NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|339895889|ref|NP_001229936|]
View 

prospero homeobox protein 2 isoform 1 [Homo sapiens]

Protein Classification

homeo-prospero domain-containing protein( domain architecture ID 10523599)

homeo-prospero domain (HPD)-containing protein similar to Drosophila melanogaster homeobox protein prospero, a homeodomain protein that controls neuronal identity

CATH:  1.10.10.500
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  12429095|15837198

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 439-592 1.13e-106

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


:

Pssm-ID: 461534  Cd Length: 154  Bit Score: 317.45  E-value: 1.13e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895889  439 GLNPGHLKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRN 518
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339895889  519 SELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ 592
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 439-592 1.13e-106

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 317.45  E-value: 1.13e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895889  439 GLNPGHLKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRN 518
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339895889  519 SELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ 592
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
 439-592 1.13e-106

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 317.45  E-value: 1.13e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339895889  439 GLNPGHLKKAKLMFFFTRYPSSNLLKVYFPDVQFNRCITSQMIKWFSNFREFYYIQMEKSARQAISDGVTNPKMLVVLRN 518
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 339895889  519 SELFQALNMHYNKGNDFEVPDCFLEIASLTLQEFFRAVSAGRDSDPSWKKPIYKIISKLDSDIPEIFKSSSYPQ 592
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH