|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02677 |
PLN02677 |
mevalonate kinase |
1-378 |
0e+00 |
|
mevalonate kinase
Pssm-ID: 215363 [Multi-domain] Cd Length: 387 Bit Score: 685.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 1 MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPlPSAENNDRLTLQLKDISLEFSWSLARIKEAIPyDSSTL 80
Cdd:PLN02677 1 MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFP-PSAENDDTLKLQLKDLGLEFSWPLARIKEALP-DLGTP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 81 CRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAAL 160
Cdd:PLN02677 79 CPSTPTSCSEETLKSIAALVEEQNIPEAKIWLSSGVSAFLWLYTSILGFNPATVVVTSELPLGSGLGSSAAFCVALSAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 161 LA--SSISEKTRGNGWSSLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTR 238
Cdd:PLN02677 159 LAasDSISVSTGGNGWSSLDETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 239 VGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQS--KDETSVTEKEERIKELMEMNQGLLLSMGVSHSSIE 316
Cdd:PLN02677 239 VGRNTKALVAGVSERALRHPDAMKSVFNAVDSISEELATIIQSpaEDELSITEKEEKLKELMEMNQGLLQCMGVSHSSIE 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334187979 317 AVILTTVKHKLVSKLTGAGGGGCVLTLLPT---GTVVDKVVEELESSGFQCFTALIGGNGAQICY 378
Cdd:PLN02677 319 TVLRTTLKYKLVSKLTGAGGGGCVLTLLPTllsGTVVDKVIAELESSGFQCFTAGIGGNGVQICY 383
|
|
| mevalon_kin |
TIGR00549 |
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ... |
7-343 |
2.82e-96 |
|
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Pssm-ID: 273130 [Multi-domain] Cd Length: 273 Bit Score: 288.04 E-value: 2.82e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRfplpsaENNDRltlqlkdislefswslarikeaiPYDSSTLCRSTPA 86
Cdd:TIGR00549 1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVI------ESSDG-----------------------SFIESDLGRGSLD 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 87 SCSEETLKSIAVLVEeqnlpkekmwlssgistFLWLYTRIIGFnPATVVINSELPYGSGLGSSAALCVALTAALLASSIs 166
Cdd:TIGR00549 52 DAPDELDGLKYVLAE-----------------FLSRFSELNPP-PLEITIESEIPPGRGLGSSAAVAVALIRALADYFG- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 167 ektrgngwsslDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGE-ITRLQSNMPLRMLITNTRVGRNTKA 245
Cdd:TIGR00549 113 -----------SELSKEELAELANEAEKIAHGKPSGIDTATSTSGGPVYFEKGEgEFTKLISLDGYFVIADTGVSGSTKE 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 246 LVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekEERIKELMEMNQGLLLSMGVSHSSIEAVILTTVKH 325
Cdd:TIGR00549 182 AVARVRQLLERFPELIDSIMDAIGELTLEAKAALQDGD-------VESLGELMNINQGLLKALGVSHPKLDQLVEIARKA 254
|
330
....*....|....*....
gi 334187979 326 K-LVSKLTGAGGGGCVLTL 343
Cdd:TIGR00549 255 GaLGAKLTGAGGGGCMIAL 273
|
|
| ERG12 |
COG1577 |
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ... |
7-343 |
1.09e-64 |
|
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441185 [Multi-domain] Cd Length: 277 Bit Score: 207.00 E-value: 1.09e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRfplPSAEnnDRLTLQLKDISLEFSWS------LARIKEAIpydsstl 80
Cdd:COG1577 1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVE---PSDD--DKLRIESPDLGGTLDLDpladaaLRYIKAAI------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 81 crstpascseetlksiAVLVEEQNLPKEkmwlssgistflwlytriigfnPATVVINSELPYGSGLGSSAALCVALTAAL 160
Cdd:COG1577 69 ----------------EAALEYLGLPLK----------------------GFDIEIDSEIPRKRGLGSSAAVAVAVIRAL 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 161 LAssisektrgngWSSLDETNLELLnKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGE-ITRLQSNMPLRMLITNTRV 239
