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Conserved domains on  [gi|334183466|ref|NP_001185277|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 1018-1176 5.29e-63

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 211.32  E-value: 5.29e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  1018 RTHSEVLNTLQSRLTKLQIVRHFWERSDIKGAIAALRKLSDHSVQADVINILTDKTEILTLDLFSQLAPVLTGLLGSKTE 1097
Cdd:pfam13925    1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  1098 RPVNVSLEMLLKLVAVFGTVIQSTVSA-RRVVGVDLHAEERLQICQSCSAELQKVQKILPLLTRRGGLIARKAQELNLVL 1176
Cdd:pfam13925   81 RYIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-260 5.34e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.43  E-value: 5.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    8 LQEFLAHSANVNCLSIGKKtSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDV 87
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   88 EEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVK 167
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  168 VWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCGLDD 247
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250
                  ....*....|....
gi 334183466  248 -SLKVYSWEPVVCH 260
Cdd:cd00200   241 gTIRVWDLRTGECV 254
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 668-906 6.88e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   668 ATNSTTVDVPVLSTRRTKSTPVRVMPVVLG-----RDTSMATDTP-PVTSTRPDRTSATNLTSDVSGVTSKrQTRTSPAP 741
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTTSPTLNTTGfaapnTTTGLPSSTHvPTNLTAPASTGPTVSTADVTSPTPA-GTTSGASP 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   742 VMPmilnqttkmkSDEPSITSTwpdRTSATDLTSDVSGVISSRQTRTSPAPVmpmklnqktkiksdeppITSTRPDRPSA 821
Cdd:pfam05109  488 VTP----------SPSPRDNGT---ESKAPDMTSPTSAVTTPTPNATSPTPA-----------------VTTPTPNATSP 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   822 T-NLTSDESPVTSTRQAKTSPAPVTPVILNQRQTTNMKSDEPPVISTRPLRTSSARVMPVILNQASTTYDERPLSSSRSA 900
Cdd:pfam05109  538 TlGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPV 617


                   ....*.
gi 334183466   901 RTSPAR 906
Cdd:pfam05109  618 VTSPPK 623
 
Name Accession Description Interval E-value
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 1018-1176 5.29e-63

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 211.32  E-value: 5.29e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  1018 RTHSEVLNTLQSRLTKLQIVRHFWERSDIKGAIAALRKLSDHSVQADVINILTDKTEILTLDLFSQLAPVLTGLLGSKTE 1097
Cdd:pfam13925    1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  1098 RPVNVSLEMLLKLVAVFGTVIQSTVSA-RRVVGVDLHAEERLQICQSCSAELQKVQKILPLLTRRGGLIARKAQELNLVL 1176
Cdd:pfam13925   81 RYIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-260 5.34e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.43  E-value: 5.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    8 LQEFLAHSANVNCLSIGKKtSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDV 87
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   88 EEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVK 167
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  168 VWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCGLDD 247
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250
                  ....*....|....
gi 334183466  248 -SLKVYSWEPVVCH 260
Cdd:cd00200   241 gTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
2-293 1.42e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.01  E-value: 1.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    2 AKRGYKLQEFLAHSANVNCLSIGKKTSRLfITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGV 81
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   82 IKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGG 161
Cdd:COG2319   144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  162 LDNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTL 241
Cdd:COG2319   224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 334183466  242 FCG-LDDSLKVYSW---EPVVCHDG-VDMGWStlgdLCIS-EGKLLGCSYYQNSVGIW 293
Cdd:COG2319   304 ASGsDDGTVRLWDLatgKLLRTLTGhTGAVRS----VAFSpDGKTLASGSDDGTVRLW 357
WD40 pfam00400
WD domain, G-beta repeat;
134-170 1.02e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 334183466   134 CIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWD 170
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 174-212 1.14e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.14e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 334183466    174 GKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWD 212
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-208 2.05e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 2.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   40 VNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLA-GASSGVIKLWDVEEAKMVRAFTGhRSNCSAVEF-HPFGEFLAS 117
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  118 GSSDANLKIWDIRK-KGCIQTYKGHSRGISTIRFTpDGRWVVSGGLDNVVKVWDLTAG------KLLHEFKFHEGPIRSL 190
Cdd:PLN00181  636 GSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFV 714

