|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
80-775 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1319.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 80 VGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNV 159
Cdd:cd00764 67 EGGTIIGSARCKEFREREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNI 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 160 VGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEG 239
Cdd:cd00764 147 VGMVGSIDNDFCGTDMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDG 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 240 WEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGV 319
Cdd:cd00764 227 WEDQMCRRLSEHRSRGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGV 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 320 EAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIP 399
Cdd:cd00764 307 EAVMALLEATPDTPACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPE 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 400 KTNCNVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKY 479
Cdd:cd00764 387 KTNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKD 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 480 LEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIK 559
Cdd:cd00764 467 LETIAYNFQKYGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 560 QSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTT 639
Cdd:cd00764 547 QSASGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTT 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 640 DFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNV 719
Cdd:cd00764 627 VFTYELYSEEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYA 706
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*.
gi 334191701 720 IFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 775
Cdd:cd00764 707 VLFEPVEELKQTTFEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
80-758 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1187.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 80 VGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNV 159
Cdd:TIGR02478 64 LGGTIIGTARCKEFRERPGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 160 VGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEG 239
Cdd:TIGR02478 144 VGLVGSIDNDMCGTDMTIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 240 WEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGV 319
Cdd:TIGR02478 224 WEDQLCHKLKRNRKAGKRKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGV 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 320 EAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIP 399
Cdd:TIGR02478 304 EAVLAVLESTPETPSPVISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLV 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 400 KTNC---NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLP 476
Cdd:TIGR02478 384 PSEAsrlRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLP 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 477 GKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCD 556
Cdd:TIGR02478 464 GDDLGTIAYYFQQHKIDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCD 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 557 RIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSEN 636
Cdd:TIGR02478 544 NIKQSASASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKV 623
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 637 YTTDFIYQLYSEEGKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISK 716
Cdd:TIGR02478 624 YTTDFIARIISEEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRG 703
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 334191701 717 RNVIFQPVA-ELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKA 758
Cdd:TIGR02478 704 SNVLFTPVKqLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
80-384 |
2.14e-151 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 445.20 E-value: 2.14e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 80 VGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGlleelarngqidkeavqKYAYLNV 159
Cdd:cd00363 62 RGGTIIGSARCKEFRTEEGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 160 VGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEG 239
Cdd:cd00363 125 IGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 240 WEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGV 319
Cdd:cd00363 205 WEEEMVDVIKKRRERGKRHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGA 284
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334191701 320 EAVIALLEATPDTPACVVSLNGNHAVRLPLMECVQMTQDVQkamderrfqdaVRLRGRSFAGNLN 384
Cdd:cd00363 285 EAVELLLEGTGGTPVGIQNLNENQVVRHPLTEAVNMTKRVG-----------VDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
81-322 |
1.97e-108 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 331.61 E-value: 1.97e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVV 160
Cdd:pfam00365 62 GGTILGTSRSKPFKTEEGREKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 161 GMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegw 240
Cdd:pfam00365 120 GIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 241 EEQMCVKLsENRARKKRLNIIIVAEGAIDTqnkpitsEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 320
Cdd:pfam00365 197 IEELCEKI-KELRKGKRFSIIVVAEGASDG-------EFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVK 268
|
..
gi 334191701 321 AV 322
Cdd:pfam00365 269 AV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
404-687 |
1.61e-105 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 324.29 E-value: 1.61e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 404 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 480
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteeGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 481 EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREkheefcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 560
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 561 SASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIqrglVLRNESCSenyTTD 640
Cdd:pfam00365 155 TASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRFSI----IVVAEGAS---DGE 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 334191701 641 FIYQLYsEEGKGvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 687
Cdd:pfam00365 227 FLAKLI-EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
81-365 |
3.94e-91 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 288.52 E-value: 3.94e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVV 160
Cdd:PRK03202 64 GGTILGSARFPEFKDEEGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 161 GMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegw 240
Cdd:PRK03202 121 GLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD--- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 241 EEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKpitSEKIKElvvtQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 320
Cdd:PRK03202 198 IEELCAKIKKGRERGKKHAIIVVAEGVMPAEEL---AKEIEE----RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAH 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 334191701 321 AVIALLEATPDTpacVVSLNGNHAVRLPLMECV-QMTQDVQKAMDE 365
Cdd:PRK03202 271 AVELLLEGKGGR---MVGIQNNKIVHVPIEEAVeNMKHPFDKDLYE 313
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
81-374 |
7.30e-91 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 288.90 E-value: 7.30e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVV 160
Cdd:COG0205 64 GGTILGSSRSKPFKTEEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 161 GMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegw 240
Cdd:COG0205 122 GIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD--- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 241 EEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPI---------------TSEKIKELVVTQLGYDTRVTILGHVQRGGT 305
Cdd:COG0205 199 LDKLLEKLKERRKRGKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGS 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334191701 306 PSAFDRILASRMGVEAVIALLEatpDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDerRFQDAVRL 374
Cdd:COG0205 279 PSAFDRVLASRLGAAAVELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
81-351 |
2.70e-83 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 267.29 E-value: 2.70e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEwsglleelarnGQIdkeavqkyaylNVV 160
Cdd:TIGR02482 62 GGTILGTARCPEFKTEEVREKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-----------GGI-----------PVI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 161 GMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegw 240
Cdd:TIGR02482 120 GLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYD--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 241 EEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPItSEKIKELVvtqlGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 320
Cdd:TIGR02482 197 IDELIQRLKEQHEAGKKHSIIIVAEGNIVGSAKEV-AKKIEEKT----GIETRVTVLGHTQRGGSPSAFDRVLASRLGAK 271
|
250 260 270
....*....|....*....|....*....|.
