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Conserved domains on  [gi|319918855|ref|NP_001188401|]
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coronin-7 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 453-862 1.21e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 1.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 453 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 528
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 529 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 608
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 609 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 688
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 689 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 768
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 769 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 840
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 319918855 841 PPDMSPVSQAPREAPARRAPSS 862
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-410 6.33e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 169.69  E-value: 6.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855   6 VSKFRHTEARPPRRESWISDIRAGTAP-SCRNHIKSSCSLIA-----------FNSDRPGVLGIVP--LQGQGEDKRRVA 71
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIAvpwqqlgstavLKHTDYGKLASNPpiLLGQEGPIIDVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  72 -----HLGCHSGSADRTVKLWRLPGPG-QALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSA-AGTTVKVWDAAKQQPLT 144
Cdd:PTZ00421  83 fnpfdPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVVNVWDVERGKAVE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 145 ELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKL 224
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 225 WDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLRGAALVPRQALAV 304
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 305 MSCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH-PSFTSCL 381
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTsPELMGAS 399

                        410       420
                 ....*....|....*....|....*....
gi 319918855 382 VPPAEPLPdtaQPAVMETPVGDADASEGF 410
Cdd:PTZ00421 400 ALSPSGKP---RHSGVSVPASTSAMTHSF 425
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 453-862 1.21e-69

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 1.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 453 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 528
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 529 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 608
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 609 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 688
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 689 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 768
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 769 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 840
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 319918855 841 PPDMSPVSQAPREAPARRAPSS 862
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 6-410 6.33e-45

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 169.69  E-value: 6.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855   6 VSKFRHTEARPPRRESWISDIRAGTAP-SCRNHIKSSCSLIA-----------FNSDRPGVLGIVP--LQGQGEDKRRVA 71
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIAvpwqqlgstavLKHTDYGKLASNPpiLLGQEGPIIDVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  72 -----HLGCHSGSADRTVKLWRLPGPG-QALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSA-AGTTVKVWDAAKQQPLT 144
Cdd:PTZ00421  83 fnpfdPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVVNVWDVERGKAVE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 145 ELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKL 224
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 225 WDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLRGAALVPRQALAV 304
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 305 MSCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH-PSFTSCL 381
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTsPELMGAS 399

                        410       420
                 ....*....|....*....|....*....
gi 319918855 382 VPPAEPLPdtaQPAVMETPVGDADASEGF 410
Cdd:PTZ00421 400 ALSPSGKP---RHSGVSVPASTSAMTHSF 425
WD40 COG2319
WD40 repeat [General function prediction only];
527-742 1.55e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 1.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 527 AAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDL 606
Cdd:COG2319  163 GAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 607 QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsq 686
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNS-VAFSPDGKLLASGSDD-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 319918855 687 seRQLLLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 742
Cdd:COG2319  310 --GTVRLWDLA--TGKLLRTLTGHTGAVRSV-AFSPD-GKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 528-686 1.13e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 528 AVTDLAWDPFDpHRLAVAGEDARIRLWRVPAEgleEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 607
Cdd:cd00200   53 PVRDVAASADG-TYLASGSSDKTIRLWDLETG---ECVRT----LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 608 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRCLLVSGFD 684
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGE----VNSVAfspDGEKLLSSSSD 198


                 ..
gi 319918855 685 SQ 686
Cdd:cd00200  199 GT 200
WD40 COG2319
WD40 repeat [General function prediction only];
66-228 5.36e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 5.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  66 DKRRVAhlgchSGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTE 145
Cdd:COG2319  173 DGKLLA-----SGSDDGTVRLWDLAT-GKLLRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 146 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRasQSTQAHENSRDSRLAW--MGTWehLVSTGFNQMrereVK 223
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFspDGKL--LASGSDDGT----VR 313


                 ....*
gi 319918855 224 LWDTR 228
Cdd:COG2319  314 LWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-277 2.75e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGPgqalpsAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:cd00200   68 SGSSDKTIRLWDLETG------ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 157 VWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRdSRLAWMGTWEHLVSTGFNqmreREVKLWDTRFFSSaLAS 236
Cdd:cd00200  142 AFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSD----GTIKLWDLSTGKC-LGT 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 319918855 237 LT--LDTSLGCLVpllDPDsGLLVLAGKGERQLYCYEVVPQQP 277
Cdd:cd00200  215 LRghENGVNSVAF---SPD-GYLLASGSEDGTIRVWDLRTGEC 253
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 790-834 4.74e-15