                         170
                  ....*....|....*...
gi 334183466  191 DFHPLEFLLATGSADRTV 208
Cdd:PLN00181  715 GLSVSDGYIATGSETNEV 732
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 668-906 6.88e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   668 ATNSTTVDVPVLSTRRTKSTPVRVMPVVLG-----RDTSMATDTP-PVTSTRPDRTSATNLTSDVSGVTSKrQTRTSPAP 741
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTTSPTLNTTGfaapnTTTGLPSSTHvPTNLTAPASTGPTVSTADVTSPTPA-GTTSGASP 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   742 VMPmilnqttkmkSDEPSITSTwpdRTSATDLTSDVSGVISSRQTRTSPAPVmpmklnqktkiksdeppITSTRPDRPSA 821
Cdd:pfam05109  488 VTP----------SPSPRDNGT---ESKAPDMTSPTSAVTTPTPNATSPTPA-----------------VTTPTPNATSP 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   822 T-NLTSDESPVTSTRQAKTSPAPVTPVILNQRQTTNMKSDEPPVISTRPLRTSSARVMPVILNQASTTYDERPLSSSRSA 900
Cdd:pfam05109  538 TlGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPV 617


                   ....*.
gi 334183466   901 RTSPAR 906
Cdd:pfam05109  618 VTSPPK 623
PRK10905 PRK10905
cell division protein DamX; Validated
 758-972 8.12e-05

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 46.08  E-value: 8.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  758 PSITSTwpDRTSATDLTSDVSGVISSRQTRTSPAPVMPMKLNQKTKIKSDE--PPITSTRpdrpsatnlTSDESPVTSTR 835
Cdd:PRK10905   23 PSTSSS--DQTASGEKSIDLAGNATDQANGVQPAPGTTSAEQTAGNTQQDVslPPISSTP---------TQGQTPVATDG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  836 Q-----------AKTSPApvtpvilNQRQTTNmksdeppVISTRPLRTSSARVMPViLNQASTTYDERPLSSSRSARTSP 904
Cdd:PRK10905   92 QqrvevqgdlnnALTQPQ-------NQQQLNN-------VAVNSTLPTEPATVAPV-RNGNASRQTAKTQTAERPATTRP 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183466  905 AR----IMPMKLNQADNMPSYEPPVALTRSARNSPARVIPVKLNQATNVTADASHIRSRQRFSPTQTLATPA 972
Cdd:PRK10905  157 ARkqavIEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPA 228
 
Name Accession Description Interval E-value
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 1018-1176 5.29e-63

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 211.32  E-value: 5.29e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  1018 RTHSEVLNTLQSRLTKLQIVRHFWERSDIKGAIAALRKLSDHSVQADVINILTDKTEILTLDLFSQLAPVLTGLLGSKTE 1097
Cdd:pfam13925    1 KDHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  1098 RPVNVSLEMLLKLVAVFGTVIQSTVSA-RRVVGVDLHAEERLQICQSCSAELQKVQKILPLLTRRGGLIARKAQELNLVL 1176
Cdd:pfam13925   81 RYIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNLLL 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-260 5.34e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 216.43  E-value: 5.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    8 LQEFLAHSANVNCLSIGKKtSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDV 87
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   88 EEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVK 167
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  168 VWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCGLDD 247
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                         250
                  ....*....|....
gi 334183466  248 -SLKVYSWEPVVCH 260
Cdd:cd00200   241 gTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
2-293 1.42e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.01  E-value: 1.42e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    2 AKRGYKLQEFLAHSANVNCLSIGKKTSRLfITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGV 81
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   82 IKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGG 161
Cdd:COG2319   144 VRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  162 LDNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTL 241
Cdd:COG2319   224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLL 303

