENQILGIPrKAFRGIADVKNLQLDNNH 120
Cdd:COG4886   117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPL--GNLTnLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQ 193

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 329755343  121 ISCIEDgAFRALRDLEILTLNNNNISRiLVTSFNHMPKIRTLRLHSNHL 169
Cdd:COG4886   194 ITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
727-787 1.54e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.48  E-value: 1.54e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329755343   727 RHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDI 787
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-434 1.91e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   62 NAERLRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGIPRKAFRGIADVKNLQldnnHISCIEDGAFRALRDLEILTLN 141
Cdd:COG4886    46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----ELDLSGNEELSNLTNLESLDLS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  142 NNNISRiLVTSFNHMPKIRTLRLHSNHLYcDchlawLSDWLRQrrtvgpFTlcmapvHLRGFNvadvqkkeyvcsgphse 221
Cdd:COG4886   122 GNQLTD-LPEELANLTNLKELDLSNNQLT-D-----LPEPLGN------LT------NLKSLD----------------- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  222 ppacnansiscpsactCSNNivdcrgkGLTEIP---ANLPEgIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDI 298
Cdd:COG4886   166 ----------------LSNN-------QLTDLPeelGNLTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  299 aPDAFQGLKSLTSLVLYGNKITEIPkglfdglvslqlLLLNANKINCLRVNtfqdlqslsllslyDNKLQTISKglFAPL 378
Cdd:COG4886   221 -PEPLANLTNLETLDLSNNQLTDLP------------ELGNLTNLEELDLS--------------NNQLTDLPP--LANL 271

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 329755343  379 QAIQTLHLAQNPFVcDCHLRWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKK 434
Cdd:COG4886   272 TNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR_8 pfam13855
Leucine rich repeat;
534-593 2.93e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 2.93e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   534 SVQELVLTGNQLETAHGRAFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRI 593
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
263-319 2.05e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.05e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 329755343   263 EIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 319
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-169 2.13e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 2.13e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 329755343   111 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 169
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
557-617 4.79e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 4.79e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329755343   557 SGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPF 617
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
751-811 1.34e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 1.34e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329755343   751 SHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 811
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
486-545 2.38e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.38e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   486 VTDLRLNDNEISVLEAtGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQL 545
Cdd:pfam13855    3 LRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-145 2.78e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.78e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343    86 KLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 588-666 2.81e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 2.81e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   588 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 664
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 329755343   665 GN 666
Cdd:TIGR00864   82 EE 83
LRR_8 pfam13855
Leucine rich repeat;
61-121 3.53e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 3.53e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329755343    61 RNAERLRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHI 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
706-763 3.63e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 3.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 329755343   706 VTELYLEGNHLTAVPKE-LSSFRHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRL 763
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
474-742 6.69e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 6.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  474 KLARIPSHLPEYVTDLRLNDNEIsvleatgifKKLP-----NLRKINLSNNRIKEVKEGAFDgaaSVQELVLTGNQLETA 548
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  549 HGRAfrgLSGLKTLMLRSNLISCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 628
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  629 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgndesscqlgprCPEQCTCVETVVRCSNRGLRALPKGIPKDVTE 708
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 329755343  709 LYLEGNHLTAVPKELSSfrHLTLIDLSNNSIGML 742
Cdd:PRK15370  372 LDVSRNALTNLPENLPA--ALQIMQASRNNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
284-329 7.27e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 7.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 329755343   284 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDG 329
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
PLN03150 PLN03150
hypothetical protein; Provisional
 719-812 1.13e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.83  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  719 VPKELSSFRHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRLR-CIPvHSFNGLRSLRVLTLHGNDISS-VPEgsfn 796
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLSGrVPA---- 508

