|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
22-484 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 714.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 22 RGFILLLTFLIYVCYHMSRKPISIIKSRLHQNCSDIVRPINDthDLNDTTWCSWSPFDKDDYKELLGAVDNAFLVAYAIG 101
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPPNI--VLNNTTWCGWAPFDGKNGTELLGALDSAFLFAYAIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 102 MFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWFGKGKRGFIM 181
Cdd:cd17344 79 MFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 182 GIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIITAVMGVITFLFLIEYPedvdctppqhhddlekerdnpedpvnsp 261
Cdd:cd17344 159 GIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP---------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 262 yssressvdiaassskeqgpepeaisflgalkiPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLFD 341
Cdd:cd17344 211 ---------------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFD 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 342 VGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIGQNGITSSIVMLIICGVLVNGPYALITTAVSADLGTHES 421
Cdd:cd17344 258 VGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKS 337
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 422 LKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGWNNVFYMLISADILACLLLCRLVYKE 484
Cdd:cd17344 338 LKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
22-481 |
5.57e-98 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 299.96 E-value: 5.57e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 22 RGFILLLTFLIYVCYHMSRKPISIIKSRLHQNcsdivrpindthdlndttwcswSPFDKDDykelLGAVDNAFLVAYAIG 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEE----------------------IGLSKDD----LGIIGSAFLIAYAVG 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 102 MFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFwnihmLWYFVLIQICNGLVQTTGWPSVVTCVGNWFGKGKRGFIM 181
Cdd:cd17312 55 KFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTS-----LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVY 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 182 GIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLIEYPedvdctppqhhddlekerdnpedpvns 260
Cdd:cd17312 130 GIWSTSHNFGGILAPILAASLASYYgWRAAFLVPGIVGLVVAIILFFFLRDSP--------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 261 pyssressvdiaassskeqgpepeaisflgalkiPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLF 340
Cdd:cd17312 183 ----------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLY 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 341 DVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPMMFLYNYIGQ--NGITSSIVMLIICGVLVNGPYALITTAVSADLGT 418
Cdd:cd17312 229 EVGGIAGTILAGLLSDKL-FGGRRAPIAVIYMLLMTLSLALFWFfpHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGR 307
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300795438 419 HEslkgnakALSTVTAIIDGTGSIGAALGPLLAGLISP-TGWNNVFYMLISADILACLLLCRLV 481
Cdd:cd17312 308 KE-------AAGTATGFVGLFGYLGASLAGLPLGYIIDhYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
24-477 |
1.58e-93 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 289.98 E-value: 1.58e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 24 FILLLTFLIYVCYHMSRKPISIIKSRLHQNCSDIVRPINDtHDLNDTTWCSWSPFDKDDYKELLGAVDNAFLVAYAIGMF 103
Cdd:cd17342 3 VVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSI-ELHEETWNANPLFPSQDDAALFLGVLDTIFLFSYAIGLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 104 ISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFW--NIHMLWYFVLIqICNGLVQTTGWPSVVTCVGNWFGKGKRGFIM 181
Cdd:cd17342 82 ISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWlhFYNKYLYCILW-VLNGLLQSTGWPCVVAIMGNWFGKSSRGFVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 182 GIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIITAVMGVITFLFLIEYPedvdctppqhhddlekerdnpedpvnsp 261
Cdd:cd17342 161 GLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 262 yssressvdiaassskeqgpepeaisflgalkiPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLFD 341
Cdd:cd17342 213 ---------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYD 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 342 VGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIGQNGITSSIVMLiICGVLVNGPYALITTAVSADLGTHES 421
Cdd:cd17342 260 VGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMT-ITGFFIGGPANLISSAISADLGRQPQ 338
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 300795438 422 LKGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPT-GWNNVFYMLISADILACLLL 477
Cdd:cd17342 339 LRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWVFYFFIIMTILTIVCI 395
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
87-477 |
1.18e-37 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 142.77 E-value: 1.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLgYFWNIHMLWYFVLIQICNGLVQTTGWPSVVT 166
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGF-VPSATSSVGLMFILLFLNGWFQGMGWPPSGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CVGNWFGKGKRGFIMGIWN-SHTSVGNILGSLI---AGVWVNQHWGLSFIVPGIITAVMGVITFLFLIEYPEDVDCTPpq 242
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPP-- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 243 hhddLEKERDNPEdpvnspyssressvDIAASSSKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYI 322
Cdd:cd17345 197 ----IEEYKGDYP--------------EEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 323 FNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISD--YTNGRATTCCVMLILAAPMMFLYNYIgqNGITSSIVMLIICGVL 400
Cdd:cd17345 259 SEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDklFKGRRAPTGIIFMILVIVALIVYWLA--PNVLVDLIALIALGFL 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 401 VNGPYALITTAVsADLGTHESLkGNAKALSTVTAIIdgtgsIGAALGPLLAGLISP-TGWNNVFYMLISADILACLLL 477
Cdd:cd17345 337 IYGPVMLIGLQA-LELVPKKAA-GTAAGLTGLFGYL-----GGSVLATALIGIIVDhFGWNGGFIVLLASCILAIIFL 407
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-483 |
1.26e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 141.55 E-value: 1.26e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 19 SWFRGFILLLTFLIYVCYHMSRKPISIIKSrlhqncsdivrPINDTHDLNDTTwcswspfdkddykelLGAVDNAFLVAY 98
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAP-----------PLQADLGLSAAQ---------------LGLLASAFFLGY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 99 AIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLgyfwnIHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWFGKGKRG 178
Cdd:COG2271 59 ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 179 FIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLIeypedvdctppqhhddlekerdnpedp 257
Cdd:COG2271 134 RALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 258 vnspyssressvdiaassskeqgpepeaisflgalkipgviefsLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLS 337
Cdd:COG2271 187 --------------------------------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLL 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 338 TLFDVGGIIGGIMAGLISDYTN-GRATTCCVMLILAAPMMFLYNYIGqnGITSSIVMLIICGVLVNGPYALITTAVSADL 416
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 417 GTHeslkgnakALSTVTAIIDGTGSIGAALGPLLAG-LISPTGWNNVFYMLISADILACLLLCRLVYK 483
Cdd:COG2271 301 PKK--------ARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
77-463 |
1.42e-35 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 136.35 E-value: 1.42e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 77 PFDKDDykelLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGlgyfWNIHmLWYFVLIQICNGLV 156
Cdd:TIGR00881 26 GLSKTD----LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG----FSTS-LWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 157 QTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWG--LSFIVPGIITAVMGVITFLFLIEYPE 234
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSwhWVFIVPGIIAIIVSLICFLLLRDSPQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 235 DVDCTPpqhhDDLEKERDNPEDPVNspyssressvdiaasssKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTF 314
Cdd:TIGR00881 177 SCGLPP----AEEMPNEEPDGDAEK-----------------KEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 315 LYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISD--YTNGRATTCCVMLILaapmMFLYNYIGQNGITSSIV 392
