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Conserved domains on  [gi|320545069|ref|NP_001188807|]
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wing blister, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2384-2539 1.85e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 118.67  E-value: 1.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2384 GSYFPGDAYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGAPMrvessLPTKY 2463
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLV-----LSSKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069 2464 ALCDNKWHNISALYDGEQIVLRIDQLPaVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 2539
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_B pfam00052
Laminin B (Domain IV);
678-818 1.02e-28

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.13  E-value: 1.02e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   678 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNilgQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESFW 756
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLN---SEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320545069   757 KyHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYikGSTNLIAKGVE 818
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVP--GGSGPPASWVE 136
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1996-2136 1.54e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1996 FRTLQPDCLLLLAAYPPeilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLEL 2075
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDF--------LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320545069  2076 MVDDELQEIRNLNGNPTVVSLPRDaggLYIGGAPPhESYTPLAPTFVNLEGAIRDVVFNNR 2136
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNLNGP---LYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1778-1945 2.60e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1778 ARHFNGLGYAQLmktRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 1857
Cdd:cd00110     1 GVSFSGSSYVRL---PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1858 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLsktvYYLGGVPPGFTSGTSKAPgadNPFLG 1937
Cdd:cd00110    77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                  ....*...
gi 320545069 1938 CMKDVQVN 1945
Cdd:cd00110   144 CIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2210-2359 4.38e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 92.10  E-value: 4.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2210 SQLKLPERHFWQRNFHLSFDFRSFYPNGML-YLSPGSKekpKHYVALVLKDGQLVLVVR-GRRREELQLTAKLNDGEWHR 2287
Cdd:cd00110     8 SYVRLPTLPAPRTRLSISFSFRTTSPNGLLlYAGSQNG---GDFLALELEDGRLVLRYDlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320545069 2288 VTISCHDRKVTMSVEIGRTDQKTSAQmkLPKKIGASQLLLVGGLPqsPVKVSSDLYVRlEPFKGCLRRVSIN 2359
Cdd:cd00110    85 VSVERNGRSVTLSVDGERVVESGSPG--GSALLNLDGPLYLGGLP--EDLKSPGLPVS-PGFVGCIRDLKVN 151
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 391-439 1.52e-16

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 75.47  E-value: 1.52e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 439
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 342-389 6.23e-16

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 73.54  E-value: 6.23e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL-TAGEGCR 389
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 861-908 3.00e-15

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 71.62  E-value: 3.00e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 320545069  861 PCHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDPNSPHGCQ 908
Cdd:cd00055     1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 486-534 5.10e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.15  E-value: 5.10e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 534
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 964-1011 5.57e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.37  E-value: 5.57e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545069  964 PCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCK 1011
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 910-959 5.36e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 5.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 320545069   910 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPN 959
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
Laminin_II super family cl05515
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 1471-1592 5.64e-08

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06009:

Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 54.03  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1471 EMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQeniSLTQTnLRLANVSLSYLEQQAE------KEQ 1544
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVN---DANKA-LDDAGRSVKKLEELAPdlldklKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 320545069  1545 QVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLeSLGPKCIRSYLP 1592
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 532-584 3.84e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 3.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 320545069   532 CGCDAEGSFtqadgSIACDSN-GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGC 584
Cdd:pfam00053    1 CDCNPHGSL-----SDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 436-484 1.04e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545069  436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 484
Cdd:cd00055     2 CD-CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1315-1582 2.62e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 2.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1315 VRKHWL--PKAEKHASHLLARSNEYARkfqptrNGARIAMLASSAHsNITEAINDARLASILAKERVYEAQRTLypSDGS 1392
Cdd:TIGR02168  655 VRPGGVitGGSAKTNSSILERRREIEE------LEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKEL--EELS 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1393 SMIERAKHSLHRSKQLQQEALKQMhksNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDgsARRQAKDSLEM 1472
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERI---AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA--QIEQLKEELKA 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1473 ADRTGEQMRAELQkakDMQKSIQNMRNSFSNLE---PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV 1549
Cdd:TIGR02168  801 LREALDELRAELT---LLNEEAANLRERLESLErriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          250       260       270
                   ....*....|....*....|....*....|...
gi 320545069  1550 WNNSMAQQLQQLrdqiAKARHAAEAIDVSLESL 1582
Cdd:TIGR02168  878 LLNERASLEEAL----ALLRSELEELSEELREL 906
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1591-1684 6.25e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member cd00110:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 151  Bit Score: 45.49  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1591 LPASYGLSTSNKIRMSFALSNhlESSPLIHLASSE-GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHtrdpkyDDAWY 1669
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTS--PNGLLLYAGSQNgGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLN------DGQWH 83

                          90
                  ....*....|....*
gi 320545069 1670 HVEANRTLNLGSLVV 1684
Cdd:cd00110    84 SVSVERNGRSVTLSV 98
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1099-1333 4.44e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1099 AVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR-ST 1177
Cdd:COG4717   288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1178 NDCAWKHFYAMGNASDAsfDESGRLEMLWRDLNQTNHRVVDMRLQVDRV-------------QEVENEAEDVLEHVRNLS 1244
Cdd:COG4717   368 LEQEIAALLAEAGVEDE--EELRAALEQAEEYQELKEELEELEEQLEELlgeleellealdeEELEEELEELEEELEELE 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1245 IRVGESHQELDELNQRISDhldpgyLEQGEGLLRLTVQRQiMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE 1324
Cdd:COG4717   446 EELEELREELAELEAELEQ------LEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREERLPPVL 518


                  ....*....
gi 320545069 1325 KHASHLLAR 1333
Cdd:COG4717   519 ERASEYFSR 527
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2384-2539 1.85e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 118.67  E-value: 1.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2384 GSYFPGDAYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGAPMrvessLPTKY 2463
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLV-----LSSKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069 2464 ALCDNKWHNISALYDGEQIVLRIDQLPaVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 2539
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_B pfam00052
Laminin B (Domain IV);
678-818 1.02e-28