                          90
                  ....*....|....*.
gi 329755343  797 dltslshlALGTNPLH 812
Cdd:PLN03150  509 --------ALGGRLLH 516
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 782-857 1.28e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.10  E-value: 1.28e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 329755343   782 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQC 857
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 686-812 1.40e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  686 TVVRCSNRGLRALPK-GIPKDVTELYLEGNHLTAVPKeLSSFRHLTLIDLSNNSIGMLTNytFSNMSHLSTLILSYNRLR 764
Cdd:cd21340     5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 329755343  765 CI-------------------P--------VHSFNGL-RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPLH 812
Cdd:cd21340    82 VVeglenltnleelhienqrlPpgekltfdPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-315 1.94e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   50 LGLRAVPRGIPRNAERLRLNKNKLQVLPELLfQSNLK--------LTRL-----------DLSENQILGIPRkafRGIAD 110
Cdd:PRK15370  188 LGLTTIPACIPEQITTLILDNNELKSLPENL-QGNIKtlyansnqLTSIpatlpdtiqemELSINRITELPE---RLPSA 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  111 VKNLQLDNNHISCIEDGAFRALRDLEILtlnNNNISrilvTSFNHMPK-IRTLRLHSNHLycdchlawlsdwlrqrrTVG 189
Cdd:PRK15370  264 LQSLDLFHNKISCLPENLPEELRYLSVY---DNSIR----TLPAHLPSgITHLNVQSNSL-----------------TAL 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  190 PFTLcmaPVHLRGFNVADvqkkEYVCSGPHSEPPACNANSIS------CPSACTCSNNIVDCRGKGLTEIPANLPEGIVE 263
Cdd:PRK15370  320 PETL---PPGLKTLEAGE----NALTSLPASLPPELQVLDVSknqitvLPETLPPTITTLDVSRNALTNLPENLPAALQI 392

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 329755343  264 IRLEQNSIKSIPAGA---FTQYKKLKRIDISKNQISDiapDAFQGLKSLTSLVLY 315
Cdd:PRK15370  393 MQASRNNLVRLPESLphfRGEGPQPTRIIVEYNPFSE---RTIQNMQRLMSSVGY 444
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 486-811 4.36e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  486 VTDLRLNDNEISVLEATGIFKkLPNLRKINLSNNRIK-EVKEGAFDGAASVQELVLTGNQLETAHGRAFrgLSGLKTLML 564
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  565 RSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNC----------NCHLAWLG------- 627
Cdd:PLN00113  148 SNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqiprelgqmkSLKWIYLGynnlsge 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  628 --------KWLRKRRIVSGNPRCQKP-----------FFLKE------IPIQDVAIQDF-TCDGNDESscqLGPRCPE-- 679
Cdd:PLN00113  228 ipyeigglTSLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLiSLDLSDNS---LSGEIPElv 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  680 -QCTCVETVVRCSN-------RGLRALPKgipkdVTELYLEGNHLTA-VPKELSSFRHLTLIDLSNNSIGMLTNYTFSNM 750
Cdd:PLN00113  305 iQLQNLEILHLFSNnftgkipVALTSLPR-----LQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSS 379

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 329755343  751 SHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 811
Cdd:PLN00113  380 GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1062 1.49e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.49e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 329755343 1026 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFSGLHCE 1062
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-169 2.90e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 2.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   52 LRAVPRGIPR--NAERLRLNKNKLQVLPELlfqSNL-KLTRLDLSENQILGIPrkAFRGIADVKNLQLDNNHISCIEDGA 128
Cdd:COG4886   217 LTDLPEPLANltNLETLDLSNNQLTDLPEL---GNLtNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKE 291

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 329755343  129 FRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 169
Cdd:COG4886   292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
LRRCT smart00082
Leucine rich repeat C-terminal domain;
809-858 4.32e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.81  E-value: 4.32e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 329755343    809 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 858
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
647-811 7.18e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 7.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  647 FLKEIPIQDVAiqdftcdgNDESSCQLGPRCPEQCtcvETVVRCSNRGLRALPKGIPKDVTELYLEGNHLTAVP------ 720
Cdd:PRK15370  153 WVKEAPAKEAA--------NREEAVQRMRDCLKNN---KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPenlqgn 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  721 -KELSSFRH------------LTLIDLSNNSIGMLTNYTfsnMSHLSTLILSYNRLRCIPVHSFNGLRSLRVltlHGNDI 787
Cdd:PRK15370  222 iKTLYANSNqltsipatlpdtIQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSV---YDNSI 295

