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Conserved domains on  [gi|334184398|ref|NP_001189585|]
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histone-lysine N-methyltransferase SUVR5 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_3rep super family cl40149
Zinc finger C2H2-type, 3 repeats; This Pfam entry includes three instances of the Zinc finger ...
 737-862 1.21e-69

Zinc finger C2H2-type, 3 repeats; This Pfam entry includes three instances of the Zinc finger C2H2-type. They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array.


The actual alignment was detected with superfamily member pfam18868:

Pssm-ID: 408638 [Multi-domain]  Cd Length: 126  Bit Score: 228.92  E-value: 1.21e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398   737 CAICLDSFVRRKLLEIHVEERHHVQFAEKCMLLQCIPCGSHFGDKEQLLVHVQAVHPSECKSLTVASECNLTNGE-FSQK 815
Cdd:pfam18868    1 CAICLDSFTNKKVLETHVQERHHVQFVEQCMLLQCIPCGSHFGNTEQLWLHVLSVHPVDFRLSKAAQQPNLSAGEdSSQK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 334184398   816 PEAGSSQIvVSQNNENTSGVHKFVCKFCGLKFNLLPDLGRHHQAEHM 862
Cdd:pfam18868   81 PEPGNSAS-VENNSENLSGVRKFVCRFCGLKFDLLPDLGRHHQAAHM 126
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1124-1381 1.67e-65

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10542:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 245  Bit Score: 222.17  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILhPSMDLVKENLQLRCSCRSSvcspvtCdhvylfgndFEDARDIYGKSMRCRFPYDGKQRIILEEGYPVYEC 1203
Cdd:cd10542     3 FQYINDYIP-GDGVKIPEDFLVGCECTED------C---------HNNNPTCCPAESGVKFAYDKQGRLRLPPGTPIYEC 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1204 NKFCGCSRTCQNRVLQNGIRAKLEVFRTES-KGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDID 1282
Cdd:cd10542    67 NSRCKCGPDCPNRVVQRGRKVPLCIFRTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1283 ANindigrlmEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPS 1362
Cdd:cd10542   147 YN--------DDDCEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGG 218

                         250       260
                  ....*....|....*....|....*..
gi 334184398 1363 EQENEH--------PCHCKATNCRGLL 1381
Cdd:cd10542   219 SSESTIpkpkdvrvPCLCGSKNCRKYL 245
 
Name Accession Description Interval E-value
zf-C2H2_3rep pfam18868
Zinc finger C2H2-type, 3 repeats; This Pfam entry includes three instances of the Zinc finger ...
 737-862 1.21e-69

Zinc finger C2H2-type, 3 repeats; This Pfam entry includes three instances of the Zinc finger C2H2-type. They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array.


Pssm-ID: 408638 [Multi-domain]  Cd Length: 126  Bit Score: 228.92  E-value: 1.21e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398   737 CAICLDSFVRRKLLEIHVEERHHVQFAEKCMLLQCIPCGSHFGDKEQLLVHVQAVHPSECKSLTVASECNLTNGE-FSQK 815
Cdd:pfam18868    1 CAICLDSFTNKKVLETHVQERHHVQFVEQCMLLQCIPCGSHFGNTEQLWLHVLSVHPVDFRLSKAAQQPNLSAGEdSSQK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 334184398   816 PEAGSSQIvVSQNNENTSGVHKFVCKFCGLKFNLLPDLGRHHQAEHM 862
Cdd:pfam18868   81 PEPGNSAS-VENNSENLSGVRKFVCRFCGLKFDLLPDLGRHHQAAHM 126
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1124-1381 1.67e-65

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 222.17  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILhPSMDLVKENLQLRCSCRSSvcspvtCdhvylfgndFEDARDIYGKSMRCRFPYDGKQRIILEEGYPVYEC 1203
Cdd:cd10542     3 FQYINDYIP-GDGVKIPEDFLVGCECTED------C---------HNNNPTCCPAESGVKFAYDKQGRLRLPPGTPIYEC 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1204 NKFCGCSRTCQNRVLQNGIRAKLEVFRTES-KGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDID 1282
Cdd:cd10542    67 NSRCKCGPDCPNRVVQRGRKVPLCIFRTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1283 ANindigrlmEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPS 1362
Cdd:cd10542   147 YN--------DDDCEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGG 218

                         250       260
                  ....*....|....*....|....*..
gi 334184398 1363 EQENEH--------PCHCKATNCRGLL 1381
Cdd:cd10542   219 SSESTIpkpkdvrvPCLCGSKNCRKYL 245
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1224-1357 1.36e-38

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 140.16  E-value: 1.36e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398   1224 AKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY--GNGDCSYILDIDAnindigrlmeeelDYAID 1301
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYdtDGAKAFYLFDIDS-------------DLCID 67

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 334184398   1302 ATTHGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGR 1357
Cdd:smart00317   68 ARRKGNLARFINHSCEPNCELLFVEVNGD----DRIVIFALRDIKPGEELTIDYGS 119
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1235-1356 2.83e-26

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 104.53  E-value: 2.83e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398  1235 GWGLRACEHILRGTFVCEYIGE-VLDQQEANKRRNQYG-----NGDCSYILDIDanindigrlmeEELDYAIDATT--HG 1306
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYdklelRLWGPYLFTLD-----------EDSEYCIDARAlyYG 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 334184398  1307 NISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYG 1356
Cdd:pfam00856   70 NWARFINHSCDPNCEVRVVYVNGGP----RIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1225-1379 3.60e-24

