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Conserved domains on  [gi|334185611|ref|NP_001189968|]
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F-box associated ubiquitination effector family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F_box_assoc_1 super family cl44343
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 56-217 1.76e-28

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


The actual alignment was detected with superfamily member TIGR01640:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 107.06  E-value: 1.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185611   56 FYHCEGLLlCILKDDsRFVVCNPYLEQTRWIEPRYSHRPYGMDRfSYALGYVNTDSCrsYKLLRFIDYYYNAPEKQFfwy 135
Cdd:TIGR01640   1 VVPCDGLI-CFSYGK-RLVVWNPSTGQSRWLPTPKSRRSNKESD-TYFLGYDPIEKQ--YKVLCFSDRSGNRNQSEH--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185611  136 EVYDFDSDLWTTLDVTPHWrIAFCNTGVPFKGNTYWCAAERNVDVDEVLanrlICFDFTSERFGPLLPLPFSG-GHHDYT 214
Cdd:TIGR01640  73 QVYTLGSNSWRTIECSPPH-HPLKSRGVCINGVLYYLAYTLKTNPDYFI----VSFDVSSERFKEFIPLPCGNsDSVDYL 147


                  ...
gi 334185611  215 TLS 217
Cdd:TIGR01640 148 SLI 150
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 56-217 1.76e-28

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 107.06  E-value: 1.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185611   56 FYHCEGLLlCILKDDsRFVVCNPYLEQTRWIEPRYSHRPYGMDRfSYALGYVNTDSCrsYKLLRFIDYYYNAPEKQFfwy 135
Cdd:TIGR01640   1 VVPCDGLI-CFSYGK-RLVVWNPSTGQSRWLPTPKSRRSNKESD-TYFLGYDPIEKQ--YKVLCFSDRSGNRNQSEH--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185611  136 EVYDFDSDLWTTLDVTPHWrIAFCNTGVPFKGNTYWCAAERNVDVDEVLanrlICFDFTSERFGPLLPLPFSG-GHHDYT 214
Cdd:TIGR01640  73 QVYTLGSNSWRTIECSPPH-HPLKSRGVCINGVLYYLAYTLKTNPDYFI----VSFDVSSERFKEFIPLPCGNsDSVDYL 147


                  ...
gi 334185611  215 TLS 217
Cdd:TIGR01640 148 SLI 150
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 162-219 8.95e-20

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 82.27  E-value: 8.95e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 334185611  162 GVPFKGNTYWCAAERNVDVDEVLanrlICFDFTSERFGPLLPLPFSGGHHDYTTLSCV 219
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEEDFL----LSFDFTTERFGPRLPLPFQSPDLDTVSLSVV 54
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 56-217 1.76e-28

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 107.06  E-value: 1.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185611   56 FYHCEGLLlCILKDDsRFVVCNPYLEQTRWIEPRYSHRPYGMDRfSYALGYVNTDSCrsYKLLRFIDYYYNAPEKQFfwy 135
Cdd:TIGR01640   1 VVPCDGLI-CFSYGK-RLVVWNPSTGQSRWLPTPKSRRSNKESD-TYFLGYDPIEKQ--YKVLCFSDRSGNRNQSEH--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185611  136 EVYDFDSDLWTTLDVTPHWrIAFCNTGVPFKGNTYWCAAERNVDVDEVLanrlICFDFTSERFGPLLPLPFSG-GHHDYT 214
Cdd:TIGR01640  73 QVYTLGSNSWRTIECSPPH-HPLKSRGVCINGVLYYLAYTLKTNPDYFI----VSFDVSSERFKEFIPLPCGNsDSVDYL 147


                  ...
gi 334185611  215 TLS 217
Cdd:TIGR01640 148 SLI 150
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 162-219 8.95e-20

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 82.27  E-value: 8.95e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 334185611  162 GVPFKGNTYWCAAERNVDVDEVLanrlICFDFTSERFGPLLPLPFSGGHHDYTTLSCV 219
Cdd:pfam07734   1 GVSLKGNTYWLAREKETNEEDFL----LSFDFTTERFGPRLPLPFQSPDLDTVSLSVV 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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