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Conserved domains on  [gi|320543151|ref|NP_001189267|]
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wolfram syndrome 1, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WCOB pfam19913
Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin ...
 730-852 1.62e-40

Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.


:

Pssm-ID: 437745  Cd Length: 120  Bit Score: 144.76  E-value: 1.62e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  730 WNRYEYELLVKVGtkrSGRLLGRstTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRS 809
Cdd:pfam19913   1 WNRYTFEVTVKMP---SGGWLDR--TADIILKADHEFKNFTLSLRPGDKVRFSGTLEGYRLGSKDPQLELKEIECLDCKS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 320543151  810 RDLGTAS--IERVVAASPMDARLQDLMRGIKYLLNALLNPLITFK 852
Cdd:pfam19913  76 SLLTASRkrKIERDWRGTLKDILRDLMRALKFLLNFLFNPLLEFK 120
WC-rich pfam20053
Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this ...
 620-729 1.19e-37

Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation.


:

Pssm-ID: 466275  Cd Length: 106  Bit Score: 136.31  E-value: 1.19e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  620 WDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNFLEDtIANYLPVWLGRMLRCLHGENISQHfk 699
Cdd:pfam20053   1 WEQYQNLCGQPAWEESNKAQTQIRCSHLEGHKVNWEGYVKNVRIKSIENSAES-VLNYLPVFLADWLRCLYGEPYPED-- 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 320543151  700 CDpKLDAQCEEWRSVFKTFNAQSGSCTLQR 729
Cdd:pfam20053  78 CD-KFLLSVQEEEELCRLKKLAKNKCHLKR 106
WEF-hand pfam19914
Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming ...
 117-207 9.88e-24

Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteriztic calcium-binding motif, suggesting it could self-dimerize or dimerize with other EF-hand-containing proteins.


:

Pssm-ID: 466231  Cd Length: 80  Bit Score: 95.34  E-value: 9.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  117 ARKAARELFACLSNGNEHITPKQLERKMRRIYNLQRKrrrRDDDRSSSSSEGEQEPECEpledvptiDLANVERRRLITE 196
Cdd:pfam19914   1 ARKAAREMFASLSNGKEFITVSQLLRNMREINATDGG---SRREPGPGSTSNKSRKVLE--------SLVSSESDRFITE 69

                          90
                  ....*....|.
gi 320543151  197 AHLVSAASNYS 207
Cdd:pfam19914  70 DDLVSAAKKYA 80
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 78-116 2.12e-11

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


:

Pssm-ID: 466262  Cd Length: 39  Bit Score: 59.10  E-value: 2.12e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320543151   78 GHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERA 116
Cdd:pfam20023   1 GHEAATELLKHCLETGKGITEENEEEVNSCLAVSWLEKA 39
TPR super family cl34042
TPR repeat [General function prediction only];
34-120 8.20e-04

TPR repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0790:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 41.84  E-value: 8.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  34 AEEGCPQMQYDLAKELLD-NSIEPNLAKgnqsqkAVNWLVSAAHNGHEDAVKLLRQCYNDGSGItAENTDEVRRCLamtp 112
Cdd:COG0790  166 AEQGDADAQYNLGVLYENgRGVPKDPAK------ALEWYRKAAEQGDADAQYNLGRLYLNGEGV-EKDLEKALRWL---- 234


                 ....*...
gi 320543151 113 gERAARKA 120
Cdd:COG0790  235 -RKAAEQA 241
 
Name Accession Description Interval E-value
WCOB pfam19913
Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin ...
 730-852 1.62e-40

Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.


Pssm-ID: 437745  Cd Length: 120  Bit Score: 144.76  E-value: 1.62e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  730 WNRYEYELLVKVGtkrSGRLLGRstTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRS 809
Cdd:pfam19913   1 WNRYTFEVTVKMP---SGGWLDR--TADIILKADHEFKNFTLSLRPGDKVRFSGTLEGYRLGSKDPQLELKEIECLDCKS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 320543151  810 RDLGTAS--IERVVAASPMDARLQDLMRGIKYLLNALLNPLITFK 852
Cdd:pfam19913  76 SLLTASRkrKIERDWRGTLKDILRDLMRALKFLLNFLFNPLLEFK 120
WC-rich pfam20053
Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this ...
 620-729 1.19e-37

Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation.


