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Conserved domains on  [gi|336391160|ref|NP_001229567|]
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interleukin-31 receptor subunit alpha isoform 4 precursor [Homo sapiens]

Protein Classification

FN3 domain-containing protein( domain architecture ID 10705451)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 136-235 7.11e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 7.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160 136 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 215
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 336391160 216 CavKESKFWSDWSQEKMGMT 235
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 434-514 5.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 5.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   434 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 513
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 336391160   514 G 514
Cdd:smart00060  81 G 81
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 40-123 1.61e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09240:

Pssm-ID: 473895  Cd Length: 96  Bit Score: 41.24  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   40 NISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 116
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*..
gi 336391160  117 DGVIKSH 123
Cdd:pfam09240  81 AGPIRSS 87
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 136-235 7.11e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 7.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160 136 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 215
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 336391160 216 CavKESKFWSDWSQEKMGMT 235
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 434-514 5.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 5.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   434 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 513
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 336391160   514 G 514
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 441-525 1.93e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160 441 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTN 517
Cdd:cd00063    8 RVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPP 85


                 ....*...
gi 336391160 518 GTSINFKT 525
Cdd:cd00063   86 SESVTVTT 93
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 40-123 1.61e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 41.24  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   40 NISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 116
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*..
gi 336391160  117 DGVIKSH 123
Cdd:pfam09240  81 AGPIRSS 87
fn3 pfam00041
Fibronectin type III domain;
137-228 1.98e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160  137 PPKIFRVKPVLGIKrmIQIEWIKPElAPVSSDLKYTLRFRTVNSTS-WMEVNFAKNRKdknqTYNLTGLQPFTEYVIALR 215
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPP-DGNGPITGYEVEYRPKNSGEpWNEITVPGTTT----SVTLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|...
gi 336391160  216 cAVKeSKFWSDWS 228
Cdd:pfam00041  75 -AVN-GGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
441-514 2.79e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 336391160  441 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 514
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 137-216 4.91e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   137 PPKIFRVKPVLgiKRMIQIEWIKPELAPVSSD-LKYTLRFRTVNStSWMEVNfaknRKDKNQTYNLTGLQPFTEYVIALR 215
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYiVGYRVEYREEGS-EWKEVN----VTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 336391160   216 C 216
Cdd:smart00060  76 A 76
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 136-235 7.11e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 7.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160 136 EPPKIFRVKPVlgIKRMIQIEWIKPElAPVSSDLKYTLRFRTVNSTSWMEVNfakNRKDKNQTYNLTGLQPFTEYVIALR 215
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 336391160 216 CavKESKFWSDWSQEKMGMT 235
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 434-514 5.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 5.57e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   434 PSEGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYIVQVMASTSA 513
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 336391160   514 G 514
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 441-525 1.93e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.64  E-value: 1.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160 441 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYIVQVMASTSAG-GTN 517
Cdd:cd00063    8 RVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGeSPP 85


                 ....*...
gi 336391160 518 GTSINFKT 525
Cdd:cd00063   86 SESVTVTT 93
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 40-123 1.61e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 41.24  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   40 NISCVYYYRKNLTCTWSPGKETSY-TQYTVKRTYAFGEKHDNCTTNSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 116
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*..
gi 336391160  117 DGVIKSH 123
Cdd:pfam09240  81 AGPIRSS 87
fn3 pfam00041
Fibronectin type III domain;
137-228 1.98e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160  137 PPKIFRVKPVLGIKrmIQIEWIKPElAPVSSDLKYTLRFRTVNSTS-WMEVNFAKNRKdknqTYNLTGLQPFTEYVIALR 215
Cdd:pfam00041   2 APSNLTVTDVTSTS--LTVSWTPPP-DGNGPITGYEVEYRPKNSGEpWNEITVPGTTT----SVTLTGLKPGTEYEVRVQ 74

                          90
                  ....*....|...
gi 336391160  216 cAVKeSKFWSDWS 228
Cdd:pfam00041  75 -AVN-GGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
441-514 2.79e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 336391160  441 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYIVQVMASTSAG 514
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 34-115 4.85e-04

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 40.10  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   34 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQytvkrTYAF-----GEKHDNC---TTNSSTSENRASCSFFLPRITIPD 105
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-----TYSFsyayeNETVKECplySTSGANSTRLFICFFPKNDVSLFV 81

                          90
                  ....*....|
gi 336391160  106 NYTIEVEAEN 115
Cdd:pfam09067  82 PLHITVVATN 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 137-216 4.91e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.52  E-value: 4.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 336391160   137 PPKIFRVKPVLgiKRMIQIEWIKPELAPVSSD-LKYTLRFRTVNStSWMEVNfaknRKDKNQTYNLTGLQPFTEYVIALR 215
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYiVGYRVEYREEGS-EWKEVN----VTPSSTSYTLTGLKPGTEYEFRVR 75


                   .
gi 336391160   216 C 216
Cdd:smart00060  76 A 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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