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Conserved domains on  [gi|363543350|ref|NP_001241688|]
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 3 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 115-320 2.94e-145

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467710  Cd Length: 204  Bit Score: 407.90  E-value: 2.94e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAM 194
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQqpRKIKQKPTTGLLAITLALHLCDL 274
Cdd:cd23982   81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDE 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 363543350 275 VHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRM 320
Cdd:cd23982  159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 115-320 2.94e-145

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 407.90  E-value: 2.94e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAM 194
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQqpRKIKQKPTTGLLAITLALHLCDL 274
Cdd:cd23982   81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDE 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 363543350 275 VHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRM 320
Cdd:cd23982  159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 81-325 1.10e-67

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 212.47  E-value: 1.10e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350   81 SAYELPYgtKGSEDLLLRVLAITsssipkNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGS 160
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVS------PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  161 KTTMRLFYPESA------HFDPKVENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 231
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  232 NPFFMEIAADKLLSLPMQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKKQTIHYYEQITLKSMAGSG-HNV 310
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 363543350  311 SQEALAIKRMLEMGA 325
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 115-320 2.94e-145

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 407.90  E-value: 2.94e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAM 194
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDTLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQqpRKIKQKPTTGLLAITLALHLCDL 274
Cdd:cd23982   81 DFYWLYEILSNEKRVRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQ--RKKKQKPTTGLLAITLALHLCDE 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 363543350 275 VHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSGHNVSQEALAIKRM 320
Cdd:cd23982  159 VHIAGFGYPDNGNSNQPIHYYNQITLKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 115-320 5.34e-113

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 326.17  E-value: 5.34e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKvENNPDTLLVLVAFKAM 194
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPE-EYDSDWLLVLVPFKSM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWIETILSDKKRV-RKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQpRKIKQKPTTGLLAITLALHLCD 273
Cdd:cd23967   80 DLLWLQAVIKGKKPNgKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG-KQGKNVPTTGIIAIVMALHYCD 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 363543350 274 LVHIAGFGYPDAyNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRM 320
Cdd:cd23967  159 EVDIAGFGYDPS-DPNAPLHYYDSLTMKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 116-320 1.77e-80

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 243.50  E-value: 1.77e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPkVENNPDTLLVLVAFKAMD 195
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDP-SHYDPNTTVVLIPFKPHD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 196 FHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR-KIKQKPTTGLLAITLALHLCDL 274
Cdd:cd23984   81 LRWLLDLLMGKKVSAKGFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKeKKPKHPTTGIIAITLALHICNE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 363543350 275 VHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEALAIKRM 320
Cdd:cd23984  161 VHIAGFKY-DFSNLNSTLHYYGNETMSVMTKNEyHNISAEQKFLKDL 206
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 81-325 1.10e-67

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 212.47  E-value: 1.10e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350   81 SAYELPYgtKGSEDLLLRVLAITsssipkNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGS 160
Cdd:pfam00777  16 SEWWLPF--TVTEELLELLPKVS------PFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  161 KTTMRLFYPESA------HFDPKVENNPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQP---PLIWDVNPKQIRIL 231
Cdd:pfam00777  88 KTTLRTMNPESAidskygNLGFSHPRDPFVEFVLVPFKGRDLLWLPAFLT-KGNVSRSLRVLYtlkEVKIPVDPDKVLFL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  232 NPFFMEIAADKLLSLPMQQPRkikqKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKKQTIHYYEQITLKSMAGSG-HNV 310
Cdd:pfam00777 167 HPDFLRYVANFWLRSHGLKGR----RPSTGLLMLSLALHLCDEVSLYGFGPFL-DSRGNSHHYYDNVLMKKGGFYGvHDM 241

                         250
                  ....*....|....*
gi 363543350  311 SQEALAIKRMLEMGA 325
Cdd:pfam00777 242 PFEFKLLQKLHKEGV 256
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 116-320 1.50e-64

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 203.05  E-value: 1.50e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfdPKV--ENNPDTLLVLVAFKA 193
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGA---PKSeqEYDPTSLFVAVLFKS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 194 MDFHWIETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPR---KIKQKPTTGLLAITL 267
Cdd:cd23983   79 VDFAWLKAMVKKEPLsfwSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRlwgWDKNVPTLGVTAVVL 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 363543350 268 ALHLCDLVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGSG-HNVSQEALAIKRM 320
Cdd:cd23983  159 ATHLCDEVSLAGFGY-DLSQPHAPLHYYDSVCMAAMNTQTmHNVTKETKFLKKL 211
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 115-320 1.07e-58

