sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1277-1548
3.00e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 224.45 E-value: 3.00e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1598-1848
1.69e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 193.64 E-value: 1.69e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
817-1028
7.25e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 171.68 E-value: 7.25e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
152-436
3.52e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 169.76 E-value: 3.52e-47
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1538-1590
1.38e-28
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
:
Pssm-ID: 240441 Cd Length: 54 Bit Score: 109.58 E-value: 1.38e-28
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1054-1273
1.67e-27
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
:
Pssm-ID: 461936 Cd Length: 195 Bit Score: 111.66 E-value: 1.67e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-740
3.71e-25
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
:
Pssm-ID: 463401 Cd Length: 163 Bit Score: 103.66 E-value: 3.71e-25
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1859-1906
4.22e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
The actual alignment was detected with superfamily member pfam16905:
Pssm-ID: 465306 Cd Length: 54 Bit Score: 43.02 E-value: 4.22e-05
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1277-1548
3.00e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 224.45 E-value: 3.00e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1598-1848
1.69e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 193.64 E-value: 1.69e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
817-1028
7.25e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 171.68 E-value: 7.25e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
152-436
3.52e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 169.76 E-value: 3.52e-47
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1538-1590
1.38e-28
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 109.58 E-value: 1.38e-28
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1054-1273
1.67e-27
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 111.66 E-value: 1.67e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-740
3.71e-25
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 103.66 E-value: 3.71e-25
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1859-1906
4.22e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 43.02 E-value: 4.22e-05
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1277-1548
3.00e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 224.45 E-value: 3.00e-66
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1598-1848
1.69e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 193.64 E-value: 1.69e-55
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
817-1028
7.25e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 171.68 E-value: 7.25e-48
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
152-436
3.52e-47
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 169.76 E-value: 3.52e-47
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1538-1590
1.38e-28
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.
Pssm-ID: 240441 Cd Length: 54 Bit Score: 109.58 E-value: 1.38e-28
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1054-1273
1.67e-27
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 111.66 E-value: 1.67e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
555-740
3.71e-25
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 103.66 E-value: 3.71e-25
Polycystin cation channel; This family contains the cation channel region from group II of ...
1634-1841
4.19e-08
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 56.13 E-value: 4.19e-08
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1859-1906
4.22e-05
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.
Pssm-ID: 465306 Cd Length: 54 Bit Score: 43.02 E-value: 4.22e-05
Polycystin cation channel; This family contains the cation channel region from group II of ...
905-999
1.72e-03
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 42.26 E-value: 1.72e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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