gi 334191701 321 AVIALLEatpDTPACVVSLNGNHAVRLPLME 351
Cdd:TIGR02482 272 AVELLLE---GKGGVMIGIQNNKIVTHPIEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
79-363 |
5.91e-70 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 232.30 E-value: 5.91e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 79 LVGGTIIGSARCQAFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLN 158
Cdd:cd00763 61 NRGGTFLGSARFPEFKDEEGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-----------LTEHG------------FP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 159 VVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEe 238
Cdd:cd00763 118 CVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 239 gwEEQMCVKLSENRARKKRLNIIIVAEGAIDtqnkpitSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMG 318
Cdd:cd00763 197 --REEVANRIKAGIERGKKHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMG 267
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 334191701 319 VEAVIALLEAtpdTPACVVSLNGNHAVRLPLMECVQMTQDVQKAM 363
Cdd:cd00763 268 AYAVELLLAG---KGGLAVGIQNEQLVHHDIIDAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
81-353 |
2.45e-60 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 206.77 E-value: 2.45e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARCQAFRT-REGRLKAACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleELARNGqidkeavqkyayLNV 159
Cdd:TIGR02483 64 GGTILGSSRTNPFKYeEDGDDKIVANLKELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 160 VGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEeg 239
Cdd:TIGR02483 121 VGVPKTIDNDLEATDYTFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD-- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 240 wEEQMCVKLSENRARKKRLNIIIVAEGA--------IDTQNKPI--------TSEKIKELVVTQLGYDTRVTILGHVQRG 303
Cdd:TIGR02483 199 -IDSVCEKVRERFARGKRFAIVVVAEGAkpkggemvVQEGVKDAfghvrlggIGNWLAEEIERRTGIETRATVLGHLQRG 277
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 334191701 304 GTPSAFDRILASRMGVEAVIALLEATPDTpacVVSLNGNHAVRLPLMECV 353
Cdd:TIGR02483 278 GSPSAFDRVLATRFGVAAVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
404-689 |
3.78e-52 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 184.89 E-value: 3.78e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 404 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 480
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKteeGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 481 EEIATQMRTHSINALLIIGGfeaylgllE--LSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 558
Cdd:COG0205 83 EKALENLKKLGIDALVVIGG--------DgsLDGAAKLAEEYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 559 KQSASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLqsnVEHLTEKMKTTIQRGLVL--------RN 630
Cdd:COG0205 155 RDTAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDG 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334191701 631 ESCSENYTTDFIYQLYSEEGKGV---------FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 689
Cdd:COG0205 231 EAVLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELL 298
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
405-746 |
7.42e-52 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 183.38 E-value: 7.42e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 405 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI- 483
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGq 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 484 ---ATQMRTHSINALLIIGGFEAYLGLLELSaarekheEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 560
Cdd:cd00763 82 akaIEQLKKHGIDALVVIGGDGSYMGAMRLT-------EHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 561 SASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNESCsenYTTD 640
Cdd:cd00763 155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 641 FIYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAklkearGRGkkfttddSICVlGISKRNVI 720
Cdd:cd00763 228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA------GKG-------GLAV-GIQNEQLV 291
|
330 340
....*....|....*....|....*.