                         170       180
                  ....*....|....*....|....
gi 329755343  788 SSVPEgsfNDLTSLSHLALGTNPL 811
Cdd:PRK15370  296 RTLPA---HLPSGITHLNVQSNSL 316
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 487-617 1.21e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  487 TDLRLNDNEISVLEAtgiFKKLPNLRKINLSNNRIKEVkEGaFDGAASVQELVLTGNQLETAHG-----RAFRGLSG-LK 560
Cdd:cd21340    49 THLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPGEKltfdpRSLAALSNsLR 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 329755343  561 TLMLRSNLISCVSNdtFAGLSSVRLLSLYDNRITTITP--GAFTTLVSLSTINLLSNPF 617
Cdd:cd21340   124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRRNT smart00013
Leucine rich repeat N-terminal domain;
677-708 2.08e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.39  E-value: 2.08e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 329755343    677 CPEQCTCVETVVRCSNRGLRALPKGIPKDVTE 708
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1026-1062 2.98e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.98e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 329755343   1026 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFS-GLHCE 1062
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 950-983 5.60e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.60e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 329755343  950 DDCED-NDCENNATCVDGVNNYVCVCPPNYTGELC 983
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1024 5.72e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 329755343  987 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYSGKLCE 1024
Cdd:cd00054     2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
207-329 6.66e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  207 DVQKKEYVCSGPHSEPPAcNANSISCPSACTCSNNIVDCRGK-GLTEIPANLPEGIVEIRLEQNSIKSIPAGAftqYKKL 285
Cdd:PRK15370  147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 329755343  286 KRIDISKNQISDIA---PDAFQGLK---------------SLTSLVLYGNKITEIPKGLFDG 329
Cdd:PRK15370  223 KTLYANSNQLTSIPatlPDTIQEMElsinritelperlpsALQSLDLFHNKISCLPENLPEE 284
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 140-202 2.07e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 2.07e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 329755343   140 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGP-FTLCMAPVHLRG 202
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQPeAALCAGPGALAG 67
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-172 2.42e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   49 GLGLRAVPRGIPRNAERLR---LNKNKLQVLP----ELLFQSNLKLTRLDLSENQIL--GIPRKAfRGIADVKNLQ---L 116
Cdd:cd00116   122 DRGLRLLAKGLKDLPPALEklvLGRNRLEGAScealAKALRANRDLKELNLANNGIGdaGIRALA-EGLKANCNLEvldL 200

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 329755343  117 DNNHISCIED----GAFRALRDLEILTLNNNNIS----RILVTSFNHM-PKIRTLRLHSNHLYCD 172
Cdd:cd00116   201 NNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTdagaAALASALLSPnISLLTLSLSCNDITDD 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-169 3.14e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   64 ERLRLNKNK-LQVLPELLFQSNLKltRLDLSENQILG-IPRKaFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLN 141
Cdd:PLN00113  455 QMLSLARNKfFGGLPDSFGSKRLE--NLDLSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100
                  ....*....|....*....|....*...
gi 329755343  142 NNNISRILVTSFNHMPKIRTLRLHSNHL 169
Cdd:PLN00113  532 HNQLSGQIPASFSEMPVLSQLDLSQNQL 559
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 914-946 4.32e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.32e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 329755343  914 NPCLHGGTCHLSEthkGGFSCSCPLGFEGQRCE 946
Cdd:cd00054     9 NPCQNGGTCVNTV---GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1030-1060 4.43e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.43e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 329755343  1030 CAAHRCRHGAQCVDAVNGYTCICPQGFSGLH 1060
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1075-1105 4.65e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 4.65e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 329755343  1075 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1105
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRRCT smart00082
Leucine rich repeat C-terminal domain;
615-664 7.33e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 7.33e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 329755343    615 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 664
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 364-425 7.80e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.77  E-value: 7.80e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 329755343   364 DNKLQTISKGLFAPLQAIQTLHLAQNPFVCDCHLRWLADYLQDNPIET---SGARCSSPRRLANK 425
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 9.37e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 9.37e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 329755343     33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 952-981 9.81e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 9.81e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 329755343   952 CEDNDCENNATCVDGVNNYVCVCPPNYTGE 981
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-169 9.85e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 9.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   61 RNAERLRLNKNKLQVLPELlfqSNLK-LTRLDLsENQILGI-------PRkAFRGIAD-VKNLQLDNNHISCIEDgaFRA 131
Cdd:cd21340    68 VNLKKLYLGGNRISVVEGL---ENLTnLEELHI-ENQRLPPgekltfdPR-SLAALSNsLRVLNISGNNIDSLEP--LAP 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 329755343  132 LRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRLHSNHL 169
Cdd:cd21340   141 LRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGNPV 180
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 677-703 9.89e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 9.89e-05
                           10        20
                   ....*....|....*....|....*..
gi 329755343   677 CPEQCTCVETVVRCSNRGLRALPKGIP 703
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 1.06e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 1.06e-04
                           10        20
                   ....*....|....*....|....*...
gi 329755343    33 ACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
987-1024 1.18e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.18e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 329755343    987 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYS-GKLCE 1024
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
950-979 1.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.65e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 329755343    950 DDCE-DNDCENNATCVDGVNNYVCVCPPNYT 979
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 283-323 2.03e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 329755343   283 KKLKRIDISKNQISDIapDAFQGLKSLTSLVLYGN-KITEIP 323
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
LRR_9 pfam14580
Leucine-rich repeat;
491-595 2.18e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.60  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   491 LNDNEISVLEAtgiFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNqletahgrafrglsglktlmlrsNLIS 570
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNN-----------------------NLQE 102