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.13  E-value: 1.02e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   678 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNilgQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESFW 756
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLN---SEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320545069   757 KyHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYikGSTNLIAKGVE 818
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVP--GGSGPPASWVE 136
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1996-2136 1.54e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1996 FRTLQPDCLLLLAAYPPeilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLEL 2075
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDF--------LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320545069  2076 MVDDELQEIRNLNGNPTVVSLPRDaggLYIGGAPPhESYTPLAPTFVNLEGAIRDVVFNNR 2136
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNLNGP---LYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2406-2542 8.27e-25

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 102.03  E-value: 8.27e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   2406 DLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGaPMRVESslpTKYALCDNKWHNISALYDGEQIVLR 2485
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSG-PARLTS---DPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 320545069   2486 IDQLPAVISVGNQGNAGkVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNE 2542
Cdd:smart00282   77 VDGGNRVSGESPGGLTI-LNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2411-2539 7.32e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 7.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2411 FRTSELSGILLSVSDPNGfPALSLELHNGNIIFSCDPGNGapmrVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLP 2490
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGSG----PESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069  2491 aVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 2539
Cdd:pfam02210   76 -VVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1778-1945 2.60e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1778 ARHFNGLGYAQLmktRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 1857
Cdd:cd00110     1 GVSFSGSSYVRL---PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1858 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLsktvYYLGGVPPGFTSGTSKAPgadNPFLG 1937
Cdd:cd00110    77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                  ....*...
gi 320545069 1938 CMKDVQVN 1945
Cdd:cd00110   144 CIRDLKVN 151
LamB smart00281
Laminin B domain;
674-803 1.04e-21

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 92.71  E-value: 1.04e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069    674 YHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGahkpLERNILGQYPLVQLH-AHSKLlldfyEYEEFEYSLN---VTHRV 749
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDG----RRGGTHVSAPDVILEgNGLRI-----SHPAEGPPLPdelTTVEV 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 320545069    750 PLHESFWKYHHtSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAA 803
Cdd:smart00281   73 RFREENWQYYG-GRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVA 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2210-2359 4.38e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 92.10  E-value: 4.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2210 SQLKLPERHFWQRNFHLSFDFRSFYPNGML-YLSPGSKekpKHYVALVLKDGQLVLVVR-GRRREELQLTAKLNDGEWHR 2287
Cdd:cd00110     8 SYVRLPTLPAPRTRLSISFSFRTTSPNGLLlYAGSQNG---GDFLALELEDGRLVLRYDlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320545069 2288 VTISCHDRKVTMSVEIGRTDQKTSAQmkLPKKIGASQLLLVGGLPqsPVKVSSDLYVRlEPFKGCLRRVSIN 2359
Cdd:cd00110    85 VSVERNGRSVTLSVDGERVVESGSPG--GSALLNLDGPLYLGGLP--EDLKSPGLPVS-PGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1808-1947 4.46e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.94  E-value: 4.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1808 FRTLDENALLFLAVDDKNNrSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSakrsteNGMLRVNN 1887
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGN------TLTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1888 DRPISGAPTLPVnihlLPDLSKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 1947
Cdd:pfam02210   74 QTVVSSLPPGES----LLLNLNGPLYLGGLPPLLLLPALPVR---AGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1971-2134 8.21e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 91.33  E-value: 8.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1971 AGFSGNGYLELP-SQSLRKRSNTALVFRTLQPDCLLLLAAypPEILGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKM 2049
Cdd:cd00110     2 VSFSGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDF--------LALELEDGRLVLRYDLGSGSLVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2050 SSnSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPhESYTPLAPTFVNLEGAIR 2129
Cdd:cd00110    72 SS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD---GPLYLGGLPE-DLKSPGLPVSPGFVGCIR 146


                  ....*
gi 320545069 2130 DVVFN 2134
Cdd:cd00110   147 DLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2230-2361 2.03e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 2.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2230 FRSFYPNGMLYLSPGSKekpKHYVALVLKDGQLVLVVR--GRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEigrtD 2307
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDFLALELVNGRLVLRYDlgSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVD----G 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069  2308 QKTSAQMKLPKKIG--ASQLLLVGGLPQSPVKVSSdlyVRLEPFKGCLRRVSINNN 2361
Cdd:pfam02210   74 QTVVSSLPPGESLLlnLNGPLYLGGLPPLLLLPAL---PVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1803-1947 2.55e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.94  E-value: 2.55e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   1803 SVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIeaarefSAKRSTENGM 1882
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRV------AVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069   1883 LRVNNDRPISG-APTLPVNIHLlpdlsKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 1947
Cdd:smart00282   75 LSVDGGNRVSGeSPGGLTILNL-----DGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
1994-2136 2.79e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 86.24  E-value: 2.79e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   1994 LVFRTLQPDCLLLLAAYPPEilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKL 2073
Cdd:smart00282    4 FSFRTTSPNGLLLYAGSKGG--GDY--------LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320545069   2074 ELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPHESYTPLaPTFVNLEGAIRDVVFNNR 2136
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNLD---GPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2225-2361 2.21e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 80.85  E-value: 2.21e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   2225 HLSFDFRSFYPNGMLyLSPGSKEKpKHYVALVLKDGQLVLVVR-GRRREELQLTA-KLNDGEWHRVTISCHDRKVTMSVe 2302
Cdd:smart00282    1 SISFSFRTTSPNGLL-LYAGSKGG-GDYLALELRDGRLVLRYDlGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSV- 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320545069   2303 igrtDQKTSAQMKLPkkIGASQL-----LLVGGLPqsPVKVSSDLYVRlEPFKGCLRRVSINNN 2361
Cdd:smart00282   78 ----DGGNRVSGESP--GGLTILnldgpLYLGGLP--EDLKLPPLPVT-PGFRGCIRNLKVNGK 132
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 391-439 1.52e-16

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 75.47  E-value: 1.52e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 439
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 342-389 6.23e-16