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 334183466  242 FCG-LDDSLKVYSW---EPVVCHDG-VDMGWStlgdLCIS-EGKLLGCSYYQNSVGIW 293
Cdd:COG2319   304 ASGsDDGTVRLWDLatgKLLRTLTGhTGAVRS----VAFSpDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
2-255 4.99e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 217.47  E-value: 4.99e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    2 AKRGYKLQEFLAHSANVNCLSI---GKktsrLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGAS 78
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFspdGK----TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   79 SGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVV 158
Cdd:COG2319   183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  159 SGGLDNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDG 238
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 342

                         250
                  ....*....|....*...
gi 334183466  239 RTLFCGLDD-SLKVYSWE 255
Cdd:COG2319   343 KTLASGSDDgTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-253 8.51e-62

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.97  E-value: 8.51e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    3 KRGYKLQEFLAHSANVNCLSIGKKTSRLFiTGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVI 82
Cdd:cd00200    39 ETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   83 KLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGL 162
Cdd:cd00200   118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  163 DNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLF 242
Cdd:cd00200   198 DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         250
                  ....*....|..
gi 334183466  243 -CGLDDSLKVYS 253
Cdd:cd00200   278 sGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-255 9.34e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.70  E-value: 9.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    8 LQEFLAHSANVNCLSIGKkTSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDV 87
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   88 EEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVK 167
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  168 VWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLF-CGLD 246
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAsGSAD 393


                  ....*....
gi 334183466  247 DSLKVYSWE 255
Cdd:COG2319   394 GTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
27-293 8.33e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.45  E-value: 8.33e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   27 TSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAV 106
Cdd:COG2319    47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  107 EFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKFHEGP 186
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  187 IRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTL-FCGLDDSLKVYSWEPVVCHDGVDM 265
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTG 286

                         250       260
                  ....*....|....*....|....*....
gi 334183466  266 GWSTLGDLCIS-EGKLLGCSYYQNSVGIW 293
Cdd:COG2319   287 HSGGVNSVAFSpDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
2-215 7.29e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.20  E-value: 7.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    2 AKRGYKLQEFLAHSANVNCLSIGKKtSRLFITGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGV 81
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   82 IKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGG 161
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 334183466  162 LDNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLET 215
Cdd:COG2319   350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
33-255 2.54e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 2.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   33 TGGDDYKVNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFG 112
Cdd:COG2319    11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  113 EFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKFHEGPIRSLDF 192
Cdd:COG2319    91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334183466  193 HPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCGLDD-SLKVYSWE 255
Cdd:COG2319   171 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 92-253 4.16e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.82  E-value: 4.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   92 MVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWDL 171
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  172 TAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCG-LDDSLK 250
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSsQDGTIK 160


                  ...
gi 334183466  251 VYS 253
Cdd:cd00200   161 LWD 163
WD40 COG2319
WD40 repeat [General function prediction only];
65-255 2.28e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 2.28e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   65 AFDSAEVLVLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWDIRKKGCIQTYKGHSRG 144
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  145 ISTIRFTPDGRWVVSGGLDNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRP 224
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 334183466  225 EATGVRSIKFHPDGRTLFCGLDD-SLKVYSWE 255
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDgTVRLWDLA 192
WD40 pfam00400
WD domain, G-beta repeat;
134-170 1.02e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 334183466   134 CIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWD 170
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 174-212 1.14e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.14e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 334183466    174 GKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWD 212
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-170 1.21e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.21e-09
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 334183466    134 CIQTYKGHSRGISTIRFTPDGRWVVSGGLDNVVKVWD 170
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 40-208 2.05e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 2.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   40 VNLWAIGKPTSLMSLCGHTSAVDSVAFDSAEVLVLA-GASSGVIKLWDVEEAKMVRAFTGhRSNCSAVEF-HPFGEFLAS 117
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAsGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  118 GSSDANLKIWDIRK-KGCIQTYKGHSRGISTIRFTpDGRWVVSGGLDNVVKVWDLTAG------KLLHEFKFHEGPIRSL 190
Cdd:PLN00181  636 GSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFV 714

