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Conserved domains on  [gi|334187975|ref|NP_001190410|]
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D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein [Arabidopsis thaliana]

Protein Classification

class IV aminotransferase( domain architecture ID 17873932)

class IV aminotransferase is a pyridoxaL 5'-phosphate dependent enzyme (PLPDE) and may be a branched-chain amino acid aminotransferase, a D-amino acid transferase, or a 4-amino-4-deoxychorismate lyase; contains a SAM-dependent methyltransferase domain

Gene Ontology:  GO:0030170
PubMed:  31989227

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 639-912 8.18e-116

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


:

Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 354.98  E-value: 8.18e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITN-GM 717
Cdd:cd01558    1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNeGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 718 FDNTHIRLslTRGKKVTSGMspaFNRYGCTLIVLAEWKPPVYDND---GGIVLVTATTRRNspNNLDSKIHhnNLLNNIL 794
Cdd:cd01558   81 EGDVYIQV--TRGVGPRGHD---FPKCVKPTVVIITQPLPLPPAElleKGVRVITVPDIRW--LRCDIKSL--NLLNNVL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 795 AKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHAD-YCLPGITRATVMELVVKENFILEERRISLSEFHTA 873
Cdd:cd01558  152 AKQEAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDnGILPGITRATVIELAKELGIPVEERPFSLEELYTA 231

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 334187975 874 DEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAY 912
Cdd:cd01558  232 DEVFLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
Sulfotransfer_5 super family cl45194
Sulfotransferase domain; This entry represents a family of sulfotransferase enzymes. This ...
 378-609 1.91e-46

Sulfotransferase domain; This entry represents a family of sulfotransferase enzymes. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 238 and 379 amino acids in length.


The actual alignment was detected with superfamily member pfam19798:

Pssm-ID: 437630  Cd Length: 226  Bit Score: 165.96  E-value: 1.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  378 MEVIhAWSAPRSLSTTLMYSFAQRDDIEVLDEPLYAAFLKSTGVDRPYKDELLSKMECDGEKVVKDIIYGPGKKKYRfcK 457
Cdd:pfam19798   1 MKII-AWSGPRNLSTAMMYSFGNRPDFEVMDEPFYAAYLARTGLDHPMRDAILASQPTDPVRVAALCASAPKTHSYQ--K 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  458 HISKQRLLGLPSELMSEGKHFILIRNPLNILPSF-EKIHPSSFHELGLGELVSIYSDLCQMgtppaIIDADELQRDPEAT 536
Cdd:pfam19798  78 HMAHHMLPGFPLDWAEGAVHLHLIRHPARVIASYgAKRDDITEADIAFAAQATLYDRVGGL-----VVDTADLRDDPAGM 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187975  537 LRSLCDDLEIPFQASMLKWEAGPIPEDGLWAPWWYETLHKSTGFSSPQ-KYPQtfpLMHYDLLEQCLPLYNILR 609
Cdd:pfam19798 153 LAKLCAEMGIPFDPAMLSWPSGGHAADGIWAAHWYNAVHRSTGFAGPEgPLPQ---VSRDDLLAAAMPFYKAMK 223
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 145-287 1.67e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 72.36  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  145 GDTGCSIWPSSLFLSEFVL--SFPELFAN----KACFEVGSGVGMVGICLA-HVKAKEVILTDGDLLtLSNMKLNLERNH 217
Cdd:pfam10294  15 NGIGGHVWDAAVVLSKYLEmkIFKELGANnlsgLNVLELGSGTGLVGIAVAlLLPGASVTITDLEEA-LELLKKNIELNA 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187975  218 LnyddeflkqpgeaqSTRVKCTHLPWETASESELSQYRP-DIVLGADVIYDPSCLPHLLRVLVALLKNPPK 287
Cdd:pfam10294  94 L--------------SSKVVVKVLDWGENLPPDLFDGHPvDLILAADCVYNEDSFPLLEKTLKDLLGKESV 150
 
Name Accession Description Interval E-value
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 639-912 8.18e-116

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 354.98  E-value: 8.18e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITN-GM 717
Cdd:cd01558    1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNeGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 718 FDNTHIRLslTRGKKVTSGMspaFNRYGCTLIVLAEWKPPVYDND---GGIVLVTATTRRNspNNLDSKIHhnNLLNNIL 794
Cdd:cd01558   81 EGDVYIQV--TRGVGPRGHD---FPKCVKPTVVIITQPLPLPPAElleKGVRVITVPDIRW--LRCDIKSL--NLLNNVL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 795 AKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHAD-YCLPGITRATVMELVVKENFILEERRISLSEFHTA 873
Cdd:cd01558  152 AKQEAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDnGILPGITRATVIELAKELGIPVEERPFSLEELYTA 231

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 334187975 874 DEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAY 912
Cdd:cd01558  232 DEVFLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 637-918 3.03e-98

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 309.43  E-value: 3.03e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 637 LAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNG 716
Cdd:COG0115    2 LIWLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVAANG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 717 MfDNTHIRLSLTRGkkvTSGMSPAFNRYGCTLIVLA-EWKPPVYDN-DGGIVLVTATTRRNSPNNLdSKIHHNNLLNNIL 794
Cdd:COG0115   82 L-EDGYIRPQVTRG---VGGRGVFAEEYEPTVIIIAsPLPAYPAEAyEKGVRVITSPYRRAAPGGL-GGIKTGNYLNNVL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 795 AKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHA-DYCLPGITRATVMELVVKENFILEERRISLSEFHTA 873
Cdd:COG0115  157 AKQEAKEAGADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLsGGILPGITRDSVIELARELGIPVEERPISLEELYTA 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 334187975 874 DEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDG 918
Cdd:COG0115  237 DEVFLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYTDIVRG 281
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 636-921 7.59e-92