Cdd:TIGR00881 236 LDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPLAVFFMAL----IIVSLLVYWLNPAANPL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300795438 393 MLIIC----GVLVNGPYALIttavsadlGTHESLKGNAKALSTVTAIIDGTGSIGAALGPL-LAGLISPTGWNNVF 463
Cdd:TIGR00881 312 MDLIClfalGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADGFGWAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
87-480 |
4.64e-27 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 111.89 E-value: 4.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLgyfwnIHMLWYFVLIQICNGLVQTTGWPSVVT 166
Cdd:cd17319 40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLieypedvdctppqhhd 245
Cdd:cd17319 115 ALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFgWRWAFIIEGLLGLLLAVLWWFYL---------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 246 dlekerdnpedpvnspyssressvdiaassskeqgpepeaisflgalkiPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNV 325
Cdd:cd17319 179 -------------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 326 AHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYT-NGRATTCCVMLILAAPMMFLYNYIGQNgITSSIVMLIICGVLVNGP 404
Cdd:cd17319 210 RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlRGARRLVIIIGLLLAAVGLLLAYLTTS-PVVAVILLSLAGFGIGAA 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 405 YALITTaVSADLgtheslkGNAKALSTVTAIIDGTGSIGAALGPLLAGLISPT--GWNNVFYMLISADILACLLLCRL 480
Cdd:cd17319 289 SPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
86-448 |
3.37e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.57 E-value: 3.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 86 LLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLgyfwnIHMLWYFVLIQICNGLVQTTGWPSVV 165
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFlieypedvdctppqhh 244
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFgWRAAFLILAILSLLAAVLLLLP---------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 245 ddlekeRDNPEDPVNSPyssressvdiaassskEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIfN 324
Cdd:pfam07690 172 ------RPPPESKRPKP----------------AEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-E 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 325 VAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATT--CCVMLILAAPMMFLYNYIGQNGItsSIVMLIICGVLVN 402
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLllALLLLILAALGLLLLSLTLSSLW--LLLALLLLGFGFG 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 300795438 403 GPYALITTAVSADLGTHESlkgnakalSTVTAIIDGTGSIGAALGP 448
Cdd:pfam07690 307 LVFPALNALVSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
93-483 |
3.38e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.50 E-value: 3.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfwniHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:COG2223 48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLieypedvdctppqhhddlekeR 251
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFL---------------------R 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 252 DNPEDPVNSPYSSRessvdiaassskeqgpepeaISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAK 331
Cdd:COG2223 182 DPPAGAAAAAKASL--------------------RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 332 EAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIGqnGITSSIVMLIICGVLVNGPYALITTA 411
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG--SLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 412 VSADLGTheslkgnaKALSTVTAIIDGTGSIGAALGPLLAG-LISPTGWNNVFYMLISADILACLLLCRLVYK 483
Cdd:COG2223 320 VPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGaLLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
87-484 |
4.61e-21 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 95.88 E-value: 4.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVVT 166
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CVGNWFGKGKRGFIMGIWN-SHtsvgNILGSLIAGVWV-------NQHWGLSFIVPGIITAVMGVITFLFLIEYPEDVDC 238
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNiSH----NLGGAGAGGVALwganyffDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGW 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 239 TPPQHHDDLEKERDNpEDPVNSPYSSRESSVDIAassskeqgpepeaisflgaLKIPGVieFSLCL--LFAKLVSYTFLY 316
Cdd:PRK09556 222 GKAEEIFGEPISEED-KETESTDMTKWQIFVEYV-------------------LKNPVI--WLLCFanIFLYIVRIGIDN 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 317 WLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNG-RATTCCVMLILAAPMMFLYNYIgqNGITSSIVMLI 395
Cdd:PRK09556 280 WSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGrRALVACIALALIIFTLGVYQHA--TSEYMYLASLF 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 396 ICGVLVNGPYALI------------TTAVSADLGTHESLKGNAKALSTVTAIIDGTGSIGAALGPLLaglispTGWNNVF 463
Cdd:PRK09556 358 ALGFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADPTKNGTPIFGYTL------TGWAGTF 431
|
410 420
....*....|....*....|.
gi 300795438 464 YMLISADILACLLLCRLVYKE 484
Cdd:PRK09556 432 AALDIAAIGCICLMAIVAVME 452
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
93-477 |
6.66e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.42 E-value: 6.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLgyfwnIHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGVWVnQHWGLSFIVPGIITAVMGVITFLFLIEYPEDVdctppqhhddlekerd 252
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAVFLIAAALALLAAILLLLVVPDP---------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 253 npedpvnspyssressVDIAASSSKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKE 332
Cdd:cd06174 177 ----------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 333 AGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIGQNgiTSSIVMLIICGVLVNGPYALITTAV 412
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL--LLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300795438 413 SADLgtheslkgNAKALSTVTAIIDGTGSIGAALGPLLAGLISP--TGWNNVFYMLISADILACLLL 477
Cdd:cd06174 319 AELF--------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAatFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
86-446 |
4.53e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 88.49 E-value: 4.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 86 LLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLgyFWNIHMLWYFVLIQicnGLVQTTGWPSVV 165
Cdd:COG2814 46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL--APSLWLLLAARFLQ---GLGAGALFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQ-HWGLSFIVPGIITAVMGVITFLFLieyPEdvdctppqhh 244
Cdd:COG2814 121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLL---PE---------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 245 ddlekerdnpedpvnspyssressvdiaassSKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFN 324
Cdd:COG2814 188 -------------------------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 325 VAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPMMFLYNYIGqnGITSSIVMLIICGVLVNGP 404
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-GRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 300795438 405 YALITTAVSADLGTHEslkgnakaLSTVTAIIDGTGSIGAAL 446
Cdd:COG2814 314 FPLLQALVAELAPPEA--------RGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
79-477 |
1.27e-18 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 87.78 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 79 DKDDykelLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGlgYFWNihmLWYFVLIQICNGLVQT 158
Cdd:cd17343 36 DKSD----LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GSSS---VWVFSILWFLNGLAQG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 159 TGWPSVVTCVGNWFGKGKRGFImgiWNSHTSVGNILGSL--IAGVWVNQH--WGLSFIVPGIITAVMGVITFLFLIEYPE 234
Cdd:cd17343 107 LGWPPCAKILRKWFSPSQFGTW---WSVLSTSMNLAGSLgpILATLLALSygWRSTLSISGTVAVVMSVVCLLFIKNEPS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 235 DVDctppqhhddLEKERDnpedpvnspyssressvdiAASSSKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTF 314
Cdd:cd17343 184 DVG---------LNNIEE-------------------EESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 315 LYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDY----------TNGRATTCCVMLILAAPMMFLYNYIGQ 384
Cdd:cd17343 236 TDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWavakhgsssrGNPRMPLALVFMAGLTVSLHLFRVHIT 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 385 NGiTSSIVMLII---CGVLVNGPYALITTAVSadlgthESLKGNAKalSTVTAIIDGTGSIGAALGPLLAGLI-SPTGWN 460
Cdd:cd17343 316 SD-SSELFILLLgflIGFSLYGPIAIFGVIAN------ESAPSHLC--GTSHAIVALAANVGGVLAGLPFSYIaKHYDWR 386
|
410
....*....|....*..
