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Conserved domains on  [gi|1063708369|ref|NP_001190150|]
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BON association protein 1 [Arabidopsis thaliana]

Protein Classification

C2 domain-containing protein( domain architecture ID 10134346)

C2 domain-containing protein similar to Arabidopsis thaliana BON1-associated protein, which may act as negative regulator of cell death and defense responses and exhibit calcium-dependent phospholipid binding properties

CATH:  2.60.40.150
Gene Ontology:  GO:0005544|GO:0005509
PubMed:  8976547|9632630
SCOP:  3000965

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C2_SRC2_like cd04051
C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins; SRC2 production ...
 19-137 2.90e-40

C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins; SRC2 production is a response to pathogen infiltration. The initial response of increased Ca2+ concentrations are coupled to downstream signal transduction pathways via calcium binding proteins. SRC2 contains a single C2 domain which localizes to the plasma membrane and is involved in Ca2+ dependent protein binding. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


:

Pssm-ID: 176016 [Multi-domain]  Cd Length: 125  Bit Score: 133.12  E-value: 2.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKID-EKCRKSNLDESRRSNPTWNYKSEMPI-----NGNEQFIFIEVFYRTGSG 92
Cdd:cd04051     1 TLEITIISAEDLKNVNLFGKMKVYAVVWIDpSHKQSTPVDRDGGTNPTWNETLRFPLderllQQGRLALTIEVYCERPSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063708369  93 HDKKIGEAKIPTNDFMGRYSPEGHLNFLSYRLRDEFGDKCGIVNL 137
Cdd:cd04051    81 GDKLIGEVRVPLKDLLDGASPAGELRFLSYQLRRPSGKPQGVLNF 125
 
Name Accession Description Interval E-value
C2_SRC2_like cd04051
C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins; SRC2 production ...
 19-137 2.90e-40

C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins; SRC2 production is a response to pathogen infiltration. The initial response of increased Ca2+ concentrations are coupled to downstream signal transduction pathways via calcium binding proteins. SRC2 contains a single C2 domain which localizes to the plasma membrane and is involved in Ca2+ dependent protein binding. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176016 [Multi-domain]  Cd Length: 125  Bit Score: 133.12  E-value: 2.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKID-EKCRKSNLDESRRSNPTWNYKSEMPI-----NGNEQFIFIEVFYRTGSG 92
Cdd:cd04051     1 TLEITIISAEDLKNVNLFGKMKVYAVVWIDpSHKQSTPVDRDGGTNPTWNETLRFPLderllQQGRLALTIEVYCERPSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063708369  93 HDKKIGEAKIPTNDFMGRYSPEGHLNFLSYRLRDEFGDKCGIVNL 137
Cdd:cd04051    81 GDKLIGEVRVPLKDLLDGASPAGELRFLSYQLRRPSGKPQGVLNF 125
C2 pfam00168
C2 domain;
19-118 9.45e-09

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 50.78  E-value: 9.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKIDEKCRKSNLDESRRS-NPTWNYKSEMPI-NGNEQFIFIEVFYRTGSGHDKK 96
Cdd:pfam00168   2 RLTVTVIEAKNLPPKDGNGTSDPYVKVYLLDGKQKKKTKVVKNTlNPVWNETFTFSVpDPENAVLEIEVYDYDRFGRDDF 81

                          90       100
                  ....*....|....*....|..
gi 1063708369  97 IGEAKIPTNDFMGRYSPEGHLN 118
Cdd:pfam00168  82 IGEVRIPLSELDSGEGLDGWYP 103
C2 smart00239
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ...
 19-115 1.74e-07

Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.


Pssm-ID: 214577 [Multi-domain]  Cd Length: 101  Bit Score: 47.48  E-value: 1.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369   19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKID---EKCRKSNLDeSRRSNPTWNYKSEMPINGNE-QFIFIEVFYRTGSGHD 94
Cdd:smart00239   1 TLTVKIISARNLPPKDKGGKSDPYVKVSLDgdpKEKKKTKVV-KNTLNPVWNETFEFEVPPPElAELEIEVYDKDRFGRD 79

                           90       100
                   ....*....|....*....|.
gi 1063708369   95 KKIGEAKIPTNDFMGRYSPEG 115
Cdd:smart00239  80 DFIGQVTIPLSDLLLGGRHEK 100
COG5038 COG5038
Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only];
20-103 6.07e-04

Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only];