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 292.93  E-value: 7.59e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 636 LLAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNnVP-TREEIKEAIFRTLIT 714
Cdd:PRK08320   3 QLIYLNGEFVPKEEAKVSVFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIMLE-IPlSKEEMTEIVLETLRK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 715 NGMFDnTHIRLSLTRGKKvTSGMSPafnrYGC---TLIVLAE-WKP---PVYDNdgGIVLVTATTRRNSPNNLDSKIHHN 787
Cdd:PRK08320  82 NNLRD-AYIRLVVSRGVG-DLGLDP----RKCpkpTVVCIAEpIGLypgELYEK--GLKVITVSTRRNRPDALSPQVKSL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 788 NLLNNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEERRIS 866
Cdd:PRK08320 154 NYLNNILAKIEANLAGVDEAIMLNDEGYVAEGTGDNIFIVKNGKLITPPTYAgALEGITRNAVIEIAKELGIPVREELFT 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334187975 867 LSEFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDGSGV 921
Cdd:PRK08320 234 LHDLYTADEVFLTGTAAEVIPVVKVDGRVIGDGKPGPITKKLLEEFRELTKKDGT 288
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 639-918 2.09e-73

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 243.81  E-value: 2.09e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGK----VFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLIT 714
Cdd:TIGR01122   1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYDTDkgpaIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  715 NGmFDNTHIRLSLTRGKKVTsGMSPafnRYGCTL-IVLAEWK-PPVYDNDG---GIVLVTATTRRNSPNNLDSKIHH-NN 788
Cdd:TIGR01122  81 NN-LRSAYIRPLVFRGDGDL-GLNP---RAGYKPdVIIAAWPwGAYLGEEAlekGIDAKVSSWRRNAPNTIPTAAKAgGN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  789 LLNNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPH-ADYCLPGITRATVMELVVKENFILEERRISL 867
Cdd:TIGR01122 156 YLNSLLAKSEARRHGYDEAILLDVEGYVAEGSGENIFIVKDGVLFTPPvTSSILPGITRDTVITLAKELGIEVVEQPISR 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 334187975  868 SEFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDG 918
Cdd:TIGR01122 236 EELYTADEAFFTGTAAEITPIREVDGRKIGNGRRGPVTKKLQEAFFDLVTG 286
Sulfotransfer_5 pfam19798
Sulfotransferase domain; This entry represents a family of sulfotransferase enzymes. This ...
 378-609 1.91e-46

Sulfotransferase domain; This entry represents a family of sulfotransferase enzymes. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 238 and 379 amino acids in length.


Pssm-ID: 437630  Cd Length: 226  Bit Score: 165.96  E-value: 1.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  378 MEVIhAWSAPRSLSTTLMYSFAQRDDIEVLDEPLYAAFLKSTGVDRPYKDELLSKMECDGEKVVKDIIYGPGKKKYRfcK 457
Cdd:pfam19798   1 MKII-AWSGPRNLSTAMMYSFGNRPDFEVMDEPFYAAYLARTGLDHPMRDAILASQPTDPVRVAALCASAPKTHSYQ--K 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  458 HISKQRLLGLPSELMSEGKHFILIRNPLNILPSF-EKIHPSSFHELGLGELVSIYSDLCQMgtppaIIDADELQRDPEAT 536
Cdd:pfam19798  78 HMAHHMLPGFPLDWAEGAVHLHLIRHPARVIASYgAKRDDITEADIAFAAQATLYDRVGGL-----VVDTADLRDDPAGM 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187975  537 LRSLCDDLEIPFQASMLKWEAGPIPEDGLWAPWWYETLHKSTGFSSPQ-KYPQtfpLMHYDLLEQCLPLYNILR 609
Cdd:pfam19798 153 LAKLCAEMGIPFDPAMLSWPSGGHAADGIWAAHWYNAVHRSTGFAGPEgPLPQ---VSRDDLLAAAMPFYKAMK 223
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 664-891 3.88e-46

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 164.84  E-value: 3.88e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  664 SVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNGMFdNTHIRLSLTRG--KKVTSGMSPAF 741
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLG-VGRLRLTVSRGpgGFGLPTSDPTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  742 nrygctLIVLAEWKPPVYDndGGIVLVTATTRRNsPNNLDSKIHHNNLLNNILAKIESNNANVDDAIMLDKDGFVSETNA 821
Cdd:pfam01063  80 ------AIFVSALPPPPES--KKKGVISSLVRRN-PPSPLPGAKTLNYLENVLARREAKAQGADDALLLDEDGNVTEGST 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187975  822 TNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKI 891
Cdd:pfam01063 151 SNVFLVKGGTLYTPPLESgILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 145-287 1.67e-14

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 72.36  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  145 GDTGCSIWPSSLFLSEFVL--SFPELFAN----KACFEVGSGVGMVGICLA-HVKAKEVILTDGDLLtLSNMKLNLERNH 217
Cdd:pfam10294  15 NGIGGHVWDAAVVLSKYLEmkIFKELGANnlsgLNVLELGSGTGLVGIAVAlLLPGASVTITDLEEA-LELLKKNIELNA 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187975  218 LnyddeflkqpgeaqSTRVKCTHLPWETASESELSQYRP-DIVLGADVIYDPSCLPHLLRVLVALLKNPPK 287
Cdd:pfam10294  94 L--------------SSKVVVKVLDWGENLPPDLFDGHPvDLILAADCVYNEDSFPLLEKTLKDLLGKESV 150
 
Name Accession Description Interval E-value
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 639-912 8.18e-116

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 354.98  E-value: 8.18e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITN-GM 717
Cdd:cd01558    1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNeGG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 718 FDNTHIRLslTRGKKVTSGMspaFNRYGCTLIVLAEWKPPVYDND---GGIVLVTATTRRNspNNLDSKIHhnNLLNNIL 794
Cdd:cd01558   81 EGDVYIQV--TRGVGPRGHD---FPKCVKPTVVIITQPLPLPPAElleKGVRVITVPDIRW--LRCDIKSL--NLLNNVL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 795 AKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHAD-YCLPGITRATVMELVVKENFILEERRISLSEFHTA 873
Cdd:cd01558  152 AKQEAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDnGILPGITRATVIELAKELGIPVEERPFSLEELYTA 231