Cdd:COG1577 111 AA-----------FYGVELSKEELF-KLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDrAEPLELPKNLPLVVGDTGV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 240 GRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekEERIKELMEMNQGLLLSMGVSHSSIEAVI 319
Cdd:COG1577 179 PASTKELVAKVRKLKERNPELYEAFLEEIGDLVEEAIEALEEGD-------LEALGELMNENHGLLRALGVSTPELDRLV 251
|
330 340
....*....|....*....|....*
gi 334187979 320 LTTVKHK-LVSKLTGAGGGGCVLTL 343
Cdd:COG1577 252 EAARKAGaLGAKLTGAGGGGCVIAL 276
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
133-211 |
4.06e-09 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 52.55 E-value: 4.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 133 TVVINSELPYGSGLGSSAALCVALTAALLAssisektrgngWSSLDetnlelLNKWAFEGEKIIH-GKPSGIDNTVSAYG 211
Cdd:pfam00288 1 DIEIESNIPLGAGLGSSAALAVALLLALNE-----------LFGLP------LAKLALEAEELAGgGRGGGMDVAASLYG 63
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02677 |
PLN02677 |
mevalonate kinase |
1-378 |
0e+00 |
|
mevalonate kinase
Pssm-ID: 215363 [Multi-domain] Cd Length: 387 Bit Score: 685.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 1 MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPlPSAENNDRLTLQLKDISLEFSWSLARIKEAIPyDSSTL 80
Cdd:PLN02677 1 MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFP-PSAENDDTLKLQLKDLGLEFSWPLARIKEALP-DLGTP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 81 CRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAAL 160
Cdd:PLN02677 79 CPSTPTSCSEETLKSIAALVEEQNIPEAKIWLSSGVSAFLWLYTSILGFNPATVVVTSELPLGSGLGSSAAFCVALSAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 161 LA--SSISEKTRGNGWSSLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTR 238
Cdd:PLN02677 159 LAasDSISVSTGGNGWSSLDETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 239 VGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQS--KDETSVTEKEERIKELMEMNQGLLLSMGVSHSSIE 316
Cdd:PLN02677 239 VGRNTKALVAGVSERALRHPDAMKSVFNAVDSISEELATIIQSpaEDELSITEKEEKLKELMEMNQGLLQCMGVSHSSIE 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334187979 317 AVILTTVKHKLVSKLTGAGGGGCVLTLLPT---GTVVDKVVEELESSGFQCFTALIGGNGAQICY 378
Cdd:PLN02677 319 TVLRTTLKYKLVSKLTGAGGGGCVLTLLPTllsGTVVDKVIAELESSGFQCFTAGIGGNGVQICY 383
|
|
| mevalon_kin |
TIGR00549 |
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ... |
7-343 |
2.82e-96 |
|
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]
Pssm-ID: 273130 [Multi-domain] Cd Length: 273 Bit Score: 288.04 E-value: 2.82e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRfplpsaENNDRltlqlkdislefswslarikeaiPYDSSTLCRSTPA 86
Cdd:TIGR00549 1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVI------ESSDG-----------------------SFIESDLGRGSLD 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 87 SCSEETLKSIAVLVEeqnlpkekmwlssgistFLWLYTRIIGFnPATVVINSELPYGSGLGSSAALCVALTAALLASSIs 166
Cdd:TIGR00549 52 DAPDELDGLKYVLAE-----------------FLSRFSELNPP-PLEITIESEIPPGRGLGSSAAVAVALIRALADYFG- 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 167 ektrgngwsslDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGE-ITRLQSNMPLRMLITNTRVGRNTKA 245
Cdd:TIGR00549 113 -----------SELSKEELAELANEAEKIAHGKPSGIDTATSTSGGPVYFEKGEgEFTKLISLDGYFVIADTGVSGSTKE 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 246 LVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekEERIKELMEMNQGLLLSMGVSHSSIEAVILTTVKH 325
Cdd:TIGR00549 182 AVARVRQLLERFPELIDSIMDAIGELTLEAKAALQDGD-------VESLGELMNINQGLLKALGVSHPKLDQLVEIARKA 254
|
330
....*....|....*....
