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Conserved domains on  [gi|301069324|ref|NP_001180264|]
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asporin isoform 2 precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-206 2.05e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  83 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKEnDFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 160
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301069324 161 LSEIPLNL--PKSLAELRIHENKVKKIqKDTFKGMNALHVLEMSANPL 206
Cdd:COG4886  194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-206 2.05e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  83 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKEnDFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 160
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301069324 161 LSEIPLNL--PKSLAELRIHENKVKKIqKDTFKGMNALHVLEMSANPL 206
Cdd:COG4886  194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
104-161 7.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 7.28e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 301069324  104 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQL 161
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-206 5.63e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  90 LGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFLTT-------------------KK 150
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 301069324 151 LRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPL 206
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTAL 319
LRRNT smart00013
Leucine rich repeat N-terminal domain;
73-103 4.16e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.08  E-value: 4.16e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 301069324    73 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 103
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-177 2.34e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  85 VHCSDLGLTSVPTNIPF-DTRMLDLQNNKIKEIKENDF-KGLTSLYgliLNNNKLTKIHPKAFLttKKLRRLYLSHNQLS 162
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLENL--VNLKKLYLGGNRIS 81

                         90
                 ....*....|....*.
gi 301069324 163 EIP-LNLPKSLAELRI 177
Cdd:cd21340   82 VVEgLENLTNLEELHI 97
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-206 2.05e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  83 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKEnDFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 160
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 301069324 161 LSEIPLNL--PKSLAELRIHENKVKKIqKDTFKGMNALHVLEMSANPL 206
Cdd:COG4886  194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-212 5.17e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 5.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  83 RVVHCSDLGLTSVPTNIPFDT--RMLDLQNNKIKEIKEnDFKGLTSLYGLILNNNKLTKIhPKAFLTTKKLRRLYLSHNQ 160
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 301069324 161 LSEIP--LNLPKsLAELRIHENKVKKIqkDTFKGMNALHVLEMSANPLDNNGIE 212
Cdd:COG4886  240 LTDLPelGNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLK 290
LRR_8 pfam13855
Leucine rich repeat;
104-161 7.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 7.28e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 301069324  104 RMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQL 161
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-206 5.63e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 5.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  90 LGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFLTT-------------------KK 150
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 301069324 151 LRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPL 206
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTAL 319
LRRNT smart00013
Leucine rich repeat N-terminal domain;
73-103 4.16e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.08  E-value: 4.16e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 301069324    73 MCPFGCQCYSRVVHCSDLGLTSVPTNIPFDT 103
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-177 2.34e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  85 VHCSDLGLTSVPTNIPF-DTRMLDLQNNKIKEIKENDF-KGLTSLYgliLNNNKLTKIHPKAFLttKKLRRLYLSHNQLS 162
Cdd:cd21340    7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLENL--VNLKKLYLGGNRIS 81

                         90
                 ....*....|....*.
gi 301069324 163 EIP-LNLPKSLAELRI 177
Cdd:cd21340   82 VVEgLENLTNLEELHI 97
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 73-100 5.59e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.93  E-value: 5.59e-07
                          10        20
                  ....*....|....*....|....*...
gi 301069324   73 MCPFGCQCYSRVVHCSDLGLTSVPTNIP 100
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
125-206 5.70e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 5.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  125 TSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPlnlpkslaelrihenkvkkiqKDTFKGMNALHVLEMSAN 204
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS---------------------PGAFSGLPSLRYLDLSGN 59


                  ..
gi 301069324  205 PL 206
Cdd:pfam13855  60 RL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-206 4.44e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKltkihpkAFLTTKKLRRLYLSHNQLSEIPLNLP--KSLAELRIHENKVK 183
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLT 149

                         90       100
                 ....*....|....*....|...
gi 301069324 184 KIQKDtFKGMNALHVLEMSANPL 206
Cdd:COG4886  150 DLPEP-LGNLTNLKSLDLSNNQL 171
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-174 5.87e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.92  E-value: 5.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  83 RVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYgliLNNNKLTKIhPKAFltTKKLRRLYLSHNQLS 162
Cdd:PRK15370 328 KTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTNL-PENL--PAALQIMQASRNNLV 401

                         90
                 ....*....|..
gi 301069324 163 EIPLNLPKSLAE 174
Cdd:PRK15370 402 RLPESLPHFRGE 413
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-185 6.66e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.53  E-value: 6.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324  83 RVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIK----------EIKENDFKGLTSL--------YGLILNNNKLTkIHPKA 144
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTalpetlppglKTLEAGENALTSLpaslppelQVLDVSKNQIT-VLPET 364

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 301069324 145 FLTTkkLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKI 185
Cdd:PRK15370 365 LPPT--ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL 403
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-166 7.82e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 7.82e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 301069324 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLS-EIPL 166
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPA 541
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-180 1.02e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 301069324 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLS-EIPLNLPK--SLAELRIHEN 180
Cdd:PLN00113 504 LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNveSLVQVNISHN 581
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-216 6.51e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.52  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069324 106 LDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFlTTKKLRRLYLSHNQLSE-IPLNLPK--SLAELRIHENKV 182
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGaVPRKLGSlsELMQLKLSENKL 511

                         90       100       110
                 ....*....|....*....|....*....|....
gi 301069324 183 KKIQKDTFKGMNALHVLEMSANPLdnNGIEPGAF 216
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHNQL--SGQIPASF 543
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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