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Conserved domains on  [gi|350539433|ref|NP_001232875|]
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prostate stem cell antigen precursor-like [Ictalurus punctatus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 55-134 3.25e-18

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23542:

Pssm-ID: 480272  Cd Length: 79  Bit Score: 73.99  E-value: 3.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  55 QAPNGRSCYSCDANS-CSVKVNCEGSEDRCISASVTQGTNTISVKGCVSNsfCAASGSTSTSGIGITSMQCCEGNLCNGA 133
Cdd:cd23542    1 GPANALQCHVCNSSSnCTNPVNCEGSERYCKTTTVVQPSGNLVKKGCAET--CPPSTSRQQVGSGISSVTCCQGDLCNSK 78


                 .
gi 350539433 134 E 134
Cdd:cd23542   79 L 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 55-134 3.25e-18

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 73.99  E-value: 3.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  55 QAPNGRSCYSCDANS-CSVKVNCEGSEDRCISASVTQGTNTISVKGCVSNsfCAASGSTSTSGIGITSMQCCEGNLCNGA 133
Cdd:cd23542    1 GPANALQCHVCNSSSnCTNPVNCEGSERYCKTTTVVQPSGNLVKKGCAET--CPPSTSRQQVGSGISSVTCCQGDLCNSK 78


                 .
gi 350539433 134 E 134
Cdd:cd23542   79 L 79
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 62-131 5.96e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.75  E-value: 5.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 350539433   62 CYSCDANS---CSVKVNCEGSEDRCISASVTQG----TNTISVKGCvSNSFCAASGSTS-TSGIGITSMQCCEGNLCN 131
Cdd:pfam00021   1 CYSCLGVSnedCLSEVTCPLSDGQCVTTTLELPegnlRGTVVSKGC-ARSSCPRLLSDFiNGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 60-131 6.26e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 36.74  E-value: 6.26e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350539433    60 RSCYSCDAN---SCSVKVNCEGSEDRCISASVTQGT---NTISVKGCVSNSFCAASGSTST-SGIGITSMQCCEGNLCN 131
Cdd:smart00134   1 LQCYSCTGNpdsSCSSEEECRSPDDVCLTVVAEVISdsrGSVVYKGCATSPICPGSHGYEInLTIAFLKVSCCQTDLCN 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 55-134 3.25e-18

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 73.99  E-value: 3.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  55 QAPNGRSCYSCDANS-CSVKVNCEGSEDRCISASVTQGTNTISVKGCVSNsfCAASGSTSTSGIGITSMQCCEGNLCNGA 133
Cdd:cd23542    1 GPANALQCHVCNSSSnCTNPVNCEGSERYCKTTTVVQPSGNLVKKGCAET--CPPSTSRQQVGSGISSVTCCQGDLCNSK 78


                 .
gi 350539433 134 E 134
Cdd:cd23542   79 L 79
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 57-131 1.30e-08

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 49.32  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  57 PNGRSCYSC---DANSCS----VKVNCEGSEDRCISASVT----QGTNTISVKGCVSNSFCAASGSTSTSGIGITSMQCC 125
Cdd:cd23558    5 PNGIQCYSCngnSTHGCSseetSKVRCRGPQTQCLEATGTtahgGKNQSYMVKGCATPSMCQSTALSLNQVLNSADVRCC 84


                 ....*.
gi 350539433 126 EGNLCN 131
Cdd:cd23558   85 NGSLCN 90
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 57-132 1.59e-05

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 41.29  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  57 PNGRSCYSCDANS---CS----VKVNCEGSEDRCISASVT----QGTNTISVKGCVSNSFCAASGSTSTSGIGITSmqCC 125
Cdd:cd23563    1 PNGVECYSCVGNSrgaCSpsnaPVVRCYGAYSGCFDGNVTltigNVTLSLPVKGCVQDGDCTRESKGGASVTLKGS--CC 78


                 ....*..
gi 350539433 126 EGNLCNG 132
Cdd:cd23563   79 SGNLCNS 85
TFP_LU_ECD_LYPD5_rpt2 cd23566
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and ...
 56-133 2.94e-05

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 5 (LYPD5) and similar proteins; LYPD5 (also called Haldisin (human antigen with LU-domains expressed in skin)) is a novel differentiation marker of stratum granulosum in squamous epithelia. LYPD5 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467096  Cd Length: 96  Bit Score: 40.47  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  56 APNGRSCYSCDANS---CSV----KVNCEGSEDRCISASVTQGTN------TISVKGCVSNSfCAASGSTStSGIGITSM 122
Cdd:cd23566    5 TPNGMECYACLSFSpddCSPenaeKVKCHGDMTRCYEGNGTVTIGndnfsvPIYIKTCQAPS-CTTPGSTS-PWTAIISQ 82

