tubulin delta chain isoform 6 [Homo sapiens]
Protein Classification
tubulin family protein( domain architecture ID 10115139)
tubulin family protein similar to tubulin delta chain that acts as a positive regulator of hedgehog signaling and regulates ciliary function
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| delta_zeta_tubulin-like | cd02189 | The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ... |
1-236 | 2.03e-97 | ||||
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies. : Pssm-ID: 276958 [Multi-domain] Cd Length: 433 Bit Score: 290.71 E-value: 2.03e-97
|
||||||||
| Name | Accession | Description | Interval | E-value | ||||
| delta_zeta_tubulin-like | cd02189 | The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ... |
1-236 | 2.03e-97 | ||||
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies. Pssm-ID: 276958 [Multi-domain] Cd Length: 433 Bit Score: 290.71 E-value: 2.03e-97
|
||||||||
| Name | Accession | Description | Interval | E-value | |||||
| delta_zeta_tubulin-like | cd02189 | The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ... |
1-236 | 2.03e-97 | |||||
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies. Pssm-ID: 276958 [Multi-domain] Cd Length: 433 Bit Score: 290.71 E-value: 2.03e-97
|
|||||||||
| Tubulin | cd06059 | The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ... |
1-236 | 8.24e-39 | |||||
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology. Pssm-ID: 276963 [Multi-domain] Cd Length: 387 Bit Score: 138.10 E-value: 8.24e-39
|
|||||||||
| alpha_tubulin | cd02186 | The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ... |
1-229 | 1.94e-05 | |||||
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Pssm-ID: 276955 [Multi-domain] Cd Length: 434 Bit Score: 44.84 E-value: 1.94e-05
|
|||||||||
| beta_tubulin | cd02187 | The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ... |
173-236 | 2.42e-04 | |||||
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Pssm-ID: 276956 [Multi-domain] Cd Length: 425 Bit Score: 41.40 E-value: 2.42e-04
|
|||||||||
| Blast search parameters | ||||
|