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 73.54  E-value: 6.23e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL-TAGEGCR 389
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 342-388 6.32e-16

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 73.54  E-value: 6.32e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL--TAGEGC 388
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 391-437 1.48e-15

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 72.77  E-value: 1.48e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFST--EGCQ 437
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
391-436 2.83e-15

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 71.57  E-value: 2.83e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 320545069    391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGC 436
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
342-388 2.91e-15

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 71.57  E-value: 2.91e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 320545069    342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTaGEGC 388
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG-PPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 861-908 3.00e-15

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 71.62  E-value: 3.00e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 320545069  861 PCHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDPNSPHGCQ 908
Cdd:cd00055     1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 486-534 5.10e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.15  E-value: 5.10e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 534
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 862-907 5.85e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.15  E-value: 5.85e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 320545069   862 CHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDP-NSPHGC 907
Cdd:pfam00053    1 CDCNPHGSlsdTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 486-534 1.61e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 66.99  E-value: 1.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRcGC 534
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG-GC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
486-529 1.08e-12

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 64.25  E-value: 1.08e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 320545069    486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG--YPEC 529
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 964-1011 5.57e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.37  E-value: 5.57e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545069  964 PCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCK 1011
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
965-1010 7.32e-12

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 61.94  E-value: 7.32e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 320545069    965 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGC 1010
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
862-907 7.72e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.25  E-value: 7.72e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 320545069    862 CHCNGR---SSDCDRETGVCQnCRGNTGGDHCHQCAEGFYGDpnSPHGC 907
Cdd:smart00180    1 CDCDPGgsaSGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD--GPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 965-999 1.65e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.13  E-value: 1.65e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 320545069   965 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQ 999
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 910-959 5.36e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 5.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 320545069   910 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPN 959
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
910-954 1.76e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.76e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 320545069    910 CPCPETNrNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDP 954
Cdd:smart00180    1 CDCDPGG-SASGTCDPDTGQ--CECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 909-963 2.06e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.36  E-value: 2.06e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320545069  909 ACPCPeTNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPNttCQ 963
Cdd:cd00055     1 PCDCN-GHGSLSGQCDPGTGQ--CECKPNTTGRRCDRCAPGYYGLPSQGGG--CQ 50
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 1471-1592 5.64e-08

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 54.03  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1471 EMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQeniSLTQTnLRLANVSLSYLEQQAE------KEQ 1544
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVN---DANKA-LDDAGRSVKKLEELAPdlldklKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 320545069  1545 QVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLeSLGPKCIRSYLP 1592
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 532-584 3.84e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 3.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 320545069   532 CGCDAEGSFtqadgSIACDSN-GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGC 584
Cdd:pfam00053    1 CDCNPHGSL-----SDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 436-484 1.04e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545069  436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 484
Cdd:cd00055     2 CD-CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
532-584 4.14e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 45.77  E-value: 4.14e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 320545069    532 CGCDAEGSFTQAdgsiaCDS-NGQCPCKSLVVGLKCDTCMQSTFGlsaQNPEGC 584
Cdd:smart00180    1 CDCDPGGSASGT-----CDPdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 531-585 1.20e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.65  E-value: 1.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069  531 RCGCDAEGSFtqadgSIACDS-NGQCPCKSLVVGLKCDTCMQSTFGLSAQnPEGCT 585
Cdd:cd00055     1 PCDCNGHGSL-----SGQCDPgTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1315-1582 2.62e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 2.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1315 VRKHWL--PKAEKHASHLLARSNEYARkfqptrNGARIAMLASSAHsNITEAINDARLASILAKERVYEAQRTLypSDGS 1392
Cdd:TIGR02168  655 VRPGGVitGGSAKTNSSILERRREIEE------LEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKEL--EELS 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1393 SMIERAKHSLHRSKQLQQEALKQMhksNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDgsARRQAKDSLEM 1472
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERI---AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA--QIEQLKEELKA 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1473 ADRTGEQMRAELQkakDMQKSIQNMRNSFSNLE---PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV 1549
Cdd:TIGR02168  801 LREALDELRAELT---LLNEEAANLRERLESLErriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          250       260       270
                   ....*....|....*....|....*....|...
gi 320545069  1550 WNNSMAQQLQQLrdqiAKARHAAEAIDVSLESL 1582
Cdd:TIGR02168  878 LLNERASLEEAL----ALLRSELEELSEELREL 906
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
436-476 4.41e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.68  E-value: 4.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 320545069    436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 476
Cdd:smart00180    1 CD-CDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 436-476 5.67e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 42.73  E-value: 5.67e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 320545069   436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 476
Cdd:pfam00053    1 CD-CNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1591-1684 6.25e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 45.49  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1591 LPASYGLSTSNKIRMSFALSNhlESSPLIHLASSE-GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHtrdpkyDDAWY 1669
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTS--PNGLLLYAGSQNgGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLN------DGQWH 83

                          90
                  ....*....|....*
gi 320545069 1670 HVEANRTLNLGSLVV 1684
Cdd:cd00110    84 SVSVERNGRSVTLSV 98
LamG smart00282
Laminin G domain;
1618-1684 4.49e-04

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 42.33  E-value: 4.49e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320545069   1618 LIHLASSEG-RHITLELYKRRVRLVWNLGGTTATVTHPmvvhtrDPKYDD-AWYHVEANRTLNLGSLVV 1684
Cdd:smart00282   15 LLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSD------PTPLNDgQWHRVAVERNGRSVTLSV 77
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1618-1684 6.22e-04

