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Conserved domains on  [gi|326381085|ref|NP_001191962|]
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Keratin-associated protein 12-1-like [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 2.99e-09

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 2.99e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 326381085   10 CQPSCCVSSPCQPSCCVSSPCQPSCCVSSPCQSACCRPAICIPV 53
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-120 3.33e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 51.72  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    7 SSGCQPSCCVSSPCQPSCCVSSPCQPSCCVSspCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCVPVSCR 86
Cdd:pfam01500  32 SSCCRPSCCQTSCCQPTTFQSSCCRPTCQPC--CQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRV 109

                          90       100       110
                  ....*....|....*....|....*....|....
gi 326381085   87 PVCVTSSCQSSGGCQPSCPTLVCRPVTCSNPSCC 120
Cdd:pfam01500 110 EGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYC 143
 
Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 2.99e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 2.99e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 326381085   10 CQPSCCVSSPCQPSCCVSSPCQPSCCVSSPCQSACCRPAICIPV 53
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-120 3.33e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 51.72  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    7 SSGCQPSCCVSSPCQPSCCVSSPCQPSCCVSspCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCVPVSCR 86
Cdd:pfam01500  32 SSCCRPSCCQTSCCQPTTFQSSCCRPTCQPC--CQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRV 109

                          90       100       110
                  ....*....|....*....|....*....|....
gi 326381085   87 PVCVTSSCQSSGGCQPSCPTLVCRPVTCSNPSCC 120
Cdd:pfam01500 110 EGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYC 143
 
Name Accession Description Interval E-value
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-53 2.99e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.92  E-value: 2.99e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 326381085   10 CQPSCCVSSPCQPSCCVSSPCQPSCCVSSPCQSACCRPAICIPV 53
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-120 3.33e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 51.72  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    7 SSGCQPSCCVSSPCQPSCCVSSPCQPSCCVSspCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCVPVSCR 86
Cdd:pfam01500  32 SSCCRPSCCQTSCCQPTTFQSSCCRPTCQPC--CQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRV 109

                          90       100       110
                  ....*....|....*....|....*....|....
gi 326381085   87 PVCVTSSCQSSGGCQPSCPTLVCRPVTCSNPSCC 120
Cdd:pfam01500 110 EGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYC 143
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
7-48 5.59e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.15  E-value: 5.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 326381085    7 SSGCQPSCCVSSPCQPSCCVSSPCQPSCCVSSPCQSACCRPA 48
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
19-68 7.55e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.45  E-value: 7.55e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 326381085   19 PCQPSCCVSSPCQPSCCVSSPCQSACCRPAICIPVryqvaCCVPVSCRPT 68
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPS-----CCRSSCCQPT 45
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 3-119 3.64e-07

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 46.35  E-value: 3.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    3 HTSCSSGCQPSCCVSSPCQPSCCVSSPCQPSCCVSSPCQSACCRPAI-CIPVRYQVACCVPVSCRPTVCMAPSCQSSVCV 81
Cdd:pfam05287  49 GSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCYSPRTsCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQ 128

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 326381085   82 PVSCRPVCVTSSCQSSGGCQP-SCPTLVCRPVTCSNPSC 119
Cdd:pfam05287 129 PLGCGSSGFRPLGCLSKGFQSlGYGSSFCRPSYVSSRSY 167
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 7-106 1.51e-06

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 44.81  E-value: 1.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    7 SSGCQPSCCVSSPCQPSC------CVSSPCQPSCCVSSPCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVC 80
Cdd:pfam05287  73 PCTSSTSYCVPSPCQRSCysprtsCVCSPCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGY 152

                          90       100
                  ....*....|....*....|....*.
gi 326381085   81 VPVSCRPVCVTSSCQSSGGCQPSCPT 106
Cdd:pfam05287 153 GSSFCRPSYVSSRSYQPSCFRPSCGS 178
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
29-70 2.16e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.60  E-value: 2.16e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 326381085   29 PCQPSCCVSSPCQSACCRPAICIPVRYQVACCVPVSCRPTVC 70
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 8-120 3.94e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 43.24  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    8 SGCQPSCCVSSPCQP-SCCVSSPCQPSCCVSSPCQSACCRPAICIPVRYQVACCVPVScrptvcmAPSCQSSVCVPVSCR 86
Cdd:pfam01500   2 ACCGTSFCGFPTCSTgGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC-------QPCCQTSCCQPTCCQ 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 326381085   87 PVCVTSSCQSSGGCQPSCPTLVCRPVTCSNPSCC 120
Cdd:pfam01500  75 TSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCR 108
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 7-94 7.41e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 42.47  E-value: 7.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 326381085    7 SSGCQPSCCVSSPCQPSCCVSSPCQPSCCVSSPCQSACCRPAICIPVRYQVACCVPVSCRPTVCMAPSCQSSVCVPVSCR 86
Cdd:pfam01500  65 TSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCG 144


                  ....*...
gi 326381085   87 PVCVTSSC 94
Cdd:pfam01500 145 QSCCRPAC 152
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
59-103 1.90e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 36.59  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 326381085   59 CCVPVSCRPTVCMAPSCQSSVCVPVSCRPVCVTSSCQSSGGCQPS 103
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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