|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
54-443 |
3.16e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 135.54 E-value: 3.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 54 TLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnndqqwRHVLQLPLSHKKGVTCITAYMVSET 133
Cdd:cd00200 4 TLKGHTGGVTCVAFSP-----------DGKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTY 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 134 damFASASSDGVVNVWDVSfpsqpseecKVVCLDSICVDTKAIVTLSLaelpqNPGRFALALGGLDNKIKLYSGErTGKF 213
Cdd:cd00200 66 ---LASGSSDKTIRLWDLE---------TGECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVE-TGKC 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 214 TSVceLKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyq 293
Cdd:cd00200 128 LTT--LRGHTDWVNSVAFS---------PDGTFVASSSQDGTIKLW------DLRTGKCVATLT---------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 294 isvesvliGHEDWVYSVEWQPpvidfiDGRlvnhqplSILSASMDKTMMIWRPEKKTgvwvnvvCVGELSHCALGFYGGH 373
Cdd:cd00200 175 --------GHTGEVNSVAFSP------DGE-------KLLSSSSDGTIKLWDLSTGK-------CLGTLRGHENGVNSVA 226
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 374 WSPNSLSILAHGYGGAFHLWRnvssskeSENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFS 443
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWD-------LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
25-444 |
3.26e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 132.73 E-value: 3.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 25 VSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnn 104
Cdd:COG2319 86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-----------DGKTLASGSADGTVRLWDLAT--- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 105 dQQWRHVLQlplSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLAel 184
Cdd:COG2319 152 -GKLLRTLT---GHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVAFS-- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 185 PQnpGRFaLALGGLDNKIKLYSGErTGKFtsVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlv 264
Cdd:COG2319 214 PD--GKL-LASGSADGTVRLWDLA-TGKL--LRTLTGHSGSVRSVAFS---------PDGRLLASGSADGTVRLW----- 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 265 gDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIW 344
Cdd:COG2319 274 -DLATGELLRTLT------------------------GHSGGVNSVAFSP------DGKL-------LASGSDDGTVRLW 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 345 RPEkkTGVWVNVVCVGELSHCALGFygghwSPNSLSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWA 424
Cdd:COG2319 316 DLA--TGKLLRTLTGHTGAVRSVAF-----SPDGKTLASGSDDGTVRLW-DLATGELLRTLT------GHTGAVTSVAFS 381
|
410 420
....*....|....*....|
gi 334183179 425 RTGEYLLSVSQDQTTRVFSA 444
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
299-750 |
6.01e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.22 E-value: 6.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 299 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 378
Cdd:COG2319 73 TLLGHTAAVLSVAFSP------DGRL-------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-------FSPDG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 379 LSILAHGYGGAFHLWrnvssskESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 458
Cdd:COG2319 133 KTLASGSADGTVRLW-------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGKL------ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 459 heLARPQVHGHDINCVAMvqGKGNHRFVSGAEEKVVRVFEAPlsflktlnhtcaggegsfpedlqadvqvlganmsalgl 538
Cdd:COG2319 197 --LRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLA-------------------------------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 539 sqkpiylhssseplerngGGEGLDTFEtvpeaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASS 618
Cdd:COG2319 235 ------------------TGKLLRTLT--------------------------------GHSGSVRSVAFSPDGRLLASG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 619 CKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRI 698
Cdd:COG2319 265 SADGT-----VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLTGHTGA 332
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 334183179 699 IWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWT 750
Cdd:COG2319 333 VRSVAFSPDGKTLASGSDDGTVRLWDLATG---ELLRTLTGHTGAVTSVAFS 381
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
299-724 |
1.41e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.09 E-value: 1.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 299 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 378
Cdd:cd00200 4 TLKGHTGGVTCVAFSP------DGKL-------LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-------ASADG 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 379 LSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 458
Cdd:cd00200 64 TYLASGSSDKTIRLW-DLETGECVRTLT------GHTSYVSSVAFSPDGRILSSSSRDKTIKV---WDVETGKC------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 459 heLARPQVHGHDINCVAMvqgKGNHRFVSGA-EEKVVRVFEaplsflktlnhtcaggegsfpedlqadvqvlganmsalg 537
Cdd:cd00200 128 --LTTLRGHTDWVNSVAF---SPDGTFVASSsQDGTIKLWD--------------------------------------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 538 lsqkpiylhssseplerngggegLDTFETVpeaapaelkeppiedqlafhtlwpesHKLYGHGNELFSLCSDHKGNLVAS 617
Cdd:cd00200 164 -----------------------LRTGKCV--------------------------ATLTGHTGEVNSVAFSPDGEKLLS 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 618 SckaqsASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFsiqRTDNGEVSHKLmakvEAHKR 697
Cdd:cd00200 195 S-----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW---DLRTGECVQTL----SGHTN 262
|
410 420
....*....|....*....|....*..
