|
Name |
Accession |
Description |
Interval |
E-value |
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
87-382 |
1.17e-132 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 381.16 E-value: 1.17e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 87 TLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTS 166
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 167 LYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSvTPVSLLADPaFIRAWVGGVGNYKLGGNYGPTVLVQQEALK 246
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGE-KGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 247 RGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 326
Cdd:cd01557 159 KGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 50658084 327 LeegrvrEVFGSGTACQVCPVHRILYKDRNlhiPTMENGPELILRFQKELKEIQYG 382
Cdd:cd01557 233 D------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
41-392 |
1.68e-124 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 363.31 E-value: 1.68e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 41 MTQKPHKKPGPGEP-------LVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQ 113
Cdd:PRK13357 1 FTVTLKPNPTSDEKraidwanLGFGYVFTDHMVVIDYKDGKWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 114 QVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAA-GTSLYVRPVLIGNEPSLGVSQPTRALLFV 192
Cdd:PRK13357 81 SIVLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVPPYGeGASLYLRPFMIATEPFLGVKPAEEYIFCV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 193 ILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQ-LTEVGTMNIF 271
Cdd:PRK13357 161 IASPVGAYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 272 -VYwthEDGVlelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRI 350
Cdd:PRK13357 240 fIT---KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 50658084 351 LYKDRNLHIPTMENGPeLILRFQKELKEIQYGIRA--HEWMFPV 392
Cdd:PRK13357 313 KYKDKEFVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
75-392 |
3.47e-91 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 277.02 E-value: 3.47e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 75 WGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEV 154
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 155 DKDWVPDA-AGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGN 233
Cdd:TIGR01123 81 NKDWVPPYgSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 234 YGPTVLVQQEALKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFR 312
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 313 VVERTITMKQLLRALEEGrvREVFGSGTACQVCPVHRILYKDRNLHIPTMENGpELILRFQKELKEIQYGIRA--HEWMF 390
Cdd:TIGR01123 235 VEERRIDIDELKAFVEAG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEdpYGWIV 311
|
..
gi 50658084 391 PV 392
Cdd:TIGR01123 312 EV 313
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
75-382 |
1.89e-69 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 220.06 E-value: 1.89e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 75 WGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIE 153
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 154 VDKDwvpdaagTSLYVRPVLIGNEPSLGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPaFIRAWVGGVGNYKlGG 232
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 233 NYGPTVLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFR 312
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELARELG-IP 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 313 VVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRIlykdRNLHIPTMENGPeLILRFQKELKEIQYG 382
Cdd:COG0115 223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI----DGRPIGDGKPGP-VTRRLRELYTDIVRG 281
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
100-350 |
1.08e-31 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 119.77 E-value: 1.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 100 QLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDWVPdaagtslYVRPVLIGNEP 178
Cdd:pfam01063 1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 179 SLGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAwvggvgNYKlGGNYGPTVLVQQEALKRGCEQVLwLYG 257
Cdd:pfam01063 69 GFGLPTSDpTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLD 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 258 PDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFG 337
Cdd:pfam01063 141 EDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFL 208
|
250
....*....|...