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 69.85  E-value: 4.74e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 319918855  790 LEPVAFRLPRVRKEFFQDDVFPDTAViWEPVLSAEAWLQGANGQP 834
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAG-TEPALTAEEWLSGKNAEP 44
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 320-362 4.14e-13

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 64.07  E-value: 4.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 319918855  320 IVPIGYHVPRKAVE-FHEDLFPDTAGCVPATDPHSWWAGDNQQV 362
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 615-646 3.07e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 3.07e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 319918855   615 LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 646
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 453-862 1.21e-69

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 239.41  E-value: 1.21e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 453 SKFRHAQGTVLHRDSHItnlkgLNLTTPGE----SDGFCANKLRVAVPLLSSGGqVAVLELRKPGRLPDTALPTLQNGAA 528
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHF-----LNVTPSTAlwdcSNTIACNDRFIAVPWQQLGS-TAVLKHTDYGKLASNPPILLGQEGP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 529 VTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQA 608
Cdd:PTZ00421  78 IIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 609 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 688
Cdd:PTZ00421 158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG-TIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 689 RQLLLYEAEALAgGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFleCNSFTSPDPHKGLVLLP 768
Cdd:PTZ00421 237 RQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTF--CSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 769 KTECDVREVELMRCLRLRQSSLEPVAFRLPRVRK-EFFQDDVFPDTAVIwEPVLSAEAWLQGANGQPWLLSLQ------- 840
Cdd:PTZ00421 314 KWSLDTRKCEIARFYALTYHSLYTIQMLLPRKQAdSELQVDVYPPTFAD-HPAITADEYFSGGNAEPLVYDMSavfdgts 392

                        410       420
                 ....*....|....*....|..
gi 319918855 841 PPDMSPVSQAPREAPARRAPSS 862
Cdd:PTZ00421 393 PELMGASALSPSGKPRHSGVSV 414
PTZ00421 PTZ00421
coronin; Provisional
 6-410 6.33e-45

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 169.69  E-value: 6.33e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855   6 VSKFRHTEARPPRRESWISDIRAGTAP-SCRNHIKSSCSLIA-----------FNSDRPGVLGIVP--LQGQGEDKRRVA 71
Cdd:PTZ00421   3 VSRFRHTQGVPARPDRHFLNVTPSTALwDCSNTIACNDRFIAvpwqqlgstavLKHTDYGKLASNPpiLLGQEGPIIDVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  72 -----HLGCHSGSADRTVKLWRLPGPG-QALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSA-AGTTVKVWDAAKQQPLT 144
Cdd:PTZ00421  83 fnpfdPQKLFTASEDGTIMGWGIPEEGlTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAgADMVVNVWDVERGKAVE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 145 ELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKL 224
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS-SVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 225 WDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQpaLSPVTQCVLESVLRGAALVPRQALAV 304
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 305 MSCEVLRVLQLSDTAIVPIGYHVPRKA--VEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPH-PSFTSCL 381
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYTIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTsPELMGAS 399

                        410       420
                 ....*....|....*....|....*....
gi 319918855 382 VPPAEPLPdtaQPAVMETPVGDADASEGF 410
Cdd:PTZ00421 400 ALSPSGKP---RHSGVSVPASTSAMTHSF 425
PTZ00420 PTZ00420
coronin; Provisional
 482-831 5.45e-37

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 147.40  E-value: 5.45e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 482 ESDGFCANKLRVAVPL-LSSGGQVAVLELRKPGRLPdtalPTLQ---NGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVP 557
Cdd:PTZ00420  30 DSCGIACSSGFVAVPWeVEGGGLIGAIRLENQMRKP----PVIKlkgHTSSILDLQFNPCFSEILASGSEDLTIRVWEIP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 558 A--EGLEEVlTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQgHQDQIFSLAWSPDGQQLA 635
Cdd:PTZ00420 106 HndESVKEI-KDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 636 TVCKDGRVRVYRPRSgPEPLQEGPGPKGGRGARIVWV----CDGRCLLVSGFDSQSERQLLLYEAEALAgGPLAVLGLDV 711
Cdd:PTZ00420 184 GTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLKNTT-SALVTMSIDN 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 712 APSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESpfFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLR-LRQSSL 790
Cdd:PTZ00420 262 ASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKnENNSSI 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 319918855 791 EPVAFRLPRVRKEFFQDDVFPDTaVIWEPVLSAEAWLQGAN 831
Cdd:PTZ00420 340 RPISFYVPRKNPTKFQEDLYPPI-LMHDPERSSRNWIDGKD 379
PTZ00420 PTZ00420
coronin; Provisional
 77-367 5.98e-32