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 334187975 874 DEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAY 912
Cdd:cd01558  232 DEVFLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 637-918 3.03e-98

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 309.43  E-value: 3.03e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 637 LAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNG 716
Cdd:COG0115    2 LIWLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVAANG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 717 MfDNTHIRLSLTRGkkvTSGMSPAFNRYGCTLIVLA-EWKPPVYDN-DGGIVLVTATTRRNSPNNLdSKIHHNNLLNNIL 794
Cdd:COG0115   82 L-EDGYIRPQVTRG---VGGRGVFAEEYEPTVIIIAsPLPAYPAEAyEKGVRVITSPYRRAAPGGL-GGIKTGNYLNNVL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 795 AKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHA-DYCLPGITRATVMELVVKENFILEERRISLSEFHTA 873
Cdd:COG0115  157 AKQEAKEAGADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLsGGILPGITRDSVIELARELGIPVEERPISLEELYTA 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 334187975 874 DEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDG 918
Cdd:COG0115  237 DEVFLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYTDIVRG 281
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 636-921 7.59e-92

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 292.93  E-value: 7.59e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 636 LLAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNnVP-TREEIKEAIFRTLIT 714
Cdd:PRK08320   3 QLIYLNGEFVPKEEAKVSVFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIMLE-IPlSKEEMTEIVLETLRK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 715 NGMFDnTHIRLSLTRGKKvTSGMSPafnrYGC---TLIVLAE-WKP---PVYDNdgGIVLVTATTRRNSPNNLDSKIHHN 787
Cdd:PRK08320  82 NNLRD-AYIRLVVSRGVG-DLGLDP----RKCpkpTVVCIAEpIGLypgELYEK--GLKVITVSTRRNRPDALSPQVKSL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 788 NLLNNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEERRIS 866
Cdd:PRK08320 154 NYLNNILAKIEANLAGVDEAIMLNDEGYVAEGTGDNIFIVKNGKLITPPTYAgALEGITRNAVIEIAKELGIPVREELFT 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334187975 867 LSEFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDGSGV 921
Cdd:PRK08320 234 LHDLYTADEVFLTGTAAEVIPVVKVDGRVIGDGKPGPITKKLLEEFRELTKKDGT 288
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 656-912 3.12e-86

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 276.40  E-value: 3.12e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 656 DSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIfRTLITNGMFDNTHIRLSLTRGkkvTS 735
Cdd:cd00449    1 DRGLHYGDGVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREAL-KELVAANNGASLYIRPLLTRG---VG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 736 GMSPAFNRYGCTLIVLAEWKPPVYDNDG--GIVLVTATTRRNSPNNLDSKIHHNNLLNNILAKIESNNANVDDAIMLDKD 813
Cdd:cd00449   77 GLGVAPPPSPEPTFVVFASPVGAYAKGGekGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEAGADEALLLDDN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 814 GFVSETNATNIFMVKKDRVLTPHADYC-LPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKID 892
Cdd:cd00449  157 GYVTEGSASNVFIVKDGELVTPPLDGGiLPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEID 236

                        250       260
                 ....*....|....*....|
gi 334187975 893 GRVIGEGKVGPVTRRLQNAY 912
Cdd:cd00449  237 GRGIGDGKPGPVTRKLRELL 256
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 639-918 2.09e-73

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 243.81  E-value: 2.09e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGK----VFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLIT 714
Cdd:TIGR01122   1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYDTDkgpaIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  715 NGmFDNTHIRLSLTRGKKVTsGMSPafnRYGCTL-IVLAEWK-PPVYDNDG---GIVLVTATTRRNSPNNLDSKIHH-NN 788
Cdd:TIGR01122  81 NN-LRSAYIRPLVFRGDGDL-GLNP---RAGYKPdVIIAAWPwGAYLGEEAlekGIDAKVSSWRRNAPNTIPTAAKAgGN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  789 LLNNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPH-ADYCLPGITRATVMELVVKENFILEERRISL 867
Cdd:TIGR01122 156 YLNSLLAKSEARRHGYDEAILLDVEGYVAEGSGENIFIVKDGVLFTPPvTSSILPGITRDTVITLAKELGIEVVEQPISR 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 334187975  868 SEFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDG 918
Cdd:TIGR01122 236 EELYTADEAFFTGTAAEITPIREVDGRKIGNGRRGPVTKKLQEAFFDLVTG 286
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
635-928 2.78e-68

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 229.84  E-value: 2.78e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 635 KLLAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLIT 714
Cdd:PRK12479   3 NQYIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEAVLQTLQK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 715 NGMFDnTHIRLSLTRGKKvTSGMSPAfNRYGCTLIVLAE----WKPPVYDNdgGIVLVTATTRRNSPNNLDSKIHHNNLL 790
Cdd:PRK12479  83 NEYAD-AYIRLIVSRGKG-DLGLDPR-SCVKPSVIIIAEqlklFPQEFYDN--GLSVVSVASRRNTPDALDPRIKSMNYL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 791 NNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPhADY--CLPGITRATVMELVVKENFILEERRISLS 868
Cdd:PRK12479 158 NNVLVKIEAAQAGVLEALMLNQQGYVCEGSGDNVFVVKDGKVLTP-PSYlgALEGITRNSVIELCERLSIPCEERPFTRH 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 869 EFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDGSGVPIPTYQE 928
Cdd:PRK12479 237 DVYVADEVFLTGTAAELIPVVKVDSREIGDGKPGSVTKQLTEEFKKLTRERGVRVPGLAE 296
PRK06606 PRK06606
branched-chain amino acid transaminase;
637-918 2.11e-62