gi 300795438 461 NVFYMLISADILACLLL 477
Cdd:cd17343 387 TAFLLLEILCAITVVIL 403
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
87-478 |
2.35e-18 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 87.46 E-value: 2.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICnGLVQTTGWPSVVT 166
Cdd:PRK11273 65 LGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFLC-GWFQGMGWPPCGR 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CVGNWFGKGKRGFIMGIWN-SHTSVGNILGSL-IAGVWVNQHWGLSFIVPGIITAVMGVITFLFLIEYPEDVDCTPPQHH 244
Cdd:PRK11273 144 TMVHWWSQKERGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEY 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 245 DDlekerDNPEDpvnspyssressvdiaASSSKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFN 324
Cdd:PRK11273 224 KN-----DYPDD----------------YNEKHEQELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 325 VAHFSAKEAGDLSTLFDVGGIIGGIMAGLISD--YTNGRATTCCVMLIL--AAPMMFLYNYIGQNGItsSIVMLIICGVL 400
Cdd:PRK11273 283 VKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDkvFRGNRGATGVFFMTLvtIATIVYWLNPAGNPTV--DMACMIVIGFL 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 401 VNGPYALIttavsadlGTHESLKGNAKALSTVTAIIDGTGSIGAALGP--LLAGLISPTGWNNVFYMLISADILACLLLC 478
Cdd:PRK11273 361 IYGPVMLI--------GLHALELAPKKAAGTAAGFTGLFGYLGGSVAAsaIVGYTVDFFGWDGGFMVMIGGSILAVILLI 432
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
86-477 |
2.47e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.48 E-value: 2.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 86 LLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWnihmlWYFVLIQICNGLVQTTGWPSVV 165
Cdd:cd17325 32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY-----WQLLLARFLQGLASAAVWPAAM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVwVNQHWGLS--FIVPGIITAVMGVITFLFLieypedvdctppqh 243
Cdd:cd17325 107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRapFLVCAALALLALVLALLLL-------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 244 hddlekerdnpEDPVNSPYSSRESSVDIAASSSKeqgpepeaISFLGALKIPGVIEFSLCLLFAKLVSYtflywLPLYIF 323
Cdd:cd17325 172 -----------PEPRPPPNKRAVSAARLRSGLRL--------LLRDRRLLALFLAIFVLAFAFGALEPF-----LPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 324 NVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPMMFLYnyigqnGITSSIVMLIICGVLVNG 403
Cdd:cd17325 228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIGLLLSAVALLLL------PLATSFWLLLLLLALLGL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300795438 404 PYALITTAVSADLG--THESLKGnakalsTVTAIIDGTGSIGAALGPLLAGLISPT-GWNNVFYMLISADILACLLL 477
Cdd:cd17325 301 GLGLVFPATLALLAdiVPPEGRG------TAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAVLF 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
87-496 |
2.43e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 77.59 E-value: 2.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVlIQICNGLVQTTGWPSVVT 166
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL-LGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CvgnwfGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIITAVMGVITFLFLIeypedvdctppqhhdd 246
Cdd:COG0738 124 L-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL---------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 247 lekerdnpedpvnspyssresSVDIAASSSKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVA 326
Cdd:COG0738 183 ---------------------RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 327 HFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPMMFLynYIGQNGITSSIVMLIICGVLVNGPYA 406
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLL--ALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 407 LITTAVSADLGTHeslkgNAKALSTVTAIidgtGSIGAALGPLLAGLISP-TGWNNVFYMLIsadILACLLLcrlvykeI 485
Cdd:COG0738 319 TIFSLALDGLGKR-----TAAAVSAVLIM----GIVGGAIGPPLIGFLADaFGLRAAFLVPL---VCYLLIL-------L 379
|
410
....*....|.
gi 300795438 486 LAWKTARSRNS 496
Cdd:COG0738 380 LALALKRKRRK 390
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
87-248 |
5.17e-15 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 77.06 E-value: 5.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfwniHMLWYFVLIQICNGLVQTTGWPSVVT 166
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLIEYPEDVDCTPPQH-- 243
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYgWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEwr 214
|
....*
gi 300795438 244 HDDLE 248
Cdd:PRK11663 215 HDALE 219
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
84-233 |
3.27e-13 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 70.90 E-value: 3.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 84 KELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfwniHMLWYFVLIQICNGLVQTTGWPS 163
Cdd:cd17488 37 KSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPP 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795438 164 VVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLIEYP 233
Cdd:cd17488 112 CARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYgWRAGMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
93-478 |
2.77e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.42 E-value: 2.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWnihmlWYFVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17328 42 VFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNF-----WQLLLFRALVGIGEASYSPIAPTIIADLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGsLIAGVWVNQ---HWGLSFIVPGIITAVMGVITFLFLIEypedvdctppqhhddleK 249
Cdd:cd17328 117 PKEKRTRALGVFYFAIPLGSGLG-YVVGGLVAQatgGWRWAFRVTGVLGVLLAILLLLFVRE-----------------P 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 250 ERDNPEDPVNSPYSSRESSVDIAASsskeqgpepeaisflgaLKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFS 329
Cdd:cd17328 179 PRGAAEGGVMAKSTATSFLADLKAL-----------------AKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 330 AKEAGDLSTLFDVGGIIG----GIMAGLISDYTN-----GRATTCCVMLILAAPMMFLYNYIGQNGITSSIVMLIICGVL 400
Cdd:cd17328 242 DLSSADVGLIFGAITCIAgvlgVLLGGILADRLRrktprADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFL 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 401 VNGPYALITTAVSADLgtHESLKGNAKALSTVTaiidgTGSIGAALGPLLAGLISPTGWNNVFYMLISADILACLLLC 478
Cdd:cd17328 322 LSLNWAPVFAILLYVV--IPTRRSTASAIQILL-----SHLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYALLL 392
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
87-478 |
4.24e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 64.65 E-value: 4.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLwYFVLIQICNGLVQTTGWPSVVT 166
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV-LMFLAGLGAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 cvgnwFGKGKRGFIMGIWNSHTSVGNILGSLIAG--VWVNQHWGLSFIVPGIItAVMGVITFLFLiEYPEDVDCTPPQhh 244