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 42.02  E-value: 6.22e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320545069  1618 LIHLASSEGRHITLELYKRRVRLVWNLGGttatvtHPMVVHTRDPKYDD-AWYHVEANRTLNLGSLVV 1684
Cdd:pfam02210   10 LLYAGGGGSDFLALELVNGRLVLRYDLGS------GPESLLSSGKNLNDgQWHSVRVERNGNTLTLSV 71
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1370-1582 8.63e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1370 LASILA--KERVYEAQRTLYPSDGSSmIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRT 1447
Cdd:COG4717    40 LAFIRAmlLERLEKEADELFKPQGRK-PELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1448 NNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEpdweiklgmaqenISLTQTNLR 1527
Cdd:COG4717   119 EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQ-------------EELEELLEQ 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320545069 1528 LANVSLSYLEQQAEKEQQVfevwnnsmAQQLQQLRDQIAKARHAAEAIDVSLESL 1582
Cdd:COG4717   186 LSLATEEELQDLAEELEEL--------QQRLAELEEELEEAQEELEELEEELEQL 232
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1404-1567 1.47e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1404 RSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIydsglrtNNISGQLQGLSDgsarRQAKDSLEMADRTGEQMRAE 1483
Cdd:TIGR04523  212 KNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI-------SNTQTQLNQLKD----EQNKIKKQLSEKQKELEQNN 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1484 lQKAKDMQKSIQNMRNSFSNL----EPDW--EIK--LGMAQENISLTQTNLRLANVSLSYLEQQA---EKEQQVFEVWNN 1552
Cdd:TIGR04523  281 -KKIKELEKQLNQLKSEISDLnnqkEQDWnkELKseLKNQEKKLEEIQNQISQNNKIISQLNEQIsqlKKELTNSESENS 359

                          170
                   ....*....|....*
gi 320545069  1553 SMAQQLQQLRDQIAK 1567
Cdd:TIGR04523  360 EKQRELEEKQNEIEK 374
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1099-1333 4.44e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1099 AVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR-ST 1177
Cdd:COG4717   288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1178 NDCAWKHFYAMGNASDAsfDESGRLEMLWRDLNQTNHRVVDMRLQVDRV-------------QEVENEAEDVLEHVRNLS 1244
Cdd:COG4717   368 LEQEIAALLAEAGVEDE--EELRAALEQAEEYQELKEELEELEEQLEELlgeleellealdeEELEEELEELEEELEELE 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1245 IRVGESHQELDELNQRISDhldpgyLEQGEGLLRLTVQRQiMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE 1324
Cdd:COG4717   446 EELEELREELAELEAELEQ------LEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREERLPPVL 518


                  ....*....
gi 320545069 1325 KHASHLLAR 1333
Cdd:COG4717   519 ERASEYFSR 527
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2384-2539 1.85e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 118.67  E-value: 1.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2384 GSYFPGDAYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGAPMrvessLPTKY 2463
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLV-----LSSKT 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069 2464 ALCDNKWHNISALYDGEQIVLRIDQLPaVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 2539
Cdd:cd00110    76 PLNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_B pfam00052
Laminin B (Domain IV);
678-818 1.02e-28

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 113.13  E-value: 1.02e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   678 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNilgQYPLVQLHAHSKLLLDFYEYEEF-EYSLNVTHRVPLHESFW 756
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLN---SEPDVILEGNGLRLSYSSPDQPPpDPGQEQTYSVRLHEENW 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320545069   757 KyHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYikGSTNLIAKGVE 818
Cdd:pfam00052   78 R-DSDGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVP--GGSGPPASWVE 136
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1996-2136 1.54e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.65  E-value: 1.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1996 FRTLQPDCLLLLAAYPPeilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLEL 2075
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDF--------LALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320545069  2076 MVDDELQEIRNLNGNPTVVSLPRDaggLYIGGAPPhESYTPLAPTFVNLEGAIRDVVFNNR 2136
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNLNGP---LYLGGLPP-LLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2406-2542 8.27e-25

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 102.03  E-value: 8.27e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   2406 DLETEFRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGaPMRVESslpTKYALCDNKWHNISALYDGEQIVLR 2485
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSG-PARLTS---DPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 320545069   2486 IDQLPAVISVGNQGNAGkVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNE 2542
Cdd:smart00282   77 VDGGNRVSGESPGGLTI-LNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2411-2539 7.32e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 99.03  E-value: 7.32e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2411 FRTSELSGILLSVSDPNGfPALSLELHNGNIIFSCDPGNGapmrVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLP 2490
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGSG----PESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069  2491 aVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 2539
Cdd:pfam02210   76 -VVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1778-1945 2.60e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 98.26  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1778 ARHFNGLGYAQLmktRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGdESKLEINTTKK 1857
Cdd:cd00110     1 GVSFSGSSYVRL---PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLG-SGSLVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1858 YNVGQWIKIeaarefSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLsktvYYLGGVPPGFTSGTSKAPgadNPFLG 1937
Cdd:cd00110    77 LNDGQWHSV------SVERNGRSVTLSVDGERVVESGSPGGSALLNLDGP----LYLGGLPEDLKSPGLPVS---PGFVG 143


                  ....*...
gi 320545069 1938 CMKDVQVN 1945
Cdd:cd00110   144 CIRDLKVN 151
LamB smart00281
Laminin B domain;
674-803 1.04e-21

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 92.71  E-value: 1.04e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069    674 YHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGahkpLERNILGQYPLVQLH-AHSKLlldfyEYEEFEYSLN---VTHRV 749
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDG----RRGGTHVSAPDVILEgNGLRI-----SHPAEGPPLPdelTTVEV 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 320545069    750 PLHESFWKYHHtSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAA 803
Cdd:smart00281   73 RFREENWQYYG-GRPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVA 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2210-2359 4.38e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 92.10  E-value: 4.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2210 SQLKLPERHFWQRNFHLSFDFRSFYPNGML-YLSPGSKekpKHYVALVLKDGQLVLVVR-GRRREELQLTAKLNDGEWHR 2287
Cdd:cd00110     8 SYVRLPTLPAPRTRLSISFSFRTTSPNGLLlYAGSQNG---GDFLALELEDGRLVLRYDlGSGSLVLSSKTPLNDGQWHS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 320545069 2288 VTISCHDRKVTMSVEIGRTDQKTSAQmkLPKKIGASQLLLVGGLPqsPVKVSSDLYVRlEPFKGCLRRVSIN 2359
Cdd:cd00110    85 VSVERNGRSVTLSVDGERVVESGSPG--GSALLNLDGPLYLGGLP--EDLKSPGLPVS-PGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1808-1947 4.46e-21