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 187.82  E-value: 1.07e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKvENNPDTLLVLVAFKAM 194
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPE-QYEKDSLFVLAGFKWQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWIETIL-SDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALHLC 272
Cdd:cd23981   80 DFKWLKYIVyKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNiPTLGSVAITMALHNC 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 363543350 273 DLVHIAGFGYpDAYNKKQTIHYYEQITLKSMAGS-GHNVSQEALAIKRM 320
Cdd:cd23981  160 DEVAVAGFGY-DMNTPNAPLHYYETIKMSAIKESwTHNIQREKEFLRKL 207
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 115-327 6.49e-49

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 164.76  E-value: 6.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfdpkVENNPDTLLVLVAFKAM 194
Cdd:cd23966   76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA-----VDLDPGVHLVLVPFKVL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWIETILSDKKRVRKgfWKQPPLIWDVNPKQIRILNPFFMEIAADKLLslpmqqpRKIKQKPTTGLLAITLALHLCDL 274
Cdd:cd23966  151 DLQWLISALTTGEITRT--YTPVKRFIKADKDKVLVINPAFIKYVHDNWT-------EHHGRYPSTGFLALIFALHICDE 221

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 275 VHIAGFGypdAYNKKQTIHYYEQitlksMAGSG-------HNVSQEALAIKRMLEMGAIK 327
Cdd:cd23966  222 VSVFGFG---ADSKGNWHHYWEK-----NRSAGafrktgvHDADFESDIIKKLAKEGKIR 273
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 55-327 2.90e-43

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 150.87  E-value: 2.90e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  55 SKLFGN-YSRDQPIFLRLEDYF--WVKTPSAYELPYGTKG-SEDLL---LRVLAITSSSIP--KNIQSLRCRRCVVVGNG 125
Cdd:cd23964   12 SPWFRErFIPDIKVLLDSEDFNpeEYNRLSHYKLPFGWGGlNREVVerlLRNLNLTSSRYMfvLRGGRPRCIRCAVVGNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 126 HRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfDPKVENNP---DTLLVLVAFKAMDFHWIETI 202
Cdd:cd23964   92 GILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLH-NSLLKHVPqdkDTKYLFIPFKIRDYDYLDAV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 203 LSDKKRVR---KGFWKQPPLIWDVNPKQIRILNPFFMeiaadkllslpmqqpRKIK---------QKPTTGLLAITLALH 270
Cdd:cd23964  171 LSGKPVPDgcdKGKRPPPLFGPKLNATNVRLLHPDFI---------------RYLFnrwlnsstsYRPTTGALMLLTALH 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 363543350 271 LCDLVHIAGFGypdaYNKKQTIHYYE-QITLKSMAGSGHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23964  236 TCDQVSVYGFG----YDPRFSLHYYDkTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 119-320 5.03e-40

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 139.03  E-value: 5.03e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 119 CVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHF--------DPKVENNPDTLLVLVA 190
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFylrgprcgCHPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 191 FKAMDFHWIetilsdkKRVRKGFWKQPPLiwdVNPKQIRILNpFFMEIaADKLLSLPMQQPRkikqKPTTGLLAITLALH 270
Cdd:cd19952   81 AAAADFKRL-------KRRKKRHDNAVLL---LTDPAPDLLS-YVRKR-LEKLGLKSFFGGN----APSSGLLAVLLALQ 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 363543350 271 LCDLVHIAGFGYPDAYNKKQTIHYYEQITLKSMAGSgHNVSQEALAIKRM 320
Cdd:cd19952  145 LCDSVDLYGFGVDSGHAPKVPYHYYDLVEAEEGTAV-HSFDLEAELLRAL 193
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 74-327 1.26e-32

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 122.29  E-value: 1.26e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  74 YFWVKTPSAYElPYGTKgseDLLLRVLAITSSSIPKNIQS-LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVA 152
Cdd:cd23979   41 YWWMMLQPQFK-PHNTK---EVLSKLFQIIPGENPYRSWDpSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 153 GYEGDVGSKTTMRLFYPESAHFDPkvennPDTLLVLVAFKAMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILN 232
Cdd:cd23979  117 GFEADVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKTLDLLWITSALS-TGQIRFTYAPVKQFL-RVDKDKVQIYN 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 233 PFFMEIAADKLlslpmqqPRKIKQKPTTGLLAITLALHLCDLVHIAGFGypdAYNKKQTIHYYEQitlKSMAG----SG- 307
Cdd:cd23979  190 PAFFKYIHDRW-------TEHHGRYPSTGMLVLFFALHVCDEVNVYGFG---ADSRGNWHHYWEN---NRYAGefrkTGv 256