Cdd:cd17333 112 -----LFEESSATRLNVLHGFFGLGALIGPLIATslLTSELSWSWAYLIIGLI-YLLLAILILLT-LFPELPSARNPQ-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 245 ddlekerdnpedpvnspyssressvdiaassskeQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFN 324
Cdd:cd17333 183 ----------------------------------QSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 325 VAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATtccVMLILAAPMMFLYNYIGQNGITSSIVMLIICGVLVNGP 404
Cdd:cd17333 229 KKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL---LVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 300795438 405 YALITTAVSADLGtheslkgnaKALSTVTAIIDGTGSIGAALGPLLAGLISPTGwnNVFYMLISADILACLLLC 478
Cdd:cd17333 306 FPTILSLGISNLP---------YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAV--GIQTAMLLITILYAIIFV 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
93-229 |
9.21e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 63.36 E-value: 9.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWnihmlWYFVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF-----WLLLLLLALLGLGLGLVFPATLALLADIV 317
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAG-VWVNQHWGLSFIVPGIITAVMGVITFLFL 229
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
87-452 |
1.66e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.76 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLfgLGYFWNIhmlWYFVLIQICNGLVQTTGWPSVVT 166
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNV---TQLLILRFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 167 CVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFLieyPEDVDCTppqhhd 245
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFYVGGIAPLLLLLLLMRFL---PESIDFL------ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 246 dLEKERDNPEDPVNSPYSSRESSVDIAASSSKEQgpEPEAISFLGALKIPGVIEFSL---CLLFAKLVSYTFLY-WLPlY 321
Cdd:TIGR00895 200 -VSKRPETVRRIVNAIAPQMQAEAQSALPEQKST--QGTKRSVFKALFQGKTARITVllwLLYFMLLVGVYFLTnWLP-K 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 322 IFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTccVMLILAApmMFLYN-YIGQNGITSSIVMLIICGVL 400
Cdd:TIGR00895 276 LMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA--LLLLLGA--VFAVLvGSTLFSPTLLLLLGAIAGFF 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 300795438 401 VNGPYALITTAvsadlgTHESLKGNAKALSTVTAIidGTGSIGAALGPLLAG 452
Cdd:TIGR00895 352 VNGGQSGLYAL------MALFYPTAIRATGVGWAI--GIGRLGAIIGPILAG 395
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
93-476 |
5.14e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.03 E-value: 5.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfWNIHMLwyfVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17324 42 AYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA--PSFALL---LLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQHWG--LSFIVPGIITAVMGVITFLFLieypedvdctppqhhddleke 250
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGwrAAFLAIAVLALLAALLLWRLL--------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 251 rdnPEDPVNSPyssressvdiaassskeqGPEPEAISFLGALKIPGVIE---FSLCLLFAKLVSYTFlywLPLYIFNVAH 327
Cdd:cd17324 175 ---PSLPPKKP------------------GSLGLLSSLLLLLRNPRLRLaylITFLLFGGFFALYTY---LAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 328 FSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTccVMLILAAPMMFLYNYIGQNGITsSIVMLIICGVLVNGPYAL 407
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL--IALLLLAAALLLLTLLGPSPLL-LLVGLVLWGLGFFAAHSA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 408 ITTAVSadlgtheslKGNAKALSTVTAIIDGTGSIGAALGPLLAGL-ISPTGWNNVFYMLISADILACLL 476
Cdd:cd17324 308 LQTRVL---------RLAPEARGLASSLYLAAYNLGGALGAALGGLvLDHGGWAGVGWVGAALLLLALLL 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
95-480 |
5.18e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 5.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 95 LVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGL-GYFWnihmLWYF--VLIQICNGLVQTTgWPSVVTcvgNW 171
Cdd:COG2807 63 LLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLaPSVA----LLLAgtALIGAGIAVGNVL-LPGLIK---RW 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 172 FGKgKRGFIMGIWNSHTSVGNILGSLIAgVWVNQHWG--LSFIVPGIITAVMGVITFLFLIEYPedvdctppqhhddlek 249
Cdd:COG2807 135 FPD-RVGLMTGLYTAAMGLGAALAAGLT-VPLAAALGwrGALAVWALLALLALLLWLPLLRRRP---------------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 250 erdnpedpvnspyssressvdiaasssKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLyIFNVAHFS 329
Cdd:COG2807 197 ---------------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPP-ILRDAGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 330 AKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIGQngiTSSIVMLIICGVLVNGPYALIT 409
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG---SLPWLWAVLLGLGQGGLFPLAL 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 410 TAVSADLGTHESlkgnAKALStvtAIIDGTGSIGAALGPLLAGLISPT--GWNNVFYMLISADILACLLLCRL 480
Cdd:COG2807 326 TLIGLRARTPAE----AAALS---GMAQSVGYLLAALGPLLVGALHDAtgSWTAALLLLAALAVLMLVAGLLA 391
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
86-234 |
1.30e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.44 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 86 LLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfWNIHMLWYFVLIQicnGLVQTTGWPSVV 165
Cdd:COG0477 50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQ---GIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQHWGLSFIVpgIITAVMGVITFLFLIEYPE 234
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGG-LLVAALGWRWIF--LINAPLGLLALVLRLRLPE 190
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
54-472 |
1.82e-09 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 59.76 E-value: 1.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 54 CSDIVRPINDTHDLNDttwcSWSPfdkddykELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFG 133
Cdd:TIGR00894 56 CLSAENELDNIKNPNF----KWSG-------ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 134 LGYfwNIHMLWYFVLiqicnGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGV------WVNQHW 207
Cdd:TIGR00894 125 WAA--GGGIALVVFC-----RVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisgwlcESWGGW 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 208 GLSFIVPGIITAVMGVITFLFLIEYPEDVDCtppqhhddlekERDNPEDPVNSpyssressvdiaaSSSKEQGPEPEAIS 287
Cdd:TIGR00894 198 PMIFYVFGIVGCAWSLLWFVFPADDPSIHPC-----------ISKFEKKYINS-------------SLQGQKGSTRQSLP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 288 FLGALKIPGVIEFSLClLFAKLVSYTFL-YWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDY-----TNGR 361
Cdd:TIGR00894 254 IKAIPKSLPVWAIWFA-IFGHFWLYTILpTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFlksskTLSL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 362 ATTCCVM-----LILAAPMMFLYnYIGQNgITSSIVMLIICGVLVNGPYALITTAvsadlgtheSLKGNAKALSTVTAII 436