Pssm-ID: 466275  Cd Length: 106  Bit Score: 136.31  E-value: 1.19e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  620 WDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNFLEDtIANYLPVWLGRMLRCLHGENISQHfk 699
Cdd:pfam20053   1 WEQYQNLCGQPAWEESNKAQTQIRCSHLEGHKVNWEGYVKNVRIKSIENSAES-VLNYLPVFLADWLRCLYGEPYPED-- 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 320543151  700 CDpKLDAQCEEWRSVFKTFNAQSGSCTLQR 729
Cdd:pfam20053  78 CD-KFLLSVQEEEELCRLKKLAKNKCHLKR 106
WEF-hand pfam19914
Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming ...
 117-207 9.88e-24

Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteriztic calcium-binding motif, suggesting it could self-dimerize or dimerize with other EF-hand-containing proteins.


Pssm-ID: 466231  Cd Length: 80  Bit Score: 95.34  E-value: 9.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  117 ARKAARELFACLSNGNEHITPKQLERKMRRIYNLQRKrrrRDDDRSSSSSEGEQEPECEpledvptiDLANVERRRLITE 196
Cdd:pfam19914   1 ARKAAREMFASLSNGKEFITVSQLLRNMREINATDGG---SRREPGPGSTSNKSRKVLE--------SLVSSESDRFITE 69

                          90
                  ....*....|.
gi 320543151  197 AHLVSAASNYS 207
Cdd:pfam19914  70 DDLVSAAKKYA 80
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 78-116 2.12e-11

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


Pssm-ID: 466262  Cd Length: 39  Bit Score: 59.10  E-value: 2.12e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320543151   78 GHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERA 116
Cdd:pfam20023   1 GHEAATELLKHCLETGKGITEENEEEVNSCLAVSWLEKA 39
TPR COG0790
TPR repeat [General function prediction only];
34-120 8.20e-04

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 41.84  E-value: 8.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  34 AEEGCPQMQYDLAKELLD-NSIEPNLAKgnqsqkAVNWLVSAAHNGHEDAVKLLRQCYNDGSGItAENTDEVRRCLamtp 112
Cdd:COG0790  166 AEQGDADAQYNLGVLYENgRGVPKDPAK------ALEWYRKAAEQGDADAQYNLGRLYLNGEGV-EKDLEKALRWL---- 234


                 ....*...
gi 320543151 113 gERAARKA 120
Cdd:COG0790  235 -RKAAEQA 241
 
Name Accession Description Interval E-value
WCOB pfam19913
Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin ...
 730-852 1.62e-40

Wolframin C-terminal OB-fold domain; OB fold domain found at the C-terminus of the wolframin protein. Localizes to the ER lumen and lacks the conserved polar residues typical of OB-fold domain-mediated nucleic acid-binding. Predicted to mediate protein-protein interactions.


Pssm-ID: 437745  Cd Length: 120  Bit Score: 144.76  E-value: 1.62e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  730 WNRYEYELLVKVGtkrSGRLLGRstTTDVILRAHHDFGNFTRLLSEGDVVLFYGILHNSRLLADNVQVKLKTIECVECRS 809
Cdd:pfam19913   1 WNRYTFEVTVKMP---SGGWLDR--TADIILKADHEFKNFTLSLRPGDKVRFSGTLEGYRLGSKDPQLELKEIECLDCKS 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 320543151  810 RDLGTAS--IERVVAASPMDARLQDLMRGIKYLLNALLNPLITFK 852
Cdd:pfam19913  76 SLLTASRkrKIERDWRGTLKDILRDLMRALKFLLNFLFNPLLEFK 120
WC-rich pfam20053
Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this ...
 620-729 1.19e-37

Wolframin cysteine-rich domain; Located N-terminal to the wolframin OB-fold domain, this region could represent an extension to the core of the OB fold domain. The observed conserved cysteine residues could contribute to disulfide-bond-mediated cross-linking in calcium-stores regulation.