gi 334183179 698 IIWACSWNPFGHQFATSSRDKTVKIWS 724
Cdd:cd00200 263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
685-724 |
1.15e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.77 E-value: 1.15e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 334183179 685 SHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 724
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
87-355 |
4.39e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 50.47 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 87 SGDSDGIIILWELStlnndqqwRHVLQLPL-SHKKGVTCITaymVSETD-AMFASASSDGVVNVWDVSfpsqpseecKVV 164
Cdd:PLN00181 550 SSNFEGVVQVWDVA--------RSQLVTEMkEHEKRVWSID---YSSADpTLLASGSDDGSVKLWSIN---------QGV 609
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 165 CLDSIcvDTKAivTLSLAELPQNPGRfALALGGLDNKIKLYSgERTGKFtSVCELKGHTDWIRSLDFSlplhtteeipNS 244
Cdd:PLN00181 610 SIGTI--KTKA--NICCVQFPSESGR-SLAFGSADHKVYYYD-LRNPKL-PLCTMIGHSKTVSYVRFV----------DS 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 245 IMLVSSSQDKVIRIWKLVLvgdVGSWRREITLASYIeGPVFVSGTFTYQISVESVLIGHED---WVYSVEWQPPVIDFID 321
Cdd:PLN00181 673 STLVSSSTDNTLKLWDLSM---SISGINETPLHSFM-GHTNVKNFVGLSVSDGYIATGSETnevFVYHKAFPMPVLSYKF 748
|
250 260 270
....*....|....*....|....*....|....
gi 334183179 322 GRLVNHQPLSILSASMDKTMMIWRPEKKTGVWVN 355
Cdd:PLN00181 749 KTIDPVSGLEVDDASQFISSVCWRGQSSTLVAAN 782
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
687-724 |
9.46e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.10 E-value: 9.46e-06
10 20 30
....*....|....*....|....*....|....*...
gi 334183179 687 KLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 724
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
212-260 |
2.52e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 2.52e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 334183179 212 KFTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWK 260
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFS---------PDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
213-259 |
8.37e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 8.37e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 334183179 213 FTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIW 259
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFS---------PDGKLLASGSDDGTVKVW 38
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
640-744 |
1.93e-04 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 44.94 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 640 VGRLQSHSLTVTHLEFS--YDDtLLLSVSRDRHFSVFSIQRTDNG--EVSHKLMAkVEAHKRIIWACSWNPFGHQFATSS 715
Cdd:PTZ00420 67 VIKLKGHTSSILDLQFNpcFSE-ILASGSEDLTIRVWEIPHNDESvkEIKDPQCI-LKGHKKKISIIDWNPMNYYIMCSS 144
|
90 100 110
....*....|....*....|....*....|
gi 334183179 716 R-DKTVKIWSVENDARIKQIlVLPPFGSSV 744
Cdd:PTZ00420 145 GfDSFVNIWDIENEKRAFQI-NMPKKLSSL 173
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
54-443 |
3.16e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 135.54 E-value: 3.16e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 54 TLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnndqqwRHVLQLPLSHKKGVTCITAYMVSET 133
Cdd:cd00200 4 TLKGHTGGVTCVAFSP-----------DGKLLATGSGDGTIKVWDLET-------GELLRTLKGHTGPVRDVAASADGTY 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 134 damFASASSDGVVNVWDVSfpsqpseecKVVCLDSICVDTKAIVTLSLaelpqNPGRFALALGGLDNKIKLYSGErTGKF 213
Cdd:cd00200 66 ---LASGSSDKTIRLWDLE---------TGECVRTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVE-TGKC 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 214 TSVceLKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyq 293
Cdd:cd00200 128 LTT--LRGHTDWVNSVAFS---------PDGTFVASSSQDGTIKLW------DLRTGKCVATLT---------------- 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 294 isvesvliGHEDWVYSVEWQPpvidfiDGRlvnhqplSILSASMDKTMMIWRPEKKTgvwvnvvCVGELSHCALGFYGGH 373
Cdd:cd00200 175 --------GHTGEVNSVAFSP------DGE-------KLLSSSSDGTIKLWDLSTGK-------CLGTLRGHENGVNSVA 226
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 374 WSPNSLSILAHGYGGAFHLWRnvssskeSENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFS 443