Pssm-ID: 227371 [Multi-domain]  Cd Length: 1227  Bit Score: 39.74  E-value: 6.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369   20 LEIDLRSAEGLK-LNRRPiKKKTFAVVKI-DEKCRKSNLdESRRSNPTWNYKSEMPING--NEQFIfIEVFYRTGSGHDK 95
Cdd:COG5038   1042 LTIMLRSGENLPsSDENG-YSDPFVKLFLnEKSVYKTKV-VKKTLNPVWNEEFTIEVLNrvKDVLT-INVNDWDSGEKND 1118


                   ....*...
gi 1063708369   96 KIGEAKIP 103
Cdd:COG5038   1119 LLGTAEID 1126
 
Name Accession Description Interval E-value
C2_SRC2_like cd04051
C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins; SRC2 production ...
 19-137 2.90e-40

C2 domain present in Soybean genes Regulated by Cold 2 (SRC2)-like proteins; SRC2 production is a response to pathogen infiltration. The initial response of increased Ca2+ concentrations are coupled to downstream signal transduction pathways via calcium binding proteins. SRC2 contains a single C2 domain which localizes to the plasma membrane and is involved in Ca2+ dependent protein binding. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176016 [Multi-domain]  Cd Length: 125  Bit Score: 133.12  E-value: 2.90e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKID-EKCRKSNLDESRRSNPTWNYKSEMPI-----NGNEQFIFIEVFYRTGSG 92
Cdd:cd04051     1 TLEITIISAEDLKNVNLFGKMKVYAVVWIDpSHKQSTPVDRDGGTNPTWNETLRFPLderllQQGRLALTIEVYCERPSL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063708369  93 HDKKIGEAKIPTNDFMGRYSPEGHLNFLSYRLRDEFGDKCGIVNL 137
Cdd:cd04051    81 GDKLIGEVRVPLKDLLDGASPAGELRFLSYQLRRPSGKPQGVLNF 125
C2 pfam00168
C2 domain;
19-118 9.45e-09

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 50.78  E-value: 9.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKIDEKCRKSNLDESRRS-NPTWNYKSEMPI-NGNEQFIFIEVFYRTGSGHDKK 96
Cdd:pfam00168   2 RLTVTVIEAKNLPPKDGNGTSDPYVKVYLLDGKQKKKTKVVKNTlNPVWNETFTFSVpDPENAVLEIEVYDYDRFGRDDF 81

                          90       100
                  ....*....|....*....|..
gi 1063708369  97 IGEAKIPTNDFMGRYSPEGHLN 118
Cdd:pfam00168  82 IGEVRIPLSELDSGEGLDGWYP 103
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
 20-114 7.08e-08

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 48.60  E-value: 7.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  20 LEIDLRSAEGLKLNRRPIKKKTFAVVKI-DEKCRKSNLDEsRRSNPTWNYKSEMPI-NGNEQFIFIEVFYRTGSGHDKKI 97
Cdd:cd00030     1 LRVTVIEARNLPAKDLNGKSDPYVKVSLgGKQKFKTKVVK-NTLNPVWNETFEFPVlDPESDTLTVEVWDKDRFSKDDFL 79

                          90
                  ....*....|....*..
gi 1063708369  98 GEAKIPTNDFMGRYSPE 114
Cdd:cd00030    80 GEVEIPLSELLDSGKEG 96
C2 smart00239
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ...
 19-115 1.74e-07

Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.


Pssm-ID: 214577 [Multi-domain]  Cd Length: 101  Bit Score: 47.48  E-value: 1.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369   19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKID---EKCRKSNLDeSRRSNPTWNYKSEMPINGNE-QFIFIEVFYRTGSGHD 94
Cdd:smart00239   1 TLTVKIISARNLPPKDKGGKSDPYVKVSLDgdpKEKKKTKVV-KNTLNPVWNETFEFEVPPPElAELEIEVYDKDRFGRD 79

                           90       100
                   ....*....|....*....|.
gi 1063708369   95 KKIGEAKIPTNDFMGRYSPEG 115
Cdd:smart00239  80 DFIGQVTIPLSDLLLGGRHEK 100
C2A_Tricalbin-like cd04044
C2 domain first repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are ...
 20-121 2.26e-04

C2 domain first repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology.