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.94  E-value: 4.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1808 FRTLDENALLFLAVDDKNNrSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSakrsteNGMLRVNN 1887
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGN------TLTLSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1888 DRPISGAPTLPVnihlLPDLSKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 1947
Cdd:pfam02210   74 QTVVSSLPPGES----LLLNLNGPLYLGGLPPLLLLPALPVR---AGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1971-2134 8.21e-21

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 91.33  E-value: 8.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1971 AGFSGNGYLELP-SQSLRKRSNTALVFRTLQPDCLLLLAAypPEILGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKM 2049
Cdd:cd00110     2 VSFSGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDF--------LALELEDGRLVLRYDLGSGSLVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 2050 SSnSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPhESYTPLAPTFVNLEGAIR 2129
Cdd:cd00110    72 SS-KTPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLD---GPLYLGGLPE-DLKSPGLPVSPGFVGCIR 146


                  ....*
gi 320545069 2130 DVVFN 2134
Cdd:cd00110   147 DLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2230-2361 2.03e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 89.02  E-value: 2.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2230 FRSFYPNGMLYLSPGSKekpKHYVALVLKDGQLVLVVR--GRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEigrtD 2307
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG---SDFLALELVNGRLVLRYDlgSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVD----G 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069  2308 QKTSAQMKLPKKIG--ASQLLLVGGLPQSPVKVSSdlyVRLEPFKGCLRRVSINNN 2361
Cdd:pfam02210   74 QTVVSSLPPGESLLlnLNGPLYLGGLPPLLLLPAL---PVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1803-1947 2.55e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.94  E-value: 2.55e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   1803 SVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIeaarefSAKRSTENGM 1882
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRV------AVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069   1883 LRVNNDRPISG-APTLPVNIHLlpdlsKTVYYLGGVPPGFTSGTSKAPgadNPFLGCMKDVQVNGE 1947
Cdd:smart00282   75 LSVDGGNRVSGeSPGGLTILNL-----DGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
2411-2541 1.68e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 1.68e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2411 FRTSELSGILLSVSDPNGFPALSLELHNGNIIFSCDPGNGApmrveSSLPTKYALCDNKWHNISALYDGEQIVLRIDQLP 2490
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGA-----AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 320545069  2491 AVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLI-SRENFKGCIRHVSIRN 2541
Cdd:pfam00054   76 RPTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLaISPSFDGCIRDVIVNG 127
LamG smart00282
Laminin G domain;
1994-2136 2.79e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 86.24  E-value: 2.79e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   1994 LVFRTLQPDCLLLLAAYPPEilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKL 2073
Cdd:smart00282    4 FSFRTTSPNGLLLYAGSKGG--GDY--------LALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSV 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320545069   2074 ELMVDDELQEIRNLNGNPTVVSLPrdaGGLYIGGAPPHESYTPLaPTFVNLEGAIRDVVFNNR 2136
Cdd:smart00282   74 TLSVDGGNRVSGESPGGLTILNLD---GPLYLGGLPEDLKLPPL-PVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2225-2361 2.21e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 80.85  E-value: 2.21e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069   2225 HLSFDFRSFYPNGMLyLSPGSKEKpKHYVALVLKDGQLVLVVR-GRRREELQLTA-KLNDGEWHRVTISCHDRKVTMSVe 2302
Cdd:smart00282    1 SISFSFRTTSPNGLL-LYAGSKGG-GDYLALELRDGRLVLRYDlGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSV- 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320545069   2303 igrtDQKTSAQMKLPkkIGASQL-----LLVGGLPqsPVKVSSDLYVRlEPFKGCLRRVSINNN 2361
Cdd:smart00282   78 ----DGGNRVSGESP--GGLTILnldgpLYLGGLP--EDLKLPPLPVT-PGFRGCIRNLKVNGK 132
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 391-439 1.52e-16

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 75.47  E-value: 1.52e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 439
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 342-389 6.23e-16

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 73.54  E-value: 6.23e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL-TAGEGCR 389
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 342-388 6.32e-16

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 73.54  E-value: 6.32e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNL--TAGEGC 388
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 391-437 1.48e-15

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 72.77  E-value: 1.48e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFST--EGCQ 437
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
391-436 2.83e-15

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 71.57  E-value: 2.83e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 320545069    391 CRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGC 436
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
342-388 2.91e-15

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 71.57  E-value: 2.91e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 320545069    342 CHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTaGEGC 388
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG-PPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 861-908 3.00e-15

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 71.62  E-value: 3.00e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 320545069  861 PCHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDPNSPHGCQ 908
Cdd:cd00055     1 PCDCNGHGSlsgQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_G_1 pfam00054
Laminin G domain;
2230-2364 3.87e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 71.19  E-value: 3.87e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2230 FRSFYPNGMLYLspGSKEKPKHYVALVLKDGQL-VLVVRGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSV-----EI 2303
Cdd:pfam00054    1 FRTTEPSGLLLY--NGTQTERDFLALELRDGRLeVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVdgearPT 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320545069  2304 GRTDQKTSAQMKLPKKIGasqlllVGGLPqsPVKVSSDLYVRLEPFKGCLRRVSINNNTQD 2364
Cdd:pfam00054   79 GESPLGATTDLDVDGPLY------VGGLP--SLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 486-534 5.10e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.15  E-value: 5.10e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 320545069   486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 534
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 862-907 5.85e-14