Cdd:cd00200 227 FSPDGYLLASGSEDGTIRVWD-------LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
25-444 |
3.26e-33 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 132.73 E-value: 3.26e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 25 VSWGASGLVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWELSTlnn 104
Cdd:COG2319 86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-----------DGKTLASGSADGTVRLWDLAT--- 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 105 dQQWRHVLQlplSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLAel 184
Cdd:COG2319 152 -GKLLRTLT---GHSGAVTSVA---FSPDGKLLASGSDDGTVRLWDLATGK---------LLRTLTGHTGAVRSVAFS-- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 185 PQnpGRFaLALGGLDNKIKLYSGErTGKFtsVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWklvlv 264
Cdd:COG2319 214 PD--GKL-LASGSADGTVRLWDLA-TGKL--LRTLTGHSGSVRSVAFS---------PDGRLLASGSADGTVRLW----- 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 265 gDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIW 344
Cdd:COG2319 274 -DLATGELLRTLT------------------------GHSGGVNSVAFSP------DGKL-------LASGSDDGTVRLW 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 345 RPEkkTGVWVNVVCVGELSHCALGFygghwSPNSLSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWA 424
Cdd:COG2319 316 DLA--TGKLLRTLTGHTGAVRSVAF-----SPDGKTLASGSDDGTVRLW-DLATGELLRTLT------GHTGAVTSVAFS 381
|
410 420
....*....|....*....|
gi 334183179 425 RTGEYLLSVSQDQTTRVFSA 444
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
22-347 |
8.71e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 113.85 E-value: 8.71e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 22 VNNVSWGASG--LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWEL 99
Cdd:COG2319 165 VTSVAFSPDGklLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-----------DGKLLASGSADGTVRLWDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 100 STlnndQQWRHVLQlplSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTL 179
Cdd:COG2319 234 AT----GKLLRTLT---GHSGSVRSVA---FSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNSV 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 180 SLAelpqnP-GRFaLALGGLDNKIKLYSGErTGKftSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRI 258
Cdd:COG2319 295 AFS-----PdGKL-LASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFS---------PDGKTLASGSDDGTVRL 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 259 WklvlvgDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMD 338
Cdd:COG2319 357 W------DLATGELLRTLT------------------------GHTGAVTSVAFSP------DGRT-------LASGSAD 393
|
....*....
gi 334183179 339 KTMMIWRPE 347
Cdd:COG2319 394 GTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
80-499 |
4.65e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 108.46 E-value: 4.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 80 LDRQYLLSGDSDGIIILWELSTLNNDQQWRHVLQLPLSHKKGVTCITAYMVSETDAMFASASSDGVVNVWDVSFPSqpse 159
Cdd:COG2319 36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL---- 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 160 eckvvCLDSICVDTKAIVTLSLAelpqnPGRFALALGGLDNKIKLYSGErTGKFtsVCELKGHTDWIRSLDFSlplhtte 239
Cdd:COG2319 112 -----LLRTLTGHTGAVRSVAFS-----PDGKTLASGSADGTVRLWDLA-TGKL--LRTLTGHSGAVTSVAFS------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 240 eiPNSIMLVSSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidf 319
Cdd:COG2319 172 --PDGKLLASGSDDGTVRLW------DLATGKLLRTLT------------------------GHTGAVRSVAFSP----- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 320 iDGRLvnhqplsILSASMDKTMMIWRPEKKTgvwvnvvCVGELSHCALGFYGGHWSPNSlSILAHG-YGGAFHLWrNVSS 398
Cdd:COG2319 215 -DGKL-------LASGSADGTVRLWDLATGK-------LLRTLTGHSGSVRSVAFSPDG-RLLASGsADGTVRLW-DLAT 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 399 SKEsenwqmQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAwkndegneaedEHWHELARPQVHGHDINCVAMVQ 478
Cdd:COG2319 278 GEL------LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL-----------ATGKLLRTLTGHTGAVRSVAFSP 340
|
410 420
....*....|....*....|.
