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Conserved domains on  [gi|334188002|ref|NP_001190418|]
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Ubiquitin system component Cue protein [Arabidopsis thaliana]

Protein Classification

CUE domain-containing protein( domain architecture ID 10198281)

CUE domain-containing protein binds ubiquitin and may promote monoubiquitination

CATH:  1.10.8.10
Gene Ontology:  GO:0043130
PubMed:  12628920|12787494
SCOP:  4003786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 48-82 6.86e-07

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


:

Pssm-ID: 270465  Cd Length: 38  Bit Score: 44.77  E-value: 6.86e-07
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 334188002  48 LLDHLAAIFPDMDKQILERAIEECGDDLDSAIRCL 82
Cdd:cd14279    3 KLEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDAL 37
HemX super family cl43751
Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis ...
 174-237 4.02e-03

Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis) [General function prediction only];


The actual alignment was detected with superfamily member COG2959:

Pssm-ID: 442199 [Multi-domain]  Cd Length: 361  Bit Score: 38.02  E-value: 4.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334188002 174 MQNLQQENMMLKQQLEAIVQENSLLKravVTQQKRQRESEDQSQELQHLRQLVTQYQEQLRTLE 237
Cdd:COG2959   55 LQQQQAELAQLAQQLAALQQQAQELR---ALAQQLQELLQQLAARLAQLEQRLAELQQQLAALQ 115
 
Name Accession Description Interval E-value
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 48-82 6.86e-07

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 44.77  E-value: 6.86e-07
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 334188002  48 LLDHLAAIFPDMDKQILERAIEECGDDLDSAIRCL 82
Cdd:cd14279    3 KLEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDAL 37
HemX COG2959
Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis ...
 174-237 4.02e-03

Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis) [General function prediction only];


Pssm-ID: 442199 [Multi-domain]  Cd Length: 361  Bit Score: 38.02  E-value: 4.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334188002 174 MQNLQQENMMLKQQLEAIVQENSLLKravVTQQKRQRESEDQSQELQHLRQLVTQYQEQLRTLE 237
Cdd:COG2959   55 LQQQQAELAQLAQQLAALQQQAQELR---ALAQQLQELLQQLAARLAQLEQRLAELQQQLAALQ 115
 
Name Accession Description Interval E-value
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 48-82 6.86e-07

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 44.77  E-value: 6.86e-07
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 334188002  48 LLDHLAAIFPDMDKQILERAIEECGDDLDSAIRCL 82
Cdd:cd14279    3 KLEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDAL 37
HemX COG2959
Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis ...
 174-237 4.02e-03

Proteobacterial HemX domain, involved in 2-ketogluconate production (unrelated to B. subtilis HemX, COG0755, no evidence of involvement in heme biosynthesis) [General function prediction only];


Pssm-ID: 442199 [Multi-domain]  Cd Length: 361  Bit Score: 38.02  E-value: 4.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334188002 174 MQNLQQENMMLKQQLEAIVQENSLLKravVTQQKRQRESEDQSQELQHLRQLVTQYQEQLRTLE 237
Cdd:COG2959   55 LQQQQAELAQLAQQLAALQQQAQELR---ALAQQLQELLQQLAARLAQLEQRLAELQQQLAALQ 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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