gi 334191701 721 FQPVAELkkqtdFEHRIPKEQWWLKL 746
Cdd:cd00763 292 HHDIIDA-----IENMKPFKKDWLAL 312
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
404-727 |
2.01e-50 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 180.19 E-value: 2.01e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 404 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI 483
Cdd:cd00363 2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSAR-CKEFRTEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 484 ----ATQMRTHSINALLIIGGFEAYLGLLEL-SAAREKHEEFcvPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 558
Cdd:cd00363 81 rakaAENLKKHGIDALVVIGGDGSYTGADLLtEEWPSKYQGF--NVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 559 KQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDlqsnVEHLTEKMKTTIQRG----LVLRNEScs 634
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 635 enyTTDFIYQLYSEEG-------KGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKlkeargrgkkfTTDD 707
Cdd:cd00363 232 ---AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEG-----------TGGT 297
|
330 340
....*....|....*....|
gi 334191701 708 SICVLGISKRNVIFQPVAEL 727
Cdd:cd00363 298 PVGIQNLNENQVVRHPLTEA 317
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
414-687 |
7.85e-50 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 177.58 E-value: 7.85e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 414 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLE---EIATQMRTH 490
Cdd:PRK03202 13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgraKAIENLKKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 491 SINALLIIGGFEAYLGLLELSaarekheEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASgTKRRVF 570
Cdd:PRK03202 93 GIDALVVIGGDGSYMGAKRLT-------EHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS-SHERVF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 571 IIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNES-CSENYTTDFIyqlyseE 649
Cdd:PRK03202 165 IVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAKEI------E 235
|
250 260 270
....*....|....*....|....*....|....*...
gi 334191701 650 GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 687
Cdd:PRK03202 236 ERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVE 273
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
404-731 |
2.46e-41 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 162.12 E-value: 2.46e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 404 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQ--IKEIGWTDVGGWTGQGGSILGTKRVL-----P 476
Cdd:TIGR02478 2 RIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARCKefrerP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 477 GKYLEeiATQMRTHSINALLIIGG---------F-EAYLGLL-EL--------SAAREKHEEFCVPMVmvpATVSNNVPG 537
Cdd:TIGR02478 82 GRLKA--ARNLVSNGIDALVVIGGdgsltgadlFrEEWPSLLeELvdtgkitaEQAEEHRHLTIVGLV---GSIDNDMCG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 538 SDFSIGADTALNTITDTCDRIKQSASGTKrRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDirdlQSNVEHLTEK 617
Cdd:TIGR02478 157 TDMTIGADSALHRICEAIDAISSTAQSHQ-RAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPE----EGWEDQLCHK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 618 MKTTIQRG----LVLRNE----SCSENYTTDFIYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAmewI 689
Cdd:TIGR02478 232 LKRNRKAGkrktIVIVAEgaidRDLNPITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEA---V 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 334191701 690 TAKLKeargrgkkfTTDDSI-CVLGISKRNVIFQPVAELKKQT 731
Cdd:TIGR02478 307 LAVLE---------STPETPsPVISLRGNKIVRKPLVEAVAQT 340
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
110-322 |
1.85e-40 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 152.53 E-value: 1.85e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 110 GITNLCVIGGDGSLtganlfrkewsGLLEELARNGQIdkeavqkyaylNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEV 189
Cdd:PRK14071 107 GLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIPKTIDNDVGATEVSIGFDTAVNIATEA 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 190 VDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPpeegWE-EQMCVKLSENRARKKRLNIIIVAEGAI 268
Cdd:PRK14071 165 LDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIP----YTlENVCKKIRERQEEGKNFCLVVVSEAVR 240
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334191701 269 DTQNKPITSEK-------------IKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 322
Cdd:PRK14071 241 TEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAV 307
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
405-773 |
2.07e-37 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 149.97 E-value: 2.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 405 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKG--QIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLE- 481
Cdd:cd00764 6 IAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARCKEFREREg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 482 --EIATQMRTHSINALLIIGG---------FEA-YLGLLE--LSAAREKHEEF-------CVPMVmvpATVSNNVPGSDF 540
Cdd:cd00764 86 rlQAAYNLIQRGITNLCVIGGdgsltgadlFRSeWPSLLEelVKDGKITEEEVakyqhlnIVGMV---GSIDNDFCGTDM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 541 SIGADTALNTITDTCDRIKQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDiRDLQsnvEHLTEKMKT 620
Cdd:cd00764 163 TIGTDSALHRICEVVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPE-DGWE---DQMCRRLSE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 621 TIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV------FDCRKNVLGHMQQGGAPSPFDRNFGTKisaRAMEWITAKLK 694
Cdd:cd00764 238 HRSRGKRLNIIIVAEGAIDDQLKPITSEDVKDLvverlgLDTRVTTLGHVQRGGTPSAFDRILASL---MGVEAVMALLE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 695 EargrgkkfTTDDSICVLGISKRNVIFQPVAELKKQTdfeHRIPKEQWWLKLRPLMKILAK-YKASYDVSDSGQLEHVQP 773
Cdd:cd00764 315 A--------TPDTPACVVSLNGNKAVRLPLMECVQLT---KDVQKAMDEKRFDEAAALRGKsFDKNWNLYKLLAIELPQP 383
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
81-271 |
1.68e-19 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 92.03 E-value: 1.68e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARcqafrTREGRLKAACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleelarngQIDKEAVQKYAYLNVV 160
Cdd:PTZ00286 152 GGTILGSSR-----GGFDPKVMVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 161 GMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPpee 238
Cdd:PTZ00286 210 GIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFD--- 286
|
170 180 190
....*....|....*....|....*....|...