                         170
                  ....*....|....*...
gi 334183466  191 DFHPLEFLLATGSADRTV 208
Cdd:PLN00181  715 GLSVSDGYIATGSETNEV 732
WD40 pfam00400
WD domain, G-beta repeat;
174-212 2.12e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 2.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 334183466   174 GKLLHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWD 212
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 12-213 6.61e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 6.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   12 LAHSANVNCLSIGKKTSRLFITGGDDYKVNLWA-----------------IGKPTSLMSLCGHT---SAVDSVAFDsaev 71
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiikdgrdihypvveLASRSKLSGICWNSyikSQVASSNFE---- 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   72 lvlagassGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFG-EFLASGSSDANLKIWDIRKKGCIQTYKGHSrGISTIRF 150
Cdd:PLN00181  555 --------GVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQF 625

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183466  151 TPD-GRWVVSGGLDNVVKVWDLTAGKL-LHEFKFHEGPIRSLDFHPLEFLLATgSADRTVKFWDL 213
Cdd:PLN00181  626 PSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 73-171 1.03e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 56.11  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   73 VLAGASSGVIKLWDVEEAKMVRAFTGHRSNCSAVEFHP-FGEFLASGSSDANLKIWDIRKKG----------CIqtYKGH 141
Cdd:PTZ00420   47 VEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDesvkeikdpqCI--LKGH 124

                          90       100       110
                  ....*....|....*....|....*....|.
gi 334183466  142 SRGISTIRFTPDGRWVV-SGGLDNVVKVWDL 171
Cdd:PTZ00420  125 KKKISIIDWNPMNYYIMcSSGFDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-128 1.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.87e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 334183466     91 KMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWD 128
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 106-228 2.58e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.51  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  106 VEFHPF-GEFLASGSSDANLKIWDIRKKGCIQT-------YKGHSRGISTIRFTPDGRWVV-SGGLDNVVKVWDLTAGKL 176
Cdd:PTZ00421   81 VAFNPFdPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKA 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 334183466  177 LHEFKFHEGPIRSLDFHPLEFLLATGSADRTVKFWDLETFELIGSTRPEATG 228
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 157-255 2.91e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  157 VVSGGLDNVVKVWDLTAGKLLHEFKFHEGPIRSLDFHPLE-FLLATGSADRTVKFWDLETFELIGSTRPEATgVRSIKFH 235
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFP 626

                          90       100
                  ....*....|....*....|.
gi 334183466  236 PD-GRTLFCGLDDSlKVYSWE 255
Cdd:PLN00181  627 SEsGRSLAFGSADH-KVYYYD 646
WD40 pfam00400
WD domain, G-beta repeat;
91-128 5.01e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 5.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 334183466    91 KMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWD 128
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
106-253 6.76e-07

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 52.99  E-value: 6.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  106 VEFHPFGEFLASGS-SDANLKIWDIRKKG----CIQTYKGHSRGIST----------IRFTPDGR--WVVSGGLDNVVkV 168
Cdd:COG2706    98 LSVDPDGRFLFVANyGGGSVSVFPIDADGslgePVQVIQHEGSGPNPerqegphahsVVFDPDGRflYVPDLGTDRIY-V 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  169 W--DLTAGKL--LHEFKFHE--GPiRSLDFHP-LEFLLATGSADRTVKFWDLE----TFELIG--STRPE-ATGVRS--- 231
Cdd:COG2706   177 YrlDPATGKLpePPEVSLPPgsGP-RHLAFHPnGRFAYVINELDSTVSVYAYDaatgTLTLIQtvSTLPEdFTGENWaad 255

                         170       180
                  ....*....|....*....|....
gi 334183466  232 IKFHPDGRTLFCG--LDDSLKVYS 253
Cdd:COG2706   256 IHISPDGRFLYVSnrGHNSIAVFA 279
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
148-242 6.87e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.84  E-value: 6.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  148 IRFTPDG-RWVVSGGLDNVVKVWDLTAGKLLHEFKFHEGPiRSLDFHPLE-FLLATGSADRTVKF----WDLETFELIGs 221
Cdd:COG3391   115 LAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGkRLYVANSGSNTVSVivsvIDTATGKVVA- 192