gi 50658084 338 SGTACQVCPVHRI 350
Cdd:pfam01063 209 TNSLRGVTPVSSI 221
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
87-382 |
1.17e-132 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 381.16 E-value: 1.17e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 87 TLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTS 166
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 167 LYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSvTPVSLLADPaFIRAWVGGVGNYKLGGNYGPTVLVQQEALK 246
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKGGE-KGVSALVSS-FRRAAPGGPGAAKAGGNYAASLLAQKEAAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 247 RGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 326
Cdd:cd01557 159 KGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPITRDELYEA 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 50658084 327 LeegrvrEVFGSGTACQVCPVHRILYKDRNlhiPTMENGPELILRFQKELKEIQYG 382
Cdd:cd01557 233 D------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
41-392 |
1.68e-124 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 363.31 E-value: 1.68e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 41 MTQKPHKKPGPGEP-------LVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQ 113
Cdd:PRK13357 1 FTVTLKPNPTSDEKraidwanLGFGYVFTDHMVVIDYKDGKWHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 114 QVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAA-GTSLYVRPVLIGNEPSLGVSQPTRALLFV 192
Cdd:PRK13357 81 SIVLFRPDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVPPYGeGASLYLRPFMIATEPFLGVKPAEEYIFCV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 193 ILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQ-LTEVGTMNIF 271
Cdd:PRK13357 161 IASPVGAYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGGNYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNFF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 272 -VYwthEDGVlelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRI 350
Cdd:PRK13357 240 fIT---KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGGI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 50658084 351 LYKDRNLHIPTMENGPeLILRFQKELKEIQYGIRA--HEWMFPV 392
Cdd:PRK13357 313 KYKDKEFVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
75-392 |
3.47e-91 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 277.02 E-value: 3.47e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 75 WGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEV 154
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 155 DKDWVPDA-AGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGN 233
Cdd:TIGR01123 81 NKDWVPPYgSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGG-LAPVSIFVTTEYDRAAPGGTGAVKVGGN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 234 YGPTVLVQQEALKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFR 312
Cdd:TIGR01123 160 YAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLAKDLG-ME 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 313 VVERTITMKQLLRALEEGrvREVFGSGTACQVCPVHRILYKDRNLHIPTMENGpELILRFQKELKEIQYGIRA--HEWMF 390
Cdd:TIGR01123 235 VEERRIDIDELKAFVEAG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGDFEdpYGWIV 311
|
..
gi 50658084 391 PV 392
Cdd:TIGR01123 312 EV 313
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
92-376 |
6.25e-80 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 245.97 E-value: 6.25e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 92 SSSLHYSLQLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKdwvpdaaGTSLYVR 170
Cdd:cd00449 1 DRGLHYGDGVFEGLRAGKG-----RLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAANN-------GASLYIR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 171 PVLIGNEPSLGVSQP--TRALLFVILCPVGAYFPGGSvTPVSLLADPAFIRAWVGGVGNYKLGGNYgPTVLVQQEALKRG 248
Cdd:cd00449 69 PLLTRGVGGLGVAPPpsPEPTFVVFASPVGAYAKGGE-KGVRLITSPDRRRAAPGGTGDAKTGGNL-NSVLAKQEAAEAG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 249 CEQVLWLYGpDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAle 328
Cdd:cd00449 147 ADEALLLDD-NGYVTEGSASNVFIVK---DG--ELVTPPLDGGILPGITRDSVIELAKELG-IKVEERPISLDELYAA-- 217
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 50658084 329 egrvREVFGSGTACQVCPVHRILYKDRnlhipTMENGPELILRFQKEL 376
Cdd:cd00449 218 ----DEVFLTGTAAEVTPVTEIDGRGI-----GDGKPGPVTRKLRELL 256
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
75-382 |
1.89e-69 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 220.06 E-value: 1.89e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 75 WGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIE 153
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 154 VDKDwvpdaagTSLYVRPVLIGNEPSLGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPaFIRAWVGGVGNYKlGG 232
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK-TG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 233 NYGPTVLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFR 312
Cdd:COG0115 150 NYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELARELG-IP 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 313 VVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRIlykdRNLHIPTMENGPeLILRFQKELKEIQYG 382
Cdd:COG0115 223 VEERPISLEELYTA------DEVFLTGTAAEVTPVTEI----DGRPIGDGKPGP-VTRRLRELYTDIVRG 281
|
|
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
53-355 |
6.44e-58 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 193.91 E-value: 6.44e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 53 EPLVFGKTFTDHMLMVEWNDKG-WGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSA 131
Cdd:PLN02782 73 DNLGFGLVPTDYMYIMKCNRDGeFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGNILLFRPEENAIRMRNGA 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 132 MRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSqPTRALLFVI-LCPVGAYFPGGsVTPVS 210
Cdd:PLN02782 153 ERMCMPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGLA-PAPEYTFLIyVSPVGNYFKEG-VAPIN 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 211 LLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLygpD--HQ--LTEVGTMNIFVYwthEDGVLElvTP 286
Cdd:PLN02782 231 LIVENEFHRATPGGTGGVKTIGNYAAVLKAQSIAKAKGYSDVLYL---DcvHKkyLEEVSSCNIFIV---KDNVIS--TP 302
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50658084 287 PLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRILYKDR 355
Cdd:PLN02782 303 AIKGTILPGITRKSIIDVARSQG-FQVEERNVTVDELLEA------DEVFCTGTAVVVSPVGSITYKGK 364
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
53-383 |
1.70e-51 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 175.89 E-value: 1.70e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 53 EPLVFGKTFTDHMLMVEWND-KGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSA 131
Cdd:PLN03117 23 EELGFALVPTDYMYVAKCKQgESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDGRITLFRPDQNALRMQTGA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 132 MRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSvtPVSL 211
Cdd:PLN03117 103 DRLCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFLIYASPVGNYHKASS--GLNL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 212 LADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWL-YGPDHQLTEVGTMNIFVYwthEDGVLElvTPPLNG 290
Cdd:PLN03117 181 KVDHKHRRAHSGGTGGVKSCTNYSPVVKSLIEAKSSGFSDVLFLdAATGKNIEELSACNIFIL---KGNIVS--TPPTSG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 291 VILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRILYKDRNLHIPTMENGpeLIL 370
Cdd:PLN03117 256 TILPGVTRKSISELARDIG-YQVEERDVSVDELLEA------EEVFCTGTAVVVKAVETVTFHDKKVKYRTGEEA--LST 326
|
330
....*....|...