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 132.00  E-value: 5.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGPGQALPSA--PGVVLGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTELAAHGDLv 153
Cdd:PTZ00420  92 SGSEDLTIRVWEIPHNDESVKEIkdPQCILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDIENEKRAFQINMPKKL- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 154 QSAVWSRDGALVGTACKDKQLRIFDPRTKPRASqSTQAHENSRDSRLAWM----GTWEHLVSTGFNQMREREVKLWDTRF 229
Cdd:PTZ00420 171 SSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIAS-SFHIHDGGKNTKNIWIdglgGDDNYILSTGFSKNNMREMKLWDLKN 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 230 FSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVvpQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEV 309
Cdd:PTZ00420 250 TTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQH--SLGSIRKVNEYKSCSPFRSFGFLPKQICDVYKCEI 327

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 310 LRVLQ-LSDTAIVPIGYHVPRK-AVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSL 367
Cdd:PTZ00420 328 GRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINI 387
WD40 COG2319
WD40 repeat [General function prediction only];
527-742 1.55e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 1.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 527 AAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDL 606
Cdd:COG2319  163 GAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-------GKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 607 QAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsq 686
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNS-VAFSPDGKLLASGSDD-- 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 319918855 687 seRQLLLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 742
Cdd:COG2319  310 --GTVRLWDLA--TGKLLRTLTGHTGAVRSV-AFSPD-GKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
458-742 6.89e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 6.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 458 AQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT------LQNGAAVTD 531
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGallatlLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 532 LAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQAGAD 611
Cdd:COG2319   84 VAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 612 RLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFDsqseRQL 691
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRS-VAFSPDGKLLASGSAD----GTV 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 319918855 692 LLYEAEalAGGPLAVLGLDVAPSTLLpSYDPDtGLVLLTGKGDTRVFLYEL 742
Cdd:COG2319  229 RLWDLA--TGKLLRTLTGHSGSVRSV-AFSPD-GRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
526-684 6.72e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 6.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 526 GAAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAegleevlTTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 605
Cdd:COG2319  246 SGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT-------GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 319918855 606 LQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGArIVWVCDGRCLLVSGFD 684
Cdd:COG2319  317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
526-650 3.14e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 3.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 526 GAAVTDLAWDPfDPHRLAVAGEDARIRLWRVpaeGLEEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 605
Cdd:COG2319  288 SGGVNSVAFSP-DGKLLASGSDDGTVRLWDL---ATGKLLRT----LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD 358

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 319918855 606 LQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 650
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 528-686 1.13e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 528 AVTDLAWDPFDpHRLAVAGEDARIRLWRVPAEgleEVLTTpetvLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 607
Cdd:cd00200   53 PVRDVAASADG-TYLASGSSDKTIRLWDLETG---ECVRT----LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 608 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGrgarIVWVC---DGRCLLVSGFD 684
Cdd:cd00200  124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG-KCVATLTGHTGE----VNSVAfspDGEKLLSSSSD 198


                 ..
gi 319918855 685 SQ 686
Cdd:cd00200  199 GT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 529-647 5.35e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 5.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 529 VTDLAWDPfDPHRLAVAGEDARIRLWRVPAEgleevltTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQA 608
Cdd:cd00200  180 VNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-------KCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRT 250

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 319918855 609 GADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYR 647
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 528-737 1.88e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.56  E-value: 1.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 528 AVTDLAWDPfDPHRLAVAGEDARIRLWRVPAEgleevltTPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQ 607
Cdd:cd00200   95 YVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 608 AGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGgrGARIVWVCDGRCLLVSG----- 682
Cdd:cd00200  166 TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHEN--GVNSVAFSPDGYLLASGsedgt 242

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 319918855 683 ---FDSQSERQLllyeaEALAGGPLAVLGLDVAPstllpsydpdTGLVLLTGKGDTRV 737
Cdd:cd00200  243 irvWDLRTGECV-----QTLSGHTNSVTSLAWSP----------DGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
66-228 5.36e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 5.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  66 DKRRVAhlgchSGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTE 145
Cdd:COG2319  173 DGKLLA-----SGSDDGTVRLWDLAT-GKLLRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 146 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRasQSTQAHENSRDSRLAW--MGTWehLVSTGFNQMrereVK 223
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFspDGKL--LASGSDDGT----VR 313