Cdd:TIGR00894 333 TAARKIFngiggLGPGIFAYALP-YLSAA-FYLTIIILTLANAVSSGPLAGVLIN---------SLDLAPRFLGFIKGIT 401
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 300795438 437 DGTGSIGAALGPLLAGLISPTG----WNNVFYMLISADIL 472
Cdd:TIGR00894 402 GLPGFIGGLIASTLAGNILSQDsknvWLIVFLIMAFVNIL 441
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
75-234 |
2.28e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 59.17 E-value: 2.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 75 WSPFDKDDYK----ELLGAVDNAFLVaYAIGMFISGIFGERLPLRYYLSAGMVLSGLftSLFGLGYFwniHMLWYFVLIQ 150
Cdd:cd17475 18 LAPFLQEDLHlslaQVGLLLSALNLG-VAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALV---GSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 151 ICNGLVQTTGWPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLI-AGVWVNQHWGLSFIVPGIITAVMGVITFLFL 229
Cdd:cd17475 92 FLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALlPPLALHYGWRAAFVVAGLVSILAAVLFWLFY 171
|
....*
gi 300795438 230 IEYPE 234
Cdd:cd17475 172 REPPA 176
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
106-478 |
3.93e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 58.34 E-value: 3.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 106 GIFGERLPLRYYLSAGMVLSGLFTSLFGL--GYFWnihMLWYFVLIQICNGLVQTTGwpsvvTCVGNWFGKGKRGFIMGI 183
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWL---LLLLVALAGIGSAAFHPEG-----ARLASQAAGGRRGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 184 WNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIITAVMGVITFLFLIeypedvdctppqhhddlekerdnpedPVNSPYS 263
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--------------------------PLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 264 SRESSVDIAASSSKeqgpepeaiSFLGALKIPGVIEFSLCLLFAKLVSYtflywLPLYiFNVAHFSAKEAGDLSTLFDVG 343
Cdd:cd17478 178 KKAAAKSSARSTLK---------GVWRALLLLLIIVFLRSWVLSSLTTF-----LPFY-LVQRGYSLVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 344 GIIGGIMAGLISDYtNGRATTCCVMLILAAPMMFLYNYigqNGITSSIVMLIICGVLVNGPYALITTAVsadlgtHESLK 423
Cdd:cd17478 243 GAIGTLIGGPLSDR-FGRRRVIIASLLLAAPFLLLFLL---TPGIWSYILLVLAGFLLFASFPVTVVLA------QELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 300795438 424 GNAkalSTVTAIIDGTG-SIGAALGPLLAGLISPTGWNNVFYMLISADILACLLLC 478
Cdd:cd17478 313 GNV---GLASGLMMGLSfGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
94-478 |
7.06e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 57.62 E-value: 7.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 94 FLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLftSLFGLGYFWNIHMLWYFVliQICNGLVQTTGWPSVVTCVGNWFg 173
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL--GFILSAFAISLPLLFLGY--GVLGGIGAGIGYITPVSTAVKWF- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 174 KGKRGFIMGIwnshTSVGNILGSLIAGVWVNQ-----HWGLSFIVPGIITAVMGVITfLFLIEYPedvdctPPQHHDDLE 248
Cdd:cd17353 122 PDKRGLATGI----VIAGFGLGSLIFSPLIAYlintvGVPTTFLILGIIFLIIIVIG-AFLIRDP------PKGWVPPGV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 249 KERDNPEDPVNSPYSSREssvdiaassskeqgpepeaisflgALKIPG--VIEFSLClLFAKLVSYTFLYWLPlYIFNVA 326
Cdd:cd17353 191 DPLANNAENSPRDYTPRE------------------------MLRTPTfwLLWLMFF-LNATAGLMLIGQAKP-IGQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 327 HFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPMMFLYNYIGQNGITssiVMLIICGVLVN--GP 404
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSVAVL---FVLGVALIGFCygGG 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300795438 405 YALITTAVSADLGTheslkgnaKALSTVTAIIDGTGSIGAALGPLLAGLISPT-GWNNVFYMLISADILACLLLC 478
Cdd:cd17353 321 FALFPALTADFFGT--------KNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTgGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
93-477 |
7.52e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 7.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfwniHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIITAVMGVITFLFLIEYPEDVDCTPPQHHDDLEKerd 252
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKK--- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 253 npedpvnspyssressvdiaassskeqgpepeaisflgALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKE 332
Cdd:cd17474 194 --------------------------------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPII 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 333 AGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIgqNGITSSIVMLIICGVLVNGPYALITTAV 412
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTTLV 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300795438 413 SADLGTHEslkgnakaLSTVTAIIDGTGSIGAALGPLLAGLISP-TGWNNVFYMLISADILACLLL 477
Cdd:cd17474 314 TELAPEEE--------RGTASSLYNFVRFLGQAVGPLLFGLLLEiFGLSAPFLVGAAIALAAAVLL 371
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
90-446 |
1.88e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 56.62 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 90 VDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYfwNIHMLWYFVLIQ-ICNGLVQttgwPSVVTCV 168
Cdd:TIGR00711 42 VITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP--NLELMIIFRVIQgFGGGPLI----PLSFSTL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 169 GNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGvWV--NQHWGLSFIVPGIITAVMGVITFLFLieyPEDVdctpPQHHDD 246
Cdd:TIGR00711 116 LNIYPPEKRGRAMAIWGLTVLVAPALGPTLGG-WIieNYHWRWIFLINVPIGIIVVVVAFFIL---PRDK----PAASEN 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 247 LekerdnpeDPVNSPYSSRE-SSVDIAASSSKEQG----PEPEAISFLGALKIPGVI-------------------EFS- 301
Cdd:TIGR00711 188 F--------DFLGLLLLSVGlGSLLYGLSEGPERGwfdsNEILILSITGLVAIIAFVvweltddnplvdlrlfkyrNFTi 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 302 --LCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRA-TTCCVMLILAAPMMFL 378
Cdd:TIGR00711 260 gcVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKlVTIGLILYAVGFYWRA 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 379 YNYIGQNGITSSIVMLIICGVLVNGPYALITTAVSADLGTHesLKGNAKALSTVTAIIdgTGSIGAAL 446
Cdd:TIGR00711 340 FTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPH--KIARGSSLSNFTRQL--GGSIGTAL 403
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
312-476 |
1.04e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 54.16 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 312 YTFLYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDY---------TNGRATTCCVMLILAAPMMFLYNYI 382
Cdd:cd17318 216 YTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWlrsrgilstTTVRKLFTSIGFLGPGVFLIALGYL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 383 GQNgITSSIVMLIICGvlvngpyALITTAVSADLGTHESLKGNAKalSTVTAIIDGTGSIGAALGPLLAGLI-----SPT 457
Cdd:cd17318 296 GSN-ATLAVVFLTLSV-------GLSGACYSGFLVNHLDLAPNYA--GTLMGITNTAATIAGIISPLIVGAIvkndqTIG 365
|
170
....*....|....*....
