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Conserved domains on  [gi|1769843774|ref|NP_001180240|]
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succinate--hydroxymethylglutarate CoA-transferase isoform 1 [Homo sapiens]

Protein Classification

CaiB/BaiF CoA transferase family protein( domain architecture ID 10004536)

CaiB/BaiF CoA transferase family protein catalyzes the reversible transfer of the CoA moiety from a fatty acid CoA ester to a fatty acid acceptor, might also act as an acyl-CoA racemase

Gene Ontology:  GO:0003824
PubMed:  11749953
SCOP:  4000567

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CaiB COG1804
Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid ...
35-458 0e+00

Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism];


:

Pssm-ID: 441409  Cd Length: 397  Bit Score: 516.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  35 MNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGtESTYYLSVNRNKKSIAVNIKDPK 114
Cdd:COG1804     1 PAMTGPLAGIRVLDLSRVLAGPFATMLLADLGADVIKVERPGGGDPTRGWGPPFDG-ESAYFLSLNRNKRSITLDLKSPE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 115 GVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENG 194
Cdd:COG1804    80 GRELLRRLVARADVLVENFRPGVLERLGLGYEALRAINPRLIYCSISGFGQTGPYADRPGYDLIAQAMSGLMSLTGEPDG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 195 DPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAF 274
Cdd:COG1804   160 PPVRVGVSVADIAAGLYAAIGILAALLHRERTGRGQVVDVSLLDAALALLANQAAEYLATGEVPERTGNRHPGIAPYGVY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 275 KTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINN 354
Cdd:COG1804   240 RTADGWVAIAAGNDRQWRRLCEALGRPDLADDPRFATNAARVANRDELDALLAAWFATRTRAEWLELLEAAGVPAAPVNT 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 355 MKNVFAEPQNAvsgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHT 434
Cdd:COG1804   320 LAEVLADPQLA--------------------------ARGMFVEVDHPDGGPVRQPGPPPRFSGTPGRVRRPAPALGEHT 373
                         410       420
                  ....*....|....*....|....
gi 1769843774 435 THILKEvLRYDDRAIGELLSAGVV 458
Cdd:COG1804   374 DEVLAE-LGYSAEEIAALRAAGVI 396
 
Name Accession Description Interval E-value
CaiB COG1804
Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid ...
35-458 0e+00

Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism];


Pssm-ID: 441409  Cd Length: 397  Bit Score: 516.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  35 MNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGtESTYYLSVNRNKKSIAVNIKDPK 114
Cdd:COG1804     1 PAMTGPLAGIRVLDLSRVLAGPFATMLLADLGADVIKVERPGGGDPTRGWGPPFDG-ESAYFLSLNRNKRSITLDLKSPE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 115 GVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENG 194
Cdd:COG1804    80 GRELLRRLVARADVLVENFRPGVLERLGLGYEALRAINPRLIYCSISGFGQTGPYADRPGYDLIAQAMSGLMSLTGEPDG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 195 DPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAF 274
Cdd:COG1804   160 PPVRVGVSVADIAAGLYAAIGILAALLHRERTGRGQVVDVSLLDAALALLANQAAEYLATGEVPERTGNRHPGIAPYGVY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 275 KTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINN 354
Cdd:COG1804   240 RTADGWVAIAAGNDRQWRRLCEALGRPDLADDPRFATNAARVANRDELDALLAAWFATRTRAEWLELLEAAGVPAAPVNT 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 355 MKNVFAEPQNAvsgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHT 434
Cdd:COG1804   320 LAEVLADPQLA--------------------------ARGMFVEVDHPDGGPVRQPGPPPRFSGTPGRVRRPAPALGEHT 373
                         410       420
                  ....*....|....*....|....
gi 1769843774 435 THILKEvLRYDDRAIGELLSAGVV 458
Cdd:COG1804   374 DEVLAE-LGYSAEEIAALRAAGVI 396
CoA_transf_3 pfam02515
CoA-transferase family III; CoA-transferases are found in organizms from all lines of descent. ...
41-434 2.66e-144

CoA-transferase family III; CoA-transferases are found in organizms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.