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 213.86  E-value: 2.11e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 637 LAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGK----VFKLEEHLDRLSDSAKALAFNnVP-TREEIKEAIFRT 711
Cdd:PRK06606   8 YIWFNGELVPWEDAKVHVLTHALHYGTGVFEGIRAYDTPkgpaIFRLREHTKRLFNSAKILRME-IPySVDELMEAQREV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 712 LITNGmFDNTHIRLSLTRGkkvTSGMSPAFNRYGCTLIVlAEWKPPVY-DNDG---GIVLVTATTRRNSPNNLDSKIHHN 787
Cdd:PRK06606  87 VRKNN-LKSAYIRPLVFVG---DEGLGVRPHGLPTDVAI-AAWPWGAYlGEEAlekGIRVKVSSWTRHAPNSIPTRAKAS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 788 -NLLNNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTP-HADYCLPGITRATVMELVvKENFI-LEERR 864
Cdd:PRK06606 162 gNYLNSILAKTEARRNGYDEALLLDVEGYVSEGSGENIFIVRDGVLYTPpLTSSILEGITRDTVITLA-KDLGIeVIERR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334187975 865 ISLSEFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAYKKLTDG 918
Cdd:PRK06606 241 ITRDELYIADEVFFTGTAAEVTPIREVDGRQIGNGKRGPITEKLQSAYFDIVRG 294
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 656-912 5.89e-47

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 168.26  E-value: 5.89e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 656 DSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNvPTREEIKEAIFRTLITNGMfDNTHIRLSLTRG---KK 732
Cdd:cd01559    1 DRGFAYGDGVFETMRALDGRLFLLDAHLARLERSARRLGIPE-PDLPRLRAALESLLAANDI-DEGRIRLILSRGpggRG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 733 VTSGMSPAFNRYGCTLIVLAEWKPPvydndgGIVLVTATTRRNSPNNLdSKIHHNNLLNNILAKIESNNANVDDAIMLDK 812
Cdd:cd01559   79 YAPSVCPGPALYVSVIPLPPAWRQD------GVRLITCPVRLGEQPLL-AGLKHLNYLENVLAKREARDRGADEALFLDT 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 813 DGFVSETNATNIFMVKKDRVLTPHADYC-LPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKI 891
Cdd:cd01559  152 DGRVIEGTASNLFFVKDGELVTPSLDRGgLAGITRQRVIELAAAKGYAVDERPLRLEDLLAADEAFLTNSLLGVAPVTAI 231

                        250       260
                 ....*....|....*....|.
gi 334187975 892 DGRvigEGKVGPVTRRLQNAY 912
Cdd:cd01559  232 DDH---DGPPGPLTRALRELL 249
Sulfotransfer_5 pfam19798
Sulfotransferase domain; This entry represents a family of sulfotransferase enzymes. This ...
 378-609 1.91e-46

Sulfotransferase domain; This entry represents a family of sulfotransferase enzymes. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 238 and 379 amino acids in length.


Pssm-ID: 437630  Cd Length: 226  Bit Score: 165.96  E-value: 1.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  378 MEVIhAWSAPRSLSTTLMYSFAQRDDIEVLDEPLYAAFLKSTGVDRPYKDELLSKMECDGEKVVKDIIYGPGKKKYRfcK 457
Cdd:pfam19798   1 MKII-AWSGPRNLSTAMMYSFGNRPDFEVMDEPFYAAYLARTGLDHPMRDAILASQPTDPVRVAALCASAPKTHSYQ--K 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  458 HISKQRLLGLPSELMSEGKHFILIRNPLNILPSF-EKIHPSSFHELGLGELVSIYSDLCQMgtppaIIDADELQRDPEAT 536
Cdd:pfam19798  78 HMAHHMLPGFPLDWAEGAVHLHLIRHPARVIASYgAKRDDITEADIAFAAQATLYDRVGGL-----VVDTADLRDDPAGM 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187975  537 LRSLCDDLEIPFQASMLKWEAGPIPEDGLWAPWWYETLHKSTGFSSPQ-KYPQtfpLMHYDLLEQCLPLYNILR 609
Cdd:pfam19798 153 LAKLCAEMGIPFDPAMLSWPSGGHAADGIWAAHWYNAVHRSTGFAGPEgPLPQ---VSRDDLLAAAMPFYKAMK 223
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 664-891 3.88e-46

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 164.84  E-value: 3.88e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  664 SVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNGMFdNTHIRLSLTRG--KKVTSGMSPAF 741
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLG-VGRLRLTVSRGpgGFGLPTSDPTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  742 nrygctLIVLAEWKPPVYDndGGIVLVTATTRRNsPNNLDSKIHHNNLLNNILAKIESNNANVDDAIMLDKDGFVSETNA 821
Cdd:pfam01063  80 ------AIFVSALPPPPES--KKKGVISSLVRRN-PPSPLPGAKTLNYLENVLARREAKAQGADDALLLDEDGNVTEGST 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187975  822 TNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKI 891
Cdd:pfam01063 151 SNVFLVKGGTLYTPPLESgILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
PRK07650 PRK07650
4-amino-4-deoxychorismate lyase; Provisional
 639-918 2.33e-44

4-amino-4-deoxychorismate lyase; Provisional


Pssm-ID: 181067  Cd Length: 283  Bit Score: 162.06  E-value: 2.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNGMf 718
Cdd:PRK07650   3 YVNGQYVEEEEARISPFDHGYLYGLGVFETFRIYNGHPFLLDDHYDRLNDALDTLQIEWTMTKDEVLLILKNLLEKNGL- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 719 DNTHIRLSltrgkkVTSGMSP---AFNRY-GCTLIVLAEWKPPVYDNDG--GIVLvtaTTRRNSPN-NLDSKIHHnnLLN 791
Cdd:PRK07650  82 ENAYVRFN------VSAGIGEiglQTEMYeEPTVIVYMKPLAPPGLPAEkeGVVL---KQRRNTPEgAFRLKSHH--YLN 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 792 NILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEERRISLSEF 870
Cdd:PRK07650 151 NILGKREIGNDPNKEGIFLTEEGYVAEGIVSNLFWVKGDIVYTPSLETgILNGITRAFVIKVLEELGIEVKEGFYTKEEL 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 334187975 871 HTADEVWTTGTMGELSPVVKIDGRVIGeGKVGPVTRRLQNAYKKLTDG 918
Cdd:PRK07650 231 LSADEVFVTNSIQEIVPLTRIEERDFP-GKVGMVTKRLQNLYEMQREK 277
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 651-912 3.47e-44