gi 334183179 479 gkGNHRFVSGAEEKVVRVFEA 499
Cdd:COG2319 341 --DGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
89-727 |
6.67e-24 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 104.99 E-value: 6.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 89 DSDGIIILWELSTLNNDQQWRHVLQLPLSHKKGVTCITAYMVSETDAMFASASSDGVVNVWDVsfpsqpseeckvvcLDS 168
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA--------------AAG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 169 ICVDTKAIVTLSLAELPQNPGRFALALGGLDNKIKLYSGERTgkfTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLV 248
Cdd:COG2319 69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFS---------PDGKTLA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 249 SSSQDKVIRIWklvlvgDVGSWRREITLAsyiegpvfvsgtftyqisvesvliGHEDWVYSVEWQPpvidfiDGRLvnhq 328
Cdd:COG2319 137 SGSADGTVRLW------DLATGKLLRTLT------------------------GHSGAVTSVAFSP------DGKL---- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 329 plsILSASMDKTMMIWRPEKktgvwvnvvcvGELSHcalgfygghwspnslsilahgyggafhlwrnvssskesenwqmq 408
Cdd:COG2319 177 ---LASGSDDGTVRLWDLAT-----------GKLLR-------------------------------------------- 198
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 409 kVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVFSAwkndegneaedEHWHELARPQVHGHDINCVAM-VQGKgnhRFVS 487
Cdd:COG2319 199 -TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL-----------ATGKLLRTLTGHSGSVRSVAFsPDGR---LLAS 263
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 488 GAEEKVVRVFeaplsflktlnhtcaggegsfpedlqaDVQvlganmsalglsqkpiylhssseplerngGGEGLDTFEtv 567
Cdd:COG2319 264 GSADGTVRLW---------------------------DLA-----------------------------TGELLRTLT-- 285
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 568 peaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHS 647
Cdd:COG2319 286 ------------------------------GHSGGVNSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHT 330
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 648 LTVTHLEFSYDDTLLLSVSRDRHFSVFSIqrtDNGEVSHKLmakvEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVEN 727
Cdd:COG2319 331 GAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTL----TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
32-260 |
1.38e-23 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 101.64 E-value: 1.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 32 LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPTSKFafkakkldrqyLLSGDSDGIIILWELSTlnndqqWRHV 111
Cdd:cd00200 108 LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-----------VASSSQDGTIKLWDLRT------GKCV 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 112 LQLPlSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVSFPSqpseeckvvCLDSICVDTKAIVTLSLaelpqNPGRF 191
Cdd:cd00200 171 ATLT-GHTGEVNSVA---FSPDGEKLLSSSSDGTIKLWDLSTGK---------CLGTLRGHENGVNSVAF-----SPDGY 232
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334183179 192 ALALGGLDNKIKLYSGErtgKFTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWK 260
Cdd:cd00200 233 LLASGSEDGTIRVWDLR---TGECVQTLSGHTNSVTSLAWS---------PDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
299-750 |
6.01e-22 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 99.22 E-value: 6.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 299 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 378
Cdd:COG2319 73 TLLGHTAAVLSVAFSP------DGRL-------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA-------FSPDG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 379 LSILAHGYGGAFHLWrnvssskESENWQMQKVPSGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 458
Cdd:COG2319 133 KTLASGSADGTVRLW-------DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGKL------ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 459 heLARPQVHGHDINCVAMvqGKGNHRFVSGAEEKVVRVFEAPlsflktlnhtcaggegsfpedlqadvqvlganmsalgl 538