Pssm-ID: 426810 [Multi-domain]  Cd Length: 367  Bit Score: 417.01  E-value: 2.66e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  41 LEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGaGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIK 120
Cdd:pfam02515   1 LAGIRVLDLTQVVAGPFATMLLADLGAEVIKVEPPG-GDPTRYVGPYAEKGGSAYFLSVNRNKRSVALDLKSEEGREVLR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 121 ELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPG 200
Cdd:pfam02515  80 RLVARADVVIENFRPGVLERLGLGYEDLRAINPRLIYCSVSGYGQTGPYADRPGYDLIAQAMSGLMSLTGEPGGPPVKVG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 201 VAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGY 280
Cdd:pfam02515 160 TPVGDIVTGLLAAIAILAALLARERTGKGQVIDVSLLEAALALMGPQLLEYLATGRVPGRVGNRHPAAAPYGLYRTADGW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 281 IVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFA 360
Cdd:pfam02515 240 VAIAAGTDKQWARLCRALGRPELADDPRFATNAARVQNRAELDAELAAWLATRTAAEWLALLAAAGVPAGPVNTVEEVLD 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769843774 361 EPQNAvsgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHT 434
Cdd:pfam02515 320 DPHLR--------------------------ARGMVVEVDHPDYGPVPVPGLPVRLSGTPGRVRRPAPALGEHT 367
PRK11430 PRK11430
putative CoA-transferase; Provisional
40-440 7.73e-87

putative CoA-transferase; Provisional


Pssm-ID: 183132 [Multi-domain]  Cd Length: 381  Bit Score: 270.70  E-value: 7.73e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  40 PLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPpFVGTESTYYLSVNRNKKSIAVNIKDPKGVKII 119
Cdd:PRK11430    9 PFEGLLVIDMTHVLNGPFGTQLLCNMGARVIKVEPPGHGDDTRTFGP-YVDGQSLYYSFINHGKESVVLDLKNDHDKSIF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 120 KELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRP 199
Cdd:PRK11430   88 INMLKQADVLAENFRPGTMEKLGFSWETLQEINPRLIYASSSGFGHTGPLKDAPAYDTIIQAMSGIMMETGYPDAPPVRV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 200 GVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDG 279
Cdd:PRK11430  168 GTSLADLCGGVYLFSGIVSALYGREKSQRGAHVDIAMFDATLSFLEHGLMAYIATGKSPQRLGNRHPYMAPFDVFDTQDK 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 280 YIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVF 359
Cdd:PRK11430  248 PITICCGNDKLFSALCQALELTELVNDPRFSSNILRVQNQAILKQYIERTLKTQAAEVWLARIHEVGVPVAPLLSVAEAI 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 360 AEPQNavsgfqsllhslahgpflhlqgSARvlhNGLVmemehpTVGKISVPGPAVRYSKFKMSEARP-PPLLGQHTTHIL 438
Cdd:PRK11430  328 NLPQT----------------------QAR---NMLI------EAGGIMMPGNPIKISGCADPHVMPgAATLDQHGEQIR 376

                  ..
gi 1769843774 439 KE 440
Cdd:PRK11430  377 QE 378
mesacon_CoA_iso TIGR04253
mesaconyl-CoA isomerase; Members of this protein family belong by homology to the family of ...
41-458 1.08e-24

mesaconyl-CoA isomerase; Members of this protein family belong by homology to the family of CoA transferases. However, the characterized member from Chloroflexus aurantiacus appears to perform an intramolecular transfer, making it an isomerase. The enzyme converts mesaconyl-C1-CoA to mesaconyl-C4-CoA as part of the bicyclic 3-hydroxyproprionate pathway for carbon fixation.