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 99.27  E-value: 3.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCsYILDIDAnindigrlmeeelDYAIDATT 1304
Cdd:COG2940     7 RIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPLHT-YLFELDD-------------DGVIDGAL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334184398 1305 HGNISRFINHSCSPNlvnhqviVESMESPlAHIGLYASMDIAAGEEITRDYGrrpvPSEQENEHPCHCKatNCRG 1379
Cdd:COG2940    73 GGNPARFINHSCDPN-------CEADEED-GRIFIVALRDIAAGEELTYDYG----LDYDEEEYPCRCP--NCRG 133
 
Name Accession Description Interval E-value
zf-C2H2_3rep pfam18868
Zinc finger C2H2-type, 3 repeats; This Pfam entry includes three instances of the Zinc finger ...
 737-862 1.21e-69

Zinc finger C2H2-type, 3 repeats; This Pfam entry includes three instances of the Zinc finger C2H2-type. They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array.


Pssm-ID: 408638 [Multi-domain]  Cd Length: 126  Bit Score: 228.92  E-value: 1.21e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398   737 CAICLDSFVRRKLLEIHVEERHHVQFAEKCMLLQCIPCGSHFGDKEQLLVHVQAVHPSECKSLTVASECNLTNGE-FSQK 815
Cdd:pfam18868    1 CAICLDSFTNKKVLETHVQERHHVQFVEQCMLLQCIPCGSHFGNTEQLWLHVLSVHPVDFRLSKAAQQPNLSAGEdSSQK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 334184398   816 PEAGSSQIvVSQNNENTSGVHKFVCKFCGLKFNLLPDLGRHHQAEHM 862
Cdd:pfam18868   81 PEPGNSAS-VENNSENLSGVRKFVCRFCGLKFDLLPDLGRHHQAAHM 126
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1124-1381 1.67e-65

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 222.17  E-value: 1.67e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILhPSMDLVKENLQLRCSCRSSvcspvtCdhvylfgndFEDARDIYGKSMRCRFPYDGKQRIILEEGYPVYEC 1203
Cdd:cd10542     3 FQYINDYIP-GDGVKIPEDFLVGCECTED------C---------HNNNPTCCPAESGVKFAYDKQGRLRLPPGTPIYEC 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1204 NKFCGCSRTCQNRVLQNGIRAKLEVFRTES-KGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDID 1282
Cdd:cd10542    67 NSRCKCGPDCPNRVVQRGRKVPLCIFRTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLD 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1283 ANindigrlmEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPS 1362
Cdd:cd10542   147 YN--------DDDCEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGG 218

                         250       260
                  ....*....|....*....|....*..
gi 334184398 1363 EQENEH--------PCHCKATNCRGLL 1381
Cdd:cd10542   219 SSESTIpkpkdvrvPCLCGSKNCRKYL 245
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 1124-1381 5.05e-63

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 215.24  E-value: 5.05e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILHPSMDLVKENLQLR-CSCRSSVCSPVTCDHVYLFGNDFEDAR---DIYGKSMRcrfpydgkqriileegyP 1199
Cdd:cd10544     3 FQYTPENVPGPGADTDPNEITFPgCDCKTSSCEPETCSCLRKYGPNYDDDGcllDFDGKYSG-----------------P 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1200 VYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYIL 1279
Cdd:cd10544    66 VFECNSMCKCSESCQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYII 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1280 DIDANINDiGRLMEEeldyAIDATTHGNISRFINHSCSPNLVNHQVIVESMespLAHIGLYASMDIAAGEEITRDYGRRP 1359
Cdd:cd10544   146 VLREHLSS-GKVLET----FVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDYSGEF 217

                         250       260       270
                  ....*....|....*....|....*....|..
gi 334184398 1360 VPSEQENEH----------PCHCKATNCRGLL 1381
Cdd:cd10544   218 SNSVESVTLarqdesksrkPCLCGAENCRGFL 249
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1124-1356 8.37e-58

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 198.75  E-value: 8.37e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILHPSMDLVKENLQLR-CSCRSSvCSPVTCdhvylfgndfedardIYGKSMRCRFPYDGKQRIIL-EEGYPVY 1201
Cdd:cd10538     3 FTYIKDNIVGKNVQPFSNIIDSVgCKCKDD-CLDSKC---------------ACAAESDGIFAYTKNGLLRLnNSPPPIF 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1202 ECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDI 1281
Cdd:cd10538    67 ECNSKCSCDDDCKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFDL 146

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334184398 1282 DaninDIGRLMEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYG 1356
Cdd:cd10538   147 D----EFSDSDGDGEELCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 1093-1381 3.17e-53

