|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
66-567 |
1.34e-145 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 436.58 E-value: 1.34e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 66 SLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:COG0553 241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRfnihsRYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:COG0553 321 LDGTRERAKGAN-----PFEDADLVITSYGLL---RRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLAL 392
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQsiYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKK 305
Cdd:COG0553 393 TGTPVENRLEELWSLLDFLNPGLLGSLKA-----FRERFARPIEK--GDEEALERLRRLLRPFLLRRTKEDVLKDLPEKT 465
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 306 DRIELCAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNV---MMQLRKMANHPllhrqyytaeklkemsQLMLKEPThce 382
Cdd:COG0553 466 EETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRGLIlaaLTRLRQICSHP----------------ALLLEEGA--- 526
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 383 anpdlifedmevmtdfelhvlckqyrhinnfqldmDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKH 462
Cdd:COG0553 527 -----------------------------------ELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEE 571
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 463 HQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEV 542
Cdd:COG0553 572 RGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDV 651
|
490 500
....*....|....*....|....*
gi 363808412 543 LVIKLISQGTIEESMLKINQQKLKL 567
Cdd:COG0553 652 QVYKLVAEGTIEEKILELLEEKRAL 676
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
67-249 |
1.80e-125 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 366.71 E-value: 1.80e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 146
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLT 226
Cdd:cd17998 81 YGSQEERKHLRYDILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160
|
170 180
....*....|....*....|...
gi 363808412 227 GTPVQNNLLELMSLLNFVMPHMF 249
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMPKPF 183
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
46-568 |
3.71e-124 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 390.70 E-value: 3.71e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 46 LTGNGGGWNIEQPSILNQSLslKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPA 124
Cdd:PLN03142 151 LGGSGGTRLLVQPSCIKGKM--RDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEyRGITGPHMVVAPK 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 125 STIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLK 204
Cdd:PLN03142 229 STLGNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVA-GKFDVCVTSFEMAIK---EKTALKRFSWRYIIIDEAHRIK 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 205 NMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKsADEQsiyekERIAHAKQI 284
Cdd:PLN03142 305 NENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA-ETFDEWFQISGE-NDQQ-----EVVQQLHKV 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 285 IKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQyyta 364
Cdd:PLN03142 378 LRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFQG---- 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 365 eklkemsqlmlkepthCEANPDLIFEDmevmtdfelHvlckqyrhinnfqldmdLILDSGKFRVLGCILSELKQKGDRVV 444
Cdd:PLN03142 454 ----------------AEPGPPYTTGE---------H-----------------LVENSGKMVLLDKLLPKLKERDSRVL 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 445 LFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTD-MDIFVFLLSTKAGGLGINLTSANVVILHDIDCNP 523
Cdd:PLN03142 492 IFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAGGLGINLATADIVILYDSDWNP 571
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 363808412 524 YNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLE 568
Cdd:PLN03142 572 QVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALD 616
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
67-249 |
1.08e-81 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 254.03 E-value: 1.08e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKErGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRfnIHSRYEDYNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:cd17919 81 YHGSQRERAQIR--AKEKLDKFDVVLTTYETL---RRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLL 155
|
170 180
....*....|....*....|....
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMF 249
Cdd:cd17919 156 TGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
67-292 |
1.23e-79 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 250.35 E-value: 1.23e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLaCEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNiHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:cd18003 81 YYGSAKERKLKRQG-WMKPNSFHVCITSYQLVVQ---DHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSSKTKSADEQS-IYEKERIAHAKQIIKPFILRR 292
Cdd:cd18003 157 TGTPLQNSLMELWSLMHFLMPHIFQSHQ-EFKEWFSNPLTAMSEGSqEENEELVRRLHKVLRPFLLRR 223
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
70-355 |
9.47e-77 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 245.29 E-value: 9.47e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 70 YQKVGLNWL-ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN--GPHLIVVPASTIDNWLREVNLWC--PTLKVL 144
Cdd:pfam00176 1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNwgGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 145 CYYGSQEERKQIrFNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLL 224
Cdd:pfam00176 81 VLHGNKRPQERW-KNDPNFLADFDVVITTYETLRK---HKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 225 LTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSktksaDEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPK 304
Cdd:pfam00176 157 LTGTPLQNNLEELWALLNFLRPGPFGSL-STFRNWFDR-----PIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPK 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 363808412 305 KDRIELCAMSEKQEQLYLGL-----FNRLKKSINNLEKNTEMCNVMMQLRKMANHP 355
Cdd:pfam00176 231 VEYILFCRLSKLQRKLYQTFllkkdLNAIKTGEGGREIKASLLNILMRLRKICNHP 286
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
67-294 |
2.72e-76 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 242.29 E-value: 2.72e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 146
Cdd:cd18009 4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQIRFNIHSR---YEDYNVIVTTYNCAIsssDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRL 223
Cdd:cd18009 84 HGTKEERERLRKKIMKRegtLQDFPVVVTSYEIAM---RDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 363808412 224 LLTGTPVQNNLLELMSLLNFVMPHMFSS-STSEIRRMFSSKTKSADEQSIYEKERIAHA----KQIIKPFILRRVK 294
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDVFDDlSSFESWFDFSSLSDNAADISNLSEEREQNIvhmlHAILKPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
67-294 |
8.59e-73 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 232.60 E-value: 8.59e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd17997 4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIhSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:cd17997 84 LIGDKEERADIIRDV-LLPGKFDVCITSYEMVIK---EKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLL 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQsiyekERIAHAKQIIKPFILRRVK 294