gi 300795438 458 GWNNVFYMLISADILACLL 476
Cdd:cd17318 366 QWRIVFFISAAIYILGAIF 384
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
93-235 |
1.05e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 54.18 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSL-FGLGYFWNihmlwyFVLIQICNGLVQTTGWPSVVTCVGNW 171
Cdd:cd17327 49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLtAAVKNFGG------LIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795438 172 FGKGKRGFIMGIWNSHTSVGNILGSLIA-------GVWVNQHWGLSFIVPGIITAVMGVITFLFLIEYPED 235
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLAygvfkilGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSK 193
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
93-446 |
1.29e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 53.73 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGyfWNIHMLWYFVLIQicnGLVQTTGWPSVVTCVGNWF 172
Cdd:cd17503 39 SYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA--PNLASLIIFRILQ---GFGGGVLIPLAQTILLRIY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQ-HWGLSFIV---PGIITAVMGVItflflieypedvdctppqhhddle 248
Cdd:cd17503 114 PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNlSWRWIFYInlpIGILALLLAPL------------------------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 249 kerdnpedpvnspyssressVDiaassskeqgpepeaisfLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHF 328
Cdd:cd17503 170 --------------------LD------------------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 329 SAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAA---PMMFLYNYIGQNGITSSIVMLIICGVLVNGPy 405
Cdd:cd17503 212 SAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALgtlLLAFLTPDTSLWLIILPLFIRGLGMGLVFMP- 290
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 300795438 406 alITTAVSADLGTHESlkGNAKALSTVTAIIdgTGSIGAAL 446
Cdd:cd17503 291 --LNTLALNSLPPEQI--GDATALFNTIRQL--GGSIGTAL 325
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
286-478 |
2.55e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.60 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 286 ISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTC 365
Cdd:cd17316 168 PALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRKKTL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 366 CVMLILAAPMMFLYNYIGQNGITSSIVMLIICGVLVNGPYALITTAVSadlgthESLKGNAKAlsTVTAIIDGTGSIGAA 445
Cdd:cd17316 247 VIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLA------ELFPTEVRA--TGVGLSYNLGRLGGG 318
|
170 180 190
....*....|....*....|....*....|...
gi 300795438 446 LGPLLAGLISPTGWNNVFYMLISADILACLLLC 478
Cdd:cd17316 319 GAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
93-454 |
4.88e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 4.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMF---ISGIFGERLPLRY-----YLSAGMVLSGLFTSLFGLGYFWNIHM-LWYFVLIQICNGLVQTTGWPS 163
Cdd:COG2211 51 ILLVARLWDAItdpLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGkLIYALVTYLLLGLAYTLVNIP 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 164 VVTCVGNWFGKGK-RGFIMGIWNSHTSVGNILGSLIAGVWVN-------QHWGLSFIVPGIITAVMGVITFLFLieyped 235
Cdd:COG2211 131 YSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAafggdaaLGYRLTALIFAVLGLLAFLLTFFGT------ 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 236 vdctppqhhddleKERDNPEDPvnspyssressvdiaASSSKEqgpepeaiSFLGALKIPGVIEFSLCLLFAKLVSYTFL 315
Cdd:COG2211 205 -------------KERPVPEEE---------------KVSLKE--------SLKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 316 YWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYnYIGQNGITSSIVMLI 395
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-FLGPGNLWLLLVLAA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 300795438 396 ICGVLVnGPYALITTAVSADLGTHESLKGNAKALSTVTAIIDGTGSIGAALGPLLAGLI 454
Cdd:COG2211 328 LAGIGL-GAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
94-228 |
2.48e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.54 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 94 FLVAYAIGMFISGI----FGERLPLRYYLSAGMVLSGLFTSLFGLgyfwnIHMLWYFVLIQICNGLVQTTGWPSVVTCVG 169
Cdd:cd06173 249 LLAAFGVGALLGALllgrLSKRRRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795438 170 NWFGKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQHWGLS--FIVPGIITAVMGVITFLF 228
Cdd:cd06173 324 LRVPDELRGRVFSVYNALNSGAMPLGALLAG-LLADALGLSavFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
94-229 |
8.36e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 8.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 94 FLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLfGLGYFWNIHMLWYFVLIQICNGLvqttGWPSVVTCVGNWF- 172
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL-GLLLLSFAGSPWMLLLAAVLYGL----GFGLLFPALQALAv 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300795438 173 ---GKGKRGFIMGIWNSHTSVGNILGSLIAGVwVNQHWGLS--FIVPGIITAVMGVITFLFL 229
Cdd:cd17489 307 dlvPPHRRGAANGTFFIFFDLGIGLGGLLLGL-VAELFGYRamFLLAAVVVLLALVLYIFLL 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
93-234 |
1.29e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLsagMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVVTCVGNWF 172
Cdd:COG2271 224 LPFLAGIVGSLLGGWLSDRLGRRRKL---VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQ-HWGLSFIVPGIITAVMGVITFLFLIEYPE 234
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
300-481 |
1.35e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 300 FSLCLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLY 379
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 380 nyigqngITSSIVMLIICGVLVNGPYALITTAVSADLGTHESLKGNAKALSTVTAIIdgtgSIGAALGPLLAG-LISPTG 458
Cdd:pfam07690 81 -------FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGF----GLGAALGPLLGGlLASLFG 149
|
170 180
....*....|....*....|...
gi 300795438 459 WNNVFYMLISADILACLLLCRLV 481
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPR 172
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
99-477 |
1.92e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 99 AIGMFISGIFGERLPLRYYLSAGMVLSGLFtslfGLGYFW--NIHMLWYFVLIQ-ICNGLVQTtgwpSVVTCVGNWFGKG 175
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIG----GVAGLFldSLYALLASRALLgIGVAGIMT----LATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 176 KRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVPGIitAVMGVITFLFLIEYPEdvdctppqhhddlekerdnpe 255
Cdd:cd17473 121 ERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLL--ALPVLILVLLFLPEPA--------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 256 dpvnspyssRESSVDIAASSSKEQGPEPEAISFLGALkipgviefslcLLFAKLVSYTFLYWLPLYIFNVAHFSAKEAGD 335
Cdd:cd17473 178 ---------RKSKSAASPGAATAAALPWKRVLPIYFL-----------AFLAMLLFYVIPIQLPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 336 LSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLynyigqnGITSSIVMLIICGVLVNGPYALITTAVSAD 415
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL-------ALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300795438 416 LGTHESLKGNAKALSTVTAIIdgtgSIGAALGPLLAGLISPTGWNNVFYMLISADILACLLL 477
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTSAF----FLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAI 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
94-230 |
3.44e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 94 FLVAYAIGMFISGIFGERLPLRYYLsagMVLSGLFTSLFGLGYFWNIHmLWYFVLIQICNGLVQTTGWPSVVTCVGNWFG 173
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIGRKPL---LLIGLLLMALGLALLLLAPS-LLLLLLLLLLLGFGLGGLLPLSFALIAELFP 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 300795438 174 KGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQHWGLSFIVpgIITAVMGVITFLFLI 230
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF--LVLAVLLLLAAILLL 378
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
88-229 |
3.78e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 88 GAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLwyfVLIQICNGLVQTTGWPSVVTC 167
Cdd:cd17380 37 GLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL---ILSRILLGLGEGVHFPSMTSL 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 168 VGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH-WGLSFIVPGIITAVMGVITFLFL 229
Cdd:cd17380 114 FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYgWPSVFYFFGLLGLLWALVWLIYL 176
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
102-230 |
8.00e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.85 E-value: 8.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 102 MFISGIFGERLPLRYYLSAGMVLSGLFTSLFglgyfWNIHMLWYFVLIQICNGLvqttgWPSVVTCVG----NWFGKGKR 177
