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Conserved domains on  [gi|334183047|ref|NP_001185142|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
215-397 2.09e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 215 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 293
Cdd:COG2319  172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 294 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 373
Cdd:COG2319  251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                        170       180
                 ....*....|....*....|....
gi 334183047 374 FGEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGT 353
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
215-397 2.09e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 215 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 293
Cdd:COG2319  172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 294 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 373
Cdd:COG2319  251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                        170       180
                 ....*....|....*....|....
gi 334183047 374 FGEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGT 353
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-397 5.40e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 5.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 214 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF--ALDWsVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 291
Cdd:cd00200   18 SPDGKL-LATGSGDGTIKVWDLETGELLRTLkgHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 292 SFASAWHPNGLILATGNQDTACRLWDIRNPSESFaVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEI 371
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG----KCV 170

                        170       180       190
                 ....*....|....*....|....*....|
gi 334183047 372 DLF----GEIAGISFSPDTEALYVGVADRT 397
Cdd:cd00200  171 ATLtghtGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 278-317 2.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 334183047   278 SGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 317
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
279-317 1.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 334183047  279 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 317
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 222-363 1.22e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 40.41  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047  222 ITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAV-VGDSTECLISDSHSGKVISSLRGHKD-YSFAsaWHP 299
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPVGQRPRGITFSKDGKLLYVcASDSDTIQVIDPATGEVLHTLPSGPDpEQFA--LHP 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334183047  300 NGLILATGNQDTA-CRLWDIrnpsESFAVLKG-NMGA-IRGLKFTPEGRFLA-MAEPADFVHIFDTQS 363
Cdd:TIGR03866  93 NGKILYIANEDDAlVTVIDI----ETRKVLAQiDVGVePEGMAVSPDGKIVVnTSETTNMAHWIDTAT 156
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
215-397 2.09e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 215 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 293
Cdd:COG2319  172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 294 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 373
Cdd:COG2319  251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                        170       180
                 ....*....|....*....|....
gi 334183047 374 FGEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGSDDGT 353
WD40 COG2319
WD40 repeat [General function prediction only];
215-397 2.75e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 2.75e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 215 PSGSlRLITANNDCKIRVFDAQSFTRVSEFAL-DWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 293
Cdd:COG2319  214 PDGK-LLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 294 ASAWHPNGLILATGNQDTACRLWDIRNPsESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 373
Cdd:COG2319  293 SVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                        170       180
                 ....*....|....*....|....
gi 334183047 374 FGEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  372 TGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
220-397 1.05e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 1.05e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 220 RLITANNDCKIRVFDAQS-FTRVSEFALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWH 298
Cdd:COG2319   92 LLASASADGTVRLWDLATgLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 299 PNGLILATGNQDTACRLWDIRNPSEsFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEIDLF---- 374
Cdd:COG2319  172 PDGKLLASGSDDGTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLtghs 246

                        170       180
                 ....*....|....*....|...
gi 334183047 375 GEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGT 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-397 5.40e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 5.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 214 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF--ALDWsVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 291
Cdd:cd00200   18 SPDGKL-LATGSGDGTIKVWDLETGELLRTLkgHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 292 SFASAWHPNGLILATGNQDTACRLWDIRNPSESFaVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEI 371
Cdd:cd00200   96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG----KCV 170

                        170       180       190
                 ....*....|....*....|....*....|
gi 334183047 372 DLF----GEIAGISFSPDTEALYVGVADRT 397
Cdd:cd00200  171 ATLtghtGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 171-397 2.59e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 2.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 171 NLILLGGFDGelLCKCVNQPGVAFCTRLSTEDNAItNTVDIyrDPSGSLrLITANNDCKIRVFDAQSFTRVSEFA--LDW 248
Cdd:cd00200   64 TYLASGSSDK--TIRLWDLETGECVRTLTGHTSYV-SSVAF--SPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRghTDW 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 249 sVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPSESfAVL 328
Cdd:cd00200  138 -VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTL 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183047 329 KGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQeidLFG---EIAGISFSPDTEALYVGVADRT 397
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGhtnSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
247-397 6.13e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 6.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 247 DWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPsESFA 326
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLR 156

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183047 327 VLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEIDLF----GEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLtghtGAVRSVAFSPDGKLLASGSADGT 227
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 214-360 9.87e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 9.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 214 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYS 292
Cdd:cd00200  144 SPDGTF-VASSSQDGTIKLWDLRTGKCVATLtGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334183047 293 FASAWHPNGLILATGNQDTACRLWDIRNPSESfAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFD 360
Cdd:cd00200  223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-397 5.72e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 5.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 216 SGSLRLITANNDCKIRVFDAQSFTRVSEFALD----WSVnntSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 291
Cdd:cd00200   61 ADGTYLASGSSDKTIRLWDLETGECVRTLTGHtsyvSSV---AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 292 SFASAWHPNGLILATGNQDTACRLWDIRNPSeSFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQei 371
Cdd:cd00200  138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-- 214