Cdd:cd17997 160 TGTPLQNNLHELWALLNFLLPDVFTSS-EDFDEWFNVNNCDDDNQ-----EVVQRLHKVLRPFLLRRIK 222
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
67-294 |
4.90e-72 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 230.53 E-value: 4.90e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 146
Cdd:cd18012 5 LRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQIRfnihsRYEDYNVIVTTYNcaisssddrsLFRRL-------KLNYAIFDEGHMLKNMGSIRYQHLMTINA 219
Cdd:cd18012 85 HGTKRKREKLR-----ALEDYDLVITSYG----------LLRRDiellkevKFHYLVLDEAQNIKNPQTKTAKAVKALKA 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 363808412 220 NNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQSiYEKERIAHAKQIIKPFILRRVK 294
Cdd:cd18012 150 DHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKR-----FKKRFAKPIEKD-GDEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
67-294 |
1.32e-65 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 214.16 E-value: 1.32e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-EGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd17996 4 LKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEkKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSKIV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIhsRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT-INANNRLL 224
Cdd:cd17996 84 YKGTPDVRKKLQSQI--RAGKFNVLLTTYEYIIK---DKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 363808412 225 LTGTPVQNNLLELMSLLNFVMPHMFSSSTSeIRRMFS---SKTKSADEQSIYEKER---IAHAKQIIKPFILRRVK 294
Cdd:cd17996 159 LTGTPLQNNLPELWALLNFLLPKIFKSCKT-FEQWFNtpfANTGEQVKIELNEEETlliIRRLHKVLRPFLLRRLK 233
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
67-292 |
4.21e-65 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 212.75 E-value: 4.21e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIwGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNI---HSRYED--YNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINAN 220
Cdd:cd18002 81 YWGNPKDRKVLRKFWdrkNLYTRDapFHVVITSYQLVVQ---DEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 363808412 221 NRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKS-ADEQSIYEKERIAHAKQIIKPFILRR 292
Cdd:cd18002 158 NRLLLTGTPIQNSMAELWALLHFIMPTLFDSH-DEFNEWFSKDIEShAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
67-292 |
5.14e-63 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 206.82 E-value: 5.14e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd17993 2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQqYGPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIR----FNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANN 221
Cdd:cd17993 82 YLGDIKSRDTIReyefYFSQTKKLKFNVLLTTYEIILK---DKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 363808412 222 RLLLTGTPVQNNLLELMSLLNFVMPHMFssstsEIRRMFSsktksaDEQSIYEKERIAHAKQIIKPFILRR 292
Cdd:cd17993 159 RLLITGTPLQNSLKELWALLHFLMPGKF-----DIWEEFE------EEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
67-292 |
1.70e-58 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 195.16 E-value: 1.70e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCpTLKVLC 145
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGiRGPFLVIAPLSTIPNWQREFETWT-DMNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFnihsrYEDY---------------NVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIR 210
Cdd:cd17995 80 YHGSGESRQIIQQ-----YEMYfkdaqgrkkkgvykfDVLITTYEMVIA---DAEELRKIPWRVVVVDEAHRLKNRNSKL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 211 YQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFSSKTKSADEQSIYEKERiahakQIIKPFIL 290
Cdd:cd17995 152 LQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEE-----FLEEFGDLKTAEQVEKLQ-----ALLKPYML 221
|
..
gi 363808412 291 RR 292
Cdd:cd17995 222 RR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
423-548 |
1.77e-56 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 186.53 E-value: 1.77e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 423 SGKFRVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAG 502
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 363808412 503 GLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLI 548
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
67-292 |
6.23e-55 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 185.33 E-value: 6.23e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLaGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIHSrYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:cd18006 81 YMGDKEKRLDLQQDIKS-TNRFHVLLTTYEICLK---DASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMFSSSTSEirRMFSSKTKSADEQSIYEKeriahAKQIIKPFILRR 292
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFPKDKLD--DFIKAYSETDDESETVEE-----LHLLLQPFLLRR 216
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
67-292 |
7.09e-54 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 183.34 E-value: 7.09e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVLCY 146
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YG-SQEERKQIRFNIHSRYedyNVIVTTYNCAISSSDDRSLFRR--LKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRL 223
Cdd:cd18001 81 HGtSKKERERNLERIQRGG---GVLLTTYGMVLSNTEQLSADDHdeFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRI 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 363808412 224 LLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKERI------AHAKQIIKPFILRR 292
Cdd:cd18001 158 ILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFENPITRGRDKDATQGEKAlgsevaENLRQIIKPYFLRR 232
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
67-305 |
1.47e-53 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 182.94 E-value: 1.47e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18064 16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNiPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIHSRYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:cd18064 96 LIGDKDQRAAFVRDVLLPGE-WDVCVTSYEMLIK---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQSIyekERIahaKQIIKPFILRRVKEEVLKQLPPKK 305
Cdd:cd18064 172 TGTPLQNNLHELWALLNFLLPDVFNSA-EDFDSWFDTNNCLGDQKLV---ERL---HMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
56-292 |
2.77e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 176.35 E-value: 2.77e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 56 EQPSIL-NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLY-QEGNNGPHLIVVPASTIDNWLRE 133
Cdd:cd18054 9 KQPSYIgGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 134 VNLWCPTLKVLCYYGSQEERKQIRFN--IHSRYE--DYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSI 209
Cdd:cd18054 89 FEIWAPEINVVVYIGDLMSRNTIREYewIHSQTKrlKFNALITTYEILLK---DKTVLGSINWAFLGVDEAHRLKNDDSL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 210 RYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKSADEQSIYekeriahakQIIKPFI 289
Cdd:cd18054 166 LYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEF--WEDFEEDHGKGRENGYQSLH---------KVLEPFL 234
|
...