                        250       260
                 ....*....|....*....|
gi 363543350 308 HNVSQEALAIKRMLEMGAIK 327
Cdd:cd23979  257 HDADFEAHIIDMLAKAGKIK 276
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 113-296 2.49e-32

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 121.53  E-value: 2.49e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 113 SLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpkvENNPDTLLVLVAFK 192
Cdd:cd23980   78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQNVSMILVPFK 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 193 AMDFHWIETILSdKKRVRKGFWKQPPLIwDVNPKQIRILNPFFMEIAADKLLslpmqqpRKIKQKPTTGLLAITLALHLC 272
Cdd:cd23980  153 TLDLEWVISATT-TGTISHTYVPVPRKI-KVKKEKILIYHPAFIKYVFDRWL-------QGHGRYPSTGILSVIFSLHVC 223

                        170       180
                 ....*....|....*....|....
gi 363543350 273 DLVHIAGFGypdAYNKKQTIHYYE 296
Cdd:cd23980  224 DEVDLYGFG---ADSKGNWHHYWE 244
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 117-327 1.33e-27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 108.89  E-value: 1.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 117 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTM---------RLFYPESAHFDPKV-----ENNP 182
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsilkRRYNSLKKNRDRDKflnrlKEYN 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 183 DTLLVLVAFkamdfhwietilSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLlslpmqQPRKIKQKPTTGL 262
Cdd:cd23963  144 GSILWYPKF------------SFKSSTNLLLKAARALKKNGLNLTVVYSNPEHFLAVQKFW------KRRGLEKRPSTGL 205

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 363543350 263 LAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAGSgHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23963  206 YLVSLALTFCDEIHLYGF-WPfptDPNGRPVPYHYYDDLSPSTKNKV-HNMPEEFKLLRELHKKGVLK 271
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 105-294 8.39e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 101.75  E-value: 8.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 105 SSIPKNIQSL----------RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTmrlFYPESAH- 173
Cdd:cd23973   62 ELIPKPKEQQllalsppggdGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAHs 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 174 ------------FDpKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIW---DVNPKQIRILNPFFMEI 238
Cdd:cd23973  139 itsslmilqkrgFK-NIPQDKDIKYILFPEGPRDYQWLEALLKNKTIPSGAYYGRRPRSYfsgDFTEDKYLVLHPDFLRY 217

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 363543350 239 AADKLL-SLPMQQPRKIKQKPTTGLLAITLALHLCDLVHIAGF------GYPDAY---NKKQTIHY 294
Cdd:cd23973  218 VKNRFLrSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSAYGFitedyrKYPDHYydkKKTKLVFY 283
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 117-320 1.63e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.04  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 117 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRL-----FYPESAHFDPKVENNPDTLLV---- 187
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqiLSKPEFNFLTDPLYRNVTLLVwdps 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 188 ------LVAFKAMDFHWIET-----ILSDKKRVrkgFWKQPPLIWDVnpkqIRILNPFFmeiaadkllslpmqqPRKIKQ 256
Cdd:cd23968  126 synvnlEKWYKKPDFDFFPNyikyrRRHPEEPF---YLIDPRFLWRL----WDILQEYT---------------PEKIKP 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 363543350 257 K-PTTGLLAITLALHLCDLVHIAGFGYPDAYNKKqtIHYYEQITLKSMA-GSGHNVSQEALAIKRM 320
Cdd:cd23968  184 NpPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDR--CHYYDVEKDLACTlGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 116-301 3.69e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 89.99  E-value: 3.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFypesAHFD-PKVENNPDTLLVLVAFKAM 194
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV----SHSSlPRLLRNAILLLAGTRAPTV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 195 DFHWietiLSDKKRVRKGFwKQPPLIW---DVNPK-QIRILNPfFMEIAADKLLSLPMQQPRKI-KQKPTTGLLAITLAL 269
Cdd:cd23965   77 VVFW----GPETKMNKDGA-GKYNLLRslsKKYPDvEFYSLTP-EKMDYADELFEKETGKSRIKsGTWLSTGWFTMLLAL 150