Pssm-ID: 211976  Cd Length: 403  Bit Score: 105.43  E-value: 1.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  41 LEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIK 120
Cdd:TIGR04253   3 LHGLRVVEGSAFVAAPLGGMTLAQLGADVIRFDPIGGGLDYKRWPLTLDGKHSLFWAGLNKGKRSIAIDIRHPRGQELLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 121 ELaaVC------DVFVENYvPGKlsaMGLGYEDIDEIAPHIIYCSITGygqtgpisQRAGYDAVASAVS---GLMHITGP 191
Cdd:TIGR04253  83 QL--ICapgdhaGLFITNF-PAK---GWLAYDALKAHRADLIMVNLTG--------RRDGGSEVDYTLNpqlGLPFMTGP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 192 ENG-DPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIA--ANYLIGQKEAKRWGT----A 264
Cdd:TIGR04253 149 TSSpDVVNHVFPAWDFISGQMIALGLLAAERHRRLTGEGQLVKIALKDVALAMIGHFGmiAEAMINDADRPRQGNylygA 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 265 HGsivpyQAFKTKDG--YIVVGAgNNQQFATVCKILDLPELID--------NSKYKTNHLRVhnRKELIKILSERFEEEL 334
Cdd:TIGR04253 229 FG-----RDFETLDGkrLMVVGL-TDLQWKALGKATGLRDAFNalaarlglDFDDEGDRFRA--RHEIAALFEPWFHART 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 335 TSKWLYLFEGSGVPYGPINNMKNVFAEPQNAVSgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAV 414
Cdd:TIGR04253 301 LAEAALIFDAHGVTWAPYRSVREAIAADPDCST------------------------DNPMFALTEQPGIGRYLMPGSPL 356
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1769843774 415 RYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVV 458
Cdd:TIGR04253 357 DFAAVPRLPAMPAPRLGEHTDEILLDILGLSEAEVGRLHDAGIV 400
 
Name Accession Description Interval E-value
CaiB COG1804
Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid ...
35-458 0e+00

Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism];


Pssm-ID: 441409  Cd Length: 397  Bit Score: 516.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  35 MNNIKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGtESTYYLSVNRNKKSIAVNIKDPK 114
Cdd:COG1804     1 PAMTGPLAGIRVLDLSRVLAGPFATMLLADLGADVIKVERPGGGDPTRGWGPPFDG-ESAYFLSLNRNKRSITLDLKSPE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 115 GVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENG 194
Cdd:COG1804    80 GRELLRRLVARADVLVENFRPGVLERLGLGYEALRAINPRLIYCSISGFGQTGPYADRPGYDLIAQAMSGLMSLTGEPDG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 195 DPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAF 274
Cdd:COG1804   160 PPVRVGVSVADIAAGLYAAIGILAALLHRERTGRGQVVDVSLLDAALALLANQAAEYLATGEVPERTGNRHPGIAPYGVY 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 275 KTKDGYIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINN 354
Cdd:COG1804   240 RTADGWVAIAAGNDRQWRRLCEALGRPDLADDPRFATNAARVANRDELDALLAAWFATRTRAEWLELLEAAGVPAAPVNT 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 355 MKNVFAEPQNAvsgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHT 434
Cdd:COG1804   320 LAEVLADPQLA--------------------------ARGMFVEVDHPDGGPVRQPGPPPRFSGTPGRVRRPAPALGEHT 373
                         410       420
                  ....*....|....*....|....
gi 1769843774 435 THILKEvLRYDDRAIGELLSAGVV 458
Cdd:COG1804   374 DEVLAE-LGYSAEEIAALRAAGVI 396
CoA_transf_3 pfam02515
CoA-transferase family III; CoA-transferases are found in organizms from all lines of descent. ...
41-434 2.66e-144

CoA-transferase family III; CoA-transferases are found in organizms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.


Pssm-ID: 426810 [Multi-domain]  Cd Length: 367  Bit Score: 417.01  E-value: 2.66e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  41 LEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGaGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIK 120
Cdd:pfam02515   1 LAGIRVLDLTQVVAGPFATMLLADLGAEVIKVEPPG-GDPTRYVGPYAEKGGSAYFLSVNRNKRSVALDLKSEEGREVLR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 121 ELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRPG 200
Cdd:pfam02515  80 RLVARADVVIENFRPGVLERLGLGYEDLRAINPRLIYCSVSGYGQTGPYADRPGYDLIAQAMSGLMSLTGEPGGPPVKVG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 201 VAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGY 280
Cdd:pfam02515 160 TPVGDIVTGLLAAIAILAALLARERTGKGQVIDVSLLEAALALMGPQLLEYLATGRVPGRVGNRHPAAAPYGLYRTADGW 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 281 IVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFA 360
Cdd:pfam02515 240 VAIAAGTDKQWARLCRALGRPELADDPRFATNAARVQNRAELDAELAAWLATRTAAEWLALLAAAGVPAGPVNTVEEVLD 319
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1769843774 361 EPQNAvsgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHT 434
Cdd:pfam02515 320 DPHLR--------------------------ARGMVVEVDHPDYGPVPVPGLPVRLSGTPGRVRRPAPALGEHT 367
PRK11430 PRK11430
putative CoA-transferase; Provisional
40-440 7.73e-87

