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Conserved domains on  [gi|300796822|ref|NP_001180015|]
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U4/U6.U5 tri-snRNP-associated protein 1 [Bos taurus]

Protein Classification

SNU66/SART1 family protein( domain architecture ID 18337532)

SNU66/SART1 family protein similar to human U4/U6.U5 tri-snRNP-associated protein 1, also called squamous cell carcinoma antigen recognized by T-cells 1 (SART-1), that plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome

Gene Ontology:  GO:0000398|GO:0046540|GO:0005681
PubMed:  11350945

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
165-755 1.41e-121

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


:

Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 377.45  E-value: 1.41e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  165 EELREKLAAAKEKRILNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFEQR 244
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  245 RQDLYSARDLQGLTVEHAIDSFREGETVILTLKDKGVL-QEEEDVLVNVNLLDKERAEKNVELRKKKPDYLPYVEDESVD 323
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLlDEEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDGE 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  324 dlaqhKPRSILSKYDEELEGERPQ-SFRLEQGGVADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKT 402
Cdd:pfam03343 149 -----GEKGILSKYDEEIDGKKKKkGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKFKKP 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  403 KRRVKKIRKKEKEvimRADDLLPLGDqtqdgdfgsrlrgrgrrrvpeadeepqeegekepmPQPPPSDDTRVENMDISDE 482
Cdd:pfam03343 224 KKKKKKKTRKKAK---KDDDLLILFP-----------------------------------GEADLGLPSDDDDMDVDSE 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  483 EEGAVLQsgSPEVLEEDEAELELQKQLEKGRRLRQLQQLRDSGEkvvEIVKRLESRQRGWEEEDPERKGAIVFNATSEFC 562
Cdd:pfam03343 266 PIGVERL--TRDVIENFVDDDDLQAALARQRRAALKKRKKLRPE---DIARQLKEEREEEEEDEEEEDGGLVIDETSEFV 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  563 RTLGEIPTYGLAGNRE---DQEELMDFERDEERSANGGSESDGEENMGWSTVNLDEEKQQQDFSAS-------STTILDE 632
Cdd:pfam03343 341 RNLGAIPTYERAGNRRkpvPVSPVADEEDEEEDMFEEDGDVDMEDESYEDAEEEEAEEEAREEEESdedladiTGTGLEE 420
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  633 EPIVNRGLAAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKYSRRE 691
Cdd:pfam03343 421 EPTVSQGLGATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEYARRE 500
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  692 EYR------GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEE 755
Cdd:pfam03343 501 NRQreqqeaRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEE 569
HIND pfam19252
HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in ...
118-137 1.55e-06

HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in spliceosomal proteins such as Snu66. The motif is bound by the Hub1 protein.


:

Pssm-ID: 466011  Cd Length: 22  Bit Score: 44.76  E-value: 1.55e-06
                          10        20
                  ....*....|....*....|
gi 300796822  118 LSIEETNKLRAKLGLKPLEV 137
Cdd:pfam19252   3 LSIEETNKLRASLGLKPIPV 22
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
165-755 1.41e-121

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 377.45  E-value: 1.41e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  165 EELREKLAAAKEKRILNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFEQR 244
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  245 RQDLYSARDLQGLTVEHAIDSFREGETVILTLKDKGVL-QEEEDVLVNVNLLDKERAEKNVELRKKKPDYLPYVEDESVD 323
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLlDEEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDGE 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  324 dlaqhKPRSILSKYDEELEGERPQ-SFRLEQGGVADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKT 402
Cdd:pfam03343 149 -----GEKGILSKYDEEIDGKKKKkGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKFKKP 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  403 KRRVKKIRKKEKEvimRADDLLPLGDqtqdgdfgsrlrgrgrrrvpeadeepqeegekepmPQPPPSDDTRVENMDISDE 482
Cdd:pfam03343 224 KKKKKKKTRKKAK---KDDDLLILFP-----------------------------------GEADLGLPSDDDDMDVDSE 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  483 EEGAVLQsgSPEVLEEDEAELELQKQLEKGRRLRQLQQLRDSGEkvvEIVKRLESRQRGWEEEDPERKGAIVFNATSEFC 562
Cdd:pfam03343 266 PIGVERL--TRDVIENFVDDDDLQAALARQRRAALKKRKKLRPE---DIARQLKEEREEEEEDEEEEDGGLVIDETSEFV 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  563 RTLGEIPTYGLAGNRE---DQEELMDFERDEERSANGGSESDGEENMGWSTVNLDEEKQQQDFSAS-------STTILDE 632
Cdd:pfam03343 341 RNLGAIPTYERAGNRRkpvPVSPVADEEDEEEDMFEEDGDVDMEDESYEDAEEEEAEEEAREEEESdedladiTGTGLEE 420
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  633 EPIVNRGLAAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKYSRRE 691
Cdd:pfam03343 421 EPTVSQGLGATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEYARRE 500
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  692 EYR------GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEE 755
Cdd:pfam03343 501 NRQreqqeaRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEE 569
HIND pfam19252
HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in ...
118-137 1.55e-06

HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in spliceosomal proteins such as Snu66. The motif is bound by the Hub1 protein.


Pssm-ID: 466011  Cd Length: 22  Bit Score: 44.76  E-value: 1.55e-06
                          10        20
                  ....*....|....*....|
gi 300796822  118 LSIEETNKLRAKLGLKPLEV 137
Cdd:pfam19252   3 LSIEETNKLRASLGLKPIPV 22
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
165-755 1.41e-121

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 377.45  E-value: 1.41e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  165 EELREKLAAAKEKRILNQKLgKIKTLGEDDpWLDDTAAWIERSRQLQKEkdlaEKRAKLLEeMDQEFGvstlvEEEFEQR 244
Cdd:pfam03343   1 EELKEKIKKAREKRERNAKL-EGKGLGEDD-EDDDAKAWVKKSKKRQKA----IAKAKARE-LEEELG-----EEEAEKA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  245 RQDLYSARDLQGLTVEHAIDSFREGETVILTLKDKGVL-QEEEDVLVNVNLLDKERAEKNVELRKKKPDYLPYVEDESVD 323
Cdd:pfam03343  69 AQAEYTSKDLAGLKVGHDLDDFLEGEEQILTLKDTGVLlDEEEDELENVNLAEKEKLKKNLELKKKKPGYDPYDDDEDGE 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  324 dlaqhKPRSILSKYDEELEGERPQ-SFRLEQGGVADGLRERELEEIRAKLRLQAQSLSTVGPRLASEYLTPEEMVTFKKT 402
Cdd:pfam03343 149 -----GEKGILSKYDEEIDGKKKKkGFTLDGQGSTAEEREALAEEIAEKLKKQLLSLDYLKLEPASDYLDESEIFKFKKP 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  403 KRRVKKIRKKEKEvimRADDLLPLGDqtqdgdfgsrlrgrgrrrvpeadeepqeegekepmPQPPPSDDTRVENMDISDE 482
Cdd:pfam03343 224 KKKKKKKTRKKAK---KDDDLLILFP-----------------------------------GEADLGLPSDDDDMDVDSE 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  483 EEGAVLQsgSPEVLEEDEAELELQKQLEKGRRLRQLQQLRDSGEkvvEIVKRLESRQRGWEEEDPERKGAIVFNATSEFC 562
Cdd:pfam03343 266 PIGVERL--TRDVIENFVDDDDLQAALARQRRAALKKRKKLRPE---DIARQLKEEREEEEEDEEEEDGGLVIDETSEFV 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  563 RTLGEIPTYGLAGNRE---DQEELMDFERDEERSANGGSESDGEENMGWSTVNLDEEKQQQDFSAS-------STTILDE 632
Cdd:pfam03343 341 RNLGAIPTYERAGNRRkpvPVSPVADEEDEEEDMFEEDGDVDMEDESYEDAEEEEAEEEAREEEESdedladiTGTGLEE 420
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  633 EPIVNRGLAAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKYSRRE 691
Cdd:pfam03343 421 EPTVSQGLGATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEYARRE 500
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300796822  692 EYR------GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHRFHGKGSGKMKTERRMKKLDEE 755
Cdd:pfam03343 501 NRQreqqeaRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEE 569
HIND pfam19252
HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in ...
118-137 1.55e-06

HIND motif; The Hub1 interacting motif (HIND) is a short motif found in 1 to 3 copies in spliceosomal proteins such as Snu66. The motif is bound by the Hub1 protein.


Pssm-ID: 466011  Cd Length: 22  Bit Score: 44.76  E-value: 1.55e-06
                          10        20
                  ....*....|....*....|
gi 300796822  118 LSIEETNKLRAKLGLKPLEV 137
Cdd:pfam19252   3 LSIEETNKLRASLGLKPIPV 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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