gi 334187979 326 K-LVSKLTGAGGGGCVLTL 343
Cdd:TIGR00549 255 GaLGAKLTGAGGGGCMIAL 273
|
|
| ERG12 |
COG1577 |
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ... |
7-343 |
1.09e-64 |
|
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis
Pssm-ID: 441185 [Multi-domain] Cd Length: 277 Bit Score: 207.00 E-value: 1.09e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRfplPSAEnnDRLTLQLKDISLEFSWS------LARIKEAIpydsstl 80
Cdd:COG1577 1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVE---PSDD--DKLRIESPDLGGTLDLDpladaaLRYIKAAI------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 81 crstpascseetlksiAVLVEEQNLPKEkmwlssgistflwlytriigfnPATVVINSELPYGSGLGSSAALCVALTAAL 160
Cdd:COG1577 69 ----------------EAALEYLGLPLK----------------------GFDIEIDSEIPRKRGLGSSAAVAVAVIRAL 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 161 LAssisektrgngWSSLDETNLELLnKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGE-ITRLQSNMPLRMLITNTRV 239
Cdd:COG1577 111 AA-----------FYGVELSKEELF-KLALEAEKIVHGNPSGLDTAASTYGGPIYYQRGDrAEPLELPKNLPLVVGDTGV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 240 GRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekEERIKELMEMNQGLLLSMGVSHSSIEAVI 319
Cdd:COG1577 179 PASTKELVAKVRKLKERNPELYEAFLEEIGDLVEEAIEALEEGD-------LEALGELMNENHGLLRALGVSTPELDRLV 251
|
330 340
....*....|....*....|....*
gi 334187979 320 LTTVKHK-LVSKLTGAGGGGCVLTL 343
Cdd:COG1577 252 EAARKAGaLGAKLTGAGGGGCVIAL 276
|
|
| PRK03926 |
PRK03926 |
mevalonate kinase; Provisional |
3-361 |
1.08e-41 |
|
mevalonate kinase; Provisional
Pssm-ID: 179677 [Multi-domain] Cd Length: 302 Bit Score: 148.28 E-value: 1.08e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 3 VKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFplpsaeNNDrltlqlkdiSLEFSWSLARIKEAIPYdsstlcr 82
Cdd:PRK03926 2 VLCSAPGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEF------NDD---------SIYIESDYGKTGEKHPY------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 83 stpascseetlksiavlveeqnlpkekmwlssgISTFLWLYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALla 162
Cdd:PRK03926 60 ---------------------------------VSAAIEKMREEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGAL-- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 163 ssisEKTRGNGWSsldetnLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGeitRLQSNMPLRMLITNTRVGRN 242
Cdd:PRK03926 105 ----NRLLGLGLS------LEEIAKLGHKVELLVQGAASPTDTYVSTMGGFVTIPDR---KKLPFPECGIVVGYTGSSGS 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 243 TKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekEERIKELMEMNQGLLLSMGVSHSSIEAVILTT 322
Cdd:PRK03926 172 TKELVANVRKLKEEYPELIEPILSSIGKISEKGEELILSGD-------YVSLGELMNINQGLLDALGVSTKELSELIYAA 244
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 334187979 323 VKH-KLVSKLTGAGGGGCVLTLLPTGTvVDKVVEELESSG 361
Cdd:PRK03926 245 RTAgALGAKITGAGGGGCMVALAAPEK-QSEVATAIKIAG 283
|
|
| PTZ00298 |
PTZ00298 |
mevalonate kinase; Provisional |
9-357 |
1.73e-17 |
|
mevalonate kinase; Provisional
Pssm-ID: 240351 [Multi-domain] Cd Length: 328 Bit Score: 82.59 E-value: 1.73e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 9 GKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFpLPSAENndrltLQLKDIslefswslariKEAIPydsstlcrstpasc 88
Cdd:PTZ00298 17 GKVILFGEHFVVYGAEAIVAGIDEYTECRLEL-TKGVPG-----LQVVDQ-----------RPAVP-------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 89 seetlKSIAVLVEEQNLPKEKMWLSSGISTflwlytriiGFNPATVVINSELPYGSGLGSSAALCVALTAALlassisek 168
Cdd:PTZ00298 66 -----GYIVEKREEQRKAHQLVLRHLNIDT---------SVDGLKMHLGGPLVPSSGIGASASDVVSLSRAL-------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 169 trgngwSSLDETNL--ELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKF--CSGE--ITRLQSNMPLRMLITNTRVGRN 242
Cdd:PTZ00298 124 ------SELYQLNLteEEVNLSAFVGEGGYHGTPSGADNTAATYGGLISYrrVNGKsvFKRIAFQQPLYLVVCSTGITAS 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 243 TKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekEERIKELMEMNQGLLLSMGVSHSSIEAVILTT 322
Cdd:PTZ00298 198 TTKVVGDVRKLKENQPTWFNRLLENYNACVSEAKEALQKGN-------LFRVGELMNANHDLCQKLTVSCRELDSIVQTC 270
|
330 340 350
....*....|....*....|....*....|....*.