                 ....*
gi 319918855 224 LWDTR 228
Cdd:COG2319  314 LWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
66-228 9.47e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 9.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  66 DKRRVAhlgchSGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPtsDG-ILVSA-AGTTVKVWDAAKQQPL 143
Cdd:COG2319  131 DGKTLA-----SGSADGTVRLWDLAT-GKLLRTLTG-----HSGAVTSVAFSP--DGkLLASGsDDGTVRLWDLATGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 144 TELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWM--GTWehLVSTGfnqmRERE 221
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHSGSVRS-VAFSpdGRL--LASGS----ADGT 269


                 ....*..
gi 319918855 222 VKLWDTR 228
Cdd:COG2319  270 VRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
66-228 9.81e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 9.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  66 DKRRVAhlgchSGSADRTVKLWRLPGPgqalpsAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTE 145
Cdd:COG2319  257 DGRLLA-----SGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 146 LAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKpRASQSTQAHENSRDSrLAWMGTWEHLVSTGFNqmreREVKLW 225
Cdd:COG2319  326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTS-VAFSPDGRTLASGSAD----GTVRLW 399


                 ...
gi 319918855 226 DTR 228
Cdd:COG2319  400 DLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 571-651 1.38e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 571 VLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRS 650
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82


                 .
gi 319918855 651 G 651
Cdd:cd00200   83 G 83
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-277 2.75e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGPgqalpsAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:cd00200   68 SGSSDKTIRLWDLETG------ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 157 VWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRdSRLAWMGTWEHLVSTGFNqmreREVKLWDTRFFSSaLAS 236
Cdd:cd00200  142 AFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSD----GTIKLWDLSTGKC-LGT 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 319918855 237 LT--LDTSLGCLVpllDPDsGLLVLAGKGERQLYCYEVVPQQP 277
Cdd:cd00200  215 LRghENGVNSVAF---SPD-GYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
66-228 5.10e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 5.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  66 DKRRVAhlgchSGSADRTVKLWRLPGPgqalpsAPGVVLGPEDLPVEVLQFHPtsDG-ILVSA-AGTTVKVWDAAKQQPL 143
Cdd:COG2319  215 DGKLLA-----SGSADGTVRLWDLATG------KLLRTLTGHSGSVRSVAFSP--DGrLLASGsADGTVRLWDLATGELL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 144 TELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWM--GTWehLVSTGfnqmRERE 221
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSpdGKT--LASGS----DDGT 353


                 ....*..
gi 319918855 222 VKLWDTR 228
Cdd:COG2319  354 VRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
77-228 1.26e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGpgqalpSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:COG2319   95 SASADGTVRLWDLAT------GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 319918855 157 VWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWMGTWEHLVSTGFNqmreREVKLWDTR 228
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRS-VAFSPDGKLLASGSAD----GTVRLWDLA 234
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 790-834 4.74e-15

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 69.85  E-value: 4.74e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 319918855  790 LEPVAFRLPRVRKEFFQDDVFPDTAViWEPVLSAEAWLQGANGQP 834
Cdd:pfam16300   1 IEPISFTVPRKSKEDFQDDLYPDTAG-TEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
77-181 3.35e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.72  E-value: 3.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGpGQALPSAPGvvlgpEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:COG2319  305 SGSDDGTVRLWDLAT-GKLLRTLTG-----HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                         90       100
                 ....*....|....*....|....*
gi 319918855 157 VWSRDGALVGTACKDKQLRIFDPRT 181
Cdd:COG2319  379 AFSPDGRTLASGSADGTVRLWDLAT 403
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 452-514 1.33e-13

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 66.37  E-value: 1.33e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 319918855  452 SSKFRHAQGTVLHRDSHITNLKglNLTTPGESDGFCANKLRVAVPLLSSG-GQVAVLELRKPGR 514
Cdd:pfam08953   5 ASKFRHVYGKPAKKELCYDNIK--VTKNAWDSNFIAANPKFLAVNWESSGgGAFAVLPLNQTGR 66
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 320-362 4.14e-13