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 161.21  E-value: 3.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 651 KVSVFDSVVQGGDSVWEGLRIYKGK-----VFKLEEHLDRLSDSAKALAFNNVPTrEEIKEAIFRTLITNGMF--DNTH- 722
Cdd:cd01557    1 SLHPATHALHYGQAVFEGLKAYRTPdgkivLFRPDENAERLNRSARRLGLPPFSV-EEFIDAIKELVKLDADWvpYGGGa 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 723 ---IR-LSLTRGKKVtsGMSPAfNRYgcTLIVLAeWKPPVYDNDG--GIVLVTATTRRNSPNN-LDSKIHhNNLLNNILA 795
Cdd:cd01557   80 slyIRpFIFGTDPQL--GVSPA-LEY--LFAVFA-SPVGAYFKGGekGVSALVSSFRRAAPGGpGAAKAG-GNYAASLLA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 796 KIESNNANVDDAIMLD-KDGFVSETNATNIFMVKKDRVLTPHADYC-LPGITRATVMELVVKENFILEERRISLSEFHTA 873
Cdd:cd01557  153 QKEAAEKGYDQALWLDgAHGYVAEVGTMNIFFVKDGELITPPLDGSiLPGITRDSILELARDLGIKVEERPITRDELYEA 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 334187975 874 DEVWTTGTMGELSPVVKIDGR--VIGEGKVGPVTRRLQNAY 912
Cdd:cd01557  233 DEVFATGTAAVVTPVGEIDYRgkEPGEGEVGPVTKKLYDLL 273
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 638-912 1.81e-40

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 150.85  E-value: 1.81e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 638 AWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEI----KEAIFRTLI 713
Cdd:PRK06680   5 AYVNGRYVNHREARVHIEDRGFQFADGIYEVCAVRDGKLVDLDRHLARLFRSLGEIRIAPPMTRAELvevlRELIRRNRV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 714 TNGMFdnthiRLSLTRGkkvTSGMSPAFNRYGC--TLIVLAEWKPPVYD---NDGGIVLVTAT----TRRNspnnldskI 784
Cdd:PRK06680  85 REGLV-----YLQVTRG---VARRDHVFPAADVkpSVVVFAKSVDFARPaaaAETGIKVITVPdnrwKRCD--------I 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 785 HHNNLLNNILAKIESNNANVDDAIMLDkDGFVSETNATNIFMVKKD-RVLTPHAD-YCLPGITRATVMELVVKENFILEE 862
Cdd:PRK06680 149 KSVGLLPNVLAKQAAKEAGAQEAWMVD-DGFVTEGASSNAWIVTKDgKLVTRPADnFILPGITRHTLIDLAKELGLEVEE 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 334187975 863 RRISLSEFHTADEVWTTGTMGELSPVVKIDGRVIGEGKVGPVTRRLQNAY 912
Cdd:PRK06680 228 RPFTLQEAYAAREAFITAASSFVFPVVQIDGKQIGNGKPGPIAKRLREAY 277
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 639-915 1.24e-38

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 145.89  E-value: 1.24e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 639 WVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNGMF 718
Cdd:PRK07544  12 WMDGELVPWRDAKVHVLTHGLHYASSVFEGERAYGGKIFKLREHSERLRRSAELLDFEIPYSVAEIDAAKKETLAANGLT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 719 DnTHIRLSLTRGKKVTsGMSPAFNRygctlIVLA----EWkPPVYDNDG---GIVLVTATTRRNSPNNLDSKIHHNNL-L 790
Cdd:PRK07544  92 D-AYVRPVAWRGSEMM-GVSAQQNK-----IHLAiaawEW-PSYFDPEAkmkGIRLDIAKWRRPDPETAPSAAKAAGLyM 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 791 NNILAKIESNNANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADYCLPGITRATVMELVVKENFILEERRISLSEF 870
Cdd:PRK07544 164 ICTISKHAAEAKGYADALMLDYRGYVAEATGANIFFVKDGVIHTPTPDCFLDGITRQTVIELAKRRGIEVVERHIMPEEL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 334187975 871 HTADEVWTTGTMGELSPVVKIDGRVIgegKVGPVTRRLQNAYKKL 915
Cdd:PRK07544 244 AGFSECFLTGTAAEVTPVSEIGEYRF---TPGAITRDLMDDYEAL 285
pabC_Proteo TIGR03461
aminodeoxychorismate lyase; Members of this protein family are aminodeoxychorismate lyase (ADC ...
 650-910 9.13e-32

aminodeoxychorismate lyase; Members of this protein family are aminodeoxychorismate lyase (ADC lyase), EC 4.1.3.38, the PabC protein of PABA biosynthesis. PABA (para-aminobenzoate) is a precursor of folate, needed for de novo purine biosynthesis. This enzyme is a pyridoxal-phosphate-binding protein in the class IV aminotransferase family (pfam01063). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 132501  Cd Length: 261  Bit Score: 125.01  E-value: 9.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  650 AKVSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNvPTREEIKEAIFrTLITNGmfDNTHIRLSLTR 729
Cdd:TIGR03461   8 TQISVSDRGLQYGDGCFTTAKVRNGKIELLDLHLERLQDAAARLGIPL-PDWDALREEMA-QLAAGY--SLGVLKVIISR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  730 GKKvTSGMSPAfnryGCT----LIVLAEW--KPPVYDNDGgIVLVTATTR--RNSpnnLDSKIHHNNLLNNILAKIESNN 801
Cdd:TIGR03461  84 GSG-GRGYSPP----GCSdptrIISVSPYpaHYSAWQQQG-IRLGVSPVRlgRNP---LLAGIKHLNRLEQVLIKAELEN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  802 ANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADYC-LPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTG 880
Cdd:TIGR03461 155 SEADEALVLDTDGNVVECTAANIFWRKGNQVFTPDLSYCgVAGVMRQHVLALLPALGYEIEEVKAGLEELLSADEVFITN 234