Cdd:COG2319 197 --LRTLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLA-------------------------------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 539 sqkpiylhssseplerngGGEGLDTFEtvpeaapaelkeppiedqlafhtlwpeshklyGHGNELFSLCSDHKGNLVASS 618
Cdd:COG2319 235 ------------------TGKLLRTLT--------------------------------GHSGSVRSVAFSPDGRLLASG 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 619 CKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRI 698
Cdd:COG2319 265 SADGT-----VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLTGHTGA 332
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 334183179 699 IWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWT 750
Cdd:COG2319 333 VRSVAFSPDGKTLASGSDDGTVRLWDLATG---ELLRTLTGHTGAVTSVAFS 381
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
594-837 |
2.60e-20 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 94.21 E-value: 2.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 594 HKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSV 673
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGT-----VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 674 FSIQrtdngevSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTGLD 753
Cdd:COG2319 189 WDLA-------TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 754 RneksgCVAVGMESGLIELSNVkiieteegttATAALALRLEPfmcHVSAVNRLAWRPTEkcesnqslRWLTSCGDDNCV 833
Cdd:COG2319 259 R-----LLASGSADGTVRLWDL----------ATGELLRTLTG---HSGGVNSVAFSPDG--------KLLASGSDDGTV 312
|
....
gi 334183179 834 RVFN 837
Cdd:COG2319 313 RLWD 316
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
594-837 |
1.29e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 92.28 E-value: 1.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 594 HKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSV 673
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 674 FSIQRTdngevshKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKqilVLPPFGSSVTAVAWTGLD 753
Cdd:COG2319 231 WDLATG-------KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---TLTGHSGGVNSVAFSPDG 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 754 RNeksgcVAVGMESGLIELSNVkiieteegttATAALALRLEPfmcHVSAVNRLAWRPTEkcesnqslRWLTSCGDDNCV 833
Cdd:COG2319 301 KL-----LASGSDDGTVRLWDL----------ATGKLLRTLTG---HTGAVRSVAFSPDG--------KTLASGSDDGTV 354
|
....
gi 334183179 834 RVFN 837
Cdd:COG2319 355 RLWD 358
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
299-724 |
1.41e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.09 E-value: 1.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 299 VLIGHEDWVYSVEWQPpvidfiDGRLvnhqplsILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCAlgfygghWSPNS 378
Cdd:cd00200 4 TLKGHTGGVTCVAFSP------DGKL-------LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-------ASADG 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 379 LSILAHGYGGAFHLWrNVSSSKESENWQmqkvpsGHFAAVTDVTWARTGEYLLSVSQDQTTRVfsaWKNDEGNEaedehw 458
Cdd:cd00200 64 TYLASGSSDKTIRLW-DLETGECVRTLT------GHTSYVSSVAFSPDGRILSSSSRDKTIKV---WDVETGKC------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 459 heLARPQVHGHDINCVAMvqgKGNHRFVSGA-EEKVVRVFEaplsflktlnhtcaggegsfpedlqadvqvlganmsalg 537
Cdd:cd00200 128 --LTTLRGHTDWVNSVAF---SPDGTFVASSsQDGTIKLWD--------------------------------------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 538 lsqkpiylhssseplerngggegLDTFETVpeaapaelkeppiedqlafhtlwpesHKLYGHGNELFSLCSDHKGNLVAS 617
Cdd:cd00200 164 -----------------------LRTGKCV--------------------------ATLTGHTGEVNSVAFSPDGEKLLS 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 618 SckaqsASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFsiqRTDNGEVSHKLmakvEAHKR 697
Cdd:cd00200 195 S-----SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW---DLRTGECVQTL----SGHTN 262
|
410 420
....*....|....*....|....*..