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 363543350 270 HLCDLVHIAGFGYPDaY-----NKKQTIHYYEQITLK 301
Cdd:cd23965  151 DVCDEIKVYGMVPEN-YcrehpNSKVPYHYYEPGGLK 186
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 115-330 1.76e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 86.70  E-value: 1.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSK---TTMrlfypesahfdpkvenNPDtlLVLVAF 191
Cdd:cd23969   63 HFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKsnlTTM----------------NPS--VIPHAY 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 192 KAMDF-HWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILN---------------PFFMEIAADKLLSlpmQQPRKIK 255
Cdd:cd23969  125 GDLVNaTDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTNeiilkhklnvktaypPLRLNHAIRGYWL---TTKFRIK 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 363543350 256 qKPTTGLLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSMAgSGHNVSQEALAIKRMLEMGAIKNLT 330
Cdd:cd23969  202 -RPSTGLLMYTLATRFCDEIHLYGF-YPfseDGNGRAVKYHYYDNRKYLTTA-RPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 62-320 1.03e-18

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 84.50  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  62 SRDQpIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRvlaitsssIPKNIQSLR-CRRCVVVGNGHRLRNSSLGDAINKY 140
Cdd:cd23986    3 SRQE-LLCELKKRVQVRTLDGKEAPFSALGWEKYVPK--------IPLSKLHLRgFRSCAVVTSAGAILNSSLGKEIDSH 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 141 DVVIRLNNAPVAGYEGDVGSKTTMRLFYPE-----SAHF--------------DPKvennPDTLLVLVAFKAMDFHwiet 201
Cdd:cd23986   74 DAVLRFNSAPTRGYEKDVGNKTTIRIINSQiltnpNHHFidsslykdvilvawDPA----PYSANLHKWYKKPDYN---- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 202 ILSDKKRVRKGFWKQPPLIwdVNPKQIRILNPFFMEIAADKLlslpmqQPrkikQKPTTGLLAITLALHLCDLVHIagFG 281
Cdd:cd23986  146 LFTPYVQYRKRNPNQPFYI--LHPKFIWQLWDIIQENTQEKI------QP----NPPSSGFIGILIMMSMCREVHV--YE 211

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 363543350 282 YPDAYNKKQTIHYYEQ-----ITLksmaGSGHNVSQEALAIKRM 320
Cdd:cd23986  212 YIPSVRQTDLCHYHERyydaaCTL----GAYHPLLYEKLLIQRM 251
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 70-296 2.39e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 83.22  E-value: 2.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  70 RLEDYFWVKTPSAYELPYGTKGSEDLLlrvlaiTSSSIPKNIQSLRcrRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNA 149
Cdd:cd23985    7 ELKDKVNVSMLEGTDFPFNTSEWEGYL------PKKSLREEVGPLG--RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 150 PVAGYEGDVGSKTTMRLFYP-----ESAHFDPKVENNPDTLLVL--VAFKAMDFHWIET----ILSDKKRVRKgfwkqpp 218
Cdd:cd23985   79 PTAGFQQDVGTKTTIRLINSqlvttEKHKFLKDSLYNEGILIVWdpAPYHSDIPEWYKNpdynFFENYKTYRR------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 219 liwdVNPKQ-IRILNPFF--------MEIAADKLlslpmqQPrkikQKPTTGLLAITLALHLCDLVHIAGFgYPdayNKK 289
Cdd:cd23985  152 ----LNPNQpFYILHPQMqwelwdiiQENSPEEI------QP----NPPSSGMLGIILMMTLCDQVDVYEF-LP---SKR 213


                 ....*....
gi 363543350 290 QT--IHYYE 296
Cdd:cd23985  214 KTdvCHYYQ 222
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 116-327 2.45e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 84.03  E-value: 2.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFY-------------------PESAH--- 173
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFStntlmnslrayagvgfngpPQSKEtry 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 174 -FDPkvENNPDTLLVLVAfkamdfhwIETILSDKKRVRKgfwKQPPLIW--DVNPKQIRILNPFFMEIAADKLLSLPMQQ 250
Cdd:cd23974  164 iFLP--DHDRDYLLVKAA--------LTHTPIDRGRDKS---KRPSKYFgkDVTAEKFKIYHPDFIRYLRNRFLWSPILN 230

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 363543350 251 P--RKIkQKPTTGLLAITLALHLCDLVHIAGFGYPDaYNKKQTiHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23974  231 TkqRDI-YRPSTGAVMLLAALHTCDQVSAYGFMTPD-YGKYSD-HYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIK 306
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 111-296 1.17e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 81.67  E-value: 1.17e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 111 IQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpKVENNPDTLLVLVA 190
Cdd:cd23970   63 FQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILE---KYYNNLLTIQDRNN 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 191 FkamdfhwietiLSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLP-----MQ------QPRKIKQKP- 258
Cdd:cd23970  140 F-----------FLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAwpgniMQhvnrywKTKHLSPKRl 208