gi 363808412 290 LRR 292
Cdd:cd18054 235 LRR 237
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
67-292 |
8.52e-49 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 169.45 E-value: 8.52e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLA---YLYQEGNNG---PHLIVVPASTIDNWLREVNLWCPT 140
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSFNSenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 141 --LKVLCYYGSQEERKQIRfnihSRYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTIN 218
Cdd:cd17999 81 afLKPLAYVGPPQERRRLR----EQGEKHNVIVASYDVLRNDIE---VLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 219 ANNRLLLTGTPVQNNLLELMSLLNFVMPHmFSSSTSEIRRMFSSK-TKSAD-EQSIYEKERIAHA-----KQIIkPFILR 291
Cdd:cd17999 154 ANHRLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLKPiLASRDsKASAKEQEAGALAlealhKQVL-PFLLR 231
|
.
gi 363808412 292 R 292
Cdd:cd17999 232 R 232
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
56-294 |
1.56e-48 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 169.04 E-value: 1.56e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 56 EQPSILNQSlSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREV 134
Cdd:cd18065 6 ESPSYVKGG-TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNiPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 135 NLWCPTLKVLCYYGSQEERKQIRFNIHSRYEdYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 214
Cdd:cd18065 85 KRWVPSLRAVCLIGDKDARAAFIRDVMMPGE-WDVCVTSYEMVIK---EKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 215 MTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSSKTKSADEQSIyekERIaHAkqIIKPFILRRVK 294
Cdd:cd18065 161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSA-DDFDSWFDTKNCLGDQKLV---ERL-HA--VLKPFLLRRIK 233
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
67-246 |
5.53e-46 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 160.57 E-value: 5.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYL-YQEGNNGPHLIVVPASTIDNWLREVNLWCPTLKVL- 144
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 145 ----CYYGSQEERKQIRFN----IHSRYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMG---SIRYQH 213
Cdd:cd18000 81 lhssGSGTGSEEKLGSIERksqlIRKVVGDGGILITTYEGFRKHKD---LLLNHNWQYVILDEGHKIRNPDaeiTLACKQ 157
|
170 180 190
....*....|....*....|....*....|...
gi 363808412 214 LMTInanNRLLLTGTPVQNNLLELMSLLNFVMP 246
Cdd:cd18000 158 LRTP---HRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
55-294 |
3.11e-44 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 157.90 E-value: 3.11e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 55 IEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLRE 133
Cdd:cd18062 12 VEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRiNGPFLIIVPLSTLSNWVYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 134 VNLWCPTLKVLCYYGSQEERKQirFNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQH 213
Cdd:cd18062 92 FDKWAPSVVKVSYKGSPAARRA--FVPQLRSGKFNVLLTTYEYIIK---DKQILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 214 LMT-INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKER---IAHAKQIIKPFI 289
Cdd:cd18062 167 LNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETiliIRRLHKVLRPFL 246
|
....*
gi 363808412 290 LRRVK 294
Cdd:cd18062 247 LRRLK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
55-294 |
1.63e-43 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 155.99 E-value: 1.63e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 55 IEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLRE 133
Cdd:cd18063 12 VEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRlNGPYLIIVPLSTLSNWTYE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 134 VNLWCPTLKVLCYYGSQEERKQIRFNIhsRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQH 213
Cdd:cd18063 92 FDKWAPSVVKISYKGTPAMRRSLVPQL--RSGKFNVLLTTYEYIIK---DKHILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 214 LMT-INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQSIYEKER---IAHAKQIIKPFI 289
Cdd:cd18063 167 LNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETiliIRRLHKVLRPFL 246
|
....*
gi 363808412 290 LRRVK 294
Cdd:cd18063 247 LRRLK 251
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
56-292 |
3.56e-43 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 154.82 E-value: 3.56e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 56 EQPSIL--NQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLR 132
Cdd:cd18053 8 KQPSYIggHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQlYGPFLLVVPLSTLTSWQR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 133 EVNLWCPTLKVLCYYGSQEERKQIR----FNIHSRYEDYNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGS 208
Cdd:cd18053 88 EIQTWAPQMNAVVYLGDINSRNMIRthewMHPQTKRLKFNILLTTYEILLK---DKSFLGGLNWAFIGVDEAHRLKNDDS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 209 IRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstSEIRRMFSSKTKSADEQSIYEKeriahakqiIKPF 288
Cdd:cd18053 165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSS--WEDFEEEHGKGREYGYASLHKE---------LEPF 233
|
....