gi 334183179 698 IIWACSWNPFGHQFATSSRDKTVKIWS 724
Cdd:cd00200 263 SVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
592-837 |
9.83e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 87.39 E-value: 9.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 592 ESHKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHF 671
Cdd:cd00200 85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-----IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 672 SVFSIQrtdngevSHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTG 751
Cdd:cd00200 160 KLWDLR-------TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGTLRGHENGVNSVAFSP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 752 LDRNeksgcVAVGMESGLIelsnvKIIETEEGTTataalalrLEPFMCHVSAVNRLAWRPTEKcesnqslrWLTSCGDDN 831
Cdd:cd00200 230 DGYL-----LASGSEDGTI-----RVWDLRTGEC--------VQTLSGHTNSVTSLAWSPDGK--------RLASGSADG 283
|
....*.
gi 334183179 832 CVRVFN 837
Cdd:cd00200 284 TIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
592-839 |
1.33e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 81.23 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 592 ESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMaeiwlWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHF 671
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKV-----WDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 672 SVFSIQrtdNGEVSHKLmakvEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTG 751
Cdd:cd00200 76 RLWDLE---TGECVRTL----TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---KCLTTLRGHTDWVNSVAFSP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 752 LDRneksgCVAVGMESGLI---ELSNVKIIETEEGttataalalrlepfmcHVSAVNRLAWRPTEkcesnqslRWLTSCG 828
Cdd:cd00200 146 DGT-----FVASSSQDGTIklwDLRTGKCVATLTG----------------HTGEVNSVAFSPDG--------EKLLSSS 196
|
250
....*....|.
gi 334183179 829 DDNCVRVFNFK 839
Cdd:cd00200 197 SDGTIKLWDLS 207
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
621-837 |
2.08e-14 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 76.10 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 621 AQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQrtdngevSHKLMAKVEAHKRIIW 700
Cdd:COG2319 52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA-------TGLLLRTLTGHTGAVR 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 701 ACSWNPFGHQFATSSRDKTVKIWSVENDariKQILVLPPFGSSVTAVAWTGLDRNeksgcVAVGMESGlielsNVKIIET 780
Cdd:COG2319 125 SVAFSPDGKTLASGSADGTVRLWDLATG---KLLRTLTGHSGAVTSVAFSPDGKL-----LASGSDDG-----TVRLWDL 191
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 334183179 781 EEGTtataalalRLEPFMCHVSAVNRLAWRPTEkcesnqslRWLTSCGDDNCVRVFN 837
Cdd:COG2319 192 ATGK--------LLRTLTGHTGAVRSVAFSPDG--------KLLASGSADGTVRLWD 232
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
594-839 |
1.52e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 68.90 E-value: 1.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 594 HKLYGHGNELFSLCSDHKGNLVASSCKAQSasmaeIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSV 673
Cdd:cd00200 45 RTLKGHTGPVRDVAASADGTYLASGSSDKT-----IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 674 FSIQRTdngevshKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKqilVLPPFGSSVTAVAWTGld 753
Cdd:cd00200 120 WDVETG-------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA---TLTGHTGEVNSVAFSP-- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 754 rneKSGCVAVGMESGlielsNVKIIETEEGTTataalalrLEPFMCHVSAVNRLAWrptekcesNQSLRWLTSCGDDNCV 833
Cdd:cd00200 188 ---DGEKLLSSSSDG-----TIKLWDLSTGKC--------LGTLRGHENGVNSVAF--------SPDGYLLASGSEDGTI 243
|
....*.