                         250       260       270
                  ....*....|....*....|....*....|
gi 334187975  881 TMGELSPVVKIDGRVIgegKVGPVTRRLQN 910
Cdd:TIGR03461 235 SLMGVVPVNAIGETSY---PSRTLTRLLQP 261
PRK06092 PRK06092
4-amino-4-deoxychorismate lyase; Reviewed
 652-909 3.10e-27

4-amino-4-deoxychorismate lyase; Reviewed


Pssm-ID: 235696  Cd Length: 268  Bit Score: 111.86  E-value: 3.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 652 VSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPT---REEIKEAIFRTlitngmfDNTHIRLSLT 728
Cdd:PRK06092  12 LSVSDRSTQYGDGCFTTARVRDGQVSLLSRHLQRLQDACERLAIPLDDWaqlEQEMKQLAAEL-------ENGVLKVIIS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 729 RGkkvTS--GMSPAfnryGC---TLIVLAEWKPPVYDN--DGGIVLVTATTRRnSPNNLDSKIHHNNLLNNILAKIESNN 801
Cdd:PRK06092  85 RG---SGgrGYSPA----GCaapTRILSVSPYPAHYSRwrEQGITLALCPTRL-GRNPLLAGIKHLNRLEQVLIRAELEQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 802 ANVDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADYC-LPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTG 880
Cdd:PRK06092 157 TEADEALVLDSEGWVIECCAANLFWRKGGVVYTPDLDQCgVAGVMRQFILELLAQSGYPVVEVDASLEELLQADEVFICN 236

                        250       260
                 ....*....|....*....|....*....
gi 334187975 881 TMGELSPVVKIDGRVIgegKVGPVTRRLQ 909
Cdd:PRK06092 237 SLMPVWPVRAIGETSY---SSGTLTRYLQ 262
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 656-924 1.61e-25

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 108.56  E-value: 1.61e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 656 DSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNGMFDNThIRLSLTRGkkvtS 735
Cdd:PLN02845  61 DHMVHRGHGVFDTATIRDGHLYELDAHLDRFLRSAAKAKIPLPFDRATLRRILLQTVAASGCRNGS-LRYWLSAG----P 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 736 G---MSPAfnryGC---TLIVLAEWKPPVYDNDGGIVLVTATTRRNSPnnLDSKIHHNNLLNNILAKIESNNANVDDAIM 809
Cdd:PLN02845 136 GgfsLSPS----GCsepAFYAVVIEDTYAQDRPEGVKVVTSSVPIKPP--QFATVKSVNYLPNALSQMEAEERGAFAGIW 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 810 LDKDGFVSETNATNIFMVKKDRVL-TPHADYCLPGITRATVMELV---VKENFI--LEERRISLSEFHTADEVWTTGTMG 883
Cdd:PLN02845 210 LDEEGFVAEGPNMNVAFLTNDGELvLPPFDKILSGCTARRVLELAprlVSPGDLrgVKQRKISVEEAKAADEMMLIGSGV 289

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 334187975 884 ELSPVVKIDGRVIGEGKVGPVTRRLQNA----YKKLTDGSGVPIP 924
Cdd:PLN02845 290 PVLPIVSWDGQPIGDGKVGPITLALHDLllddMRSGPPGVRTPVP 334
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
662-912 5.66e-25

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 105.81  E-value: 5.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 662 GDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIkeaifRTLITNGM--FD---NTHIRLSLTRGKKVTSG 736
Cdd:PRK13356  33 GSTVFDGARAFEGVTPDLDLHCARVNRSAEALGLKPTVSAEEI-----EALAREGLkrFDpdtALYIRPMYWAEDGFASG 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 737 MSPAfnrYGCTLIVLAEWKPPVyDNDGGIVLVTATTRRNSPNN--LDSKIhhnNLL--NNILAKIESNNANVDDAIMLDK 812
Cdd:PRK13356 108 VAPD---PESTRFALCLEEAPM-PEPTGFSLTLSPFRRPTLEMapTDAKA---GCLypNNARALREARSRGFDNALVLDM 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 813 DGFVSETNATNIFMVKKDRVLTPHADYC-LPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKI 891
Cdd:PRK13356 181 LGNVAETATSNVFMVKDGVVFTPVPNGTfLNGITRQRVIALLREDGVTVVETTLTYEDFLEADEVFSTGNYSKVVPVTRF 260

                        250       260
                 ....*....|....*....|.
gi 334187975 892 DGRVIgegKVGPVTRRLQNAY 912
Cdd:PRK13356 261 DDRSL---QPGPVTRRARELY 278
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
 659-914 1.88e-24

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 104.71  E-value: 1.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 659 VQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALAFNNVPTREEIKEAIFRTLITNGMFDNTHIRLSLTRGKKVTS--- 735
Cdd:PRK12400  30 LQFGDGVYEVIRLYKGNFHLLDPHITRLYRSMEEIELTLPFSKAELITLLYKLIENNNFHEDGTIYLQVSRGVQARThtf 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 736 --GMSPAFNRYgctliVLAEWKPPVYDNDGGIVLVTATTRRnspnnLDSKIHHNNLLNNILAKIESNNANVDDAIMLdKD 813
Cdd:PRK12400 110 syDVPPTIYAY-----ITKKERPALWIEYGVRAISEPDTRW-----LRCDIKSLNLLPNILAATKAERKGCKEALFV-RN 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 814 GFVSETNATNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKID 892
Cdd:PRK12400 179 GTVTEGSHSNFFLIKNGTLYTHPANHlILNGIIRQYVLSLAKTLRIPVQEELFSVRDVYQADECFFTGTTIEILPMTHLD 258