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 68.15  E-value: 5.85e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 320545069   862 CHCNGRSS---DCDRETGVCQnCRGNTGGDHCHQCAEGFYGDP-NSPHGC 907
Cdd:pfam00053    1 CDCNPHGSlsdTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPsDPPQGC 49
Laminin_G_1 pfam00054
Laminin G domain;
1996-2139 8.57e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 70.42  E-value: 8.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1996 FRTLQPDCLLLLAAYPPEilGDYdakdikgnFSISLVDGQLHVWVNSGRSFIKMSSNSsQMNDGEFHVVHLIKTGRKLEL 2075
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE--RDF--------LALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKWHSVELERNGRSGTL 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545069  2076 MVDDELQE-IRNLNGNPTVVSLPrdaGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFNNRTIN 2139
Cdd:pfam00054   70 SVDGEARPtGESPLGATTDLDVD---GPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 486-534 1.61e-13

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 66.99  E-value: 1.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320545069  486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRcGC 534
Cdd:cd00055     2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGG-GC 49
Laminin_G_1 pfam00054
Laminin G domain;
1808-1950 1.99e-13

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 69.27  E-value: 1.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1808 FRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGD-ESKLEINTtkKYNVGQWIKIEaarefsAKRSTENGMLRVN 1886
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSgAAVVRSGD--KLNDGKWHSVE------LERNGRSGTLSVD 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545069  1887 NDRPISGAPTLPVNIHLlpDLSKTvYYLGGVPPgftSGTSKAPGADNP-FLGCMKDVQVNGETYD 1950
Cdd:pfam00054   73 GEARPTGESPLGATTDL--DVDGP-LYVGGLPS---LGVKKRRLAISPsFDGCIRDVIVNGKPLD 131
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
486-529 1.08e-12

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 64.25  E-value: 1.08e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 320545069    486 CECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG--YPEC 529
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGdgPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 964-1011 5.57e-12

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 62.37  E-value: 5.57e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545069  964 PCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCK 1011
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLpsQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
965-1010 7.32e-12

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 61.94  E-value: 7.32e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 320545069    965 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGC 1010
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
862-907 7.72e-11

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 59.25  E-value: 7.72e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 320545069    862 CHCNGR---SSDCDRETGVCQnCRGNTGGDHCHQCAEGFYGDpnSPHGC 907
Cdd:smart00180    1 CDCDPGgsaSGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD--GPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 965-999 1.65e-10

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 58.13  E-value: 1.65e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 320545069   965 CNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQ 999
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 910-959 5.36e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 5.36e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 320545069   910 CPCPEtNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPN 959
Cdd:pfam00053    1 CDCNP-HGSLSDTCDPETGQ--CLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
910-954 1.76e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.76e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 320545069    910 CPCPETNrNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDP 954
Cdd:smart00180    1 CDCDPGG-SASGTCDPDTGQ--CECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 909-963 2.06e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 52.36  E-value: 2.06e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320545069  909 ACPCPeTNRNFARGCNVWDGEvsCVCKPGYTGRLCERCQAGYFGDPMRYPNttCQ 963
Cdd:cd00055     1 PCDCN-GHGSLSGQCDPGTGQ--CECKPNTTGRRCDRCAPGYYGLPSQGGG--CQ 50
Laminin_II pfam06009
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ...
 1471-1592 5.64e-08

Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 368703 [Multi-domain]  Cd Length: 138  Bit Score: 54.03  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1471 EMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQeniSLTQTnLRLANVSLSYLEQQAE------KEQ 1544
Cdd:pfam06009    3 ELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVN---DANKA-LDDAGRSVKKLEELAPdlldklKPL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 320545069  1545 QVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLeSLGPKCIRSYLP 1592
Cdd:pfam06009   79 KQLEVNSSSLSDNISRIKELIAQARKAANSIKVSV-SFDGDSIVELRP 125
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 532-584 3.84e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.89  E-value: 3.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 320545069   532 CGCDAEGSFtqadgSIACDSN-GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGC 584
Cdd:pfam00053    1 CDCNPHGSL-----SDTCDPEtGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 436-484 1.04e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 47.35  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 320545069  436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQAR-LGCR 484
Cdd:cd00055     2 CD-CNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
532-584 4.14e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 45.77  E-value: 4.14e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 320545069    532 CGCDAEGSFTQAdgsiaCDS-NGQCPCKSLVVGLKCDTCMQSTFGlsaQNPEGC 584
Cdd:smart00180    1 CDCDPGGSASGT-----CDPdTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 531-585 1.20e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.65  E-value: 1.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320545069  531 RCGCDAEGSFtqadgSIACDS-NGQCPCKSLVVGLKCDTCMQSTFGLSAQnPEGCT 585
Cdd:cd00055     1 PCDCNGHGSL-----SGQCDPgTGQCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1315-1582 2.62e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 2.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1315 VRKHWL--PKAEKHASHLLARSNEYARkfqptrNGARIAMLASSAHsNITEAINDARLASILAKERVYEAQRTLypSDGS 1392
Cdd:TIGR02168  655 VRPGGVitGGSAKTNSSILERRREIEE------LEEKIEELEEKIA-ELEKALAELRKELEELEEELEQLRKEL--EELS 725

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1393 SMIERAKHSLHRSKQLQQEALKQMhksNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDgsARRQAKDSLEM 1472
Cdd:TIGR02168  726 RQISALRKDLARLEAEVEQLEERI---AQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA--QIEQLKEELKA 800

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1473 ADRTGEQMRAELQkakDMQKSIQNMRNSFSNLE---PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEV 1549
Cdd:TIGR02168  801 LREALDELRAELT---LLNEEAANLRERLESLErriAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877

                          250       260       270
                   ....*....|....*....|....*....|...
gi 320545069  1550 WNNSMAQQLQQLrdqiAKARHAAEAIDVSLESL 1582
Cdd:TIGR02168  878 LLNERASLEEAL----ALLRSELEELSEELREL 906
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
436-476 4.41e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.68  E-value: 4.41e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 320545069    436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 476
Cdd:smart00180    1 CD-CDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 436-476 5.67e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 42.73  E-value: 5.67e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 320545069   436 CQrCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWG 476
Cdd:pfam00053    1 CD-CNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYG 40
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1591-1684 6.25e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 45.49  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1591 LPASYGLSTSNKIRMSFALSNhlESSPLIHLASSE-GRHITLELYKRRVRLVWNLGGTTATVTHPMVVHtrdpkyDDAWY 1669
Cdd:cd00110    12 LPTLPAPRTRLSISFSFRTTS--PNGLLLYAGSQNgGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLN------DGQWH 83