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 188.27  E-value: 3.17e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1093 DISFGKESVPI-CVVDDDlwNSEKPYempwecFTYVTNSILHP--SMDLVKENLqLRCSC-------RSSVCSPVTCDHV 1162
Cdd:cd10517     8 DISYGKEGVPIpCVNEID--NSSPPY------VEYSKERIPGKgvNINLDPDFL-VGCDCtdgcrdkSKCACQQLTIEAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1163 YL--FGNDFEDARDIYGKSMRCrfpydgkqriiLEEGypVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRA 1240
Cdd:cd10517    79 AAtpGGQINPSAGYQYRRLMEK-----------LPTG--VYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRC 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1241 CEHILRGTFVCEYIGEVLDQQEANKRRNQYGNgdcSYILDIDaNINDIGRLME------EELDYAIDATTHGNISRFINH 1314
Cdd:cd10517   146 LDDIPKGSFVCIYAGQILTEDEANEEGLQYGD---EYFAELD-YIEVVEKLKEgyesdvEEHCYIIDAKSEGNLGRYLNH 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184398 1315 SCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGrRPVPSEQENEHPCHCKATNCRGLL 1381
Cdd:cd10517   222 SCSPNLFVQNVFVDTHDLRFPWVAFFASRYIRAGTELTWDYN-YEVGSVPGKVLYCYCGSSNCRGRL 287
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1124-1378 3.22e-49

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 174.83  E-value: 3.22e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNS--ILHPSMDLVKENLQLrCSCRSSvCSPVTCDHVylfgndfedardiyGKSMRCRFPYDG--KQRIILEEGYP 1199
Cdd:cd10543     3 FLYVTENceTSPLNIDRNITSLQT-CSCRDD-CSSDNCVCG--------------RLSVRCWYDKEGrlLPDFNKLDPPL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1200 VYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRnqygngDCSYIL 1279
Cdd:cd10543    67 IFECNRACSCWRNCRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSRE------DDSYLF 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1280 DIDANINDIgrlmeeeldYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRp 1359
Cdd:cd10543   141 DLDNKDGET---------YCIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDYGEK- 210

                         250
                  ....*....|....*....
gi 334184398 1360 VPSEQENEHPCHCKATNCR 1378
Cdd:cd10543   211 FWRIKGKYFTCRCGSPKCK 229
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 1184-1381 1.80e-48

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 173.91  E-value: 1.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1184 FPYDGKQRIILEEGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEA 1263
Cdd:cd20073    53 FAYDEYGRVRANTGSIIYECNENCDCGINCPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1264 NKRRNQYGNGDCSYILDIDanindigrLMEEELD--YAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYA 1341
Cdd:cd20073   133 EIRGKKYDNVGVTYLFDLD--------LFEDQVDeyYTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFA 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 334184398 1342 SMDIAAGEEITRDYGRRPVPSE--------------QENEHPCHCKATNCRGLL 1381
Cdd:cd20073   205 IKDIPALEELTFDYSGRNNFDQlgfignrsnskyinLKNKRPCYCGSANCRGWL 258
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 1124-1356 2.54e-45

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 163.73  E-value: 2.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILHPSMDLVKenLQLRCSCRSSvCSPVTCDHVYLFGNDFEdardiygksmrcrFPYDGKQRIIleEGYP-VYE 1202
Cdd:cd10545     3 FTYTVKLIIPPGVSLPV--PSTGCDCKNR-CTDGASDCACVKKNGGE-------------IPYNFNGRLI--RAKPaIYE 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1203 CNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRnqyGNGDcsYILDID 1282
Cdd:cd10545    65 CGPLCKCPPSCYNRVTQKGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRS---GNDD--YLFDID 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1283 ---------------ANINDIGRLMEEE---LDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMD 1344
Cdd:cd10545   140 nrqtnrgwdggqrldVGMSDGERSSAEDeesSEFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADN 219

                         250
                  ....*....|..
gi 334184398 1345 IAAGEEITRDYG 1356
Cdd:cd10545   220 IPPLQELTYDYG 231
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1179-1378 1.41e-44

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 161.64  E-value: 1.41e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1179 SMRCRFPYDGkqRIILE----EGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYI 1254
Cdd:cd10535    44 SMRCWYDKDG--RLLPEfnmaEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1255 GEVLDQQEANKRRnqygngDCSYILDIDANINDIgrlmeeeldYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPL 1334
Cdd:cd10535   122 GELISDSEADVRE------EDSYLFDLDNKDGEV---------YCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRF 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 334184398 1335 AHIGLYASMDIAAGEEITRDYGRRpVPSEQENEHPCHCKATNCR 1378
Cdd:cd10535   187 PRIAFFSTRLIEAGEQLGFDYGER-FWDIKGKLFSCRCGSPKCR 229
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1184-1381 2.93e-43

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 158.13  E-value: 2.93e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1184 FPYDGKQRIILEEGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTES-KGWGLRACEHILRGTFVCEYIGEVLDQQE 1262
Cdd:cd10532    44 FAYNEHGQLKIPPGTPIYECNSRCKCGPDCPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEE 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1263 ANKRRNQYGNGDCSYILDIDAnindigrlmeEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYAS 1342
Cdd:cd10532   124 AERRGQFYDSKGITYLFDLDY----------ESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFST 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 334184398 1343 MDIAAGEEITRDY---GRRPVPSEQENEHP--------CHCKATNCRGLL 1381
Cdd:cd10532   194 RTIKAGEELTFDYqmkGSGDLSSDSIDNSPakkrvrtvCKCGAVTCRGYL 243
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 1179-1381 8.07e-42

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 154.28  E-value: 8.07e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1179 SMRCRFPYDGKQRIILEEGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTES-KGWGLRACEHILRGTFVCEYIGEV 1257
Cdd:cd10525    41 ASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1258 LDQQEANKRRNQYGNGDCSYILDIDAnINDIgrlmeeeldYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHI 1337
Cdd:cd10525   121 ITSEEAERRGQIYDRQGATYLFDLDY-VEDV---------YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRI 190