gi 50658084 371 RFQKELKEIQYGI 383
Cdd:PLN03117 327 KLHLILTNIQMGV 339
|
|
| PLN02883 |
PLN02883 |
Branched-chain amino acid aminotransferase |
55-354 |
4.85e-47 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 178471 Cd Length: 384 Bit Score: 164.89 E-value: 4.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 55 LVFGKTFTDHMLMVE-WNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMR 133
Cdd:PLN02883 57 LGFSLVRTDFMFATKsCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKIGAER 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 134 LCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTpVSLLA 213
Cdd:PLN02883 137 MCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFKEGTAA-LNLYV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 214 DPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYG-PDHQLTEVGTMNIFVYWTHedgvlELVTPPLNGVI 292
Cdd:PLN02883 216 EEVIPRAYLGGTGGVKAISNYGPVLEVMRRAKSRGFSDVLYLDAdTGKNIEEVSAANIFLVKGN-----IIVTPATSGTI 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 50658084 293 LPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRILYKD 354
Cdd:PLN02883 291 LGGITRKSIIEIALDLG-YKVEERRVPVEELKEA------EEVFCTGTAAGVASVGSITFKN 345
|
|
| PLN02259 |
PLN02259 |
branched-chain-amino-acid aminotransferase 2 |
27-383 |
4.52e-45 |
|
branched-chain-amino-acid aminotransferase 2
Pssm-ID: 177901 Cd Length: 388 Bit Score: 159.89 E-value: 4.52e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 27 YASSSFKAADLQLEMTQKPHKKPGPGE-------PLVFGKTFTDHMLMVEWNDKG-WGQPRIQPFQNLTLHPASSSLHYS 98
Cdd:PLN02259 26 FAKYNAQAASALREERKKPLYQNGDDVyadldwdNLGFGLNPADYMYVMKCSKDGeFTQGELSPYGNIQLSPSAGVLNYG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 99 LQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEP 178
Cdd:PLN02259 106 QAIYEGTKAYRKENGKLLLFRPDHNAIRMKLGAERMLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 179 SLGVSQPTRALLFVILCPVGAYFPGGsVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGP 258
Cdd:PLN02259 186 ILGLGPAPEYTFIVYASPVGNYFKEG-MAALNLYVEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDSV 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 259 DHQ-LTEVGTMNIFVYWTHedgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFG 337
Cdd:PLN02259 265 KKKyLEEASSCNVFVVKGR-----TISTPATNGTILEGITRKSVMEIASDQG-YQVVEKAVHVDEVMDA------DEVFC 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 50658084 338 SGTACQVCPVHRILYKDRNLHIPTMENgpELILRFQKELKEIQYGI 383
Cdd:PLN02259 333 TGTAVVVAPVGTITYQEKRVEYKTGDE--SVCQKLRSVLVGIQTGL 376
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
100-350 |
1.08e-31 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 119.77 E-value: 1.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 100 QLFEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIEVDKDWVPdaagtslYVRPVLIGNEP 178
Cdd:pfam01063 1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 179 SLGVSQPT-RALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAwvggvgNYKlGGNYGPTVLVQQEALKRGCEQVLwLYG 257
Cdd:pfam01063 69 GFGLPTSDpTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP------GAK-TLNYLENVLARREAKAQGADDAL-LLD 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 258 PDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFG 337
Cdd:pfam01063 141 EDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA------DEAFL 208
|
250
....*....|...