Pssm-ID: 176009 [Multi-domain]  Cd Length: 124  Bit Score: 39.46  E-value: 2.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  20 LEIDLRSAEGLKlnRRPIKKKT---FAVVKIdekcrkSNLDESRR-------SNPTWNYKSEMPINGNEQFIFIEVFYRT 89
Cdd:cd04044     4 LAVTIKSARGLK--GSDIIGGTvdpYVTFSI------SNRRELARtkvkkdtSNPVWNETKYILVNSLTEPLNLTVYDFN 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1063708369  90 GSGHDKKIGEAKIPTNDFMGRYSPEG-HLNFLS 121
Cdd:cd04044    76 DKRKDKLIGTAEFDLSSLLQNPEQENlTKNLLR 108
COG5038 COG5038
Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only];
20-103 6.07e-04

Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only];


Pssm-ID: 227371 [Multi-domain]  Cd Length: 1227  Bit Score: 39.74  E-value: 6.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369   20 LEIDLRSAEGLK-LNRRPiKKKTFAVVKI-DEKCRKSNLdESRRSNPTWNYKSEMPING--NEQFIfIEVFYRTGSGHDK 95
Cdd:COG5038   1042 LTIMLRSGENLPsSDENG-YSDPFVKLFLnEKSVYKTKV-VKKTLNPVWNEEFTIEVLNrvKDVLT-INVNDWDSGEKND 1118


                   ....*...
gi 1063708369   96 KIGEAKIP 103
Cdd:COG5038   1119 LLGTAEID 1126
C2_putative_Elicitor-responsive_gene cd04049
C2 domain present in the putative elicitor-responsive gene; In plants elicitor-responsive ...
 19-127 1.49e-03

C2 domain present in the putative elicitor-responsive gene; In plants elicitor-responsive proteins are triggered in response to specific elicitor molecules such as glycolproteins, peptides, carbohydrates and lipids. A host of defensive responses are also triggered resulting in localized cell death. Antimicrobial secondary metabolites, such as phytoalexins, or defense-related proteins, including pathogenesis-related (PR) proteins are also produced. There is a single C2 domain present here. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members have a type-II topology.


Pssm-ID: 176014 [Multi-domain]  Cd Length: 124  Bit Score: 36.93  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  19 TLEIDLRSAEGLKLNRRPIKKKTFAVVKIDEKCRKSNLDESRRSNPTWN----YKSEMPINGNEQFIFIEVFYRTGSGHD 94
Cdd:cd04049     2 TLEVLLISAKGLQDTDFLGKIDPYVIIQCRTQERKSKVAKGDGRNPEWNekfkFTVEYPGWGGDTKLILRIMDKDNFSDD 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1063708369  95 KKIGEAKIPTNDF--MGRYSPEGHLNFLSYRLRDE 127
Cdd:cd04049    82 DFIGEATIHLKGLfeEGVEPGTAELVPAKYNVVLE 116
C2C_Tricalbin-like cd04045
C2 domain third repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are ...
 20-108 1.89e-03

C2 domain third repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.


Pssm-ID: 176010 [Multi-domain]  Cd Length: 120  Bit Score: 36.80  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  20 LEIDLRSAEGLKlnrrpikkKTFAVVKID----------EKCRKSNLDESRrsNPTWNYKSEMPINGNEQFIFIEVF-YR 88
Cdd:cd04045     3 LRLHIRKANDLK--------NLEGVGKIDpyvrvlvngiVKGRTVTISNTL--NPVWDEVLYVPVTSPNQKITLEVMdYE 72

                          90       100
                  ....*....|....*....|
gi 1063708369  89 TgSGHDKKIGEAKIPTNDFM 108
Cdd:cd04045    73 K-VGKDRSLGSVEINVSDLI 91
C2D_Tricalbin-like cd04040
C2 domain fourth repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are ...
 20-106 2.72e-03

C2 domain fourth repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the fifth C2 repeat, C2E, and has a type-II topology.


Pssm-ID: 176005 [Multi-domain]  Cd Length: 115  Bit Score: 36.01  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063708369  20 LEIDLRSAEGLKLNRRPIKKKTFAVVKID-EKCRKSnlDESRRS-NPTWNYKSEMPING--NEQFIfIEVFYRTGSGHDK 95
Cdd:cd04040     1 LTVDVISAENLPSADRNGKSDPFVKFYLNgEKVFKT--KTIKKTlNPVWNESFEVPVPSrvRAVLK-VEVYDWDRGGKDD 77

                          90
                  ....*....|.
gi 1063708369  96 KIGEAKIPTND 106
Cdd:cd04040    78 LLGSAYIDLSD 88
C2C_MCTP_PRT_plant cd04019
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); ...
 59-113 5.85e-03

C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset; MCTPs are involved in Ca2+ signaling at the membrane. Plant-MCTPs are composed of a variable N-terminal sequence, four C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.


Pssm-ID: 175986 [Multi-domain]  Cd Length: 150  Bit Score: 35.72  E-value: 5.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063708369  59 SRRSNPTWNyksempingnEQFIF-----------IEVFYRTGSGHDKKIGEAKIPTNDFMGRYSP 113
Cdd:cd04019    41 TRNGNPSWN----------EELMFvaaepfedhliLSVEDRVGPNKDEPLGRAVIPLNDIERRVDD 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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