                        250       260
                 ....*....|....*....|..
gi 334187975 893 GRVIGEGKVGPVTRRLQNAYKK 914
Cdd:PRK12400 259 GTAIQDGQVGPITKMLQRSFSQ 280
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 794-917 1.55e-15

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 79.04  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 794 LAKIESNNANVDDAIMLD-KDG-FVSETNATNIFMVKKD-RVLTPHADYCLPGITRATVMELVVKENFILEERRISLSEF 870
Cdd:PRK13357 206 LAQAEAKEKGCDQVLYLDaVEHtYIEEVGGMNFFFITKDgTVTPPLSGSILPGITRDSLLQLAEDLGLTVEERPVSIDEW 285

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334187975 871 HTA------DEVWTTGTMGELSPVVKIDGR----VIGEGKVGPVTRRLqnaYKKLTD 917
Cdd:PRK13357 286 QADaasgefTEAFACGTAAVITPIGGIKYKdkefVIGDGEVGPVTQKL---YDELTG 339
PRK07849 PRK07849
aminodeoxychorismate lyase;
652-894 2.26e-15

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 77.69  E-value: 2.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 652 VSVFDSVVQGGDSVWEGLRIYKGKVFKLEEHLDRLSDSAKALafnNVPT------REEIKEAIfRTLITNGmfDNTHIRL 725
Cdd:PRK07849  28 LHADDLAAVRGDGVFETLLVRDGRPCNLEAHLERLARSAALL---DLPEpdldrwRRAVELAI-EEWRAPE--DEAALRL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 726 SLTRGKKVTSGMSpAFnrygctlIVLAewkpPVYDNDG-----GIVLVT------ATTRRNSPNnldskihhnnLLNNil 794
Cdd:PRK07849 102 VYSRGRESGGAPT-AW-------VTVS----PVPERVArarreGVSVITldrgypSDAAERAPW----------LLAG-- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 795 AKIESNNAN-----------VDDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADY-CLPGITRATVMELVVKENFILEE 862
Cdd:PRK07849 158 AKTLSYAVNmaalryaarrgADDVIFTSTDGYVLEGPTSTVVIATDDRLLTPPPWYgILPGTTQAALFEVAREKGWDCEY 237

                        250       260       270
                 ....*....|....*....|....*....|..
gi 334187975 863 RRISLSEFHTADEVWTTGTMGELSPVVKIDGR 894
Cdd:PRK07849 238 RALRPADLFAADGVWLVSSVRLAARVHTLDGR 269
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 145-287 1.67e-14

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 72.36  E-value: 1.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975  145 GDTGCSIWPSSLFLSEFVL--SFPELFAN----KACFEVGSGVGMVGICLA-HVKAKEVILTDGDLLtLSNMKLNLERNH 217
Cdd:pfam10294  15 NGIGGHVWDAAVVLSKYLEmkIFKELGANnlsgLNVLELGSGTGLVGIAVAlLLPGASVTITDLEEA-LELLKKNIELNA 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187975  218 LnyddeflkqpgeaqSTRVKCTHLPWETASESELSQYRP-DIVLGADVIYDPSCLPHLLRVLVALLKNPPK 287
Cdd:pfam10294  94 L--------------SSKVVVKVLDWGENLPPDLFDGHPvDLILAADCVYNEDSFPLLEKTLKDLLGKESV 150
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 643-881 1.97e-13

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 72.66  E-value: 1.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 643 EIVPREMAKVSVFDSVVQGGDSVWEGLRIYKGK-----VFKLEEHLDRLSDSAKALAFNnVPTREEIKEAIFRTLITNGM 717
Cdd:PLN03117  50 KIVPYGDISISPCAGILNYGQGLFEGLKAYRTEdgritLFRPDQNALRMQTGADRLCMT-PPSLEQFVEAVKQTVLANKK 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 718 F------DNTHIRlSLTRGKKVTSGMSPA----FNRYGCtlivlaewkpPV----YDNDGGIVLVTATTRRNSPNNLDSK 783
Cdd:PLN03117 129 WvpppgkGTLYIR-PLLIGSGAVLGVAPApeytFLIYAS----------PVgnyhKASSGLNLKVDHKHRRAHSGGTGGV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 784 IHHNNLLNNILAKIESNNANVDDAIMLD----KDgfVSETNATNIFMVKKDRVLTPH-ADYCLPGITRATVMELVVKENF 858
Cdd:PLN03117 198 KSCTNYSPVVKSLIEAKSSGFSDVLFLDaatgKN--IEELSACNIFILKGNIVSTPPtSGTILPGVTRKSISELARDIGY 275

                        250       260
                 ....*....|....*....|...
gi 334187975 859 ILEERRISLSEFHTADEVWTTGT 881
Cdd:PLN03117 276 QVEERDVSVDELLEAEEVFCTGT 298
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 658-916 1.97e-13

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 73.34  E-value: 1.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 658 VVQGGDSVWEGLRIYKGK-----VFKLEEHLDRLSDSAKALAFNNvPTREEIKEAIFRTLITNGMF------DNTHIRlS 726
Cdd:PLN02782 115 VLNYGQGLFEGLKAYRKEdgnilLFRPEENAIRMRNGAERMCMPA-PTVEQFVEAVKETVLANKRWvpppgkGSLYIR-P 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 727 LTRGKKVTSGMSPAfNRYgcTLIVLAEwkpPV--YDNDG--GIVLVTATT-RRNSPNNLDSKIHHNNLLNNILAKIESNN 801
Cdd:PLN02782 193 LLMGSGAVLGLAPA-PEY--TFLIYVS---PVgnYFKEGvaPINLIVENEfHRATPGGTGGVKTIGNYAAVLKAQSIAKA 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 802 ANVDDAIMLD--KDGFVSETNATNIFMVKKDRVLTPHAD-YCLPGITRATVMELVVKENFILEERRISLSEFHTADEVWT 878
Cdd:PLN02782 267 KGYSDVLYLDcvHKKYLEEVSSCNIFIVKDNVISTPAIKgTILPGITRKSIIDVARSQGFQVEERNVTVDELLEADEVFC 346