gi 363808412 289 ILRR 292
Cdd:cd18053 234 LLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
67-292 |
5.42e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 149.90 E-value: 5.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHsKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSqeerkqirfnihsryedyNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLL 225
Cdd:cd17994 81 YVGD------------------HVLLTSYELI---SIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLL 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 363808412 226 TGTPVQNNLLELMSLLNFVMPHMFSSSTSeirrmFssktkSADEQSIYEKERIAHAKQIIKPFILRR 292
Cdd:cd17994 140 TGTPLQNNLEELFHLLNFLTPERFNNLQG-----F-----LEEFADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
67-292 |
1.30e-40 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 147.82 E-value: 1.30e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLaLVHkhGlnGILADEMGLGKTIQAIA----------FLAYLYQEGNNGPH--------LIVVPASTID 128
Cdd:cd18008 1 LLPYQKQGLAWM-LPR--G--GILADEMGLGKTIQALAlilatrpqdpKIPEELEENSSDPKklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 129 NWLREVN--LWCPTLKVLCYYGSQEERkqirfNIHSrYEDYNVIVTTYN-CAISSSDDRSLFRRLKLNYA---------- 195
Cdd:cd18008 76 QWKDEIEkhTKPGSLKVYVYHGSKRIK-----SIEE-LSDYDIVITTYGtLASEFPKNKKGGGRDSKEKEasplhrirwy 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 196 --IFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNF--VMP-HMFSSSTSEIRRMFSSktksadeq 270
Cdd:cd18008 150 rvILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFlrVEPfGDYPWFNSDISKPFSK-------- 221
|
250 260
....*....|....*....|..
gi 363808412 271 siYEKERIAHAKQIIKPFILRR 292
Cdd:cd18008 222 --NDRKALERLQALLKPILLRR 241
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
67-292 |
2.31e-40 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 147.05 E-value: 2.31e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWL--ALVHKHGLNG---ILADEMGLGKTIQAIAFLAYLYQEGNNGPH-----LIVVPASTIDNWLREVNL 136
Cdd:cd18004 1 LRPHQREGVQFLydCLTGRRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPtakkaLIVCPSSLVGNWKAEFDK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 137 WCP--TLKVLCYYGSQEERKQIRFNIHSRyEDYNVIVTTYNCAISSSddRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHL 214
Cdd:cd18004 81 WLGlrRIKVVTADGNAKDVKASLDFFSSA-STYPVLIISYETLRRHA--EKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 215 MTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMF------SSKTKSADEQSIYEKERIAHAKQIIKPF 288
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSL-ASFRKVFeepilrSRDPDASEEDKELGAERSQELSELTSRF 236
|
....
gi 363808412 289 ILRR 292
Cdd:cd18004 237 ILRR 240
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
67-292 |
1.81e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 141.33 E-value: 1.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 146
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQI-RFNIHSRYED---------YNVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 216
Cdd:cd18058 80 HGSQISRQMIqQYEMYYRDEQgnplsgifkFQVVITTFEMILA---DCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 363808412 217 INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 292
Cdd:cd18058 157 MALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
67-292 |
2.18e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 141.36 E-value: 2.18e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSkGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 206
Cdd:cd18057 81 YTGDKESRSVIRENEFS-FEDnairsgkkvfrmkkeaqikFHVLLTSYELI---TIDQAILGSIEWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 207 GSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIK 286
Cdd:cd18057 157 QSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLG 226
|
....*.
gi 363808412 287 PFILRR 292
Cdd:cd18057 227 PHMLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
67-292 |
1.78e-37 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 139.05 E-value: 1.78e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQ-------------EGNNGPH--------LIVVPAS 125
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGktgtrrdrennrpRFKKKPPassakkpvLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 126 TIDNWLREVNLWcPTLKVLCYYGSQEERKQIRFNIHSRYEdynVIVTTYncaisssddrSLFRR-------LKLNYAIFD 198
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDELEGRLKAGRLE---VVVTTY----------DTLRRcidslnsINWSAVIAD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 199 EGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFS-------SKTKSADEQS 271
Cdd:cd18005 147 EAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSR-SQFKKHFSepikrgqRHTATARELR 225
|
250 260
....*....|....*....|.
gi 363808412 272 IYEKeRIAHAKQIIKPFILRR 292
Cdd:cd18005 226 LGRK-RKQELAVKLSKFFLRR 245
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
67-292 |
8.82e-37 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 136.70 E-value: 8.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 146
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQIRFN-----------IHSRYEdYNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLM 215
Cdd:cd18059 80 HGSQASRRTIQLYemyfkdpqgrvIKGSYK-FHAIITTFEMILTDCPE---LRNIPWRCVVIDEAHRLKNRNCKLLEGLK 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 363808412 216 TINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 292
Cdd:cd18059 156 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
67-292 |
2.36e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 135.91 E-value: 2.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTkGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 206
Cdd:cd18055 81 YTGDKDSRAIIRENEFS-FDDnavkggkkafkmkreaqvkFHVLLTSYELV---TIDQAALGSIRWACLVVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 207 GSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIK 286
Cdd:cd18055 157 QSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF-------AD---ISKEDQIKKLHDLLG 226
|
....*.