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334184398 1338 GLYASMDIAAGEEITRDYGRRPVPSEQENEH--------------------PCHCKATNCRGLL 1381
Cdd:cd10525   191 ALFATRTIRAGEELTFDYNMQVDPVDAESTKmdsnfglaglpgspkkrvriECKCGVRSCRKYL 254
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 1124-1381 4.74e-41

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 152.86  E-value: 4.74e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILHPSMDLVKENLQLRCSCRSSV-CSPVTCDhvYLFGNDFEDARDIYGKsmrcRFPY--DGKQRIILEEGY-- 1198
Cdd:cd19473     3 FRFIEKSILGEGVELADEEFRSGCECTDDEdCMYSGCL--CLQDVDPDDDRDPGKK----KNAYhsSGAKKGCLRGHMln 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1199 ---PVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTES-KGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGD 1274
Cdd:cd19473    77 srlPIYECHEGCACSDDCPNRVVERGRKVPLQIFRTSDgRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATIAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1275 CS--YILDIDANINDIGrlMEEELD---YAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGE 1349
Cdd:cd19473   157 RKdvYLFALDKFSDPDS--LDPRLRgdpYEIDGEFMSGPTRFINHSCDPNLRIFARVGDHADKHIHDLAFFAIKDIPRGT 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 334184398 1350 EITRDY--------GRRPVPSEQENEHPCHCKATNCRGLL 1381
Cdd:cd19473   235 ELTFDYvdgvtgldDDAGDEEKEKEMTKCLCGSPKCRGYL 274
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 1124-1378 5.84e-41

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 151.32  E-value: 5.84e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1124 FTYVTNSILHPSMDLVKENLQLR-CSCRSSvCSPVTCdhvyLFGNdfedardiygKSMRCRfpYDGKQRIILE----EGY 1198
Cdd:cd10533     3 YKYISENCETSTMNIDRNITHLQhCTCVDD-CSSSNC----LCGQ----------LSIRCW--YDKDGRLLQEfnkiEPP 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1199 PVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRnqygngDCSYI 1278
Cdd:cd10533    66 LIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE------DDSYL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1279 LDIDANINDIgrlmeeeldYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRR 1358
Cdd:cd10533   140 FDLDNKDGEV---------YCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDR 210

                         250       260
                  ....*....|....*....|
gi 334184398 1359 pVPSEQENEHPCHCKATNCR 1378
Cdd:cd10533   211 -FWDIKSKYFTCQCGSEKCK 229
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 1194-1379 4.80e-40

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 149.60  E-value: 4.80e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1194 LEEGYP--VYECNKFCGCSRT-CQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLdqQEANKRRNQY 1270
Cdd:cd10523    75 LQEPIPsgLYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKTEKKGWGVRCLDDIDKGTFVCIYAGRVL--SRARSPTEPL 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1271 GNGDCSYILDID-----ANINDIGRLMEEELdYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDI 1345
Cdd:cd10523   153 PPKLELPSENEVevvtsWLILSKKRKLRENV-CFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVV 231

                         170       180       190
                  ....*....|....*....|....*....|....
gi 334184398 1346 AAGEEITRDYGRRPvPSEQENEHPCHCKATNCRG 1379
Cdd:cd10523   232 KAGTELTWDYSYDA-GTSPEQEIPCLCGVNKCQK 264
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 1185-1381 5.13e-39

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 145.76  E-value: 5.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1185 PYDGKQRIILEEGYP--VYECNKFCGCSRT-CQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQ 1261
Cdd:cd10541    50 PTAGYQYKRLEECLPtgVYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1262 EANKRRNQYGNgdcsyilDIDANINDIgrlmeEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYA 1341
Cdd:cd10541   130 FADKEGLEMGD-------EYFANLDHI-----EESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 334184398 1342 SMDIAAGEEITRDYGRRpVPSEQENEHPCHCKATNCRGLL 1381
Cdd:cd10541   198 SKRIKAGTELTWDYNYE-VGSVEGKELLCCCGSNECRGRL 236
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1224-1357 1.36e-38

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 140.16  E-value: 1.36e-38
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398   1224 AKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY--GNGDCSYILDIDAnindigrlmeeelDYAID 1301
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYdtDGAKAFYLFDIDS-------------DLCID 67

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 334184398   1302 ATTHGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGR 1357
Cdd:smart00317   68 ARRKGNLARFINHSCEPNCELLFVEVNGD----DRIVIFALRDIKPGEELTIDYGS 119
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 1224-1381 3.84e-37

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 136.56  E-value: 3.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1224 AKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYgngdcsyildiDANINDIGRLMEEELDYAIDAT 1303
Cdd:cd19172     2 AKVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEY-----------AREGNRHYYFMALKSDEIIDAT 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1304 THGNISRFINHSCSPN------LVNHQVivesmesplaHIGLYASMDIAAGEEITRDY-----GRRPVpseqenehPCHC 1372
Cdd:cd19172    71 KKGNLSRFINHSCEPNcetqkwTVNGEL----------RVGFFAKRDIPAGEELTFDYqferyGKEAQ--------KCYC 132


                  ....*....
gi 334184398 1373 KATNCRGLL 1381
Cdd:cd19172   133 GSPNCRGYI 141
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 1225-1378 6.64e-37