putative CoA-transferase; Provisional


Pssm-ID: 183132 [Multi-domain]  Cd Length: 381  Bit Score: 270.70  E-value: 7.73e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  40 PLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPpFVGTESTYYLSVNRNKKSIAVNIKDPKGVKII 119
Cdd:PRK11430    9 PFEGLLVIDMTHVLNGPFGTQLLCNMGARVIKVEPPGHGDDTRTFGP-YVDGQSLYYSFINHGKESVVLDLKNDHDKSIF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 120 KELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVRP 199
Cdd:PRK11430   88 INMLKQADVLAENFRPGTMEKLGFSWETLQEINPRLIYASSSGFGHTGPLKDAPAYDTIIQAMSGIMMETGYPDAPPVRV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 200 GVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDG 279
Cdd:PRK11430  168 GTSLADLCGGVYLFSGIVSALYGREKSQRGAHVDIAMFDATLSFLEHGLMAYIATGKSPQRLGNRHPYMAPFDVFDTQDK 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 280 YIVVGAGNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVF 359
Cdd:PRK11430  248 PITICCGNDKLFSALCQALELTELVNDPRFSSNILRVQNQAILKQYIERTLKTQAAEVWLARIHEVGVPVAPLLSVAEAI 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 360 AEPQNavsgfqsllhslahgpflhlqgSARvlhNGLVmemehpTVGKISVPGPAVRYSKFKMSEARP-PPLLGQHTTHIL 438
Cdd:PRK11430  328 NLPQT----------------------QAR---NMLI------EAGGIMMPGNPIKISGCADPHVMPgAATLDQHGEQIR 376

                  ..
gi 1769843774 439 KE 440
Cdd:PRK11430  377 QE 378
PRK05398 PRK05398
formyl-coenzyme A transferase; Provisional
39-458 4.44e-75

formyl-coenzyme A transferase; Provisional


Pssm-ID: 180055  Cd Length: 416  Bit Score: 241.41  E-value: 4.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  39 KPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKI 118
Cdd:PRK05398    3 KPLEGIKVLDFTHVQSGPSCTQLLAWFGADVIKVERPGVGDVTRNQLRDIPDVDSLYFTMLNSNKRSITLDTKTPEGKEV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 119 IKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVASAVSGLMHITGPENGDPVR 198
Cdd:PRK05398   83 LEKLIREADVLVENFGPGALDRMGFTWERIQEINPRLIVASIKGFGPGSPYEDVKAYENVAQCAGGAASTTGFWDGPPTV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 199 PGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDC-------NL----LSSQVAcLSHIA-----ANYLIGQ--KEAKR 260
Cdd:PRK05398  163 SGAALGDSNTGMHLAIGILAALLQREKTGRGQRVTVsmqdavlNLcrvkLRDQQR-LDHLGyleeyPQYPNGTfgDAVPR 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 261 WGTAHGSIVPYQAFKTKDG--------YIVVgagNNQQFATVCKILDLPELIDNSKYKTNHLRVHNRKELIKILsERFEE 332
Cdd:PRK05398  242 AGNASGGGQPGWILKCKGWetdpnayiYFII---QPQGWEPICKAIGKPEWITDPAYATPEARQPHLFDIFAEI-EKWTM 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 333 ELTsKW--LYLFEGSGVPYGPINNMKNVFAEPqnavsgfqsllhSLAhgpflhlqgsarvlHNGLVMEMEHPTVGKISVP 410
Cdd:PRK05398  318 TKT-KFeaVDILNAFDIPCGPVLSMKEIAEDP------------SLR--------------ASGTIVEVDHPLRGKYLTV 370
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1769843774 411 GPAVRYSKFKmSEARPPPLLGQHTTHILKEvLRYDDRAIGELLSAGVV 458
Cdd:PRK05398  371 GSPIKLSDSP-PDVKRSPLLGEHTDEVLAE-LGYSDDQIAALKQNGAI 416
mesacon_CoA_iso TIGR04253
mesaconyl-CoA isomerase; Members of this protein family belong by homology to the family of ...
41-458 1.08e-24

mesaconyl-CoA isomerase; Members of this protein family belong by homology to the family of CoA transferases. However, the characterized member from Chloroflexus aurantiacus appears to perform an intramolecular transfer, making it an isomerase. The enzyme converts mesaconyl-C1-CoA to mesaconyl-C4-CoA as part of the bicyclic 3-hydroxyproprionate pathway for carbon fixation.