gi 334187979 323 VKH-KLVSKLTGAGGGGCVLTLLPTGTVVDKVVEEL 357
Cdd:PTZ00298 271 RTYgALGAKMSGTGRGGLVVALAASEDQRDAIAKAV 306
|
|
| COG2605 |
COG2605 |
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ... |
3-363 |
6.49e-16 |
|
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];
Pssm-ID: 442017 [Multi-domain] Cd Length: 328 Bit Score: 77.91 E-value: 6.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 3 VKARAPGKIILAG------EHAVVHGSTAVAAAIDLYTYVTLRfplpsAENNDRLTLQLKDISLEFSW-SLARIKEAIpy 75
Cdd:COG2605 1 IISRAPLRISFAGggtdlpPYYLEHGGAVLNAAIDKYAYVTLE-----PRFDGKIRLSSSDTERVETVdEDDDIPHPV-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 76 dsstlcrstpascseetlksIAVLVEEQNLPKekmwlssgistflwlytriiGFNpatVVINSELPYGSGLGSSAALCVA 155
Cdd:COG2605 74 --------------------IREALKLFGIGD--------------------GLE---ITTDSDAPAGSGLGSSSALTVA 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 156 LTAALLASsisektRGNGWSSLDetnlelLNKWAFEGEKIIHGKPSGI-DNTVSAYG--NMIKFCSGEITRLQsnmPLR- 231
Cdd:COG2605 111 LLNALHAL------LGLPLSPYD------LARLAYEIERNDLGEPGGKqDQYAAAFGgfNFIEFGPDGRVIVN---PLRi 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 232 -----------MLITNTRVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDetsvtekeerIKELME- 299
Cdd:COG2605 176 speilnelesnLLLFYTGITRESSDILKEQVKNVEDGDEATLEALHEMKELALEMKEALLKGD----------LDEFGEl 245
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334187979 300 MNQGLL----LSMGVSHSSIEAVILTTVKH-KLVSKLTGAGGGGCVLTLLPtGTVVDKVVEELESSGFQ 363
Cdd:COG2605 246 LNEGWElkkrLASGISNPAIDEIYELARKAgALGGKLLGAGGGGFLLFYAP-PERREAVREALSKAGLR 313
|
|
| GalK |
COG0153 |
Galactokinase [Carbohydrate transport and metabolism]; |
5-374 |
1.05e-12 |
|
Galactokinase [Carbohydrate transport and metabolism];
Pssm-ID: 439923 [Multi-domain] Cd Length: 380 Bit Score: 68.64 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 5 ARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRfplpsaENNDRL----TLQLKDislEFSWSLARIKEAIPYDSSTL 80
Cdd:COG0153 21 FSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAAR------PRDDRKvrvySADFDE---EVEFDLDDLEPGEEDGWANY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 81 crstpascseetLKSIAVLVEEQNLPkekmwlssgistflwlytrIIGFNpatVVINSELPYGSGLGSSAALCVALTAAL 160
Cdd:COG0153 92 ------------VRGVAWALQERGYK-------------------LGGFD---LVIDGDVPLGAGLSSSAALEVAVALAL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 161 lassisektrgNGWSSLDETNLELLnKWAFEGEKIIHGKPSGI-DNTVSAYGNMIKF----C-SGEITRLQSNMP-LRML 233
Cdd:COG0153 138 -----------NDLFGLGLDPVELA-KIGQRAENEFVGVPCGImDQFASALGKKGHAllldCrSLEYEYVPLPLEgYALV 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 234 ITNTRVGRntkALVSgvSQRAVRhPDAMKSVFNAVDSIS------KELAAIIQS-KDETS-------VTEkEERIKELME 299
Cdd:COG0153 206 IVDTNVKH---SLAD--SEYNER-RAECEAAAAILGVKSlrdvtlEDLEAARARlGDEVLrrrarhvVTE-NQRVLEAVE 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 300 -MNQGLLLSMGV----SH---------SSIE---AV-ILTTVKHKLVSKLTGAGGGGCVLTLLPTG---TVVDKVVEELE 358
Cdd:COG0153 279 aLRAGDLEAFGKlmnaSHaslrddyevSCPEldtLVeLALAEAGVLGARMTGGGFGGCTIALVPKDavdEFIEAVAEAYA 358
|
410
....*....|....*....
gi 334187979 359 SSGF---QCFTALIgGNGA 374
Cdd:COG0153 359 EKTGlepDFYVVKP-SDGA 376
|
|
| GHMP_kinases_N |
pfam00288 |
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ... |
133-211 |
4.06e-09 |
|
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 395225 [Multi-domain] Cd Length: 64 Bit Score: 52.55 E-value: 4.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 133 TVVINSELPYGSGLGSSAALCVALTAALLAssisektrgngWSSLDetnlelLNKWAFEGEKIIH-GKPSGIDNTVSAYG 211
Cdd:pfam00288 1 DIEIESNIPLGAGLGSSAALAVALLLALNE-----------LFGLP------LAKLALEAEELAGgGRGGGMDVAASLYG 63
|
|
| GHMP_kinases_C |
pfam08544 |
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ... |
292-361 |
3.80e-05 |
|
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.
