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Conserved domains on  [gi|306966158|ref|NP_001182473|]
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leucine-rich repeat-containing protein 3C precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12156038)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
61-119 4.62e-18

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.64  E-value: 4.62e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 306966158   61 RKLYLDANQLASVPAGAFQHLPALEELDLSHNALVHLSGAAFQGLEGtLRHLDLSANQL 119
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
61-119 4.62e-18

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.64  E-value: 4.62e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 306966158   61 RKLYLDANQLASVPAGAFQHLPALEELDLSHNALVHLSGAAFQGLEGtLRHLDLSANQL 119
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-139 3.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  40 QTFRCSRAGLSAVPNGIPNDT--RKLYLDANQLASVPAgAFQHLPALEELDLSHNALVHLSgAAFQGLEGtLRHLDLSAN 117
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTN-LETLDLSNN 238

                         90       100
                 ....*....|....*....|...
gi 306966158 118 QLASVP-VAAFVGLQIqVNLSAN 139
Cdd:COG4886  239 QLTDLPeLGNLTNLEE-LDLSNN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-123 3.12e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  24 PLALPQGCYVAEeAGEQTFRCsraglsaVPNGIPNDTRKLYLDANQLASVPagafQHLP-ALEELDLSHNALVHLSgaaf 102
Cdd:PRK15370 320 PETLPPGLKTLE-AGENALTS-------LPASLPPELQVLDVSKNQITVLP----ETLPpTITTLDVSRNALTNLP---- 383

                         90       100
                 ....*....|....*....|.
gi 306966158 103 QGLEGTLRHLDLSANQLASVP 123
Cdd:PRK15370 384 ENLPAALQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-139 5.96e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 5.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  61 RKLYLDANQLASVpAGaFQHLPALEELDLSHNAL-----VHLSGAAFQGLEGTLRHLDLSANQLASV-PVAAFVGLQiQV 134
Cdd:cd21340   71 KKLYLGGNRISVV-EG-LENLTNLEELHIENQRLppgekLTFDPRSLAALSNSLRVLNISGNNIDSLePLAPLRNLE-QL 147


                 ....*
gi 306966158 135 NLSAN 139
Cdd:cd21340  148 DASNN 152
LRR smart00370
Leucine-rich repeats, outliers;
81-104 5.91e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 5.91e-04
                           10        20
                   ....*....|....*....|....
gi 306966158    81 LPALEELDLSHNALVHLSGAAFQG 104
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
61-119 4.62e-18

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.64  E-value: 4.62e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 306966158   61 RKLYLDANQLASVPAGAFQHLPALEELDLSHNALVHLSGAAFQGLEGtLRHLDLSANQL 119
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-139 3.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  40 QTFRCSRAGLSAVPNGIPNDT--RKLYLDANQLASVPAgAFQHLPALEELDLSHNALVHLSgAAFQGLEGtLRHLDLSAN 117
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTN-LETLDLSNN 238

                         90       100
                 ....*....|....*....|...
gi 306966158 118 QLASVP-VAAFVGLQIqVNLSAN 139
Cdd:COG4886  239 QLTDLPeLGNLTNLEE-LDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-139 1.80e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  40 QTFRCSRAGLSAVPNGIPNDT--RKLYLDANQLASVPAgAFQHLPALEELDLSHNALVHLSgAAFQGLEgTLRHLDLSAN 117
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNLT-NLKELDLSNN 192

                         90       100
                 ....*....|....*....|....
gi 306966158 118 QLASVP--VAAFVGLQiQVNLSAN 139
Cdd:COG4886  193 QITDLPepLGNLTNLE-ELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
82-140 3.33e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 3.33e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 306966158   82 PALEELDLSHNALVHLSGAAFQGLEGtLRHLDLSANQLASVPVAAFVGL-QIQV-NLSANP 140
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLpSLRYlDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-139 1.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.55  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  40 QTFRCSRAGLSAVPNGIPNDT--RKLYLDANQLASVPAgaFQHLPALEELDLSHNALVHLSGAAfqGLEGtLRHLDLSAN 117
Cdd:COG4886  208 EELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTN-LKTLDLSNN 282

                         90       100
                 ....*....|....*....|..
gi 306966158 118 QLASVPVAAFVGLQIQVNLSAN 139
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLL 304
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-139 2.49e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  61 RKLYLDANQlasvpagAFQHLPALEELDLSHNALVHLsGAAFQGLEGtLRHLDLSANQLASVP--VAAFVGLQiQVNLSA 138
Cdd:COG4886   99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTN-LKELDLSNNQLTDLPepLGNLTNLK-SLDLSN 168


                 .
gi 306966158 139 N 139
Cdd:COG4886  169 N 169
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
24-123 3.12e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  24 PLALPQGCYVAEeAGEQTFRCsraglsaVPNGIPNDTRKLYLDANQLASVPagafQHLP-ALEELDLSHNALVHLSgaaf 102
Cdd:PRK15370 320 PETLPPGLKTLE-AGENALTS-------LPASLPPELQVLDVSKNQITVLP----ETLPpTITTLDVSRNALTNLP---- 383

                         90       100
                 ....*....|....*....|.
gi 306966158 103 QGLEGTLRHLDLSANQLASVP 123
Cdd:PRK15370 384 ENLPAALQIMQASRNNLVRLP 404
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-139 5.96e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 5.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  61 RKLYLDANQLASVpAGaFQHLPALEELDLSHNAL-----VHLSGAAFQGLEGTLRHLDLSANQLASV-PVAAFVGLQiQV 134
Cdd:cd21340   71 KKLYLGGNRISVV-EG-LENLTNLEELHIENQRLppgekLTFDPRSLAALSNSLRVLNISGNNIDSLePLAPLRNLE-QL 147


                 ....*
gi 306966158 135 NLSAN 139
Cdd:cd21340  148 DASNN 152
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
39-131 1.34e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  39 EQTFRCSRAGLSAVPNGIPNDTRKLYLDANQLASVP-------------AGAFQHLPA-----LEELDLSHNALVHLSga 100
Cdd:PRK15370 180 KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPenlqgniktlyanSNQLTSIPAtlpdtIQEMELSINRITELP-- 257

                         90       100       110
                 ....*....|....*....|....*....|.
gi 306966158 101 afQGLEGTLRHLDLSANQLASVPVAAFVGLQ 131
Cdd:PRK15370 258 --ERLPSALQSLDLFHNKISCLPENLPEELR 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-139 4.90e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 4.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306966158  40 QTFRCSRAGLSAVPN--GIPNdTRKLYLDANQLASVPAGAfqHLPALEELDLSHNALVHLSGAAFQGLEGTLRHLDLSAN 117
Cdd:COG4886  231 ETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                         90       100
                 ....*....|....*....|..
gi 306966158 118 QLASVPVAAFVGLQIQVNLSAN 139
Cdd:COG4886  308 LNLLELLILLLLLTTLLLLLLL 329
LRR smart00370
Leucine-rich repeats, outliers;
81-104 5.91e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 5.91e-04
                           10        20
                   ....*....|....*....|....
gi 306966158    81 LPALEELDLSHNALVHLSGAAFQG 104
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
81-104 5.91e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 5.91e-04
                           10        20
                   ....*....|....*....|....
gi 306966158    81 LPALEELDLSHNALVHLSGAAFQG 104
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 61-95 6.37e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 6.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 306966158   61 RKLYLDANQLASVPAgaFQHLPALEELDLSHNALV 95
Cdd:pfam12799   4 EVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKI 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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