                          90       100
                  ....*....|....*....|.
gi 334183466  222 TRPEATGVRSIKFHPDGRTLF 242
Cdd:COG3391   193 TIPVGGGPVGVAVSPDGRRLY 213
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 668-906 6.88e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.22  E-value: 6.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   668 ATNSTTVDVPVLSTRRTKSTPVRVMPVVLG-----RDTSMATDTP-PVTSTRPDRTSATNLTSDVSGVTSKrQTRTSPAP 741
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTTSPTLNTTGfaapnTTTGLPSSTHvPTNLTAPASTGPTVSTADVTSPTPA-GTTSGASP 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   742 VMPmilnqttkmkSDEPSITSTwpdRTSATDLTSDVSGVISSRQTRTSPAPVmpmklnqktkiksdeppITSTRPDRPSA 821
Cdd:pfam05109  488 VTP----------SPSPRDNGT---ESKAPDMTSPTSAVTTPTPNATSPTPA-----------------VTTPTPNATSP 537

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   822 T-NLTSDESPVTSTRQAKTSPAPVTPVILNQRQTTNMKSDEPPVISTRPLRTSSARVMPVILNQASTTYDERPLSSSRSA 900
Cdd:pfam05109  538 TlGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPV 617


                   ....*.
gi 334183466   901 RTSPAR 906
Cdd:pfam05109  618 VTSPPK 623
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 66-184 8.06e-05

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 44.96  E-value: 8.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466    66 FDSAEVLVLAGASSGVIKLWDVEeAKMVRAFTGHRSNCsaVEFHPFGEFLAS---GSSDANLKIWDIRKKGCIQTYKgHS 142
Cdd:pfam08662   69 PNGKEFAVIYGYMPAKVSFFDLK-GNVIHSFGEQPRNT--IFWSPFGRLVLLagfGNLAGDIEFWDVVNKKKIATAE-AS 144

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 334183466   143 RGiSTIRFTPDGRWVVSGGL------DNVVKVWDLTaGKLLHEFKFHE 184
Cdd:pfam08662  145 NA-TLCEWSPDGRYFLTATTaprlrvDNGFKIWHYN-GALVYKYDFDE 190
PRK10905 PRK10905
cell division protein DamX; Validated
 758-972 8.12e-05

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 46.08  E-value: 8.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  758 PSITSTwpDRTSATDLTSDVSGVISSRQTRTSPAPVMPMKLNQKTKIKSDE--PPITSTRpdrpsatnlTSDESPVTSTR 835
Cdd:PRK10905   23 PSTSSS--DQTASGEKSIDLAGNATDQANGVQPAPGTTSAEQTAGNTQQDVslPPISSTP---------TQGQTPVATDG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  836 Q-----------AKTSPApvtpvilNQRQTTNmksdeppVISTRPLRTSSARVMPViLNQASTTYDERPLSSSRSARTSP 904
Cdd:PRK10905   92 QqrvevqgdlnnALTQPQ-------NQQQLNN-------VAVNSTLPTEPATVAPV-RNGNASRQTAKTQTAERPATTRP 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183466  905 AR----IMPMKLNQADNMPSYEPPVALTRSARNSPARVIPVKLNQATNVTADASHIRSRQRFSPTQTLATPA 972
Cdd:PRK10905  157 ARkqavIEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPA 228
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
135-242 1.46e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  135 IQTYKGHSRGISTIRFTPDGRWV-VSGGLDNVVKVWDLTAGKLLHEFKFHEGPiRSLDFHP-LEFLLATGSADRTVKFWD 212
Cdd:COG3391    60 LGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPdGGRLYVADSGNGRVSVID 138

                          90       100       110
                  ....*....|....*....|....*....|
gi 334183466  213 LETFELIGSTrPEATGVRSIKFHPDGRTLF 242
Cdd:COG3391   139 TATGKVVATI-PVGAGPHGIAVDPDGKRLY 167
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
13-141 1.84e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.41  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   13 AHSANVNCLSIgkKTSRLFITGGDDYKVNLWAIG-----------KPTSLMSLcghTSAVDSVAFDSAEVLVLA-GASSG 80
Cdd:COG5170   170 AHPYHINSISF--NSDKETLLSADDLRINLWNLEiidgsfnivdiKPHNMEEL---TEVITSAEFHPEMCNVFMySSSKG 244