gi 334191701 239 gWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQ 271
Cdd:PTZ00286 287 -IPLEGVLEYIEQRLQKKGHCVIVVAEGAGQSL 318
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
405-691 |
1.95e-18 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 87.82 E-value: 1.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 405 VAVINVGAPAAGMNAAVRSAVRVGIAD-GHRMLAIYDGFDGFAKG--QIKEIGWTDVGGWTGQGGSILGT-KRVLPGKY- 479
Cdd:PRK14071 7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTtNKGDPFAFp 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 480 ---------LEEIATQMRTHSINALLIIGGfEAYLGLLelsaaREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNT 550
Cdd:PRK14071 87 mpdgslrdrSQEIIDGYHSLGLDALIGIGG-DGSLAIL-----RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 551 ITDTCDRIKQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIrdlqsnvEHLTEKMKTTIQRG----L 626
Cdd:PRK14071 161 ATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfcL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 627 VLRNESC----SENYTTDF---------IYQLYSEE--GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITA 691
Cdd:PRK14071 233 VVVSEAVrteeGEQVTKTQalgedryggIGQYLAEQiaERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
149-327 |
1.72e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 79.52 E-value: 1.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 149 EAVQKYAY-LNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV-----D-AIMTTaqsHQRTFVLEVMGRHCGYLALVSA 221
Cdd:PRK14072 124 QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleaalDvAAMAN---TSKVFILEVMGRHAGWLAAAAA 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 222 LAC-----GADWVFLPESPPEegwEEQMCVKLSENRARKKRLnIIIVAEGAIDTQNKPITSEK----------------- 279
Cdd:PRK14072 201 LAKqnpddAPHLIYLPERPFD---EEKFLADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAGlaedafghaqlggvapv 276
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 334191701 280 IKELVVTQLGYDTRVTILGHVQR--GGTPSAFDRILASRMGVEAVIALLE 327
Cdd:PRK14072 277 LANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
81-267 |
2.72e-12 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 69.51 E-value: 2.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARcqafrtreGRLKAAC---NLLQRGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGqidkeavQKYAyl 157
Cdd:PRK06830 148 GGTILGSSR--------GPQDPEEivdTLERMNINILFVIGGDGTLRGA-------SAIAEEIERRG-------LKIS-- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 158 nVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALACG-ADWVFLPESP 235
Cdd:PRK06830 204 -VIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVP 282
|
170 180 190
....*....|....*....|....*....|..
gi 334191701 236 PEEGWEEQMCVKLsENRARKKRLNIIIVAEGA 267
Cdd:PRK06830 283 FDLEGPNGLLAAL-EKRLAERGHAVIVVAEGA 313
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
81-267 |
4.36e-12 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 69.01 E-value: 4.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 81 GGTIIGSARcqafrTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavQKYAylnVV 160
Cdd:PLN02564 152 GGTILGTSR-----GGHDTSKIVDSIQDRGINQVYIIGGDGTQKGASV-------IYEEIRRRG-------LKVA---VA 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 161 GMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALAC-GADWVFLPESP--- 235
Cdd:PLN02564 210 GIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPfyl 289
|
170 180 190
....*....|....*....|....*....|...