gi 334183179 834 RVFNFK 839
Cdd:cd00200 244 RVWDLR 249
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
10-152 |
2.21e-10 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 63.39 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 10 KRVFIGAGCNRVVNNVSWGASG--LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLS 87
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-----------DGKTLAS 347
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183179 88 GDSDGIIILWELSTlnndqqwRHVLQLPLSHKKGVTCITaymVSETDAMFASASSDGVVNVWDVS 152
Cdd:COG2319 348 GSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVA---FSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
621-837 |
6.05e-07 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 52.61 E-value: 6.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 621 AQSASMAEIWLWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTdngevshKLMAKVEAHKRIIW 700
Cdd:COG2319 10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-------ALLATLLGHTAAVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 701 ACSWNPFGHQFATSSRDKTVKIWSVENDARIKQilvLPPFGSSVTAVAWTgldRNEKSgcVAVGMESGlielsNVKIIET 780
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRT---LTGHTGAVRSVAFS---PDGKT--LASGSADG-----TVRLWDL 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 334183179 781 EEGTtataalalRLEPFMCHVSAVNRLAWRPTEKcesnqslrWLTSCGDDNCVRVFN 837
Cdd:COG2319 150 ATGK--------LLRTLTGHSGAVTSVAFSPDGK--------LLASGSDDGTVRLWD 190
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
685-724 |
1.15e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.77 E-value: 1.15e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 334183179 685 SHKLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 724
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
87-355 |
4.39e-06 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 50.47 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 87 SGDSDGIIILWELStlnndqqwRHVLQLPL-SHKKGVTCITaymVSETD-AMFASASSDGVVNVWDVSfpsqpseecKVV 164
Cdd:PLN00181 550 SSNFEGVVQVWDVA--------RSQLVTEMkEHEKRVWSID---YSSADpTLLASGSDDGSVKLWSIN---------QGV 609
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 165 CLDSIcvDTKAivTLSLAELPQNPGRfALALGGLDNKIKLYSgERTGKFtSVCELKGHTDWIRSLDFSlplhtteeipNS 244
Cdd:PLN00181 610 SIGTI--KTKA--NICCVQFPSESGR-SLAFGSADHKVYYYD-LRNPKL-PLCTMIGHSKTVSYVRFV----------DS 672
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 245 IMLVSSSQDKVIRIWKLVLvgdVGSWRREITLASYIeGPVFVSGTFTYQISVESVLIGHED---WVYSVEWQPPVIDFID 321
Cdd:PLN00181 673 STLVSSSTDNTLKLWDLSM---SISGINETPLHSFM-GHTNVKNFVGLSVSDGYIATGSETnevFVYHKAFPMPVLSYKF 748
|
250 260 270
....*....|....*....|....*....|....
gi 334183179 322 GRLVNHQPLSILSASMDKTMMIWRPEKKTGVWVN 355
Cdd:PLN00181 749 KTIDPVSGLEVDDASQFISSVCWRGQSSTLVAAN 782
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
687-724 |
9.46e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.10 E-value: 9.46e-06
10 20 30
....*....|....*....|....*....|....*...
gi 334183179 687 KLMAKVEAHKRIIWACSWNPFGHQFATSSRDKTVKIWS 724
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
212-260 |
2.52e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.91 E-value: 2.52e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 334183179 212 KFTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIWK 260
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFS---------PDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
213-259 |
8.37e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 8.37e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 334183179 213 FTSVCELKGHTDWIRSLDFSlplhtteeiPNSIMLVSSSQDKVIRIW 259
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFS---------PDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
22-101 |
1.08e-04 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 45.67 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 22 VNNVSWGASG--LVSFGAQNAVAVFCPKTAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWEL 99
Cdd:COG2319 333 VRSVAFSPDGktLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-----------DGRTLASGSADGTVRLWDL 401
|
..
gi 334183179 100 ST 101
Cdd:COG2319 402 AT 403
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
640-744 |
1.93e-04 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 44.94 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183179 640 VGRLQSHSLTVTHLEFS--YDDtLLLSVSRDRHFSVFSIQRTDNG--EVSHKLMAkVEAHKRIIWACSWNPFGHQFATSS 715
Cdd:PTZ00420 67 VIKLKGHTSSILDLQFNpcFSE-ILASGSEDLTIRVWEIPHNDESvkEIKDPQCI-LKGHKKKISIIDWNPMNYYIMCSS 144
|
90 100 110
....*....|....*....|....*....|
gi 334183179 716 R-DKTVKIWSVENDARIKQIlVLPPFGSSV 744
Cdd:PTZ00420 145 GfDSFVNIWDIENEKRAFQI-NMPKKLSSL 173
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
48-98 |
5.79e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.06 E-value: 5.79e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 334183179 48 TAQILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWE 98
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSP-----------DGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
50-98 |
8.81e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 34.63 E-value: 8.81e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 334183179 50 QILTTLPGHKASVNCTHWLPtskfafkakklDRQYLLSGDSDGIIILWE 98
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSP-----------DGKLLASGSDDGTVKVWD 39
|
|
|