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 135.85  E-value: 6.64e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGD--CSYILDIDAnindigrlmeeelDYAIDA 1302
Cdd:cd10531     1 KLELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGksNFYILSLSD-------------DVVIDA 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334184398 1303 TTHGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGrrpvpSEQENEH--PCHCKATNCR 1378
Cdd:cd10531    68 TRKGNLSRFINHSCEPNCETQKWIVNGE----YRIGIFALRDIPAGEELTFDYN-----FVNYNEAkqVCLCGAQNCR 136
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 1214-1378 5.94e-35

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 130.79  E-value: 5.94e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1214 QNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY---GNGDCsYILDIDAnindigr 1290
Cdd:cd10518     4 RFRQLRSRLKERLRVGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYdeeGGGGT-YMFRIDE------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1291 lmeeelDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYgrrPVPSEQENEHPC 1370
Cdd:cd10518    76 ------DLVIDATKKGNIARFINHSCDPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDY---KFPIEDEEKIPC 142


                  ....*...
gi 334184398 1371 HCKATNCR 1378
Cdd:cd10518   143 LCGAPNCR 150
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 1225-1381 2.15e-33

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 125.99  E-value: 2.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRrnqygngdcsyILDIDANINDIGRLMEEELDYAIDATT 1304
Cdd:cd19175     1 KMKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEER-----------LWDMKHKGEKNFYMCEIDKDMVIDATF 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184398 1305 HGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGRRPVPSEQEnehpCHCKATNCRGLL 1381
Cdd:cd19175    70 KGNLSRFINHSCDPNCELQKWQVDGE----TRIGVFAIRDIKKGEELTYDYQFVQFGADQD----CHCGSKNCRGKL 138
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1225-1381 3.15e-33

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 125.48  E-value: 3.15e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRN-QYGNGDCSYILDIDANIndigrlmeeeldyAIDAT 1303
Cdd:cd19174     1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIeQYHNHSHHYCLNLDSGM-------------VIDGY 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1304 THGNISRFINHSCSPNL------VNHQvivesmesplAHIGLYASMDIAAGEEITRDYGRRPVpsEQENEHPCHCKATNC 1377
Cdd:cd19174    68 RMGNEARFVNHSCDPNCemqkwsVNGV----------YRIGLFALKDIPAGEELTYDYNFHSF--NVEKQQPCKCGSPNC 135


                  ....
gi 334184398 1378 RGLL 1381
Cdd:cd19174   136 RGVI 139
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 1224-1381 2.37e-30

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 117.42  E-value: 2.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1224 AKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCS--YILDIDAnindigrlmeeelDYAID 1301
Cdd:cd19173     2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITnfYMLTLDK-------------DRIID 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1302 ATTHGNISRFINHSCSPNL------VNHQVivesmesplaHIGLYASMDIAAGEEITRDYGrrpVPSEQENEHPCHCKAT 1375
Cdd:cd19173    69 AGPKGNLSRFMNHSCQPNCetqkwtVNGDT----------RVGLFAVRDIPAGEELTFNYN---LDCLGNEKKVCRCGAP 135


                  ....*.
gi 334184398 1376 NCRGLL 1381
Cdd:cd19173   136 NCSGFL 141
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1223-1378 3.08e-29

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 114.36  E-value: 3.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1223 RAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY---GNGDcSYILDIDAnindigrlmeeelDYA 1299
Cdd:cd19169    12 KKQLKFAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYeaiGIGS-SYLFRVDD-------------DTI 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334184398 1300 IDATTHGNISRFINHSCSPNLVNHQVIVESMESplahIGLYASMDIAAGEEITRDYgrrPVPSEqENEHPCHCKATNCR 1378
Cdd:cd19169    78 IDATKCGNLARFINHSCNPNCYAKIITVESQKK----IVIYSKRPIAVNEEITYDY---KFPIE-DEKIPCLCGAPQCR 148
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 1236-1378 2.02e-26

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 106.35  E-value: 2.02e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1236 WGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY---GNGDcSYILDIDAnindigrlmeeelDYAIDATTHGNISRFI 1312
Cdd:cd20072    25 WGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYlrqGIGS-SYLFRIDD-------------DTVVDATKKGNIARFI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334184398 1313 NHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYgrrPVPSEqENEHPCHCKATNCR 1378
Cdd:cd20072    91 NHCCDPNCTAKIIKVEGEK----RIVIYAKRDIAAGEELTYDY---KFPRE-EDKIPCLCGAPNCR 148
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1235-1356 2.83e-26

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 104.53  E-value: 2.83e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398  1235 GWGLRACEHILRGTFVCEYIGE-VLDQQEANKRRNQYG-----NGDCSYILDIDanindigrlmeEELDYAIDATT--HG 1306
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYdklelRLWGPYLFTLD-----------EDSEYCIDARAlyYG 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 334184398  1307 NISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYG 1356
Cdd:pfam00856   70 NWARFINHSCDPNCEVRVVYVNGGP----RIVIFALRDIKPGEELTIDYG 115
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 1235-1356 1.54e-25

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 102.71  E-value: 1.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1235 GWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILdidaNINDigrlmeeelDYAIDATTHGNISRFINH 1314
Cdd:cd10519    12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSSYLF----NLND---------QFVVDATRKGNKIRFANH 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 334184398 1315 SCSPN------LVNHQvivesmesplAHIGLYASMDIAAGEEITRDYG 1356
Cdd:cd10519    79 SSNPNcyakvmMVNGD----------HRIGIFAKRDIEAGEELFFDYG 116
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 1216-1381 9.64e-25

