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Conserved domains on  [gi|665399513|ref|NP_001188885|]
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pou domain motif 3, isoform F [Drosophila melanogaster]

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
1108-1200 4.97e-29

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 110.99  E-value: 4.97e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSsalaaqmyaaqlstqqqnmFEKLDITPKSAQK 1187
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICR-------------------FEALQLSFKNMCK 62

                            90
                    ....*....|...
gi 665399513   1188 IKPVLERWMKEAE 1200
Cdd:smart00352   63 LKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
1226-1282 2.84e-18

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.84e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399513  1226 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1282
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1108-1200 4.97e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 110.99  E-value: 4.97e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSsalaaqmyaaqlstqqqnmFEKLDITPKSAQK 1187
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICR-------------------FEALQLSFKNMCK 62

                            90
                    ....*....|...
gi 665399513   1188 IKPVLERWMKEAE 1200
Cdd:smart00352   63 LKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1110-1200 2.11e-28

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 108.90  E-value: 2.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513  1110 IDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSsalaaqmyaaqlstqqqnmFEKLDITPKSAQKIK 1189
Cdd:pfam00157    1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICR-------------------FEKLDLSLKNMCKLK 61

                           90
                   ....*....|.
gi 665399513  1190 PVLERWMKEAE 1200
Cdd:pfam00157   62 PLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
1226-1282 2.84e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.84e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399513  1226 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1282
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1225-1281 9.05e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 9.05e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399513   1225 KRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1281
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1226-1283 2.15e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.51  E-value: 2.15e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399513 1226 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNT 1283
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1222-1281 2.63e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 51.67  E-value: 2.63e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513 1222 PSKKRKRRTsfTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1281
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1108-1200 4.97e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 110.99  E-value: 4.97e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSsalaaqmyaaqlstqqqnmFEKLDITPKSAQK 1187
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICR-------------------FEALQLSFKNMCK 62

                            90
                    ....*....|...
gi 665399513   1188 IKPVLERWMKEAE 1200
Cdd:smart00352   63 LKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1110-1200 2.11e-28

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 108.90  E-value: 2.11e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513  1110 IDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICSsalaaqmyaaqlstqqqnmFEKLDITPKSAQKIK 1189
Cdd:pfam00157    1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICR-------------------FEKLDLSLKNMCKLK 61

                           90
                   ....*....|.
gi 665399513  1190 PVLERWMKEAE 1200
Cdd:pfam00157   62 PLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
1226-1282 2.84e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.84e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399513  1226 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1282
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1225-1281 9.05e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 9.05e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399513   1225 KRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1281
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1226-1283 2.15e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.51  E-value: 2.15e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399513 1226 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNT 1283
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1222-1281 2.63e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 51.67  E-value: 2.63e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399513 1222 PSKKRKRRTsfTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1281
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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