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 64.07  E-value: 4.14e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 319918855  320 IVPIGYHVPRKAVE-FHEDLFPDTAGCVPATDPHSWWAGDNQQV 362
Cdd:pfam16300   1 IEPISFTVPRKSKEdFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-60 3.15e-12

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 62.52  E-value: 3.15e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855    3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFN--SDRPGVLGIVPL 60
Cdd:pfam08953   2 FVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNweSSGGGAFAVLPL 61
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-178 3.64e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 3.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGpGQALpsapgVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:cd00200  194 SSSSDGTIKLWDLST-GKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL 267

                         90       100
                 ....*....|....*....|..
gi 319918855 157 VWSRDGALVGTACKDKQLRIFD 178
Cdd:cd00200  268 AWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-228 4.71e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 4.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGpGQALpsapgVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:cd00200   26 TGSGDGTIKVWDLET-GELL-----RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSV 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 319918855 157 VWSRDGALVGTACKDKQLRIFDPRTKpRASQSTQAHENSRDSrLAWMGTwEHLVSTGfnqMREREVKLWDTR 228
Cdd:cd00200  100 AFSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTDWVNS-VAFSPD-GTFVASS---SQDGTIKLWDLR 165
WD40 COG2319
WD40 repeat [General function prediction only];
77-228 6.78e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.40  E-value: 6.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  77 SGSADRTVKLWRLPGPGQALPsapgvvLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSA 156
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLAT------LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 319918855 157 VWSRDGALVGTACKDKQLRIFDPRTkPRASQSTQAHENSRDSrLAWMGTWEHLVSTGFNqmreREVKLWDTR 228
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTS-VAFSPDGKLLASGSDD----GTVRLWDLA 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-228 1.26e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 110 PVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRAsqST 189
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV--RT 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 319918855 190 QAHENSRDSRLAWMGTwEHLVSTGfnqMREREVKLWDTR 228
Cdd:cd00200   89 LTGHTSYVSSVAFSPD-GRILSSS---SRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
541-742 4.01e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 541 RLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAAnVLASSSYDLTVRIWDLQAGADRLKLQGHQD 620
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855 621 QIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGarIVWVCDGRCLLVSGFDsqseRQLLLYEAEalA 700
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS--VAFSPDGKTLASGSAD----GTVRLWDLA--T 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 319918855 701 GGPLAVL-GLDVAPSTLlpSYDPDtGLVLLTGKGDTRVFLYEL 742
Cdd:COG2319  152 GKLLRTLtGHSGAVTSV--AFSPD-GKLLASGSDDGTVRLWDL 191
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 615-646 3.07e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 3.07e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 319918855   615 LQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 646
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 567-605 6.85e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.85e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 319918855   567 TPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 605
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
614-646 9.42e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 9.42e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 319918855  614 KLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVY 646
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
567-605 3.98e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.98e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 319918855  567 TPETVLTGHTEKICSLRFHPlAANVLASSSYDLTVRIWD 605
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 602-646 3.05e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 3.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 319918855  602 RIWDLQAGADRLKlqghqdqIFSLAWSPDGQQLATVCKDGRVRVY 646
Cdd:pfam12894  28 RVWTLSPDKEDLE-------VTSLAWRPDGKLLAVGYSDGTVRLL 65
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 498-651 2.49e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.56  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  498 LSSGGQVAVLELR--------KPG---RLPDTAlptlqnGAAVTDLAWDPfDPHRLAVA----GEDArirLWRVPAEGLE 562
Cdd:COG4946   309 LSPDGKRVAFEARgevftvpaEKGptrNLTNTP------GVRERLPAWSP-DGKSIAYFsdasGEYE---LYIAPADGSG 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 319918855  563 EV--LTTPETvltghtekicSLRFHPLAANV---LASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWSPDGQQLAT 636
Cdd:COG4946   379 EPkqLTLGDL----------GRVFNPVWSPDgkkIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAY 448

                         170
                  ....*....|....*....
gi 319918855  637 VCKDG----RVRVYRPRSG 651
Cdd:COG4946   449 SKPGPnqlsQIFLYDVETG 467
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 622-697 9.26e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.02  E-value: 9.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 319918855  622 IFSLAWSPDGQQLATVCKDGRVRVYRPRSGpEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAE 697
Cdd:COG4946   391 VFNPVWSPDGKKIAFTDNRGRLWVVDLASG-KVRKVDTDGYGDGISDLAWSPDSKWLAYSKPGPNQLSQIFLYDVE 465
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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