                           90       100
                   ....*....|....*....|....*
gi 329755343   571 CVSNDTFAGLSSVRLLSLYDNRITT 595
Cdd:pfam14580  103 LGDLDPLASLKKLTFLSLLRNPVTN 127
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1035-1056 2.84e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.24  E-value: 2.84e-04
                           10        20
                   ....*....|....*....|..
gi 329755343  1035 CRHGAQCVDAVNGYTCICPQGF 1056
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-324 3.21e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   66 LRLNKNKLQVLPELLFQSNLKLtrLDLSENQILGIPrkafrGIADVKNL---QLDNNHISCIEDgaFRALRDLEILTLNN 142
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKV--LYLYDNKITKIE-----NLEFLTNLthlYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  143 NNISRilVTSFNHMPKIRTLRLhsnhlycdchlawlsdwLRQRrtvgpftlcmapvhlrgfnvadVQKKEYVCSGPHSep 222
Cdd:cd21340    78 NRISV--VEGLENLTNLEELHI-----------------ENQR----------------------LPPGEKLTFDPRS-- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  223 pacnANSIScpsactCSNNIVDCRGKGLTEIpanlpegiveirleqNSIKSIpagaftqyKKLKRIDISKNQISDIAP-- 300
Cdd:cd21340   115 ----LAALS------NSLRVLNISGNNIDSL---------------EPLAPL--------RNLEQLDASNNQISDLEEll 161

                         250       260
                  ....*....|....*....|....
gi 329755343  301 DAFQGLKSLTSLVLYGNKITEIPK 324
Cdd:cd21340   162 DLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 693-763 3.69e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 329755343  693 RGLRALPkgipkDVTELYLEGNHLTAV-PKELSSFRHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRL 763
Cdd:PLN00113  493 RKLGSLS-----ELMQLKLSENKLSGEiPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-618 3.91e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   86 KLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHISC-IEDGAFRALRDLEILTLNNNNISRILVTSFnhMPKIRTLRL 164
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  165 HSNHLYCDCHLawlsdwlrqrrTVGPFTlcmapvhlrGFNVADVQKKEYVcsgphSEPPACNANSISCPSACTCSNNIVD 244
Cdd:PLN00113  148 SNNMLSGEIPN-----------DIGSFS---------SLKVLDLGGNVLV-----GKIPNSLTNLTSLEFLTLASNQLVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  245 crgkgltEIPANLPE--GIVEIRLEQNSIK-SIPAgAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT- 320
Cdd:PLN00113  203 -------QIPRELGQmkSLKWIYLGYNNLSgEIPY-EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSg 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  321 EIPKGLFdglvslqllllNANKINCLRVNtfqdlqslsllslyDNKLQTISKGLFAPLQAIQTLHLAQNPFVCdchlrwl 400
Cdd:PLN00113  275 PIPPSIF-----------SLQKLISLDLS--------------DNSLSGEIPELVIQLQNLEILHLFSNNFTG------- 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  401 adylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRfSSECFMDLVC-------PDRCRCEGTIVDC--- 470
Cdd:PLN00113  323 ---------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH-NNLTVLDLSTnnltgeiPEGLCSSGNLFKLilf 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  471 SNQKLARIPSHLP--EYVTDLRLNDNEISVlEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQLETA 548
Cdd:PLN00113  389 SNSLEGEIPKSLGacRSLRRVRLQDNSFSG-ELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG 467