Pssm-ID: 430063 [Multi-domain] Cd Length: 85 Bit Score: 41.69 E-value: 3.80e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334187979 292 ERIKELMEMNQGLL---LSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTGTVVDKVVEELESSG 361
Cdd:pfam08544 11 EELGKLLTESAESLeplLVVGILPPELDELLEALLELGLGAKLSGSGGGPTVFALFKDEDDAEEVARALREAG 83
|
|
| PRK03817 |
PRK03817 |
galactokinase; Provisional |
4-160 |
2.86e-04 |
|
galactokinase; Provisional
Pssm-ID: 235163 [Multi-domain] Cd Length: 351 Bit Score: 42.29 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 4 KARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTL----RFPLPSAENNDRLTLQLKDISLEFSWslarikeaIPYdsst 79
Cdd:PRK03817 2 KVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIekseKFIFYSENFNEEKTFELDKLEKLNSW--------ADY---- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 80 lcrstpascseetLKSIAVLVEEQNLpkekmwlssgistflwlytRIIGFNpatVVINSELPYGSGLGSSAALCVALTAA 159
Cdd:PRK03817 70 -------------IKGVIWVLEKRGY-------------------EVGGVK---GKVSSNLPIGAGLSSSASLEVAVAYA 114
|
.
gi 334187979 160 L 160
Cdd:PRK03817 115 L 115
|
|
| PRK01212 |
PRK01212 |
homoserine kinase; Provisional |
131-214 |
9.42e-04 |
|
homoserine kinase; Provisional
Pssm-ID: 234920 [Multi-domain] Cd Length: 301 Bit Score: 40.52 E-value: 9.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 131 PATVVINSELPYGSGLGSSAALCVAltAALLAssisektrgNGWSSLDETNLELLNkWAFEGEkiIHGkpsgiDNTVSAY 210
Cdd:PRK01212 81 GLRIELEKNIPLGRGLGSSAASIVA--GLVAA---------NELAGLPLSKEELLQ-LATEGE--GHP-----DNVAPAL 141
|
....*
gi 334187979 211 -GNMI 214
Cdd:PRK01212 142 lGGLV 146
|
|
| Pmev_kin_ERG8 |
TIGR01219 |
phosphomevalonate kinase, ERG8-type, eukaryotic branch; This enzyme is part of the mevalonate ... |
144-305 |
4.25e-03 |
|
phosphomevalonate kinase, ERG8-type, eukaryotic branch; This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents plant and fungal forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]
Pssm-ID: 273509 [Multi-domain] Cd Length: 454 Bit Score: 39.16 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 144 SGLGSSAALCVALTAALLaSSISEKTRGNGWSSL--DETNLELLNKWAFEGEKIIHGK-PSGIDNTVSAYGN-------- 212
Cdd:TIGR01219 153 TGLGSSAAMTTALVAALL-HYLGVVDLSDPDKEGkfGCSDLDVIHNLAQTAHCLAQGKvGSGFDVSAAVYGSqryrrfsp 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 213 -MIKFCSGEITRLQSNMPLRMLIT----NTRV-----------------GRNTKALVSGVSQRAVRHPDAMKSVFNAVDS 270
Cdd:TIGR01219 232 eLISFLQVAITGLPLNEVLGTIVKgkwdNKRTefslpplmnlfmgdpggGSSTPSMVGKVKKWQMSDPEESRENWQNLSD 311
|
170 180 190
....*....|....*....|....*....|....*..
gi 334187979 271 ISKELAAIIQSKDETSVTEKE--ERIKELMEMNQGLL 305
Cdd:TIGR01219 312 ANLELETKLNDLSKLAKDHWDvyLRVIKVLTSEKCVL 348
|
|
| ThrB |
COG0083 |
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ... |
134-214 |
5.60e-03 |
|
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 439853 [Multi-domain] Cd Length: 302 Bit Score: 38.16 E-value: 5.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187979 134 VVINSELPYGSGLGSSAALCVA-LTAA--LLASSISEKtrgngwssldetnlELLNkWAFEGEKiiHGkpsgiDNTVSA- 209
Cdd:COG0083 81 IEIEKGIPLGRGLGSSAAAIVAgLVAAnaLLGLPLSKE--------------ELLE-LATEGEG--HP-----DNVAPAl 138
|
....*
gi 334187979 210 YGNMI 214
Cdd:COG0083 139 LGGLV 143
|
|
| |