gi 334191701 236 -PEEGWEEQMCVKLSENRARkkrlnIIIVAEGA 267
Cdd:PLN02564 290 eGKGGLFEFIEKRLKENGHM-----VIVVAEGA 317
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
108-359 |
2.68e-10 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 63.29 E-value: 2.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 108 QRGITNLCVIGGDGSLTGANLfrkewsglleelarngqIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIGTDSALHRII 187
Cdd:PLN02884 141 ARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQ 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 188 EVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsENRARKKRLNIIIVAE 265
Cdd:PLN02884 204 RAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHL-EHLIETKGSAVVCVAE 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 266 GA-IDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPS-----------------AFDRILASRMGVEAVIAlle 327
Cdd:PLN02884 283 GAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAVHG--- 359
|
250 260 270
....*....|....*....|....*....|..
gi 334191701 328 ATPDTPACVVSLNGNHAVRLPLMECVQMTQDV 359
Cdd:PLN02884 360 AFAGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
405-583 |
1.14e-09 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 61.21 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 405 VAVINVGAPAAGMNAAVRSAVRVGIADGH--RMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEE 482
Cdd:PTZ00286 90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSR--GGFDPKV 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 483 IATQMRTHSINALLIIGGFEAYLGLLELS--AAREKHEefcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 560
Cdd:PTZ00286 168 MVDTLIRHGINILFTLGGDGTHRGALAIYkeLRRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244
|
170 180
....*....|....*....|...
gi 334191701 561 SASGTKRRVFIIETMGGYCGYLA 583
Cdd:PTZ00286 245 EAKSAKNGVGIVKLMGRDSGFIA 267
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
69-223 |
1.05e-07 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 55.01 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 69 HRFpcpgrhalvGGTIIGSARCQAFRT---------REGR--LKAACNLLQR-GITNLCVIGGDGSLTGAnlfrkewSGL 136
Cdd:PRK06555 68 HRY---------GGSPIGNSRVKLTNVadcvkrglvKEGEnpLKVAAERLAAdGVDILHTIGGDDTNTTA-------ADL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 137 LEELARNGqidkeavqkYAyLNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGY 215
Cdd:PRK06555 132 AAYLAENG---------YD-LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGW 201
|
....*...
gi 334191701 216 LALVSALA 223
Cdd:PRK06555 202 LTAATARA 209
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
404-583 |
8.88e-06 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 48.65 E-value: 8.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 404 NVAVINVGAPAAGMNAAVRSAV-RVGIADGHRMLAIYDGFDGFAKGQIKEIGWTD--VGGWTGQGGSILGTKRvlPGKYL 480
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRkvVQNIHLSGGSLLGVSR--GGAKT 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 481 EEIATQMRTHSINALLIIGGFEAYLGllelsaAREKHEEfC------VPMVMVPATVSNNVPGSDFSIGADTALNTITDT 554
Cdd:PLN02884 133 SDIVDSIEARGINMLFVLGGNGTHAG------ANAIHNE-CrkrkmkVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRA 205
|
170 180
....*....|....*....|....*....
gi 334191701 555 CDRIKQSASGTKRRVFIIETMGGYCGYLA 583
Cdd:PLN02884 206 INSAYIEAHSAYHGIGLVKLMGRSSGFIA 234
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
416-583 |
4.49e-05 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 46.66 E-value: 4.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 416 GMNAAVRSAVrVGIADG---HRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEEIATQMRTHSI 492
Cdd:PLN02564 101 GLNTVIREIV-CGLSYMygvTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSR--GGHDTSKIVDSIQDRGI 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 493 NALLIIGGFEAYLGllelsaAREKHEE-----FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKR 567
Cdd:PLN02564 178 NQVYIIGGDGTQKG------ASVIYEEirrrgLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVEN 251
|
170
....*....|....*.
gi 334191701 568 RVFIIETMGGYCGYLA 583
Cdd:PLN02564 252 GIGLVKLMGRYSGFIA 267
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
111-269 |
6.06e-04 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 43.49 E-value: 6.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 111 ITNLCVIGGDGSLTGAnlfrkewsGLLEELARNGQIDkeavqkyayLNVVGMVGSIDNDFC--GTDMTIGTDSALHRIIE 188
Cdd:PTZ00287 272 LNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSE 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334191701 189 VVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVK-----LSENRARKKRLNIII 262
Cdd:PTZ00287 335 VIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSLKDIVSnivntILKRRSLNKNYGVIL 414
|
....*..
gi 334191701 263 VAEGAID 269
Cdd:PTZ00287 415 IPEGLIE 421
|
|
| |