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  549 HGRAFRGlSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 618
Cdd:PLN00113  468 LPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 225-329 3.93e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 41.76  E-value: 3.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   225 CNANSISCPSACT---------CSNnivdcrgkgLTEIpaNLPEGIVEIR--------LE----QNSIKSIPAGAFTQYK 283
Cdd:pfam13306   11 CSLTSITIPSSLTsigeyafsnCTS---------LKSI--TLPSSLTSIGsyafyncsLTsitiPSSLTSIGEYAFSNCS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 329755343   284 KLKRIDISKNqISDIAPDAFQGLkSLTSLVLyGNKITEIPKGLFDG 329
Cdd:pfam13306   80 NLKSITLPSN-LTSIGSYAFSNC-SLKSITI-PSSVTTIGSYAFSN 122
LRRCT smart00082
Leucine rich repeat C-terminal domain;
389-419 4.66e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 4.66e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 329755343    389 NPFVCDCHLRWLADYLQDNPI--ETSGARCSSP 419
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1116-1263 5.89e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 41.99  E-value: 5.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  1116 GKDSYVELASAKVRPQAN-ISLQVATDKDNG---ILLYKGDNDPLALELYQ-GHVRLVYDSLSSPPTTVYSVETVNDGQF 1190
Cdd:pfam13385    2 GGSDYVTLPDALLPTSDFtVSAWVKPDSLPGwarAIISSSGGGGYSLGLDGdGRLRFAVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 329755343  1191 HSVELVMLNQTLNLVVDkGAPKSLGKLQKQPAVSINSPLYLGGiptstglsalRQGMDRPlggFHGCIHEVRI 1263
Cdd:pfam13385   82 THVAVTYDGGTLRLYVN-GVLVGSSTLTGGPPPGTGGPLYIGR----------SPGGDDY---FNGLIDEVRI 140
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1029-1062 5.94e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 5.94e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 329755343 1029 DCAA-HRCRHGAQCVDAVNGYTCICPQGFSG-LHCE 1062
Cdd:cd00053     1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
LRRNT smart00013
Leucine rich repeat N-terminal domain;
232-263 7.16e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 7.16e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 329755343    232 CPSACTCSNNIVDCRGKGLTEIPANLPEGIVE 263
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 232-258 7.85e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.99  E-value: 7.85e-04
                           10        20
                   ....*....|....*....|....*..
gi 329755343   232 CPSACTCSNNIVDCRGKGLTEIPANLP 258
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 707-791 8.86e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 8.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  707 TELYLEGNHLTavPKELSSF---------RHLTLIDLSNNSIGMLTNytFSNMSHLSTLILSYNRLRCIP--VHSFNGLR 775
Cdd:cd21340    93 EELHIENQRLP--PGEKLTFdprslaalsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                          90
                  ....*....|....*.
gi 329755343  776 SLRVLTLHGNDISSVP 791
Cdd:cd21340   169 SLRELDLTGNPVCKKP 184
LRRNT smart00013
Leucine rich repeat N-terminal domain;
457-487 1.18e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.18e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 329755343    457 CPDRCRCEGTIVDCSNQKLARIPSHLPEYVT 487
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 86-322 1.94e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   86 KLTRLDLSENQILGIPrkafrGIADVKNLQ---LDNNHISCIEDgaFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTL 162
Cdd:cd21340     3 RITHLYLNDKNITKID-----NLSLCKNLKvlyLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  163 RLHSNHLycdchlawlsdwlrqrRTVGPFTLCMAPVHLRgfnvadvqkkeyvcsgphseppacnansiscpsactCSNNi 242
Cdd:cd21340    74 YLGGNRI----------------SVVEGLENLTNLEELH------------------------------------IENQ- 100