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 334187975 879 TGTMGELSPVVKI---DGRV-IGEGKVGPVTRRLqnaYKKLT 916
Cdd:PLN02782 347 TGTAVVVSPVGSItykGKRVsYGEGGFGTVSQQL---YTVLT 385
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 624-918 1.70e-09

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 60.89  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 624 PPPSLPVPENAKLLAWVGDEIVPREMAKVSVFDSVVQGGDSVWEGLRIYK---GKV--FKLEEHLDRLSDSAKALAFNNv 698
Cdd:PLN02259  67 PADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRkenGKLllFRPDHNAIRMKLGAERMLMPS- 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 699 PTREEIKEAIFRTLITNGMF------DNTHIRlSLTRGKKVTSGMSPAfNRYgcTLIVLAEwkpPV--YDNDGGIVL--- 767
Cdd:PLN02259 146 PSVDQFVNAVKQTALANKRWvppagkGTLYIR-PLLMGSGPILGLGPA-PEY--TFIVYAS---PVgnYFKEGMAALnly 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 768 VTATTRRNSPNNLDSKIHHNNLLNNILAKIESNNANVDDAIMLD--KDGFVSETNATNIFMVKKDRVLTPHAD-YCLPGI 844
Cdd:PLN02259 219 VEEEYVRAAPGGAGGVKSITNYAPVLKALSRAKSRGFSDVLYLDsvKKKYLEEASSCNVFVVKGRTISTPATNgTILEGI 298

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334187975 845 TRATVMELVVKENFILEERRISLSEFHTADEVWTTGTMGELSPVVKI---DGRVIGEGKVGPVTRRLQNAYKKLTDG 918
Cdd:PLN02259 299 TRKSVMEIASDQGYQVVEKAVHVDEVMDADEVFCTGTAVVVAPVGTItyqEKRVEYKTGDESVCQKLRSVLVGIQTG 375
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 806-919 1.64e-08

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 57.80  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 806 DAIMLDKD--GFVSETNATNIFMVKKDRVLTPH-ADYCLPGITRATVMELVVKENFILEERRISLSEFHTADEVWTTGTM 882
Cdd:PLN02883 253 DVLYLDADtgKNIEEVSAANIFLVKGNIIVTPAtSGTILGGITRKSIIEIALDLGYKVEERRVPVEELKEAEEVFCTGTA 332

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 334187975 883 GELSPVVKIDGR-VIGEGKVGP--VTRRLQNAYKKLTDGS 919
Cdd:PLN02883 333 AGVASVGSITFKnTRTEYKVGDgiVTQQLRSILLGIQTGS 372
PRK09266 PRK09266
hypothetical protein; Provisional
 805-912 7.59e-04

hypothetical protein; Provisional


Pssm-ID: 236438  Cd Length: 266  Bit Score: 42.27  E-value: 7.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 805 DDAIMLDKDGFVSETNATNIFMVKKDRVLTPHADyCLPGITRAtVMELVVKENFILEERR-ISLSEFHTADEVWTTGTMG 883
Cdd:PRK09266 154 DDALFVDPDGRVSEGATWNLGFWDGGAVVWPQAP-ALPGVTMA-LLQRGLERLGIPQRTRpVTLADLGRFAGAFACNAWR 231

                         90       100
                 ....*....|....*....|....*....
gi 334187975 884 ELSPVVKIDGRVIGEGKvgPVTRRLQNAY 912
Cdd:PRK09266 232 GQRAVSAIDDVALPDSH--ALLELLRRAY 258
PRK07546 PRK07546
hypothetical protein; Provisional
 674-877 1.19e-03

hypothetical protein; Provisional


Pssm-ID: 169002 [Multi-domain]  Cd Length: 209  Bit Score: 41.12  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 674 GKVFKLEEHLDRLSDSAKALAFnnvPTREEikeAIFRTLITNGMFDNTHIRLSLTrgkkvtsgmspaFNRYGCTLIVLAE 753
Cdd:PRK07546  16 AGFPRLDRHLARLERSARALGF---PCDPA---AVRAKLAEAVAGAQGPLRLRLT------------LARDGRLTVETAP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187975 754 WKPPVYDNDGGIVLvtATTRrnspnnLDSkihHNNLLNN--------ILAKIESNNANVDDAIMLDKDGFVSETNATNIF 825
Cdd:PRK07546  78 LPPLPPDTVWRVAI--ARTR------LDS---ADPLLRYkttrraayDAARAELPPAEADEVILLNERGEVCEGTITNVF 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334187975 826 MVKKDRVLT--PHADYCLPGITRAtvmELVvkENFILEERRISLSEFHTADEVW 877
Cdd:PRK07546 147 LDRGGGMLTtpPLSCGLLPGVLRA---ELL--DAGRAREAVLTVDDLKSARAIW 195
PRK07101 PRK07101
hypothetical protein; Provisional
 806-876 6.12e-03

hypothetical protein; Provisional


Pssm-ID: 235934  Cd Length: 187  Bit Score: 38.77  E-value: 6.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187975 806 DAIMLDKDGFVSETNATNIFMVKKDRVLTPhADYCLPGITRATVMElvvkENFIlEERRISLSEFHTADEV 876
Cdd:PRK07101 114 DEIIIIKNGLVTDTSIGNLAFFDGKQWFTP-KKPLLKGTQRARLLD----EGKI-KEKDITVEDLLQYEEI 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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