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Conserved domains on  [gi|308153283|ref|NP_001184010|]
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vitronectin L homeolog precursor [Xenopus laevis]

Protein Classification

Somatomedin_B and HX domain-containing protein( domain architecture ID 10470560)

Somatomedin_B and HX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 129-433 2.53e-43

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 150.54  E-value: 2.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 129 ELCSGQPFDAFTNIkNGSIYAFRGKYFYELDDKSAlEGYPKLIKDVW-GIDGPVDAAFTRMNcQGKTYLFKGKEYWRFSN 207
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKP-PGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 208 GVLESDYPRNISE-GFHDIPDNIDAAFALPannhnDREKVYFFKGNKYWQYEFQNQPSRKDCqdsaqselftyyvtlqkd 286
Cdd:cd00094   79 KNLEPGYPKPISDlGFPPTVKQIDAALRWP-----DNGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 287 swedffsflfgpsmkrstagPWYINKDWKGVPNNVDAVlpsriyvpkqtrrsrrrksrrrnnrkksggmrslwsdfsfdp 366
Cdd:cd00094  136 --------------------PKLIETDFPGVPDKVDAA------------------------------------------ 153

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308153283 367 ldglFDYDDEqsdpdwlpperpadcqptqNVYFFKNDKYYRVNLRTKRVDyvyPPYPRSIAQYWLGC 433
Cdd:cd00094  154 ----FRWLDG-------------------YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
24-63 1.50e-12

Somatomedin B domain;


:

Pssm-ID: 460034  Cd Length: 40  Bit Score: 61.55  E-value: 1.50e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308153283   24 ESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 129-433 2.53e-43

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 150.54  E-value: 2.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 129 ELCSGQPFDAFTNIkNGSIYAFRGKYFYELDDKSAlEGYPKLIKDVW-GIDGPVDAAFTRMNcQGKTYLFKGKEYWRFSN 207
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKP-PGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 208 GVLESDYPRNISE-GFHDIPDNIDAAFALPannhnDREKVYFFKGNKYWQYEFQNQPSRKDCqdsaqselftyyvtlqkd 286
Cdd:cd00094   79 KNLEPGYPKPISDlGFPPTVKQIDAALRWP-----DNGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 287 swedffsflfgpsmkrstagPWYINKDWKGVPNNVDAVlpsriyvpkqtrrsrrrksrrrnnrkksggmrslwsdfsfdp 366
Cdd:cd00094  136 --------------------PKLIETDFPGVPDKVDAA------------------------------------------ 153

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308153283 367 ldglFDYDDEqsdpdwlpperpadcqptqNVYFFKNDKYYRVNLRTKRVDyvyPPYPRSIAQYWLGC 433
Cdd:cd00094  154 ----FRWLDG-------------------YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
24-63 1.50e-12

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 61.55  E-value: 1.50e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308153283   24 ESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 22-64 1.03e-11

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 59.31  E-value: 1.03e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 308153283    22 AEESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPKE 64
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 181-226 1.75e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 53.02  E-value: 1.75e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 308153283   181 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISEGFHDIP 226
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 181-220 4.98e-08

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 48.72  E-value: 4.98e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308153283  181 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISE 220
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD 38
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 129-433 2.53e-43

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 150.54  E-value: 2.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 129 ELCSGQPFDAFTNIkNGSIYAFRGKYFYELDDKSAlEGYPKLIKDVW-GIDGPVDAAFTRMNcQGKTYLFKGKEYWRFSN 207
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKP-PGSPFLISSFWpSLPSPVDAAFERPD-TGKIYFFKGDKYWVYTG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 208 GVLESDYPRNISE-GFHDIPDNIDAAFALPannhnDREKVYFFKGNKYWQYEFQNQPSRKDCqdsaqselftyyvtlqkd 286
Cdd:cd00094   79 KNLEPGYPKPISDlGFPPTVKQIDAALRWP-----DNGKTYFFKGDKYWRYDEKTQKMDPGY------------------ 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153283 287 swedffsflfgpsmkrstagPWYINKDWKGVPNNVDAVlpsriyvpkqtrrsrrrksrrrnnrkksggmrslwsdfsfdp 366
Cdd:cd00094  136 --------------------PKLIETDFPGVPDKVDAA------------------------------------------ 153

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 308153283 367 ldglFDYDDEqsdpdwlpperpadcqptqNVYFFKNDKYYRVNLRTKRVDyvyPPYPRSIAQYWLGC 433
Cdd:cd00094  154 ----FRWLDG-------------------YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
Somatomedin_B pfam01033
Somatomedin B domain;
24-63 1.50e-12

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 61.55  E-value: 1.50e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308153283   24 ESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPK 63
Cdd:pfam01033   1 ESCKGRCGESFDRGRLCQCDDDCVKYGDCCPDYESLCLGE 40
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 22-64 1.03e-11

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 59.31  E-value: 1.03e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 308153283    22 AEESCAGRCFSGFDGNKKCQCDIICVHFESCCIDYLTLCKPKE 64
Cdd:smart00201   1 AIGSCKGRCGESFNEGNACRCDALCLSYGDCCTDYESVCKKEV 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 181-226 1.75e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 53.02  E-value: 1.75e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 308153283   181 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISEGFHDIP 226
Cdd:smart00120   1 IDAAFELRD--GKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 181-220 4.98e-08

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 48.72  E-value: 4.98e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 308153283  181 VDAAFTRMNcqGKTYLFKGKEYWRFSNGVLESDYPRNISE 220
Cdd:pfam00045   1 IDAAFEDRD--GKTYFFKGRKYWRFDPQRVEPGYPKLISD 38
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 136-175 9.98e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 48.01  E-value: 9.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 308153283   136 FDAFTNIKNGSIYAFRGKYFYELDDKSALEGYPKLIKDVW 175
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFF 40
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 136-177 1.71e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 47.56  E-value: 1.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 308153283  136 FDAFTNIKNGSIYAFRGKYFYELDDKSALEGYPKLIKDVWGI 177
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDFPGL 42
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 229-261 1.82e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 38.76  E-value: 1.82e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 308153283   229 IDAAFALPannhndREKVYFFKGNKYWQYEFQN 261
Cdd:smart00120   1 IDAAFELR------DGKTYFFKGDKYWRFDPKR 27
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 229-263 1.41e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.39  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 308153283  229 IDAAFALPANnhndreKVYFFKGNKYWQYEFQNQP 263
Cdd:pfam00045   1 IDAAFEDRDG------KTYFFKGRKYWRFDPQRVE 29
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 397-432 1.97e-03

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 36.07  E-value: 1.97e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 308153283   397 VYFFKNDKYYRVNLRTKRvdyvyPPYPRSIAQYWLG 432
Cdd:smart00120  12 TYFFKGDKYWRFDPKRVD-----PGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 397-433 4.13e-03

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 34.85  E-value: 4.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 308153283  397 VYFFKNDKYYRVNLRTKRvdyvyPPYPRSIAQY-WLGC 433
Cdd:pfam00045  12 TYFFKGRKYWRFDPQRVE-----PGYPKLISDFpGLPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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