                          90
                  ....*....|....*
gi 320545069 1670 HVEANRTLNLGSLVV 1684
Cdd:cd00110    84 SVSVERNGRSVTLSV 98
TNFRSF1A_teleost cd15834
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in teleosts; also known as ...
 879-1020 1.17e-04

Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in teleosts; also known as TNFR1; This subfamily of TNFRSF1 ((also known as type I TNFR, TNFR1, DR1, TNFRSF1A, CD120a, p55) is found in teleosts. It binds TNF-alpha, through the death domain (DD), and activates NF-kappaB, mediates apoptosis and activates signaling pathways controlling inflammatory, immune, and stress responses. It mediates signal transduction by interacting with antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRAF2 and TRADD that play regulatory roles. The human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS), or periodic fever syndrome, is associated with germline mutations of the extracellular domains of this receptor, possibly due to impaired receptor clearance. Serum levels of TNFRSF1A are elevated in schizophrenia and bipolar disorder, and high levels are also associated with cognitive impairment and dementia. Knockout studies in zebrafish embryos have shown that a signaling balance between TNFRSF1A and TNFRSF1B is required for endothelial cell integrity. TNFRSF1A signals apoptosis through caspase-8, whereas TNFRSF1B signals survival via NF-kappaB in endothelial cells. Thus, this apoptotic pathway seems to be evolutionarily conserved, as TNFalpha promotes apoptosis of human endothelial cells and triggers caspase-2 and P53 activation in these cells via TNFRSF1A.


Pssm-ID: 276930 [Multi-domain]  Cd Length: 150  Bit Score: 44.79  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  879 QNCRGNTGGDHCHQCAEGFYGDP-NSPHGCQACpcpetnrnfaRGCNVWDGEVSCVCKPgYTGRLCeRCQAGYFGDPMRY 957
Cdd:cd15834    25 EECTAPGERSQCTPCPEGTYLEQiNYSPNCRRC----------TLCKVKNEEEVSPCKK-SSNTVC-RCKKGYYKSRIDS 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545069  958 PNTTCQPC-NCHPDGIQTEGCDVETGR-CYCREGvtglkcdkcqaerHHLVDNGCKICDNCTLLL 1020
Cdd:cd15834    93 ETRECLKCkTCGPGEIEIQPCTPESNTvCECKDN-------------YYRNNNKCKPCQKCSLDC 144
TNFRSF cd00185
Tumor necrosis factor receptor superfamily (TNFRSF); Members of TNFR superfamily (TNFRSF) ...
 871-965 2.36e-04

Tumor necrosis factor receptor superfamily (TNFRSF); Members of TNFR superfamily (TNFRSF) interactions with TNF superfamily (TNFSF) ligands (TNFL) control key cellular processes such as differentiation, proliferation, apoptosis, and cell growth. Dysregulation of these pathways has been shown to result in a wide range of pathological conditions, including autoimmune diseases, inflammation, cancer, and viral infection. There are 29 very diverse family members of TNFRSF reported in humans: 22 are type I transmembrane receptors (single pass with the N terminus on extracellular side of the cell membrane) and have a clear signal peptide; the remaining 7 members are either type III transmembrane receptors (single pass with the N terminus on extracellular side of the membrane but no signal sequence; TNFR13B, TNFR13C, TNFR17, and XEDAR), or attached to the membrane via a glycosylphosphatidylinositol (GPI) linker (TNFR10C), or secreted as soluble receptors (TNFR11B and TNFR6B). All TNFRs contain relatively short cysteine-rich domains (CRDs) in the ectodomain, and are involved in interaction with the TNF homology domain (THD) of their ligands. TNFRs often have multiple CRDs (between one and six), with the most frequent configurations of three or four copies; most CRDs possess three disulfide bridges, but could have between one and four. Localized or genome-wide duplication and evolution of the TNFRSF members appear to have paralleled the emergence of the adaptive immune system; teleosts (i.e. ray-finned, bony fish), which possess an immune system with B and T cells, possess primary and secondary lymphoid organs, and are capable of adaptive responses to pathogens also display several characteristics that are different from the mammalian immune system, making teleost TNFSF orthologs and paralogs of interest to better understand immune system evolution and the immunological pathways elicited to pathogens.


Pssm-ID: 276900 [Multi-domain]  Cd Length: 87  Bit Score: 42.20  E-value: 2.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  871 CDRETGVCQNCRGNTGGDhCHQCAEGFY-GDPNSPHGCQAC-PCPETNRNFARGCNVWDGEVsCVCKPGYTGRLCERCQa 948
Cdd:cd00185     5 CPPGEYLSSDCTATTDTV-CSPCPPGTYsESWNSLSKCLPCtTCGGGNQVEKTPCTATDNRC-CTCKPGFYCDEGTNVE- 81

                          90
                  ....*....|....*..
gi 320545069  949 gyfgdpmrypntTCQPC 965
Cdd:cd00185    82 ------------ECKPC 86
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 2417-2539 2.83e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 43.53  E-value: 2.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  2417 SGILLSVSDPNGFpalSLEL-HNGNIIFSCDPGNGAPMRVESSLPtkyaLCDNKWHNISALYDGEQIVLRID-QLPAVIS 2494
Cdd:pfam13385   34 ARAIISSSGGGGY---SLGLdGDGRLRFAVNGGNGGWDTVTSGAS----VPLGQWTHVAVTYDGGTLRLYVNgVLVGSST 106

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 320545069  2495 VGNQGNAGkvqTRSPLYIGGLPESAPsgslisreNFKGCIRHVSI 2539
Cdd:pfam13385  107 LTGGPPPG---TGGPLYIGRSPGGDD--------YFNGLIDEVRI 140
LamG smart00282
Laminin G domain;
1618-1684 4.49e-04