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 363543350 259 TTGLLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYE 296
Cdd:cd23970  209 STGILMYTLASAICEEIHLYGF-WPfgfDPTGTPLPYHYYD 248
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 81-327 1.23e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 81.79  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350  81 SAYELPYGTKG--SEDL--LLRVLAITSSS--IPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGY 154
Cdd:cd23972   41 SQRKVPYGWKGlsHQVVasTLSLLNDSANAklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 155 EGDVGSKTTmrlFYpesaHFDPKVENNPdtllvLVAFKAMDFH-----------WIETILSDKKRVRKGFWKQP-PLIWD 222
Cdd:cd23972  121 EEDVGTKTS---FY----GFTVNTMKNS-----LISYWNLGFTrtpqgqdlqyiFIPSDIRDYVMLRSAILGVPvPEGLD 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 223 ------------VNPKQIRILNPFFMEIAADKLLS---LPMQQPRKIkqKPTTGLLAITLALHLCDLVHIAGFGYPDaYN 287
Cdd:cd23972  189 kgdrphkyfgpeASAKKFKLLHPDFISYLTDRFLKsklLNTHYGHLY--MPSTGALMLLTALHTCDQVSAYGFITSN-YW 265

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 363543350 288 KKQTiHYYEQITLKSMAGSGHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23972  266 KFSD-HYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 106-327 3.77e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 80.00  E-value: 3.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 106 SIPKNIQSL----------RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSK---TTM------RL 166
Cdd:cd23988   44 NISQNLHSLlpevspmknrRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKsdfITMnpsvvqRA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 167 F-----YPESAHFDPKVENNPDTLLVLVAF--KAMDFH--WI-ETILSDKKRVRKGFwkqPPLiwdvnpKQIRILNPFFM 236
Cdd:cd23988  124 FggfrnESDREKFVHRLSMLNDSVLWIPAFmvKGGEKHveWVnALILKNKLKVRTAY---PSL------RLIHAVRGYWL 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 237 eiaADKLlslpmqqprKIKqKPTTGLLAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQITLKSMAGSG-HNVSQE 313
Cdd:cd23988  195 ---TNKV---------NIK-RPSTGLLMYTLATRFCDEIHLYGFwPFPkDANGNPVKYHYYDDLKYRYFSNAGpHRMPLE 261

                        250
                 ....*....|....
gi 363543350 314 ALAIKRMLEMGAIK 327
Cdd:cd23988  262 FKTLNVLHNRGALK 275
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 118-327 6.11e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 73.45  E-value: 6.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 118 RCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAgYEGDVGSKTTM--------RLFYPE----SAHFDPKVENNPDTL 185
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNlkkrRRPFVERMKVYGNAL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 186 LVLVAFKamdFHwIETILSDK-KRVRKGFWKQPPLIWdVNPKQIRILNPFFmeiaadklLSLPMQQPRkikqkPTTGLLA 264
Cdd:cd23971  145 LLLPAFS---YT-SNTEPSLRaLYTLEDFGSPQKVLF-FNPEYLRNLSRYW--------KSKGLKARR-----LSTGLML 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 363543350 265 ITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQItlksMAGSG-HNVSQEALAIKRMLEMGAIK 327
Cdd:cd23971  207 VSAALELCENVHLYGF-WPfstDLDGNPISHHYYDNV----LPKKGvHAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 116-296 2.38e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 71.42  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpKVENNPDTLLVLVAFKAMD 195
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVY---RVLRRPQEFLNRTPETTLI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 196 FhW--IETILSDKKRVRKGFWKQPPLI------WDVNPKQIRILNPFF-MEIAADKllslpmqqpRKIKQKPTTGLLAIT 266
Cdd:cd23978   78 F-WgpPNKMQKDGKSNLFRIIQRASMTfpnmsaFVVSPRRMRQFDDLFrGETGRDR---------KKSHSWLSTGWFTMV 147