Cdd:cd17471 252 MLLAGLLAKRFGKRRLLLAGFLAGVLFYLGL-----ALATSLWQLIALQLLNAI-----FIGITAGLGisyfQDLMPGQP 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 300795438 178 GFIMGIWNSHTSVGNILGSLIAGVWVnQHWGLSFIVpgIITAVMGVITFLFLI 230
Cdd:cd17471 322 GLATTLYSNASRIGSLLGGLLAGVIA-QYFGYRAVF--LVCAVLALLALVLLL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
92-454 |
8.35e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 8.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 92 NAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLfTSLFGlGYFWNIHMLWYFVLIQ-ICNGLVQttgwPSVVTCVGN 170
Cdd:cd17321 38 NAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGL-ASLLC-ALAPSLAFLIAARALQgIGAAAIM----PASLALIAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 171 WFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQ-HWGLSFIVPGIItavmGVITFLFlieypedvdctppqhhddlek 249
Cdd:cd17321 112 TFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELfGWRWIFLINVPI----GLVALLL--------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 250 erdnpedpvnspyssressvdiaassskeqgpepeAISFLGAlkipgviefSLCLLFAKLVSYTFLYWLPLYIFNVAHFS 329
Cdd:cd17321 167 -----------------------------------ARTFSGA---------VLAAFLLGAALGGLLFLLPLYLQGVLGYS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 330 AKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNYIGQNGITSSIVMLIICGVLVNGPYALIT 409
Cdd:cd17321 203 PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLT 282
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 300795438 410 TAVSADLGTHESlkgnakalSTVTAIIDGTGSIGAALGPLLAGLI 454
Cdd:cd17321 283 NAALSSVPKEKA--------GAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
85-228 |
1.48e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.11 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 85 ELLGAvdNAFLVAYAIG-MFISGI----FGERLPLRYYLSAGMVLSGLFTSLFGLGYFWnIHMLWYFVLIQICNGLVQTT 159
Cdd:cd17335 226 QDLGG--SKTLIGLLWTvGVVSEIpfffFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSF-LENPWLVLPIELLHGLTFAL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300795438 160 GWPSVVTCVGNWFGKGKRGFIMGIWNS-HTSVGNILGSLIAGVWVNqHWG--LSFIVPGIITAVMGVITFLF 228
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLQGlYFGLGGGLGSLIGGYLYE-AFGarTTFRFFAIAALAGLLAFFLI 373
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
93-230 |
2.03e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFglgYFWNIHMLWYF----VLIQICNGLVQTTGWPSVVTCV 168
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLlvlaALAGIGLGAILVLPWAMLADVV 348
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300795438 169 --GNW-FGKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQHWGLSFIVPGIITAVMGVITFLFLI 230
Cdd:COG2211 349 dyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAG-LLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
93-480 |
3.48e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLftSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVVTcvgNWF 172
Cdd:cd17320 42 AYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFIL--ASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVR---DLY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 173 GKGKR----GFIMGIWNSHTSVGNILGSLIAGVWvnqHWGLSFIVPGIITAVMGVITFLFLieyPEdvdcTPPQHHddle 248
Cdd:cd17320 117 SGAELakifSLLMMILAIAPALAPLLGGLLLLFF---GWRAIFVFLALLGLLLLLLVLLFL---PE----TLPEEK---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 249 kerdnpedpvnspyssressvdiaasssKEQGPEPEAISFLGALKIPGVIEFSLCLLFAKLVSYTFLYWLPLYIFNVAHF 328
Cdd:cd17320 183 ----------------------------RKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 329 SakeAGDLSTLFdvggiIGGIMAGLISDYTNGRATTCC----------VMLILAAPMMFLYNYIGQNGITSSIVMLIICG 398
Cdd:cd17320 235 S---PAQFGLLF-----ALNAIALILGSLLNGRLVRRFgprrllrlglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 399 VLVNgpyALITTAVSADLGTHESLKGNAKALSTVTAIIdgtgsIGAALGPLLAGLISPTGWNNVFYMLISAdILACLLLC 478
Cdd:cd17320 307 FGFG---LIFPNATSLALEPFPHVAGTASALLGFLQFL-----IGALAGALVGLLPNGTALPMGLLILVLG-LLALLLLI 377
|
..
gi 300795438 479 RL 480
Cdd:cd17320 378 LL 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
304-481 |
4.35e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 304 LLFAKLVSYTFLYWLPLYIFNVA--------HFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPM 375
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPAlpliaadlGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 376 MFLYnyigqnGITSSIVMLIICGVLVNGPYALITTAVSADLGTHESLKGNAKALSTVTAIIdgtgSIGAALGPLLAGLIS 455
Cdd:COG2814 89 SLLC------ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGL----GLGPALGPLLGGLLA 158
|
170 180
....*....|....*....|....*..
gi 300795438 456 PT-GWNNVFYMLISADILACLLLCRLV 481
Cdd:COG2814 159 DLfGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
87-228 |
6.73e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISG-IFGERLPLRYYLSAGMVLSGLftslfGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVV 165
Cdd:cd17474 236 IGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYAL-----SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVnQHWGLS--FIVPGIITAVMGVITFLF 228
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSapFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
88-465 |
8.43e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 8.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 88 GAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTslfgLGYFWnIHMLWYFVLIQICNGLVQTTGWPSVVTC 167
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT----LLYLL-ATSVALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 168 VGNWFGKGKRGFIMGIWNSHTSVGNILGSLIaGVWVNQHWGLSFIvpGIITAVMGVITFL--FLIEYPedvdctppqhhd 245
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVL--FIVAAVLALLALLlvFLVKDP------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 246 dlekerdNPEDPVNSPYSSRESSVDIaassskeqgpEPEAIsflgalkIPGVIEFSLCLLFAKLVSYtflywLPLYifnV 325
Cdd:cd17489 174 -------PPVAAEEAEAGTRAFRRLV----------EKKVL-------PPALILFLASIAYGAISTF-----LPLY---A 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 326 AHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLYNyigqngiTSSIVMLIICGVLVNGPY 405
Cdd:cd17489 222 AERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF-------AGSPWMLLLAAVLYGLGF 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795438 406 ALITTAVSADLGTHESLKGNAKALSTVTAIIDgtgsIGAALGPLLAGLISP-TGWNNVFYM 465
Cdd:cd17489 295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFD----LGIGLGGLLLGLVAElFGYRAMFLL 351
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
93-230 |
1.05e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.38 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGwPSVVTCVGNwF 172
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAH-SALQTRVLR-L 315
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 173 GKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQHWGLSFIvpGIITAVMGVITFLFLI 230
Cdd:cd17324 316 APEARGLASSLYLAAYNLGGALGAALGG-LVLDHGGWAGV--GWVGAALLLLALLLAL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
93-230 |
1.11e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 93 AFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLftSLFGLGYFWNIHMLWY-FVLIQICNGLVQTTGWPSVVTCVGnw 171
Cdd:cd17370 242 LFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLAL--AYLGFALGSSLWLLLLgFILWGLYMGAQESIERAAVADLVP-- 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 172 fgKGKRGFIMGIWNSHTSVGNILGSLIAGV-WvnQHWGLSFIVpgIITAVMGVITFLFLI 230
Cdd:cd17370 318 --AELRGTAYGLFNTVVGIGWLLASLIAGYlW--DLISPSAAF--LFSAVLALIALLLLL 371
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
87-229 |
1.44e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 87 LGAVDNAFLVAYAIGMFISG-IFGERLPLRYYLSAGMVLSGLftSLFGLGYFWNihmLWYFVLIQICNGLVQTTGWPSVV 165
Cdd:cd17490 232 LGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGA--YCFLIPFAPN---LTLLYLLQALNGFGTGILFPLLM 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQHWGLS--FIVPGIITAVMGVITFLFL 229
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVG-IISEAFGLQtgFFVIGVIALLAAILSLAYY 371
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
313-464 |
3.31e-03 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 39.98 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 313 TFLYWLPLYIFN---------VAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGR----ATTCCVMLILAAPMMFLY 379
Cdd:cd17322 294 DFFYFFSYYIFSdylytvlqvAVGESITSATRITNLYSFVSTVAGIFVGFLIRKT-RRykvlVIIGVPLYIVGMGLLIRY 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 380 NYIGQNG---ITSSIVMLIICGVLVNGPYALITTAVSadlgtHESLkgnakalSTVTAIIDGTGSIGAALGPLLAGLIsp 456
Cdd:cd17322 373 RGGSGSHggiIGALILIGIGGGLFTYPVQVSVQASVS-----HQEM-------AVVTALLLTVYSIGGAVGAAISGAI-- 438
|
....*...