gi 50658084 338 SGTACQVCPVHRI 350
Cdd:pfam01063 209 TNSLRGVTPVSSI 221
|
|
| ilvE_I |
TIGR01122 |
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ... |
75-392 |
1.65e-26 |
|
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130192 Cd Length: 298 Bit Score: 107.45 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 75 WGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGkDQQVRLFRPWLNMDRMLRSAMRLCLP-SFDKLELLECIRRLIE 153
Cdd:TIGR01122 1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYDT-DKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 154 VDKDwvpdaagTSLYVRPVLIGNEPSLGVSQP--TRALLFVILCPVGAYfpggsvtpvslLADPAF---IRAWVGGV--- 225
Cdd:TIGR01122 80 KNNL-------RSAYIRPLVFRGDGDLGLNPRagYKPDVIIAAWPWGAY-----------LGEEALekgIDAKVSSWrrn 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 226 ------GNYKLGGNYGPTVLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQ 299
Cdd:TIGR01122 142 apntipTAAKAGGNYLNSLLAKSEARRHGYDEAILL-DVEGYVAEGSGENIFIV---KDGV--LFTPPVTSSILPGITRD 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 300 SLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRIlykdRNLHIPTMENGPeLILRFQKELKEI 379
Cdd:TIGR01122 216 TVITLAKELG-IEVVEQPISREELYTA------DEAFFTGTAAEITPIREV----DGRKIGNGRRGP-VTKKLQEAFFDL 283
|
330
....*....|....*
gi 50658084 380 QYG-IRAH-EWMFPV 392
Cdd:TIGR01122 284 VTGgTEDYwGWLTYV 298
|
|
| PRK06606 |
PRK06606 |
branched-chain amino acid transaminase; |
67-350 |
1.00e-25 |
|
branched-chain amino acid transaminase;
Pssm-ID: 235841 Cd Length: 306 Bit Score: 105.61 E-value: 1.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 67 MVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVrLFRPWLNMDRMLRSA--MRLCLPsFDKLEL 144
Cdd:PRK06606 2 MADRAGYIWFNGELVPWEDAKVHVLTHALHYGTGVFEGIRAYDTPKGPA-IFRLREHTKRLFNSAkiLRMEIP-YSVDEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 145 LECIRRLIEVDKdwvPDAAgtslYVRP-VLIGNEpSLGVSQ---PTRALLFVIlcPVGAYFPGGS--------------- 205
Cdd:PRK06606 80 MEAQREVVRKNN---LKSA----YIRPlVFVGDE-GLGVRPhglPTDVAIAAW--PWGAYLGEEAlekgirvkvsswtrh 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 206 ---VTPVslladpafiRAwvggvgnyKLGGNYGPTVLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVle 282
Cdd:PRK06606 150 apnSIPT---------RA--------KASGNYLNSILAKTEARRNGYDEALLL-DVEGYVSEGSGENIFIV---RDGV-- 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 50658084 283 LVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRI 350
Cdd:PRK06606 207 LYTPPLTSSILEGITRDTVITLAKDLG-IEVIERRITRDELYIA------DEVFFTGTAAEVTPIREV 267
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
102-350 |
2.01e-18 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 84.19 E-value: 2.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 102 FEGMKAFKGKdqqvrLFRPWLNMDRMLRSAMRLCLPS-FDKLELLECIRRLIEvdKDWVPDAAGtslYVRpVLIGNEP-S 179
Cdd:cd01558 28 YEVIRVYNGK-----PFALDEHLDRLYRSAKELRIDIpYTREELKELIRELVA--KNEGGEGDV---YIQ-VTRGVGPrG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 180 LGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPaFIRaWvgGVGNYKLGgNYGPTVLVQQEALKRGCEQVlWLYGPD 259
Cdd:cd01558 97 HDFPKCVKPTVVIITQPLPLPPAELLEKGVRVITVP-DIR-W--LRCDIKSL-NLLNNVLAKQEAKEAGADEA-ILLDAD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 260 HQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAleegrvREVFGSG 339
Cdd:cd01558 171 GLVTEGSSSNVFIV---KNGVL--VTPPLDNGILPGITRATVIELAKELG-IPVEERPFSLEELYTA------DEVFLTS 238
|
250
....*....|.