gi 363808412 287 PFILRR 292
Cdd:cd18055 227 PHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
67-292 |
3.91e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 135.19 E-value: 3.91e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNN-GPHLIVVPASTIDNWLREVNLWCPTLKVLC 145
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSkGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGSQEERKQIRFNIHSrYED-------------------YNVIVTTYNCAissSDDRSLFRRLKLNYAIFDEGHMLKNM 206
Cdd:cd18056 81 YVGDKDSRAIIRENEFS-FEDnairggkkasrmkkeasvkFHVLLTSYELI---TIDMAILGSIDWACLIVDEAHRLKNN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 207 GSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMfssktksADeqsIYEKERIAHAKQIIK 286
Cdd:cd18056 157 QSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEF-------AD---IAKEDQIKKLHDMLG 226
|
....*.
gi 363808412 287 PFILRR 292
Cdd:cd18056 227 PHMLRR 232
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
67-292 |
5.06e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 134.41 E-value: 5.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 146
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQIRfnihsRYEDY---------------NVIVTTYNCAISssdDRSLFRRLKLNYAIFDEGHMLKNMGSIRY 211
Cdd:cd18060 80 HGSLASRQMIQ-----QYEMYckdsrgrlipgaykfDALITTFEMILS---DCPELREIEWRCVIIDEAHRLKNRNCKLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 212 QHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILR 291
Cdd:cd18060 152 DSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLR 221
|
.
gi 363808412 292 R 292
Cdd:cd18060 222 R 222
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
67-262 |
1.55e-35 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 133.57 E-value: 1.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLN--WLALVHKHGLNG-----ILADEMGLGKTIQAIAFL-AYLYQEGNNGPHLIVVPASTIDNWLREVNLWC 138
Cdd:cd18007 1 LKPHQVEGVRflWSNLVGTDVGSDegggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 139 P----TLKVLCYYGSQEERKQIRFNIHSRYED-------YNVIVTTYNCAISSSDDRSLFRRLKL----NYAIFDEGHML 203
Cdd:cd18007 81 PpdlrPLLVLVSLSASKRADARLRKINKWHKEggvlligYELFRNLASNATTDPRLKQEFIAALLdpgpDLLVLDEGHRL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 363808412 204 KNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMFSS 262
Cdd:cd18007 161 KNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLK-EFKKKFVK 218
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
67-292 |
5.11e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 123.19 E-value: 5.11e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCpTLKVLCY 146
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 YGSQEERKQI-RFNIHSRYED---------YNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLMT 216
Cdd:cd18061 80 HGSLISRQMIqQYEMYFRDSQgriirgayrFQAIITTFEMILGGCPE---LNAIDWRCVIIDEAHRLKNKNCKLLEGLKL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 363808412 217 INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTksadeqsiyeKERIAHAKQIIKPFILRR 292
Cdd:cd18061 157 MNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
67-246 |
7.37e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 116.44 E-value: 7.37e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLalvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVP-ASTIDNWLREVNLWCP--TLKV 143
Cdd:smart00487 9 LRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPslGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 144 LCYYGSQEERKQIRFNIHSryeDYNVIVTTYNCAISSSDDRSLFRRlKLNYAIFDEGHMLKNMGsiRYQHLMTI-----N 218
Cdd:smart00487 86 VGLYGGDSKREQLRKLESG---KTDILVTTPGRLLDLLENDKLSLS-NVDLVILDEAHRLLDGG--FGDQLEKLlkllpK 159
|
170 180 190
....*....|....*....|....*....|.
gi 363808412 219 ANNRLLLTGTP---VQNNLLELMSLLNFVMP 246
Cdd:smart00487 160 NVQLLLLSATPpeeIENLLELFLNDPVFIDV 190
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
67-258 |
1.64e-29 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 115.77 E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWlALvhKHGLNGILADEMGLGKTIQAIAFLAYLYQEgnnGPHLIVVPASTIDNWLREVNLWCPTLKVlcy 146
Cdd:cd18010 1 LLPFQREGVCF-AL--RRGGRVLIADEMGLGKTVQAIAIAAYYREE---WPLLIVCPSSLRLTWADEIERWLPSLPP--- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 147 ygsqeerkqirfnihsryEDYNVIVTTyNCAISSSDDR------SLFRRL-------KLNYAIFDEGHMLKNMGSIRYQH 213
Cdd:cd18010 72 ------------------DDIQVIVKS-KDGLRDGDAKvvivsyDLLRRLekqllarKFKVVICDESHYLKNSKAKRTKA 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 363808412 214 LMTI--NANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRR 258
Cdd:cd18010 133 ALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRR 179
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
67-292 |
2.01e-29 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 116.48 E-value: 2.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWL-----ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPH------LIVVPASTIDNWLREVN 135
Cdd:cd18066 1 LRPHQREGIEFLyecvmGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikraLIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 136 LWCPTLKVLCYYGSQEerKQIRFNIHSRYedYNVIVTTYNCAISSSDDrslFRRLKLNYAIFDEGHMLKNMGSIRYQHLM 215
Cdd:cd18066 81 KWLGSERIKVFTVDQD--HKVEEFIASPL--YSVLIISYEMLLRSLDQ---ISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 216 TINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFsSSTSEIRRMF------SSKTKSADEQSIYEKERIAHAKQIIKPFI 289
Cdd:cd18066 154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGIL-GSLSTYRKVYeepivrSREPTATPEEKKLGEARAAELTRLTGLFI 232
|
...