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 101.70  E-value: 9.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1216 RVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY-GNGDCSYILDIDanindigrlmee 1294
Cdd:cd19170     6 RHLRKTAKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYeSKGIGCYMFRID------------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1295 eLDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYgrrPVPSEqENEHPCHCKA 1374
Cdd:cd19170    74 -DDEVVDATMHGNAARFINHSCEPNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDY---KFPIE-DVKIPCTCGS 144


                  ....*..
gi 334184398 1375 TNCRGLL 1381
Cdd:cd19170   145 KKCRKYL 151
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 1227-1381 1.19e-24

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 101.22  E-value: 1.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1227 EVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCS--YILDIDAnindigrlmeeelDYAIDATT 1304
Cdd:cd19211     5 KIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDIThfYMLTIDK-------------DRIIDAGP 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184398 1305 HGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGRRPVPSEQEnehPCHCKATNCRGLL 1381
Cdd:cd19211    72 KGNYSRFMNHSCQPNCETQKWTVNGD----TRVGLFAVCDIPAGTELTFNYNLDCLGNEKT---VCRCGAPNCSGFL 141
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1225-1379 3.60e-24

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 99.27  E-value: 3.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCsYILDIDAnindigrlmeeelDYAIDATT 1304
Cdd:COG2940     7 RIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPLHT-YLFELDD-------------DGVIDGAL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334184398 1305 HGNISRFINHSCSPNlvnhqviVESMESPlAHIGLYASMDIAAGEEITRDYGrrpvPSEQENEHPCHCKatNCRG 1379
Cdd:COG2940    73 GGNPARFINHSCDPN-------CEADEED-GRIFIVALRDIAAGEELTYDYG----LDYDEEEYPCRCP--NCRG 133
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1227-1381 6.63e-24

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 98.84  E-value: 6.63e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1227 EVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKR-RNQYGNGDCS-YILDIDAnindigrlmeeelDYAIDATT 1304
Cdd:cd19212     5 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRiKRAHENSVTNfYMLTVTK-------------DRIIDAGP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1305 HGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDY-------GRRpvpseqenehPCHCKATNC 1377
Cdd:cd19212    72 KGNYSRFMNHSCNPNCETQKWTVNGD----VRVGLFALCDIPAGMELTFNYnldclgnGRT----------ECHCGADNC 137


                  ....
gi 334184398 1378 RGLL 1381
Cdd:cd19212   138 SGFL 141
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 1230-1379 9.66e-24

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 98.66  E-value: 9.66e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1230 RTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCS-YILDIDAnindigrlmeeelDYAIDATTHGNI 1308
Cdd:cd19171    20 RSRIQGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNRGiYMFRIDN-------------DWVIDATMTGGP 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334184398 1309 SRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYgrRPVPSEQENEHPCHCKATNCRG 1379
Cdd:cd19171    87 ARYINHSCNPNCVAEVVTFDKEK----KIIIISNRRIAKGEELTYDY--KFDFEDDQHKIPCLCGAPNCRK 151
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1225-1381 3.78e-23

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 96.92  E-value: 3.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCS--YILDIDAnindigrlmeeelDYAIDA 1302
Cdd:cd19210     3 EVEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITnfYMLTLDK-------------DRIIDA 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334184398 1303 TTHGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGRRPVPSeqeNEHPCHCKATNCRGLL 1381
Cdd:cd19210    70 GPKGNYARFMNHCCQPNCETQKWTVNGD----TRVGLFALCDIKAGTELTFNYNLECLGN---GKTVCKCGAPNCSGFL 141
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 1223-1382 2.97e-21

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 91.62  E-value: 2.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1223 RAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY---GNGDcSYILDIDAnindigrlmeeelDYA 1299
Cdd:cd19204    13 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYvqeGIGS-SYLFRVDH-------------DTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1300 IDATTHGNISRFINHSCSPNLVNHQVIVESMESplahIGLYASMDIAAGEEITRDYgRRPVpseQENEHPCHCKATNCRG 1379
Cdd:cd19204    79 IDATKCGNLARFINHCCTPNCYAKVITIESQKK----IVIYSKQPIGVNEEITYDY-KFPI---EDNKIPCLCGTENCRG 150


                  ...
gi 334184398 1380 LLS 1382
Cdd:cd19204   151 TLN 153
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 1216-1358 3.65e-21

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 91.10  E-value: 3.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1216 RVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYG---NGDCsYILDIDANindiGRlm 1292
Cdd:cd10528     9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAkdpSTGC-YMYYFQYK----GK-- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334184398 1293 eeelDYAIDATTH-GNISRFINHSC-SPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYGRR 1358
Cdd:cd10528    82 ----TYCVDATKEsGRLGRLINHSKkKPNLKTKLLVIDGVP----HLILVAKRDIKPGEELLYDYGDR 141
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 1094-1216 1.53e-20

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 87.86  E-value: 1.53e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398  1094 ISFGKESVPICV---VDDDLwnsekpyemPWECFTYVTNSILHPSMDLVKENlqlRCSCRSsvCSPVTCDHVYLFGNDFe 1170
Cdd:pfam05033    1 ISKGKENVPIPVvneVDDEP---------PPPDFTYITSYIYPKEFLLIIPQ---GCDCGD--CSSEKCSCAQLNGGEF- 65