                        170       180
                 ....*....|....*....|....*....
gi 334183047 372 dLFG---EIAGISFSPDTEALYVGVADRT 397
Cdd:cd00200  215 -LRGhenGVNSVAFSPDGYLLASGSEDGT 242
WD40 COG2319
WD40 repeat [General function prediction only];
215-320 1.64e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 1.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 215 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 293
Cdd:COG2319  298 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                         90       100
                 ....*....|....*....|....*..
gi 334183047 294 ASAWHPNGLILATGNQDTACRLWDIRN 320
Cdd:COG2319  377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
213-397 1.78e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 213 RDPSGSLRLITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYS 292
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 293 FASAWHPNGLILATGNQDTACRLWDIRNPSEsFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEID 372
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLR 156

                        170       180
                 ....*....|....*....|....*....
gi 334183047 373 LF----GEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319  157 TLtghsGAVTSVAFSPDGKLLASGSDDGT 185
WD40 COG2319
WD40 repeat [General function prediction only];
254-397 2.99e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 254 SVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPSESfAVLKGNMG 333
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334183047 334 AIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDLFGEIAGISFSPDTEALYVGVADRT 397
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 282-397 4.13e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 4.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 282 ISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDT 361
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 334183047 362 QSGFLQSQEIDLFGEIAGISFSPDTEALYVGVADRT 397
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 278-317 2.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 334183047   278 SGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 317
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
279-317 1.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 334183047  279 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 317
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 256-290 1.58e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 334183047  256 SPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKD 290
Cdd:pfam12894  47 RPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
196-285 4.67e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 4.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047 196 TRLSTEDNAITNTVD-------IYRDPSGSLRLITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAVV--- 265
Cdd:COG3391   93 SVIDLATGKVVATIPvgggprgLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVAnsg 172

                         90       100
                 ....*....|....*....|..
gi 334183047 266 GDSTECLIS--DSHSGKVISSL 285
Cdd:COG3391  173 SNTVSVIVSviDTATGKVVATI 194
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 222-363 1.22e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 40.41  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047  222 ITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAV-VGDSTECLISDSHSGKVISSLRGHKD-YSFAsaWHP 299
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPVGQRPRGITFSKDGKLLYVcASDSDTIQVIDPATGEVLHTLPSGPDpEQFA--LHP 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334183047  300 NGLILATGNQDTA-CRLWDIrnpsESFAVLKG-NMGA-IRGLKFTPEGRFLA-MAEPADFVHIFDTQS 363
Cdd:TIGR03866  93 NGKILYIANEDDAlVTVIDI----ETRKVLAQiDVGVePEGMAVSPDGKIVVnTSETTNMAHWIDTAT 156
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 229-375 4.04e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047  229 KIRVFDAQSFTRVseFALDWSvnntsvsPDGKLLAVVGDSTECLISDSHSGK---VISSLRGHKDYSFasAWHPNGLILA 305
Cdd:COG4946   379 EPKQLTLGDLGRV--FNPVWS-------PDGKKIAFTDNRGRLWVVDLASGKvrkVDTDGYGDGISDL--AWSPDSKWLA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047  306 ----TGNQDTACRLWDIRNpSESFAVLKGNMGAIRgLKFTPEGRFLAMA-----EPA----DFVHIFDTQSG----FLQS 368
Cdd:COG4946   448 yskpGPNQLSQIFLYDVET-GKTVQLTDGRYDDGS-PAFSPDGKYLYFLssrdfNPTygdlDFDLAFPRTTRiyavPLRK 525


                  ....*..
gi 334183047  369 QEIDLFG 375
Cdd:COG4946   526 DAPSPFA 532
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 254-417 4.48e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.25  E-value: 4.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047  254 SVSPDGKLLAVVGDST--ECL----ISDSHSGKVISSLrGHKDYsFASAWHPNGLILATGNQDTacRLW--DIRNPSESf 325
Cdd:COG4946   349 AWSPDGKSIAYFSDASgeYELyiapADGSGEPKQLTLG-DLGRV-FNPVWSPDGKKIAFTDNRG--RLWvvDLASGKVR- 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183047  326 AVLKGNMGA-IRGLKFTPEGRFLAMAEPADF----VHIFDTQSGflQSQEI--DLFGEIAGIsFSPDTEALYVgVADRTY 398
Cdd:COG4946   424 KVDTDGYGDgISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVETG--KTVQLtdGRYDDGSPA-FSPDGKYLYF-LSSRDF 499

                         170
                  ....*....|....*....
gi 334183047  399 GSLLeykrrkDNHYMDSFY 417
Cdd:COG4946   500 NPTY------GDLDFDLAF 512
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 279-318 5.17e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 334183047  279 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDI 318
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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