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Conserved domains on  [gi|336391158|ref|NP_001229566|]
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interleukin-31 receptor subunit alpha isoform 3 [Homo sapiens]

Protein Classification

FN3 domain-containing protein( domain architecture ID 10705451)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 155-254 5.26e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 5.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158 155 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 234
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 336391158 235 CavKESKFWSDWSQEKMGMT 254
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 453-533 4.54e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 4.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   453 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 532
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 336391158   533 G 533
Cdd:smart00060  81 G 81
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 59-142 2.05e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 473895  Cd Length: 96  Bit Score: 40.86  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   59 NISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 135
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*..
gi 336391158  136 DGVIKSH 142
Cdd:pfam09240  81 AGPIRSS 87
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 155-254 5.26e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 5.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158 155 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 234
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 336391158 235 CavKESKFWSDWSQEKMGMT 254
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 453-533 4.54e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 4.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   453 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 532
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 336391158   533 G 533
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 460-544 1.63e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158 460 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTN 536
Cdd:cd00063    8 RVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPP 85


                 ....*...
gi 336391158 537 GTSINFKT 544
Cdd:cd00063   86 SESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
156-247 1.49e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158  156 PPKIFRVKPVLGIKrmIQIEWIKPElAPVSSDLKYTLRFRTVNSTS-WMEVNFAKNRKdknqTYNLTGLQPFTEYVIALR 234
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPP-DGNGPITGYEVEYRPKNSGEpWNEITVPGTTT----SVTLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|...
gi 336391158  235 cAVKeSKFWSDWS 247
Cdd:pfam00041  75 -AVN-GGGEGPPS 85
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 59-142 2.05e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 40.86  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   59 NISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 135
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*..
gi 336391158  136 DGVIKSH 142
Cdd:pfam09240  81 AGPIRSS 87
fn3 pfam00041
Fibronectin type III domain;
460-533 2.18e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 336391158  460 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 533
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 156-235 3.70e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 3.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   156 PPKIFRVKPVLgiKRMIQIEWIKPELAPVSSD-LKYTLRFRTVNStSWMEVNfaknRKDKNQTYNLTGLQPFTEYVIALR 234
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYiVGYRVEYREEGS-EWKEVN----VTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 336391158   235 C 235
Cdd:smart00060  76 A 76
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 155-254 5.26e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.96  E-value: 5.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158 155 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 234
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 336391158 235 CavKESKFWSDWSQEKMGMT 254
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 453-533 4.54e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 4.54e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   453 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 532
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 336391158   533 G 533
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 460-544 1.63e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158 460 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTN 536
Cdd:cd00063    8 RVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPP 85


                 ....*...
gi 336391158 537 GTSINFKT 544
Cdd:cd00063   86 SESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
156-247 1.49e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.86  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158  156 PPKIFRVKPVLGIKrmIQIEWIKPElAPVSSDLKYTLRFRTVNSTS-WMEVNFAKNRKdknqTYNLTGLQPFTEYVIALR 234
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPP-DGNGPITGYEVEYRPKNSGEpWNEITVPGTTT----SVTLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|...
gi 336391158  235 cAVKeSKFWSDWS 247
Cdd:pfam00041  75 -AVN-GGGEGPPS 85
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 59-142 2.05e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 40.86  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   59 NISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 135
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*..
gi 336391158  136 DGVIKSH 142
Cdd:pfam09240  81 AGPIRSS 87
fn3 pfam00041
Fibronectin type III domain;
460-533 2.18e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 2.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 336391158  460 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 533
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 156-235 3.70e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 3.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   156 PPKIFRVKPVLgiKRMIQIEWIKPELAPVSSD-LKYTLRFRTVNStSWMEVNfaknRKDKNQTYNLTGLQPFTEYVIALR 234
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYiVGYRVEYREEGS-EWKEVN----VTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 336391158   235 C 235
Cdd:smart00060  76 A 76
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 53-134 6.76e-04

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 39.71  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391158   53 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQytvkrTYAF-----GEKHDNC---TTNSSTSENRASCSFFLPRITIPD 124
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-----TYSFsyayeNETVKECplySTSGANSTRLFICFFPKNDVSLFV 81

                          90
                  ....*....|
gi 336391158  125 NYTIEVEAEN 134
Cdd:pfam09067  82 PLHITVVATN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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