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 334184398  1171 dardiygksmrcRFPYDGKQRIILEEGYPVYECNKFCGCSRTCQNR 1216
Cdd:pfam05033   66 ------------RFPYDKDGLLVPESKPPIYECNPLCGCPPSCPNR 99
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 1216-1382 5.46e-20

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 88.16  E-value: 5.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1216 RVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGN-GDCSYILDIDanindigrlmee 1294
Cdd:cd19206     6 RHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSkGIGCYMFRID------------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1295 elDY-AIDATTHGNISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYgRRPVpSEQENEHPCHCK 1373
Cdd:cd19206    74 --DSeVVDATMHGNAARFINHSCEPNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDY-KFPI-EDASNKLPCNCG 145


                  ....*....
gi 334184398 1374 ATNCRGLLS 1382
Cdd:cd19206   146 AKKCRKFLN 154
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 1233-1356 2.19e-19

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 85.09  E-value: 2.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1233 SKGWGLRACEHILRGTFVCEYIGEVLDQQEANkRRNQYGNGDcSYILDIDANIndigrlmeeeldYAIDATTHGNISRFI 1312
Cdd:cd10522    12 HNGLGLFAAETIAKGEFVGEYTGEVLDRWEED-RDSVYHYDP-LYPFDLNGDI------------LVIDAGKKGNLTRFI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 334184398 1313 NHSCSPNLvnhqvivESMESPLA---HIGLYASMDIAAGEEITRDYG 1356
Cdd:cd10522    78 NHSDQPNL-------ELIVRTLKgeqHIGFVAIRDIKPGEELFISYG 117
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 1223-1382 3.10e-18

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 83.18  E-value: 3.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1223 RAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY---GNGDcSYILDIDAnindigrlmeeelDYA 1299
Cdd:cd19205    13 KKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYedeGIGS-SYMFRVDH-------------DTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1300 IDATTHGNISRFINHSCSPNLVNHQVIVESMESplahIGLYASMDIAAGEEITRDYgRRPVPSEQEnehPCHCKATNCRG 1379
Cdd:cd19205    79 IDATKCGNFARFINHSCNPNCYAKVITVESQKK----IVIYSKQHINVNEEITYDY-KFPIEDVKI---PCLCGSENCRG 150


                  ...
gi 334184398 1380 LLS 1382
Cdd:cd19205   151 TLN 153
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 1210-1378 9.04e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 81.60  E-value: 9.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1210 SRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY-GNGDCSYILDIDAnindi 1288
Cdd:cd19208     1 SKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYeSQNRGVYMFRIDN----- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1289 grlmeeelDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESplahIGLYASMDIAAGEEITRDYgrRPVPSEQENEH 1368
Cdd:cd19208    76 --------DHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGHK----IIISSSRRIQKGEELCYDY--KFDFEDDQHKI 141

                         170
                  ....*....|
gi 334184398 1369 PCHCKATNCR 1378
Cdd:cd19208   142 PCHCGAVNCR 151
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 1237-1352 5.13e-17

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 78.47  E-value: 5.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1237 GLRACEHILRGTFVCEYIGEVLDQQEAnKRRNQYGNGDCSYILDIDANindigrlmeEELDYAIDATTHGNISRFINHSC 1316
Cdd:cd10529    18 GLVATEDISPGEPILEYKGEVSLRSEF-KEDNGFFKRPSPFVFFYDGF---------EGLPLCVDARKYGNEARFIRRSC 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 334184398 1317 SPNLVNHQVIVEsmESPLaHIGLYASMDIAAGEEIT 1352
Cdd:cd10529    88 RPNAELRHVVVS--NGEL-RLFIFALKDIRKGTEIT 120
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 1221-1355 1.73e-16

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 76.88  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1221 GIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILdidaNINDigrlmeeelDYAI 1300
Cdd:cd19218     1 GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLF----NLNN---------DFVV 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334184398 1301 DATTHGNISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDY 1355
Cdd:cd19218    68 DATRKGNKIRFANHSVNPNCYAKVMMVNGDH----RIGIFAKRAIQTGEELFFDY 118
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 1210-1378 2.10e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 77.81  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1210 SRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCS-YILDIDAnindi 1288
Cdd:cd19209     2 SKSSQYRRLKTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGiYMFRINN----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1289 grlmeeelDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESplahIGLYASMDIAAGEEITRDYgrRPVPSEQENEH 1368
Cdd:cd19209    77 --------EHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDK----IIIISSRRIPKGEELTYDY--QFDFEDDQHKI 142

                         170
                  ....*....|
gi 334184398 1369 PCHCKATNCR 1378
Cdd:cd19209   143 PCHCGAWNCR 152
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 1216-1382 2.17e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 77.76  E-value: 2.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1216 RVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQY-GNGDCSYILDIDanindigrlmee 1294
Cdd:cd19207     6 RHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYdSKGIGCYMFRID------------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1295 ELDyAIDATTHGNISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDYgRRPVpSEQENEHPCHCKA 1374
Cdd:cd19207    74 DFD-VVDATMHGNAARFINHSCEPNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDY-KFPI-EDASNKLPCNCGA 146


                  ....*...
gi 334184398 1375 TNCRGLLS 1382
Cdd:cd19207   147 KRCRRFLN 154
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 1219-1355 6.61e-15

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 72.79  E-value: 6.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1219 QNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILdidaNINDigrlmeeelDY 1298
Cdd:cd19217     1 QRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLF----NLNN---------DF 67

