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Conserved domains on  [gi|358030322|ref|NP_001239595|]
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dematin isoform 4 [Mus musculus]

Protein Classification

actin-binding LIM protein; villin family protein( domain architecture ID 11241350)

actin-binding LIM protein (abLIM) may act as a scaffold protein for signaling modules of the actin cytoskeleton| villin family protein similar to Oryza sativa villin-4, a Ca(2+)-regulated actin-binding protein involved in actin filament bundling, severing and capping

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-308 5.70e-75

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


:

Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 234.29  E-value: 5.70e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322    7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEV---WAESRTLGI 83
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDDRLERQSYGESLSTLSPSSEDSYDSRelrQRRSSSPGS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322   84 ISQA--STPRTTGTPRTSLPHFHHPET--------------------------------TRPDSNIYKKPPIYKQRESVG 129
Cdd:pfam16182 106 IGSPtySRHGYTPTLSRSPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGTSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322  130 GSPQSkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRKRkasrkgaeeeeeeedddseeeikair 209
Cdd:pfam16182 186 SASQS----SEDIIHSSRFPAS----------------------GGEEEGWNRR-------------------------- 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322  210 ERQKEELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSE 287
Cdd:pfam16182 214 LLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYGSD 293

                         330       340
                  ....*....|....*....|....*.
gi 358030322  288 AGSPG-----LQIYPYEMLVVTNKGR 308
Cdd:pfam16182 294 GDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
323-358 6.26e-14

Villin headpiece domain;


:

Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.03  E-value: 6.26e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 358030322   323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-308 5.70e-75

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 234.29  E-value: 5.70e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322    7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEV---WAESRTLGI 83
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDDRLERQSYGESLSTLSPSSEDSYDSRelrQRRSSSPGS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322   84 ISQA--STPRTTGTPRTSLPHFHHPET--------------------------------TRPDSNIYKKPPIYKQRESVG 129
Cdd:pfam16182 106 IGSPtySRHGYTPTLSRSPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGTSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322  130 GSPQSkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRKRkasrkgaeeeeeeedddseeeikair 209
Cdd:pfam16182 186 SASQS----SEDIIHSSRFPAS----------------------GGEEEGWNRR-------------------------- 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322  210 ERQKEELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSE 287
Cdd:pfam16182 214 LLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYGSD 293

                         330       340
                  ....*....|....*....|....*.
gi 358030322  288 AGSPG-----LQIYPYEMLVVTNKGR 308
Cdd:pfam16182 294 GDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
323-358 6.26e-14

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.03  E-value: 6.26e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 358030322   323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
323-358 2.88e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 60.47  E-value: 2.88e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 358030322  323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-308 5.70e-75

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 234.29  E-value: 5.70e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322    7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEHVELPRSRECSLSPKSTSPPPSPEV---WAESRTLGI 83
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDDRLERQSYGESLSTLSPSSEDSYDSRelrQRRSSSPGS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322   84 ISQA--STPRTTGTPRTSLPHFHHPET--------------------------------TRPDSNIYKKPPIYKQRESVG 129
Cdd:pfam16182 106 IGSPtySRHGYTPTLSRSPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGTSA 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322  130 GSPQSkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRKRkasrkgaeeeeeeedddseeeikair 209
Cdd:pfam16182 186 SASQS----SEDIIHSSRFPAS----------------------GGEEEGWNRR-------------------------- 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358030322  210 ERQKEELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HSGTSKSSSLPSYGRTTLSRLQSTEFSPSGSE 287
Cdd:pfam16182 214 LLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYGSD 293

                         330       340
                  ....*....|....*....|....*.
gi 358030322  288 AGSPG-----LQIYPYEMLVVTNKGR 308
Cdd:pfam16182 294 GDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
323-358 6.26e-14

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.03  E-value: 6.26e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 358030322   323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
323-358 2.88e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 60.47  E-value: 2.88e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 358030322  323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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