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 42.33  E-value: 4.49e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320545069   1618 LIHLASSEG-RHITLELYKRRVRLVWNLGGTTATVTHPmvvhtrDPKYDD-AWYHVEANRTLNLGSLVV 1684
Cdd:smart00282   15 LLYAGSKGGgDYLALELRDGRLVLRYDLGSGPARLTSD------PTPLNDgQWHRVAVERNGRSVTLSV 77
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1618-1684 6.22e-04

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 42.02  E-value: 6.22e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320545069  1618 LIHLASSEGRHITLELYKRRVRLVWNLGGttatvtHPMVVHTRDPKYDD-AWYHVEANRTLNLGSLVV 1684
Cdd:pfam02210   10 LLYAGGGGSDFLALELVNGRLVLRYDLGS------GPESLLSSGKNLNDgQWHSVRVERNGNTLTLSV 71
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1370-1582 8.63e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1370 LASILA--KERVYEAQRTLYPSDGSSmIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRT 1447
Cdd:COG4717    40 LAFIRAmlLERLEKEADELFKPQGRK-PELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1448 NNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEpdweiklgmaqenISLTQTNLR 1527
Cdd:COG4717   119 EKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQ-------------EELEELLEQ 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 320545069 1528 LANVSLSYLEQQAEKEQQVfevwnnsmAQQLQQLRDQIAKARHAAEAIDVSLESL 1582
Cdd:COG4717   186 LSLATEEELQDLAEELEEL--------QQRLAELEEELEEAQEELEELEEELEQL 232
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1200-1504 9.99e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 9.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1200 GRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDvleHVRNLSIRVGESHQELDELNQRISDhldpgyLEQGeglLRL 1279
Cdd:TIGR02168  239 EELEELQEELKEAEEELEELTAELQELEEKLEELRL---EVSELEEEIEELQKELYALANEISR------LEQQ---KQI 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1280 TVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHAShLLARSNEYARKFQPTRNGARiamlassahs 1359
Cdd:TIGR02168  307 LRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELES-LEAELEELEAELEELESRLE---------- 375

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1360 NITEAINDARLASILAKERVYEAQRTLypSDGSSMIERAKHSLHRSKQLQQEALKQMHKSnvlkdKLHRQEQQVEGIKST 1439
Cdd:TIGR02168  376 ELEEQLETLRSKVAQLELQIASLNNEI--ERLEARLERLEDRRERLQQEIEELLKKLEEA-----ELKELQAELEELEEE 448

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320545069  1440 IYDSGLRTNNISGQLqglsdgsarRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNL 1504
Cdd:TIGR02168  449 LEELQEELERLEEAL---------EELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGF 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1404-1567 1.47e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1404 RSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIydsglrtNNISGQLQGLSDgsarRQAKDSLEMADRTGEQMRAE 1483
Cdd:TIGR04523  212 KNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEI-------SNTQTQLNQLKD----EQNKIKKQLSEKQKELEQNN 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  1484 lQKAKDMQKSIQNMRNSFSNL----EPDW--EIK--LGMAQENISLTQTNLRLANVSLSYLEQQA---EKEQQVFEVWNN 1552
Cdd:TIGR04523  281 -KKIKELEKQLNQLKSEISDLnnqkEQDWnkELKseLKNQEKKLEEIQNQISQNNKIISQLNEQIsqlKKELTNSESENS 359

                          170
                   ....*....|....*
gi 320545069  1553 SMAQQLQQLRDQIAK 1567
Cdd:TIGR04523  360 EKQRELEEKQNEIEK 374
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
1465-1571 4.09e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 41.35  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1465 QAKDSLEMADRTGEQMRAELQKAKD-------MQKSIQNMRNSFSNLEPDWEIKLGMAqenisLTQTNLRLAnvsLSYLE 1537
Cdd:COG1842    20 KAEDPEKMLDQAIRDMEEDLVEARQalaqviaNQKRLERQLEELEAEAEKWEEKARLA-----LEKGREDLA---REALE 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 320545069 1538 QQAEKEQQVfevwnNSMAQQLQQLRDQIAKARHA 1571
Cdd:COG1842    92 RKAELEAQA-----EALEAQLAQLEEQVEKLKEA 120
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1099-1333 4.44e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1099 AVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR-ST 1177
Cdd:COG4717   288 LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQlEE 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1178 NDCAWKHFYAMGNASDAsfDESGRLEMLWRDLNQTNHRVVDMRLQVDRV-------------QEVENEAEDVLEHVRNLS 1244
Cdd:COG4717   368 LEQEIAALLAEAGVEDE--EELRAALEQAEEYQELKEELEELEEQLEELlgeleellealdeEELEEELEELEEELEELE 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069 1245 IRVGESHQELDELNQRISDhldpgyLEQGEGLLRLTVQRQiMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE 1324
Cdd:COG4717   446 EELEELREELAELEAELEQ------LEEDGELAELLQELE-ELKAELRELAEEWAALKLALELLEEAREEYREERLPPVL 518


                  ....*....
gi 320545069 1325 KHASHLLAR 1333
Cdd:COG4717   519 ERASEYFSR 527
TNFRSF4 cd13406
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ...
 890-974 7.90e-03

Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus.


Pssm-ID: 276911 [Multi-domain]  Cd Length: 142  Bit Score: 39.30  E-value: 7.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545069  890 CHQCAEGFYGDPNSPHGCQACpcpetnrnfaRGCNVWDGEVS-----------CVCKPGYT-------GRLCERCQAGYF 951
Cdd:cd13406    36 CSPCEPGFYNEAVNYEPCKPC----------TQCNQRSGSEEkqkctktsdtvCRCRPGTQpldsykpGVDCVPCPPGHF 105

                          90       100
                  ....*....|....*....|....*.
gi 320545069  952 --GDpmrypNTTCQP-CNCHPDGIQT 974
Cdd:cd13406   106 srGD-----NQACKPwTNCSLAGKRT 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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