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334183466   81 VIKLWDVEEAKM----------------VRAFTGHRSNCSAVEFHPFGEFLASGSSDAnLKIWDIR-KKGCIQTYKGH 141
Cdd:COG5170   245 EIKLNDLRQSALcdnskklfeltidgvdVDFFEEIVSSISDFKFSDNGRYILSRDYLT-VKIWDVNmAKNPIKTIPMH 321
PTZ00421 PTZ00421
coronin; Provisional
 51-146 3.59e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   51 LMSLCGHTSAVDSVAF--DSAEVLVLAGASSgVIKLWDVEEAKMVRAFTGHRSNCSAVEFHPFGEFLASGSSDANLKIWD 128
Cdd:PTZ00421  118 IVHLQGHTKKVGIVSFhpSAMNVLASAGADM-VVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196

                          90
                  ....*....|....*...
gi 334183466  129 IRKKGCIQTYKGHSRGIS 146
Cdd:PTZ00421  197 PRDGTIVSSVEAHASAKS 214
Lactonase pfam10282
Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases ...
 148-253 4.17e-04

Lactonase, 7-bladed beta-propeller; This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.


Pssm-ID: 431196 [Multi-domain]  Cd Length: 340  Bit Score: 44.14  E-value: 4.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   148 IRFTPDGRWVVSG--GLDNVVkVWDLTA--GKLLHEFKFH----EGPiRSLDFHPLE-FLLATGSADRTV---------- 208
Cdd:pfam10282  148 VDLTPDGKFLVVPdlGTDRVR-VYKLDAggGKLTPPASVQtppgSGP-RHLAFHPNGkYAYVVNELSSTVtvfeydpatg 225

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 334183466   209 KFWDLETFELIGSTRPEATGVRSIKFHPDGRTLFCG--LDDSLKVYS 253
Cdd:pfam10282  226 TFEELQTVSTLPEGFTGTNGAAAIRVSPDGKFLYVSnrGHDSIAVFA 272
WD40 pfam00400
WD domain, G-beta repeat;
49-86 5.39e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.39e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 334183466    49 TSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWD 86
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PHA03255 PHA03255
BDLF3; Provisional
 691-863 7.56e-04

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 42.58  E-value: 7.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  691 VMPVVLGRDTSMATdtppvTSTRPDRTSATNLTSDVSgVTSKRQTRTSPAPvmpmilNQTTKMKSDEPSITSTWPDRTSA 770
Cdd:PHA03255   11 VLAMILICETSLIW-----TSSGSSTASAGNVTGTTA-VTTPSPSASGPST------NQSTTLTTTSAPITTTAILSTNT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466  771 TDLTSDVSGVISSRQTRTSPAPVMPMKLNQKTKIKSDEPPITSTRPDRPSATNLTSDESPVTSTRQAKTSPAPVTPVILN 850
Cdd:PHA03255   79 TTVTSTGTTVTPVPTTSNASTINVTTKVTAQNITATEAGTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTS 158

                         170
                  ....*....|...
gi 334183466  851 QRQTTNMKSDEPP 863
Cdd:PHA03255  159 NATKTTAELPTVP 171
Tymo_45kd_70kd pfam03251
Tymovirus 45/70Kd protein; Tymoviruses are single stranded RNA viruses. This family includes a ...
 707-947 1.01e-03

Tymovirus 45/70Kd protein; Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.