gi 363808412 290 LRR 292
Cdd:cd18066 233 LRR 235
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
67-292 |
1.66e-27 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 111.02 E-value: 1.66e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWL----ALVHKHGLNG-ILADEMGLGKTIQAIAFLAYLYQEGNNGPHLI-----VVPASTIDNWLREVNL 136
Cdd:cd18067 1 LRPHQREGVKFLyrcvTGRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaivVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 137 WC-PTLKVLCYYGSQEE---RKQIRF-NIHSRYEDYNVIVTTYNCAISSSDdrsLFRRLKLNYAIFDEGHMLKNMGSIRY 211
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKeidRKLVQWaSQQGRRVSTPVLIISYETFRLHVE---VLQKGEVGLVICDEGHRLKNSDNQTY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 212 QHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSStSEIRRMFSS------KTKSADEQSIYEKERIAHAKQII 285
Cdd:cd18067 158 QALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTA-AEFKKNFELpilkgrDADASEKERQLGEEKLQELISIV 236
|
....*..
gi 363808412 286 KPFILRR 292
Cdd:cd18067 237 NRCIIRR 243
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
67-291 |
1.65e-25 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 105.89 E-value: 1.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLaLVHKhglnGILADEMGLGKTIQAIAFLA----------------------YLYQEGNN----GPHLI 120
Cdd:cd18070 1 LLPYQRRAVNWM-LVPG----GILADEMGLGKTVEVLALILlhprpdndldaadddsdemvccPDCLVAETpvssKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 121 VVPASTIDNWLREVNLWCPT-LKVLCYYGsQEERKQIRFNIHSRYEDYNVIVTTYN-------CAISSSDDRSLfRRLKL 192
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPSsLKVLTYQG-VKKDGALASPAPEILAEYDIVVTTYDvlrtelhYAEANRSNRRR-RRQKR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 193 NYAI-------------FDEGHMLKnmGSIRYQHLMT--INANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIR 257
Cdd:cd18070 154 YEAPpsplvlvewwrvcLDEAQMVE--SSTSKAAEMArrLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWWAR 231
|
250 260 270
....*....|....*....|....*....|....
gi 363808412 258 RMFssktksadeQSIYEKERIAHAKQIIKPFILR 291
Cdd:cd18070 232 VLI---------RPQGRNKAREPLAALLKELLWR 256
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
424-537 |
1.35e-24 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 98.44 E-value: 1.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 424 GKFRVLGCILSelKQKGDRVVLFSQFTMMLDIlEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDmDIFVfLLSTKAGG 503
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKG-KIDV-LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 363808412 504 LGINLTSANVVILHDIDCNPYNDKQAEDRCHRVG 537
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
85-260 |
3.41e-23 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 98.35 E-value: 3.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 85 GLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNLWCP-----------TLKVLCYYGSQEER 153
Cdd:cd18069 28 GFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWLPppealpnvrprPFKVFILNDEHKTT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 154 KQIRFNIHSRYEDYNVIVTTYncaisssddrSLFR-RLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQN 232
Cdd:cd18069 108 AARAKVIEDWVKDGGVLLMGY----------EMFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQN 177
|
170 180
....*....|....*....|....*...
gi 363808412 233 NLLELMSLLNFVMPHMFSSSTsEIRRMF 260
Cdd:cd18069 178 NLIEYWCMVDFVRPDFLGTRQ-EFSNMF 204
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
67-292 |
7.38e-22 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 94.85 E-value: 7.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLALVHKHGLNG-ILADEMGLGKTIQAIAFLayLYQEGN-------------------------NGPHLI 120
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALI--LAQKNTqnrkeeekekalteweskkdstlvpSAGTLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 121 VVPASTIDNWLREVN--LWCPTLKVLCYYGSQEERKQirfnihSRYEDYNVIVTTYNCAIS------SSDDRSLFRRLKL 192
Cdd:cd18072 79 VCPASLVHQWKNEVEsrVASNKLRVCLYHGPNRERIG------EVLRDYDIVITTYSLVAKeiptykEESRSSPLFRIAW 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 193 NYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSstseirrmFSSKTKSADEQSI 272
Cdd:cd18072 153 ARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDD--------LKVWKKQVDNKSR 224
|
250 260
....*....|....*....|
gi 363808412 273 YEKERIAhakQIIKPFILRR 292
Cdd:cd18072 225 KGGERLN---ILTKSLLLRR 241
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
85-244 |
1.39e-21 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 94.07 E-value: 1.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 85 GLNGILADEMGLGKTIQAIAFLAYlyqegnnGPHLIVVPASTIDNWLREV--NLWCPTLKVLCYYGSQEERKQirfnihS 162
Cdd:cd18071 48 VRGGILADDMGLGKTLTTISLILA-------NFTLIVCPLSVLSNWETQFeeHVKPGQLKVYTYHGGERNRDP------K 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 163 RYEDYNVIVTTYNCAIS--SSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSL 240
Cdd:cd18071 115 LLSKYDIVLTTYNTLASdfGAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSL 194
|
....