Pssm-ID: 466275  Cd Length: 106  Bit Score: 136.31  E-value: 1.19e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  620 WDRFHALCAQPVHEQPNKIKAQLRCSLLNGMPVIWEGSVTKVEISRVSNFLEDtIANYLPVWLGRMLRCLHGENISQHfk 699
Cdd:pfam20053   1 WEQYQNLCGQPAWEESNKAQTQIRCSHLEGHKVNWEGYVKNVRIKSIENSAES-VLNYLPVFLADWLRCLYGEPYPED-- 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 320543151  700 CDpKLDAQCEEWRSVFKTFNAQSGSCTLQR 729
Cdd:pfam20053  78 CD-KFLLSVQEEEELCRLKKLAKNKCHLKR 106
WEF-hand pfam19914
Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming ...
 117-207 9.88e-24

Wolframin EF-hand domain; Contains two characteriztic copies of the bihelical repeat forming the basic EF-hand unit. The absence of the characteriztic calcium-binding motif, suggesting it could self-dimerize or dimerize with other EF-hand-containing proteins.


Pssm-ID: 466231  Cd Length: 80  Bit Score: 95.34  E-value: 9.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  117 ARKAARELFACLSNGNEHITPKQLERKMRRIYNLQRKrrrRDDDRSSSSSEGEQEPECEpledvptiDLANVERRRLITE 196
Cdd:pfam19914   1 ARKAAREMFASLSNGKEFITVSQLLRNMREINATDGG---SRREPGPGSTSNKSRKVLE--------SLVSSESDRFITE 69

                          90
                  ....*....|.
gi 320543151  197 AHLVSAASNYS 207
Cdd:pfam19914  70 DDLVSAAKKYA 80
WSLR pfam20023
Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This ...
 78-116 2.12e-11

Wolframin Sel1-like repeat; N-terminal Sel1-like repeats found in the wolframin protein. This region has been linked to calmodulin-binding, suggesting these repeats may mediate a protein interaction.


Pssm-ID: 466262  Cd Length: 39  Bit Score: 59.10  E-value: 2.12e-11
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 320543151   78 GHEDAVKLLRQCYNDGSGITAENTDEVRRCLAMTPGERA 116
Cdd:pfam20023   1 GHEAATELLKHCLETGKGITEENEEEVNSCLAVSWLEKA 39
TPR COG0790
TPR repeat [General function prediction only];
34-120 8.20e-04

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 41.84  E-value: 8.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  34 AEEGCPQMQYDLAKELLD-NSIEPNLAKgnqsqkAVNWLVSAAHNGHEDAVKLLRQCYNDGSGItAENTDEVRRCLamtp 112
Cdd:COG0790  166 AEQGDADAQYNLGVLYENgRGVPKDPAK------ALEWYRKAAEQGDADAQYNLGRLYLNGEGV-EKDLEKALRWL---- 234


                 ....*...
gi 320543151 113 gERAARKA 120
Cdd:COG0790  235 -RKAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
34-131 1.20e-03

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 41.45  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320543151  34 AEEGCPQMQYDLAKELLD-NSIEPNLAKgnqsqkAVNWLVSAAHNGHEDAVKLLRQCYNDGSGItAENTDEVRRCLamtp 112
Cdd:COG0790  130 AEQGDADAQYNLGLLYLNgEGVPKDPAK------AAEWYRKAAEQGDADAQYNLGVLYENGRGV-PKDPAKALEWY---- 198

                         90       100
                 ....*....|....*....|...
gi 320543151 113 gERAARK----AARELFACLSNG 131
Cdd:COG0790  199 -RKAAEQgdadAQYNLGRLYLNG 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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