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  243 vdcrgkglteipaNLPEGiVEIRLEQNSIKSIPagaftqyKKLKRIDISKNQISDIAPdaFQGLKSLTSLVLYGNKITEI 322
Cdd:cd21340   101 -------------RLPPG-EKLTFDPRSLAALS-------NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL 157
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 953-981 2.55e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.55e-03
                          10        20
                  ....*....|....*....|....*....
gi 329755343  953 EDNDCENNATCVDGVNNYVCVCPPNYTGE 981
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
LRR smart00370
Leucine-rich repeats, outliers;
508-531 3.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 3.13e-03
                            10        20
                    ....*....|....*....|....
gi 329755343    508 LPNLRKINLSNNRIKEVKEGAFDG 531
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
508-531 3.13e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 3.13e-03
                            10        20
                    ....*....|....*....|....
gi 329755343    508 LPNLRKINLSNNRIKEVKEGAFDG 531
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 911-944 3.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.47e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 329755343   911 CIQNPCLHGGTCHlseTHKGGFSCSCPLGFEGQR 944
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 997-1021 3.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.47e-03
                           10        20
                   ....*....|....*....|....*
gi 329755343   997 CQHEAKCISLDRGFRCECPPGYSGK 1021
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGK 30
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 957-976 3.53e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.16  E-value: 3.53e-03
                           10        20
                   ....*....|....*....|
gi 329755343   957 CENNATCVDGVNNYVCVCPP 976
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
LRR smart00370
Leucine-rich repeats, outliers;
774-797 4.92e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 4.92e-03
                            10        20
                    ....*....|....*....|....
gi 329755343    774 LRSLRVLTLHGNDISSVPEGSFND 797
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
774-797 4.92e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 4.92e-03
                            10        20
                    ....*....|....*....|....
gi 329755343    774 LRSLRVLTLHGNDISSVPEGSFND 797
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1418-1471 5.27e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 37.38  E-value: 5.27e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 329755343   1418 SCATASKIPVMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEELERHLECGC 1471
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGC 77
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 489-526 5.28e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 5.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 329755343   489 LRLNDNEISVLEAtgiFKKLPNLRKINLS-NNRIKEVKE 526
Cdd:pfam12799    6 LDLSNNQITDIPP---LAKLPNLETLDLSgNNKITDLSD 41
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 45-167 5.55e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   45 VDCHGLG---LRAVPRGIPRN--AERLRLNKNKLQVLPELL------FQSNLKLTRLDLSEN--QILGIPR-KAFRGIAD 110
Cdd:cd00116    30 LEGNTLGeeaAKALASALRPQpsLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNalGPDGCGVlESLLRSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  111 VKNLQLDNN--------------------------------HISCIE-DGAFRALRDLEILTLNNNNIS----RILVTSF 153
Cdd:cd00116   110 LQELKLNNNglgdrglrllakglkdlppaleklvlgrnrleGASCEAlAKALRANRDLKELNLANNGIGdagiRALAEGL 189

                         170
                  ....*....|....
gi 329755343  154 NHMPKIRTLRLHSN 167
Cdd:cd00116   190 KANCNLEVLDLNNN 203
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 870-905 6.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 6.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 329755343  870 DPCLS-SPCKNNGTCsQDPVEGHRCACSHGYKGRDCT 905
Cdd:cd00054     3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 872-903 7.05e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 7.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 329755343   872 CLSSPCKNNGTCSQDPvEGHRCACSHGYKGRD 903
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 693-821 8.22e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 8.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  693 RGLRALPKGI---PKDVTELYLEGNHLTAVP-----KELSSFRHLTLIDLSNNSIGM-LTNYTFSNM---SHLSTLILSY 760
Cdd:cd00116   123 RGLRLLAKGLkdlPPALEKLVLGRNRLEGAScealaKALRANRDLKELNLANNGIGDaGIRALAEGLkanCNLEVLDLNN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343  761 NRLRCIPV----HSFNGLRSLRVLTLHGNDISSVP-----EGSFNDLTSLSHLALGTNPLHCD------------CSLRW 819
Cdd:cd00116   203 NGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDgakdlaevlaekESLLE 282


                  ..
gi 329755343  820 LS 821
Cdd:cd00116   283 LD 284
EGF_CA smart00179
Calcium-binding EGF-like domain;
914-946 8.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 8.47e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 329755343    914 NPCLHGGTCHLSEthkGGFSCSCPLGFE-GQRCE 946
Cdd:smart00179    9 NPCQNGGTCVNTV---GSYRCECPPGYTdGRNCE 39
LRR smart00370
Leucine-rich repeats, outliers;
306-329 8.96e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.96e-03
                            10        20
                    ....*....|....*....|....
gi 329755343    306 LKSLTSLVLYGNKITEIPKGLFDG 329
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
306-329 8.96e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 8.96e-03
                            10        20
                    ....*....|....*....|....
gi 329755343    306 LKSLTSLVLYGNKITEIPKGLFDG 329
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 729-809 9.37e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 9.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 329755343   729 LTLIDLSNN--SIGmltNYTFSNMSHLSTLILSYNrLRCIPVHSFNGLrSLRVLTLHGNdISSVPEGSFNDLTSLSHLAL 806
Cdd:pfam13306   13 LTSITIPSSltSIG---EYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITL 86


                   ...
gi 329755343   807 GTN 809
Cdd:pfam13306   87 PSN 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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