gi 363808412 241 LNFV 244
Cdd:cd18071 195 LSFL 198
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
67-260 |
1.60e-20 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 91.10 E-value: 1.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWL---------ALVHKHGLNGILADEMGLGKTIQAIAFLAYLY---QEGNNGPHLIVVPASTIDNWLREV 134
Cdd:cd18068 1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTFLHTVLlceKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 135 NLWCPTLK--------VLCYYGSQEERkqiRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKL-------------N 193
Cdd:cd18068 81 EKWQEGLKdeekievnELATYKRPQER---SYKLQRWQEEGGVMIIGYDMYRILAQERNVKSREKLkeifnkalvdpgpD 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 363808412 194 YAIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTsEIRRMF 260
Cdd:cd18068 158 FVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIK-EFRNRF 223
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
454-537 |
4.33e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 81.87 E-value: 4.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 454 DILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMdiFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRC 533
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 363808412 534 HRVG 537
Cdd:smart00490 79 GRAG 82
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
67-242 |
7.86e-19 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 85.03 E-value: 7.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNwLALVHKHgLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREvnLW-CPTLKVLC 145
Cdd:cd18011 1 PLPHQIDAVL-RALRKPP-VRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDE--LQdKFGLPFLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 146 YYGsqEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTI------NA 219
Cdd:cd18011 77 LDR--ETAAQLRRLIGNPFEEFPIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNSGGGKETKRYKLgrllakRA 154
|
170 180
....*....|....*....|....*.
gi 363808412 220 NNRLLLTGTPVQNN---LLELMSLLN 242
Cdd:cd18011 155 RHVLLLTATPHNGKeedFRALLSLLD 180
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
65-229 |
1.05e-10 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 60.38 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 65 LSLKPYQKVGL-NWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDN-WLREVNLWCPTLK 142
Cdd:pfam04851 2 LELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPRKDLLEqALEEFKKFLPNYV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 143 VLCYYGSQEERKQIrfnihsrYEDYNVIVTTYNCAISSSDDRSL-FRRLKLNYAIFDEGHMLknmGSIRYQHLMTINANN 221
Cdd:pfam04851 82 EIGEIISGDKKDES-------VDDNKIVVTTIQSLYKALELASLeLLPDFFDVIIIDEAHRS---GASSYRNILEYFKPA 151
|
....*....
gi 363808412 222 RLL-LTGTP 229
Cdd:pfam04851 152 FLLgLTATP 160
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
67-229 |
1.36e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 56.93 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGL-NWLAlvHKHGLNGILADEMGLGKTIQAIAFLAYLYQEgnngPHLIVVP-ASTIDNWLREvnlwcptlkvL 144
Cdd:cd17926 1 LRPYQEEALeAWLA--HKNNRRGILVLPTGSGKTLTALALIAYLKEL----RTLIVVPtDALLDQWKER----------F 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 145 CYYGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLnYAIFDEGHmlkNMGSIRYQHLMTI-NANNRL 223
Cdd:cd17926 65 EDFLGDSSIGLIGGGKKKDFDDANVVVATYQSLSNLAEEEKDLFDQFG-LLIVDEAH---HLPAKTFSEILKElNAKYRL 140
|
....*.
gi 363808412 224 LLTGTP 229
Cdd:cd17926 141 GLTATP 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
64-230 |
2.82e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 59.65 E-value: 2.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 64 SLSLKPYQKVGLN-WLALVHKHGLNGILADEMGLGKTIQAIAFLAYLYqegNNGPHLIVVPASTI-DNWLREVnlwcptL 141
Cdd:COG1061 78 SFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTVLALALAAELL---RGKRVLVLVPRRELlEQWAEEL------R 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 142 KVLCYYGSQEERKQIrfnihsryeDYNVIVTTYNCAISSSDDRSLFRRLKLnyAIFDEGHmlkNMGSIRYQHLMT-INAN 220
Cdd:COG1061 149 RFLGDPLAGGGKKDS---------DAPITVATYQSLARRAHLDELGDRFGL--VIIDEAH---HAGAPSYRRILEaFPAA 214
|
170
....*....|
gi 363808412 221 NRLLLTGTPV 230
Cdd:COG1061 215 YRLGLTATPF 224
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
67-237 |
3.16e-09 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 57.36 E-value: 3.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 67 LKPYQKVGLNWLAlvhKHGLNGILADeMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTI-DNWLREVNLW--CPTLKV 143
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVArSTWPDEVEKWnhLRNLTV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 144 LCYYGSQEERkqirfnihSRYEDYNVIVTTYN-----CAISSSDDRSLFRRLklnyaIFDEGHMLKNMGSIRYQHLMTIN 218
Cdd:cd18013 77 SVAVGTERQR--------SKAANTPADLYVINrenlkWLVNKSGDPWPFDMV-----VIDELSSFKSPRSKRFKALRKVR 143
|
170 180
....*....|....*....|.