gi 50658084 340 TACQVCPVHRI 350
Cdd:cd01558 239 TTAEVMPVVEI 249
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
94-350 |
6.57e-16 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 76.58 E-value: 6.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 94 SLHYSLQLFEGMKAFKGkdqQVRLFRPWLnmDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKdwVPDAAGTSLYVRPVL 173
Cdd:cd01559 3 GFAYGDGVFETMRALDG---RLFLLDAHL--ARLERSARRLGIPEPDLPRLRAALESLLAAND--IDEGRIRLILSRGPG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 174 IGNEPSLGVSQPTRaLLFVILCPVGAYFPGGSV--TPVSLLADPAFIRAwvggvgnyKlGGNYGPTVLVQQEALKRGCEQ 251
Cdd:cd01559 76 GRGYAPSVCPGPAL-YVSVIPLPPAWRQDGVRLitCPVRLGEQPLLAGL--------K-HLNYLENVLAKREARDRGADE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 252 VLWLYGPDHqLTEVGTMNIFvyWTHeDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGEfRVVERTITMKQLLRAleegr 331
Cdd:cd01559 146 ALFLDTDGR-VIEGTASNLF--FVK-DG--ELVTPSLDRGGLAGITRQRVIELAAAKGY-AVDERPLRLEDLLAA----- 213
|
250
....*....|....*....
gi 50658084 332 vREVFGSGTACQVCPVHRI 350
Cdd:cd01559 214 -DEAFLTNSLLGVAPVTAI 231
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
102-350 |
8.45e-10 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 59.11 E-value: 8.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 102 FEGMKAFKGkdqqvRLFRPWLNMDRMLRSAMRLCL-PSFDKLELLECIrrlIE-VDKDWVPDAagtslYVRPVLIGNEPS 179
Cdd:PRK08320 33 FEGIRAYNG-----RVFRLKEHIDRLYDSAKAIMLeIPLSKEEMTEIV---LEtLRKNNLRDA-----YIRLVVSRGVGD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 180 LGV-----SQPTralLFVILCPVGAYFP-----GGSVTPVSlladpafIRAWVGGVGNYKLGG-NYGPTVLVQQEALKRG 248
Cdd:PRK08320 100 LGLdprkcPKPT---VVCIAEPIGLYPGelyekGLKVITVS-------TRRNRPDALSPQVKSlNYLNNILAKIEANLAG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 249 CEQVLWLygpDHQ--LTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRA 326
Cdd:PRK08320 170 VDEAIML---NDEgyVAEGTGDNIFIV---KNGKL--ITPPTYAGALEGITRNAVIEIAKELG-IPVREELFTLHDLYTA 240
|
250 260
....*....|....*....|....