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 363543350 267 LALHLCDLVHIAGFGYPDAYNKKQTI-----HYYE 296
Cdd:cd23978  148 IAVELCDNVHVYGMVPPNYCSKRPTPkkmpyHYYE 182
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 115-327 2.76e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 71.89  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 115 RCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMrlfypesahfdpkVENNPDtlLVLVAFK-A 193
Cdd:cd23987   63 HFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-------------VTMNPS--VVQRAFEdL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 194 MDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLP------------MQQPRKIKqKPTTG 261
Cdd:cd23987  128 VNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVNDLILKHHINVRTAYPslrllhavrgywLTNKVHIK-RPTTG 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 262 LLAITLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLK-SMAGSGHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23987  207 LLMYTLATRFCNRIHLYGF-WPfprDQNQNPVKYHYYDSLKYGyTSQASPHTMPLEFKALKNLHQQGALK 275
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 117-327 1.83e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 66.70  E-value: 1.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 117 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEG-DVGSKTTMRLFYP------------ESAHFDPKVENNPD 183
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNISkDVGSKTNLVTANPsiisikyaklneRRKPFLETVSVYGD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 184 TLLVLVAFK-----AMDFHWIETILSDKKRVRKGFWkqppliwdvNPKQIRILNPFFmeiaadklLSLPMQQPRKikqkp 258
Cdd:cd23991  145 AFLLLPAFSyrsntALSFKVYYTLEDFKAKQKVIFF---------HPIYLKHLAQFW--------RSKGVQVYRL----- 202

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 363543350 259 TTGLLAITLALHLCDLVHIAGFgYPDAYN---KKQTIHYYEQITLKSmagSGHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23991  203 STGLMITSAALELCEEVKLYGF-WPFSKNtegKPISHHYYDNQLPKP---GFHSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 116-166 4.63e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.80  E-value: 4.63e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRL 166
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRV 51
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 114-296 1.77e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.27  E-value: 1.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 114 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHfdpKVENNPDTLLVlVAFKA 193
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ---RILRNRNELLN-VSQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 194 MDFHWIETilSDKKRVRKGF-WKQPPLIWDVNPK-QIRILNPFFMeIAADKLLSLPMQQPRKIKQK-PTTGLLAITLALH 270
Cdd:cd23976   89 VFIFWGPS--NYMRRDGKGLvYNNLQLMNQILPKlKVYTITRHKM-LQFDELFKRETGKDRKISNTwLSTGWFTMIIALE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 363543350 271 LCDLVHIAGFGYP----DAYNKKQTIHYYE 296
Cdd:cd23976  166 LCDRINVYGMVPPdfcrDPNHPSVPYHYYE 195
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 114-327 2.86e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 60.23  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 114 LRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVA-GYEGDVGSKTTMRLFYPesAHFDPKVENnpdTLLVLVAF- 191
Cdd:cd23989   61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLSrEYTDDVGTKTQLVTANP--SIIDKRFQN---LLWSRKSFv 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 192 ---KAMDFHWIET-ILSDKKRVRKGFWKQPPLIwDVNPKQIRIL-NPFFMEIAAdkllslPMQQPRKIK-QKPTTGLLAI 265
Cdd:cd23989  136 esmKVYGRSYIYMpAFSMKTGTDPSLRVYYTLA-DVGANQTVLFaNPNFLRNVG------KFWKSKGVHaKRLSTGLFLV 208

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 363543350 266 TLALHLCDLVHIAGFgYP---DAYNKKQTIHYYEQITLKSmagSGHNVSQEALAIKRMLEMGAIK 327
Cdd:cd23989  209 SAALGLCEEVTIYGF-WPfsvDLDERTISHHYYDNVLPDS---GFHAMPEEFLQLWHLHKSGVLR 269
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 117-298 2.41e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 54.46  E-value: 2.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 117 RRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAG-YEGDVGSKTTMRLFYP----ESAH--------FDPKVENNPD 183
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGVKTDVVTINPsiitERFHklekwrrpFYEVLQVYEN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363543350 184 TLLVLVAFkamdFHWIETILSDK-KRVRKGFwkqppliwdVNPKQIRILNPFFMEIAADKLLSLPMQQPRkikqkPTTGL 262
Cdd:cd23990  145 ASVVLPAF----YNTRNTDVSIRvKYVLDDF---------ESQQAVYYFHPQYLLNVSRFWLRQGVRAKR-----ISSGL 206

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 363543350 263 LAITLALHLCDLVHIAGF-GYP-DAYNKKQTIHYYEQI 298
Cdd:cd23990  207 MLVTAALELCEEVHLYGFwAFPmNPSGIFITHHYYDNV 244
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 116-183 6.81e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 52.63  E-value: 6.81e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 363543350 116 CRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAhfdPKVENNPD 183
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSV---PLLLKNPD 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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