gi 363808412 219 --ANNRLLLTGTPVQNNLLEL 237
Cdd:cd18013 144 pvIKRLIGLTGTPSPNGLMDL 164
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
87-228 |
4.13e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 46.63 E-value: 4.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 87 NGILADEMGLGKTIQA--IAFLAYLYQEGNNgphLIVVPASTIDN----WLREvnLWCPTLKVLCYYG--SQEERKQIRF 158
Cdd:cd00046 3 NVLITAPTGSGKTLAAllAALLLLLKKGKKV---LVLVPTKALALqtaeRLRE--LFGPGIRVAVLVGgsSAEEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 363808412 159 NihsryeDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHML----KNMGSIRYQHLMTINANNR-LLLTGT 228
Cdd:cd00046 78 G------DADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALlidsRGALILDLAVRKAGLKNAQvILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
95-232 |
4.34e-05 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 44.16 E-value: 4.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 95 GLGKTiqAIAFLAYLYQ--EGNNGPH-LIVVP--------ASTIDNWLREVNLwcptlKVLCYYGSQEERKQIRfnihsR 163
Cdd:pfam00270 24 GSGKT--LAFLLPALEAldKLDNGPQaLVLAPtrelaeqiYEELKKLGKGLGL-----KVASLLGGDSRKEQLE-----K 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 363808412 164 YEDYNVIVTTYNCAISSSDDRSLFRRLKlnYAIFDEGHMLKNMGSIR--YQHLMTINANNR-LLLTGTPVQN 232
Cdd:pfam00270 92 LKGPDILVGTPGRLLDLLQERKLLKNLK--LLVLDEAHRLLDMGFGPdlEEILRRLPKKRQiLLLSATLPRN 161
|
|
| DpdE |
NF041062 |
protein DpdE; |
90-302 |
4.41e-05 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 46.50 E-value: 4.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 90 LADEMGLGKTIQA-IAFLAYLYQEgnngPH---LIVVPASTIDNWLREvnlwcptLKVlcyygsqeerkqiRFNI-HSRY 164
Cdd:NF041062 175 LADEVGLGKTIEAgLVIRQHLLDN----PDarvLVLVPDALVRQWRRE-------LRD-------------KFFLdDFPG 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 165 EDYNVivttynCAISS-SDDRSLFRRLKLnyAIFDEGHMLKNMG-------SIRYQHLMTI--NANNRLLLTGTPVQNNL 234
Cdd:NF041062 231 ARVRV------LSHEEpERWEPLLDAPDL--LVVDEAHQLARLAwsgdppeRARYRELAALahAAPRLLLLSATPVLGNE 302
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 363808412 235 LELMSLLNFVMPHMFSSSTSEirrmfssktksADEQSIYEKERIAHAKQIIKP----FILRRVKEEVLKQLP 302
Cdd:NF041062 303 ETFLALLHLLDPDLYPLDDLE-----------AFRERLEEREELGRLVLGLDPdnpnFLLRQALDELRALFP 363
|
|
| PRK04914 |
PRK04914 |
RNA polymerase-associated protein RapA; |
90-231 |
9.09e-04 |
|
RNA polymerase-associated protein RapA;
Pssm-ID: 235319 [Multi-domain] Cd Length: 956 Bit Score: 42.52 E-value: 9.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 90 LADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVnlwcptLKvlcyygsqeerkqiRFNIH------SR 163
Cdd:PRK04914 174 LADEVGLGKTIEAGMIIHQQLLTGRAERVLILVPETLQHQWLVEM------LR--------------RFNLRfslfdeER 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 164 YED-----YNVIVTTyNCAISSSDdrsLFRRLKLNY----------AIFDEGHML---KNMGSIRYQHLMTINANNR--L 223
Cdd:PRK04914 234 YAEaqhdaDNPFETE-QLVICSLD---FLRRNKQRLeqalaaewdlLVVDEAHHLvwsEEAPSREYQVVEQLAEVIPgvL 309
|
....*...
gi 363808412 224 LLTGTPVQ 231
Cdd:PRK04914 310 LLTATPEQ 317
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
424-515 |
1.63e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 39.54 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 363808412 424 GKFRVLGCILSELKQkGDRVVLFSQFTMMLD-ILEVLLKhhqhrYLrLDGKTQISERIHLIDEF-----NTdmdIFVfll 497
Cdd:cd18789 34 NKLRALEELLKRHEQ-GDKIIVFTDNVEALYrYAKRLLK-----PF-ITGETPQSEREEILQNFregeyNT---LVV--- 100
|
90
....*....|....*...
gi 363808412 498 sTKAGGLGINLTSANVVI 515
Cdd:cd18789 101 -SKVGDEGIDLPEANVAI 117
|
|
| |