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 334184398 1299 AIDATTHGNISRFINHSCSPNLVNHQVIVESMEsplaHIGLYASMDIAAGEEITRDY 1355
Cdd:cd19217    68 VVDATRKGNKIRFANHSVNPNCYAKVVMVNGDH----RIGIFAKRAIQQGEELFFDY 120
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 1235-1358 5.33e-14

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 69.91  E-value: 5.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1235 GWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDIDANIndigrlmeeeldyAIDATTHGNISRFINH 1314
Cdd:cd19168    13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQEGI-------------WVDAAIYGNLSRYINH 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 334184398 1315 S--------CSPNLV--NHQVivesmesplaHIGLYASMDIAAGEEITRDYGRR 1358
Cdd:cd19168    80 AtdkvktgnCMPKIMyvNHEW----------RIKFTAIKDIKIGEELFFNYGDN 123
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1225-1356 5.18e-12

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 62.65  E-value: 5.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1225 KLEVFRTESKGWGLRACEHILRGTFVCeyigevldqqeankrrnqygngdcsyildidanindigrlmeeeldyaidatt 1304
Cdd:cd08161     1 EIRPSTIPGAGFGLFATRDIPKGEVIG----------------------------------------------------- 27

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 334184398 1305 hgnISRFINHSCSPNLVnhqvIVESMESPLAHIGLYASMDIAAGEEITRDYG 1356
Cdd:cd08161    28 ---LARFINHSCEPNCE----FEEVYVGGKPRVFIVALRDIKAGEELTVDYG 72
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 1224-1371 7.97e-09

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 56.64  E-value: 7.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1224 AKLEVFRTESKGW-GLRACEHILRGTFVCEYIGEVLDQQEankrrnqygngdcsYILDidaNINDIGRL--------MEE 1294
Cdd:cd19183     1 TEISSIGLANASRfGLFADRPIPAGDPIQELLGEIGLQSE--------------YIAD---PENQYQILgapkphvfFHP 63

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184398 1295 ELDYAIDATTHGNISRFINHSCSPNLVnhQVIVESMESPLAHIGLYASMDIAAGEEITrdygrrpVPSEQENEHPCH 1371
Cdd:cd19183    64 QSPLYIDTRRSGSVARFIRRSCRPNAE--LVTVASDSGSVLKFVLYASRDISPGEEIT-------IGWDWDNPHPFR 131
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 1091-1208 1.91e-08

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 53.19  E-value: 1.91e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398   1091 CKDISFGKESVPICVVDDdlWNSEKPYEMpwecFTYVTNSILHPSMDLVKENLQLR-CSCrSSVCSPvtcdhvylfGNDF 1169
Cdd:smart00468    1 CLDISNGKENVPVPLVNE--VDEDPPPPD----FEYISEYIYGQGVPIDRSPSPLVgCSC-SGDCSS---------SNKC 64

                            90       100       110
                    ....*....|....*....|....*....|....*....
gi 334184398   1170 EDARDIYGKsmrcrFPYDGKQRIILEEGYPVYECNKFCG 1208
Cdd:smart00468   65 ECARKNGGE-----FAYELNGGLRLKRKPLIYECNSRCS 98
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 1238-1377 8.97e-06

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 46.92  E-value: 8.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184398 1238 LRACEHILRGTFVCEYIGEVLDQQ--EANkrrNQYGNGDCSYILdIDANINdigrlmeeELDYAIDATTHGNISRFINHS 1315
Cdd:cd19181    21 LRAARDLALDTLIIEYRGKVMLRQqfEVN---GHFFKRPYPFVL-FYSKFN--------GVEMCVDARTFGNDARFIRRS 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334184398 1316 CSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEITRDYGRRPVPSEQENEHPCHCKATNC 1377
Cdd:cd19181    89 CTPNAEVRHMIADGM----IHLCIYAVAAIAKDAEVTIAFDYEYSNCNYKVDCACHKGNRNC 146
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 1296-1356 3.23e-05

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 44.88  E-value: 3.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334184398 1296 LDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMesplAHIGLYASMDIAAGEEIT----RDYG 1356
Cdd:cd19182    69 LEMCVDARTFGNEARFIRRSCTPNAEVRHVIEDGT----IHLYIYSIRSIPKGTEITiafdFDYG 129
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 1311-1374 2.22e-04

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 42.36  E-value: 2.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334184398 1311 FINHSCSPNlvnhqviVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPSEQENEH-------PCHCKA 1374
Cdd:cd20071    58 LLNHSCDPN-------AVVVFDGNGTLRVRALRDIKAGEELTISYIDPLLPRTERRREllekygfTCSCPR 121
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 1310-1357 2.78e-04

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 42.65  E-value: 2.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 334184398 1310 RFINHSCSPNlvnhqVIVESMESPLAHIglYASMDIAAGEEITRDYGR 1357
Cdd:cd10524    78 AFINHDCRPN-----CKFVPTGKSTACV--KVLRDIEPGEEITVYYGD 118
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 1311-1374 3.76e-03

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 40.36  E-value: 3.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334184398 1311 FINHSCSPNLVNH---QVIVesmesplahigLYASMDIAAGEEITRDYG----RRPVPSEQE---NEH--PCHCKA 1374
Cdd:cd10536   153 LLNHSCDPNTIRSfygNTIV-----------VRATRPIKKGEEITICYGphfsRMKRSERQRllkEQYffDCSCEA 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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