gi 300795438 457 tgWNNVFY 464
Cdd:cd17322 439 --WTQTLP 444
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
174-228 |
7.01e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 7.01e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 174 KGKRGFIMGIWNSHTSVGNILGSLIAGVW-VNQHWGLS-------FIVPGIITAVMGVITFLF 228
Cdd:cd17346 334 AKFAGFMMGLWFLASALGNILAGYLAGFYaQPKDPLASalvytdyFGLIGVIALVAGIILLLL 396
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
327-506 |
7.07e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 327 HFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTNGRATTCCVMLILAAPMMFLynyigqnGITSSIVMLIICGVLVnGPYA 406
Cdd:COG2223 36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL-------ALAVSYWLLLLLGLLL-GIGG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 407 LITTAVSADLGT---HESLKGnakalsTVTAIIDGTGSIGAALGPLLAG-LISPTGWNNVFYMLISAdILACLLLCRLVY 482
Cdd:COG2223 108 GGSFAVGIALVSkwfPPDRRG------LALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLILGIL-LLVVAVLAWLFL 180
|
170 180
....*....|....*....|....*.
gi 300795438 483 KEI--LAWKTARSRNSGSSLALTHPR 506
Cdd:COG2223 181 RDPpaGAAAAAKASLRDQLEALRDPR 206
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
86-241 |
7.27e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 7.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 86 LLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWNIHMLWYFVLIQICNGLVQTTGWPSVV 165
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVnQHWGLSFIVPGIITAVMGVITFLFLIEYPEDVDCTPP 241
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGES 189
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
86-458 |
7.75e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 86 LLGAVdnaFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTSLFGLGYFWnihmlWYFVLIQICNGLVQTTGWPSVV 165
Cdd:cd17371 38 LLGTV---TLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNY-----WQLLILRALAGLGFGGEWAAGA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 166 TCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGvWVNQH------WGLSFIVpGIITAVMGVITFLFLIEypedvdct 239
Cdd:cd17371 110 ALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAA-LLFPLlppeiaWRVLFLL-GALPALLVLFIRRFVKE-------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 240 PPQhhddlekerdnpedpvnspyssressvdiaASSSKEQGPEPEAISFLGALKIPGV----IEFSLCLLFAKLVSYTFL 315
Cdd:cd17371 180 PPQ------------------------------WQAARAARRHFADRPSLRELFSPPLlrttLLASLLATGALGGYYGIT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 316 YWLPLYIFNVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDYTnGRATTCCVMLILAAPMMFLYNYIGQNgITSSIVMLI 395
Cdd:cd17371 230 TWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI-GRRNNFALFALGSAISILLYFFLPLS-PTLILILGF 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300795438 396 ICGVLVNGPYALITTAVSadlgthESLKGNAKAlsTVTAIIDGTGSIGAALGPLLAGLISPTG 458
Cdd:cd17371 308 PLGFFASGPFSGMGAYLT------ELFPTAVRA--TAQGFCYNVGRIIGALFPFLVGFLATSG 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
92-230 |
7.87e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 7.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 92 NAFLVAyaIGMFISGIFGERLPLRYYLSAGMVLSGLftSLFGLGYFWNihmLWYFVLIQICNGLVQTTGWPSVVTCVGNW 171
Cdd:cd17329 245 NALLIV--LLQFPVARLVERFRLRKILMIGILLFAI--GFAVLAFANT---LAVLILAMIVLTLGEMLVFPAVQTLVAAL 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 300795438 172 FGKGKRGFIMGIWNSHTSVGNILGSLIAGVWVNQH--WGLSFIVpgiitAVMGVITFLFLI 230
Cdd:cd17329 318 APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLgpGLPWLIL-----AALGLIAAALLL 373
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
84-477 |
8.54e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.34 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 84 KELLGAVDNAFLVAYAIGMFISGIFGERLPLRYYLSAGMVLSGLFTslFGLGYFWNIHMlwyFVLIQICNGLVQTTGWPS 163
Cdd:cd17365 33 PAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFT--LLTAFAQSVLQ---LALLRFLTGLGLGAAMPN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 164 VVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAgVWVNQHWGLSFIVpgIITAVMGVITFLFLIeypedvdctppqh 243
Cdd:cd17365 108 AITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLA-AALIPAFGWRSVF--LLGGVPPLILLPLLR------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 244 hddlekerdnpedpvnspyssressvdiaassskeqgpepeaisflgalkipGVIEFSLCLLFAKLVSYTFLYWLPlYIF 323
Cdd:cd17365 172 ----------------------------------------------------GTLLLWVTFFMGLLLVYLLNSWLP-KLM 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300795438 324 NVAHFSAKEAGDLSTLFDVGGIIGGIMAGLISDyTNGRATTCCVMLILAAPMMFLynyIGQNGITSSI--VMLIICGVLV 401
Cdd:cd17365 199 VEAGYSLSQALTITLLLNIGGVIGSLLLGWLAD-RFGPKRVLALFFALGAVSLAL---LGVSPASLVLlyVLVFLAGACV 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300795438 402 NGPYALItTAVSADLGTheslkgnAKALSTVTAIIDGTGSIGAALGPLLAGLISPTGW--NNVFYMLISADILACLLL 477
Cdd:cd17365 275 NGAQVGL-YALAARFYP-------TEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLgpESVFLALAIPAALGALAV 344
|
|
| |