                         90
                 ....*....|...
gi 350539433 123 Q--CCEGNLCNGA 133
Cdd:cd23566   83 QgsCCSGSLCNGP 95
TFP_LU_ECD_Sax cd23600
extracellular domain (ECD) found in Drosophila melanogaster Saxophone and similar proteins; ...
 61-134 6.56e-05

extracellular domain (ECD) found in Drosophila melanogaster Saxophone and similar proteins; Saxophone (Sax) is the Drosophila bone morphogenetic protein (BMP) type I receptor that transmits signal through Mad. It functions as a Dpp (Decapentaplegic) receptor in Drosophila embryos, but that its activity is normally inhibited by the O-linked glycosyltransferase Sxc (Super sex combs). Saxophone is the ortholog of the human activin receptor-like kinase (ALK)-1/2. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467129  Cd Length: 89  Bit Score: 39.59  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350539433  61 SCYSCDANSCSVKVNCEGSEdRCISASVTQGTNTISV-KGCVSNS-----FCAASGSTSTSGIGIT----SMQCCEGNLC 130
Cdd:cd23600    5 KCYSCEPPDCDPTTVCSNAI-QCWKSRVRDSDGKERVsRGCITEPdqvpfTCNTKSHSGSSKKKPNsgqySVECCQGDFC 83


                 ....
gi 350539433 131 NGAE 134
Cdd:cd23600   84 NNGS 87
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 61-122 1.45e-04

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 38.56  E-value: 1.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 350539433  61 SCYSCDANSCSVK--VNCEGSEDRCISASVTQGTN----TISVKGCVSNSFCAASGSTSTSGIGITSM 122
Cdd:cd23572    7 ACYSEGSDSCKSEetVNCTGEETQCIEFSGTISGGgssvKFAMKGCATESACDLGKGSLPFGGTSVNI 74
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 62-131 5.96e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.75  E-value: 5.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 350539433   62 CYSCDANS---CSVKVNCEGSEDRCISASVTQG----TNTISVKGCvSNSFCAASGSTS-TSGIGITSMQCCEGNLCN 131
Cdd:pfam00021   1 CYSCLGVSnedCLSEVTCPLSDGQCVTTTLELPegnlRGTVVSKGC-ARSSCPRLLSDFiNGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 60-131 6.26e-04

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 36.74  E-value: 6.26e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350539433    60 RSCYSCDAN---SCSVKVNCEGSEDRCISASVTQGT---NTISVKGCVSNSFCAASGSTST-SGIGITSMQCCEGNLCN 131
Cdd:smart00134   1 LQCYSCTGNpdsSCSSEEECRSPDDVCLTVVAEVISdsrGSVVYKGCATSPICPGSHGYEInLTIAFLKVSCCQTDLCN 79
TFP_LU_ECD_Ly6PGE cd23553
extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) ...
 62-131 3.95e-03

extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) and similar proteins; Ly6PGE is an uncharacterized Ly-6/uPAR family protein. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467083  Cd Length: 77  Bit Score: 34.36  E-value: 3.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 350539433  62 CYSCDA--NSCS--VKVNCEGSEDRCISASVTQGTNTISVKGCVSNSFCAASGSTSTSGIGIT-SMQCCEGNLCN 131
Cdd:cd23553    3 CYQCVGseDDCNkqKSVVCPSSHDRCITVTGRNEGKTTVTKSCSYKSFCDQASESCSLVKREGcNVSCCDSDGCN 77
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 61-131 4.42e-03

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 34.36  E-value: 4.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 350539433  61 SCYSCDAN-SCSVKVNCEGSEDRCISASVTQGTNTIS----VKGCvSNSFCAASGSTSTSGIGITSMQ--CCEGNLCN 131
Cdd:cd23556    2 RCYSCKSNgDCRVEEVCALGQDLCRTTVMTLWEEGEElelvVKGC-DVSGKTNASSSYRTGLNINSLQetVCSSDLCN 78
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 62-131 8.14e-03

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 33.45  E-value: 8.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 350539433  62 CYSCD--ANSCSVKVNCEGSEDRCIsaSVTQGTNTISvkGCVSNSFCaaSGSTSTSGIGITSMQ--CCEGNLCN 131
Cdd:cd23554    3 CYNCPnpTSNCNTNVTCSSNLDACL--IVKAGNRIYR--QCWKYSDC--NFDFISERFGESNFKyrCCQKDLCN 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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