gi 50658084 327 leegrvREVFGSGTACQVCPVHRI 350
Cdd:PRK08320 241 ------DEVFLTGTAAEVIPVVKV 258
|
|
| PRK07544 |
PRK07544 |
branched-chain amino acid aminotransferase; Validated |
67-350 |
5.53e-09 |
|
branched-chain amino acid aminotransferase; Validated
Pssm-ID: 181025 Cd Length: 292 Bit Score: 56.91 E-value: 5.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 67 MVEWNDKgwgqpriqpfqnlTLHPASSSLHYSLQLFEGMKAFKGKdqqvrLFRPWLNMDRMLRSAMRLCLPSFDKLELLE 146
Cdd:PRK07544 17 LVPWRDA-------------KVHVLTHGLHYASSVFEGERAYGGK-----IFKLREHSERLRRSAELLDFEIPYSVAEID 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 147 CIRRLIeVDKDWVPDAagtslYVRPVLIGNEPSLGVS-QPTRALLFVILCPVGAYF-PGGSVTPVSL-LA-----DPAFI 218
Cdd:PRK07544 79 AAKKET-LAANGLTDA-----YVRPVAWRGSEMMGVSaQQNKIHLAIAAWEWPSYFdPEAKMKGIRLdIAkwrrpDPETA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 219 RAwvggvgNYKLGGNYGPTVLVQQEALKRGCEQVLWLygpDH--QLTEVGTMNIFVYwthEDGVLELVTPplnGVILPGV 296
Cdd:PRK07544 153 PS------AAKAAGLYMICTISKHAAEAKGYADALML---DYrgYVAEATGANIFFV---KDGVIHTPTP---DCFLDGI 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 50658084 297 VRQSLLDMAQTWGeFRVVERTItmkqllRALEEGRVREVFGSGTACQVCPVHRI 350
Cdd:PRK07544 218 TRQTVIELAKRRG-IEVVERHI------MPEELAGFSECFLTGTAAEVTPVSEI 264
|
|
| PRK13356 |
PRK13356 |
branched-chain amino acid aminotransferase; |
102-357 |
5.65e-07 |
|
branched-chain amino acid aminotransferase;
Pssm-ID: 237362 Cd Length: 286 Bit Score: 50.72 E-value: 5.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 102 FEGMKAFKGKdqqvrlfRPWLNM--DRMLRSAMRLCL-PSFDKLEL----LECIRRLievdkdwvpdAAGTSLYVRPVLI 174
Cdd:PRK13356 37 FDGARAFEGV-------TPDLDLhcARVNRSAEALGLkPTVSAEEIealaREGLKRF----------DPDTALYIRPMYW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 175 GNEPSLGVSQP----TRALLFVILCPVGAyfPGGSVTPVSlladpAFIRAWVG-GVGNYKLGGNYGPTVLVQQEALKRGC 249
Cdd:PRK13356 100 AEDGFASGVAPdpesTRFALCLEEAPMPE--PTGFSLTLS-----PFRRPTLEmAPTDAKAGCLYPNNARALREARSRGF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 250 EQVLWLYGPDHqLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVERTITMKQLLRAlee 329
Cdd:PRK13356 173 DNALVLDMLGN-VAETATSNVFMV---KDGV--VFTPVPNGTFLNGITRQRVIALLREDG-VTVVETTLTYEDFLEA--- 242
|
250 260
....*....|....*....|....*...
gi 50658084 330 grvREVFGSGTACQVCPVHRIlyKDRNL 357
Cdd:PRK13356 243 ---DEVFSTGNYSKVVPVTRF--DDRSL 265
|
|
| PRK06680 |
PRK06680 |
D-amino acid aminotransferase; Reviewed |
236-350 |
4.13e-06 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 180656 [Multi-domain] Cd Length: 286 Bit Score: 48.00 E-value: 4.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 236 PTVLVQQEALKRGCeQVLWLYGpDHQLTEVGTMNIFVywTHEDGVLelVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVE 315
Cdd:PRK06680 155 PNVLAKQAAKEAGA-QEAWMVD-DGFVTEGASSNAWI--VTKDGKL--VTRPADNFILPGITRHTLIDLAKELG-LEVEE 227
|
90 100 110
....*....|....*....|....*....|....*
gi 50658084 316 RTITMKQLLRAleegrvREVFGSGTACQVCPVHRI 350
Cdd:PRK06680 228 RPFTLQEAYAA------REAFITAASSFVFPVVQI 256
|
|
| PRK12400 |
PRK12400 |
D-amino acid aminotransferase; Reviewed |
68-347 |
1.54e-05 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 171470 Cd Length: 290 Bit Score: 46.16 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 68 VEWNDKGWGQPRIQPFQNLTlhpaSSSLHYSLQLFEGMKAFKGkdqQVRLFRPwlNMDRMLRS--AMRLCLPsFDKLELL 145
Cdd:PRK12400 7 VLWNDAVIDTTKQKTYIELE----ERGLQFGDGVYEVIRLYKG---NFHLLDP--HITRLYRSmeEIELTLP-FSKAELI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 146 ECIRRLIEvDKDWVPDAagtSLYVrpvlignEPSLGVSQPTRALLFVILCPVGAYFPGGSVTP------VSLLADP--AF 217
Cdd:PRK12400 77 TLLYKLIE-NNNFHEDG---TIYL-------QVSRGVQARTHTFSYDVPPTIYAYITKKERPAlwieygVRAISEPdtRW 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 218 IRAWVGGVgnyklggNYGPTVLVQQEALKRGCEQVLWLYgpDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVV 297
Cdd:PRK12400 146 LRCDIKSL-------NLLPNILAATKAERKGCKEALFVR--NGTVTEGSHSNFFLI---KNGTL--YTHPANHLILNGII 211
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 50658084 298 RQSLLDMAQTWgEFRVVERTITMKQLLRAleegrvREVFGSGTACQVCPV 347
Cdd:PRK12400 212 RQYVLSLAKTL-RIPVQEELFSVRDVYQA------DECFFTGTTIEILPM 254
|
|
| PRK12479 |
PRK12479 |
branched-chain-amino-acid transaminase; |
233-350 |
1.18e-03 |
|
branched-chain-amino-acid transaminase;
Pssm-ID: 183549 [Multi-domain] Cd Length: 299 Bit Score: 40.32 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 233 NYGPTVLVQQEALKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGvlELVTPPLNGVILPGVVRQSLLDMAQTWGeFR 312
Cdd:PRK12479 155 NYLNNVLVKIEAAQAGVLEALML-NQQGYVCEGSGDNVFVV---KDG--KVLTPPSYLGALEGITRNSVIELCERLS-IP 227
|
90 100 110
....*....|....*....|....*....|....*...
gi 50658084 313 VVERTITMKQLLRAleegrvREVFGSGTACQVCPVHRI 350
Cdd:PRK12479 228 CEERPFTRHDVYVA------DEVFLTGTAAELIPVVKV 259
|
|
| PLN02845 |
PLN02845 |
Branched-chain-amino-acid aminotransferase-like protein |
233-328 |
1.39e-03 |
|
Branched-chain-amino-acid aminotransferase-like protein
Pssm-ID: 215454 [Multi-domain] Cd Length: 336 Bit Score: 40.38 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 233 NYGPTVLVQQEALKRGCEQVLWLYGpDHQLTEVGTMNI-FVywTHEDgvlELVTPPLNGvILPGVVRQSLLDMAQTW--- 308
Cdd:PLN02845 188 NYLPNALSQMEAEERGAFAGIWLDE-EGFVAEGPNMNVaFL--TNDG---ELVLPPFDK-ILSGCTARRVLELAPRLvsp 260
|
90 100
....*....|....*....|.
gi 50658084 309 GEFRVVE-RTITMKQLLRALE 328
Cdd:PLN02845 261 GDLRGVKqRKISVEEAKAADE 281
|
|
| PRK07849 |
PRK07849 |
aminodeoxychorismate lyase; |
102-326 |
1.48e-03 |
|
aminodeoxychorismate lyase;
Pssm-ID: 236114 [Multi-domain] Cd Length: 292 Bit Score: 39.94 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 102 FEGMKAFKGKdqqVRLFRPWLnmDRMLRSAMRLCLPSFDklelLECIRRLIE-VDKDWVPDAAGTSL---YVRpvliGNE 177
Cdd:PRK07849 42 FETLLVRDGR---PCNLEAHL--ERLARSAALLDLPEPD----LDRWRRAVElAIEEWRAPEDEAALrlvYSR----GRE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 178 pslGVSQPTralLFVILCPVGAYFPGGSVTPVSLLADPafiRAWVGGVGN---YKLGG----NYGPTVLVQQEALKRGCE 250
Cdd:PRK07849 109 ---SGGAPT---AWVTVSPVPERVARARREGVSVITLD---RGYPSDAAErapWLLAGaktlSYAVNMAALRYAARRGAD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50658084 251 QVlwlygpdhqltevgtmnIFvywTHEDG-VLE-------------LVTPPLNGVILPGVVRQSLLDMAQTWGeFRVVER 316
Cdd:PRK07849 180 DV-----------------IF---TSTDGyVLEgptstvviatddrLLTPPPWYGILPGTTQAALFEVAREKG-WDCEYR 238
|
250
....*....|
gi 50658084 317 TITMKQLLRA 326
Cdd:PRK07849 239 ALRPADLFAA 248
|
|
| |