Pssm-ID: 281269 [Multi-domain]  Cd Length: 468  Bit Score: 43.24  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   707 PPVTSTRPDRTSATNLTSDVSGVTSKRQTRTSPApVMPMILNQTTKMKSDEPSiTSTWPDRTSATDLTSDVSGVISSRQT 786
Cdd:pfam03251  147 PDVLPSVPDHGPVLTETKPRTSVRQPRSATRGPS-FRPILLPKVVHVHDDPPH-SSLRPRGSRSRQLQPTVRRPLLAPNQ 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   787 RTSPAPVMPMklnqktkikSDEPPITSTRPDRPSATN------LTSDESPVTSTRQAKTSP--APVTPVILNQRQTTNMK 858
Cdd:pfam03251  225 FHSPRQPPPL---------SDDPGILGPRPLAPHSTRdppprpITPGPSNTHDLRPLSVLPrtSPRRGLLPNPRRHRTST 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   859 SDEPPVISTRPLRTSSARVMPVILNQAST-TYDERPLSSSRSA--RTSPARIMPMKLNQADNMPSYE-PPVALTRSARNS 934
Cdd:pfam03251  296 GHIPPTTTSRPTGPPSRLQRPVHLYQSSPhTPNFRPSSIRKDAllQTGPRLGHLERLGQPANLRTSErSPPTKRRLPRSS 375

                          250
                   ....*....|...
gi 334183466   935 PARVIPVKLNQAT 947
Cdd:pfam03251  376 EPNRLPKPLPEAT 388
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 47-86 1.70e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.70e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 334183466     47 KPTSLMSLCGHTSAVDSVAFDSAEVLVLAGASSGVIKLWD 86
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 623-852 2.58e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.87  E-value: 2.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   623 THSEDKAASATVVHSSNSVEEEPLTASVQTVSMMPTQVMPVKLDQATNSTTVDVPVLSTRRTKSTPVRVMPVVLGRDTSM 702
Cdd:pfam17823  119 ASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   703 ATDTPP-VTSTRPDRTSATNLTSDVSGVTSKRQTRTSPAPVmpmilNQTTKMKSDEPSITSTWPDRTSATDLTSDVSGVI 781
Cdd:pfam17823  199 ASSAPAtLTPARGISTAATATGHPAAGTALAAVGNSSPAAG-----TVTAAVGTVTPAALATLAAAAGTVASAAGTINMG 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   782 SSRQTRTSPAPVMPMKLNQKT--------------KIKSDEPPITSTRPDRPSATNLTSDESP-----------VTSTR- 835
Cdd:pfam17823  274 DPHARRLSPAKHMPSDTMARNpaapmgaqaqgpiiQVSTDQPVHNTAGEPTPSPSNTTLEPNTpksvastnlavVTTTKa 353

                          250
                   ....*....|....*..
gi 334183466   836 QAKTSPAPVTPVILNQR 852
Cdd:pfam17823  354 QAKEPSASPVPVLHTSM 370
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 620-874 2.74e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.87  E-value: 2.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   620 EKITHSEDKAASATVVHSSNSVEEEPLTAsvqtvsmmPTQVMPVKLDQATNSTTVDVPVLSTrrtkSTPVRVMPVVlgrD 699
Cdd:pfam17823   89 EHTPHGTDLSEPATREGAADGAASRALAA--------AASSSPSSAAQSLPAAIAALPSEAF----SAPRAAACRA---N 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   700 TSMATDTPPVTSTRPDRTSATNLTSDVSGVTSKRQTRTSPAPvmpmilnqTTKMKSDEPSITSTWPDRTSATDLTSDVSG 779
Cdd:pfam17823  154 ASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAP--------TTAASSAPATLTPARGISTAATATGHPAAG 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183466   780 VISSRQTRTSPAP------VMPMKLNQKTKIKSDEPPITSTRPDRPSATNLTSDESPVTSTRQAKTSPAPVTPVILNQRQ 853
Cdd:pfam17823  226 TALAAVGNSSPAAgtvtaaVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQG 305

                          250       260
                   ....*....|....*....|.
gi 334183466   854 TTNMKSDEPPVISTRPLRTSS 874
Cdd:pfam17823  306 PIIQVSTDQPVHNTAGEPTPS 326
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 144-215 5.77e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 40.29  E-value: 5.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334183466  144 GISTIRFTPDGRWVV----SGGLDNVvkvwDLTAGKLLHEFK-FHEGPIRSLDFHPLEFLLATGSADRTVKFWDLET 215
Cdd:cd22857   225 PIKAVAEDPDGHTVYvgdtSGDLASI----DLRTGKLLGCFKgKCGGSIRSIARHPELPLIASCGLDRYLRIWDTET 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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