Pssm-ID: 211976  Cd Length: 403  Bit Score: 105.43  E-value: 1.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  41 LEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIK 120
Cdd:TIGR04253   3 LHGLRVVEGSAFVAAPLGGMTLAQLGADVIRFDPIGGGLDYKRWPLTLDGKHSLFWAGLNKGKRSIAIDIRHPRGQELLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 121 ELaaVC------DVFVENYvPGKlsaMGLGYEDIDEIAPHIIYCSITGygqtgpisQRAGYDAVASAVS---GLMHITGP 191
Cdd:TIGR04253  83 QL--ICapgdhaGLFITNF-PAK---GWLAYDALKAHRADLIMVNLTG--------RRDGGSEVDYTLNpqlGLPFMTGP 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 192 ENG-DPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIA--ANYLIGQKEAKRWGT----A 264
Cdd:TIGR04253 149 TSSpDVVNHVFPAWDFISGQMIALGLLAAERHRRLTGEGQLVKIALKDVALAMIGHFGmiAEAMINDADRPRQGNylygA 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 265 HGsivpyQAFKTKDG--YIVVGAgNNQQFATVCKILDLPELID--------NSKYKTNHLRVhnRKELIKILSERFEEEL 334
Cdd:TIGR04253 229 FG-----RDFETLDGkrLMVVGL-TDLQWKALGKATGLRDAFNalaarlglDFDDEGDRFRA--RHEIAALFEPWFHART 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 335 TSKWLYLFEGSGVPYGPINNMKNVFAEPQNAVSgfqsllhslahgpflhlqgsarvlHNGLVMEMEHPTVGKISVPGPAV 414
Cdd:TIGR04253 301 LAEAALIFDAHGVTWAPYRSVREAIAADPDCST------------------------DNPMFALTEQPGIGRYLMPGSPL 356
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1769843774 415 RYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSAGVV 458
Cdd:TIGR04253 357 DFAAVPRLPAMPAPRLGEHTDEILLDILGLSEAEVGRLHDAGIV 400
PRK03525 PRK03525
L-carnitine CoA-transferase;
40-458 3.70e-21

L-carnitine CoA-transferase;


Pssm-ID: 179589  Cd Length: 405  Bit Score: 95.21  E-value: 3.70e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774  40 PLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGAGDDTRtwgppfvgtESTYYLSVN-RNKKSIAVNIKDPKGVKI 118
Cdd:PRK03525   11 PLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIR---------VQPNYPQLSrRNLHALSLNIFKDEGREA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 119 IKELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTG--PISQRAGYDAVASAVSGLMHitgpENGDP 196
Cdd:PRK03525   82 FLKLMETTDIFIEASKGPAFARRGITDEVLWEHNPKLVIAHLSGFGQYGteEYTNLPAYNTIAQAFSGYLI----QNGDV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 197 VRPGVAM---TDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQVACLSHIAANYLIGQKEAKRWGTAHGsivPYQA 273
Cdd:PRK03525  158 DQPMPAFpytADYFSGLTATTAALAALHKARETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKD---PYYA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 274 ----FKTKDGYIV---VGAGNNQQFatvCKILDLPELIDNSKYKTNHLRVHN----RKELIKilsERFEEELTSKwlylf 342
Cdd:PRK03525  235 gcglYKCADGYIVmelVGITQIKEC---FKDIGLAHLLGTPEIPEGTQLIHRiecpYGPLVE---EKLDAWLAAH----- 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1769843774 343 egsgvpygPINNMKNVFAEPQNAVSGFQSLLHSLAHgPFLHLQGSARVLHNglvMEMEhptvgkiSVPGPAVrYSKFKMS 422
Cdd:PRK03525  304 --------TIAEVEARFAELNIACAKVLTIPELESN-PQYVARESITQWQT---MDGR-------TCKGPNI-MPKFKNN 363
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1769843774 423 EA---RPPPLLGQHTTHILKEvLRYDDRAIGELLSAGVV 458
Cdd:PRK03525  364 PGqiwRGMPSHGMDTAAILKN-IGYSEEDIQELVAKGLA 401
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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