NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|386763786|ref|NP_001245516|]
View 

ciboulot, isoform D [Drosophila melanogaster]

Protein Classification

thymosin beta-4 family protein( domain architecture ID 12015452)

thymosin beta-4 family protein similar to Drosophila melanogaster ciboulot

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Thymosin pfam01290
Thymosin beta-4 family;
98-129 2.55e-07

Thymosin beta-4 family;


:

Pssm-ID: 396038  Cd Length: 39  Bit Score: 44.26  E-value: 2.55e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 386763786   98 IENFDAKKLKHTETNEKNVLPTKEVIEAEKQA 129
Cdd:pfam01290   8 VESFDKSKLKKTETQEKNPLPTKEDIEQEKQH 39
Thymosin pfam01290
Thymosin beta-4 family;
10-53 4.22e-07

Thymosin beta-4 family;


:

Pssm-ID: 396038  Cd Length: 39  Bit Score: 43.49  E-value: 4.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 386763786   10 DLPKVAEnlksqLEGFNQDKLKNASTQEKIILPTAEDVAAEKTQ 53
Cdd:pfam01290   1 DKPKVSE-----VESFDKSKLKKTETQEKNPLPTKEDIEQEKQH 39
Thymosin super family cl27586
Thymosin beta-4 family;
57-93 5.36e-07

Thymosin beta-4 family;


The actual alignment was detected with superfamily member smart00152:

Pssm-ID: 421525  Cd Length: 37  Bit Score: 43.35  E-value: 5.36e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 386763786    57 FEGITAFNQNNLKHTETNEKNPLPDKEAIEQEKEKNQ 93
Cdd:smart00152   1 IDEIEHFDSENLKKTETIEKNVLPSKEDIEQEKQHLE 37
 
Name Accession Description Interval E-value
Thymosin pfam01290
Thymosin beta-4 family;
98-129 2.55e-07

Thymosin beta-4 family;


Pssm-ID: 396038  Cd Length: 39  Bit Score: 44.26  E-value: 2.55e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 386763786   98 IENFDAKKLKHTETNEKNVLPTKEVIEAEKQA 129
Cdd:pfam01290   8 VESFDKSKLKKTETQEKNPLPTKEDIEQEKQH 39
Thymosin pfam01290
Thymosin beta-4 family;
10-53 4.22e-07

Thymosin beta-4 family;


Pssm-ID: 396038  Cd Length: 39  Bit Score: 43.49  E-value: 4.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 386763786   10 DLPKVAEnlksqLEGFNQDKLKNASTQEKIILPTAEDVAAEKTQ 53
Cdd:pfam01290   1 DKPKVSE-----VESFDKSKLKKTETQEKNPLPTKEDIEQEKQH 39
THY smart00152
Thymosin beta actin-binding motif;
57-93 5.36e-07

Thymosin beta actin-binding motif;


Pssm-ID: 128457  Cd Length: 37  Bit Score: 43.35  E-value: 5.36e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 386763786    57 FEGITAFNQNNLKHTETNEKNPLPDKEAIEQEKEKNQ 93
Cdd:smart00152   1 IDEIEHFDSENLKKTETIEKNVLPSKEDIEQEKQHLE 37
Thymosin pfam01290
Thymosin beta-4 family;
60-89 5.83e-06

Thymosin beta-4 family;


Pssm-ID: 396038  Cd Length: 39  Bit Score: 40.41  E-value: 5.83e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 386763786   60 ITAFNQNNLKHTETNEKNPLPDKEAIEQEK 89
Cdd:pfam01290   8 VESFDKSKLKKTETQEKNPLPTKEDIEQEK 37
WH2_BetaT cd22059
Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in beta-Thymosin, and similar ...
 15-48 1.77e-04

Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in beta-Thymosin, and similar proteins; This family contains beta-thymosin (betaT; also called thymosin beta or Tbeta) domain which is similar to the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2). Proteins in the beta-thymosin family are small peptides that act as actin monomer (G-actin) sequestering factors. They bind to G-actin into a 1:1 complex, rendering G-actin resistant to polymerization into filaments (F-actin). Thymosin beta 4 (Tbeta4 or TB4) and beta10 (Tbeta10) are minor variants of betaT that bind skeletal muscle actin and inhibit actin polymerization. Thymosin beta4 can also bind to polymerized F-actin. The roles of beta-thymosins also appear to extend beyond G-actin sequestration. Thymosin beta4 has also been linked to a number of additional biological events, including angiogenesis, wound healing, inflammation, and intracellular signaling through kinase activation. Research on thymosin beta10 in breast cancer cells has suggested a relationship with actin cytoskeletal remodeling and cell motility. In addition, thymosins beta4, beta10, and beta15 are highly expressed in several tumor cells, and these have been associated with a higher metastatic potential, possibly due to their function in cell proliferation.


Pssm-ID: 409202  Cd Length: 34  Bit Score: 36.56  E-value: 1.77e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 386763786  15 AENLKSQLEGFNQDKLKNASTQEKIILPTAEDVA 48
Cdd:cd22059    1 AENLKSQLEGFDKSKLKKTETQEKNPLPSKETIE 34
THY smart00152
Thymosin beta actin-binding motif;
95-129 2.33e-04

Thymosin beta actin-binding motif;


Pssm-ID: 128457  Cd Length: 37  Bit Score: 36.42  E-value: 2.33e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 386763786    95 IAGIENFDAKKLKHTETNEKNVLPTKEVIEAEKQA 129
Cdd:smart00152   1 IDEIEHFDSENLKKTETIEKNVLPSKEDIEQEKQH 35
 
Name Accession Description Interval E-value
Thymosin pfam01290
Thymosin beta-4 family;
98-129 2.55e-07

Thymosin beta-4 family;


Pssm-ID: 396038  Cd Length: 39  Bit Score: 44.26  E-value: 2.55e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 386763786   98 IENFDAKKLKHTETNEKNVLPTKEVIEAEKQA 129
Cdd:pfam01290   8 VESFDKSKLKKTETQEKNPLPTKEDIEQEKQH 39
Thymosin pfam01290
Thymosin beta-4 family;
10-53 4.22e-07

Thymosin beta-4 family;


Pssm-ID: 396038  Cd Length: 39  Bit Score: 43.49  E-value: 4.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 386763786   10 DLPKVAEnlksqLEGFNQDKLKNASTQEKIILPTAEDVAAEKTQ 53
Cdd:pfam01290   1 DKPKVSE-----VESFDKSKLKKTETQEKNPLPTKEDIEQEKQH 39
THY smart00152
Thymosin beta actin-binding motif;
57-93 5.36e-07

Thymosin beta actin-binding motif;


Pssm-ID: 128457  Cd Length: 37  Bit Score: 43.35  E-value: 5.36e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 386763786    57 FEGITAFNQNNLKHTETNEKNPLPDKEAIEQEKEKNQ 93
Cdd:smart00152   1 IDEIEHFDSENLKKTETIEKNVLPSKEDIEQEKQHLE 37
Thymosin pfam01290
Thymosin beta-4 family;
60-89 5.83e-06

Thymosin beta-4 family;


Pssm-ID: 396038  Cd Length: 39  Bit Score: 40.41  E-value: 5.83e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 386763786   60 ITAFNQNNLKHTETNEKNPLPDKEAIEQEK 89
Cdd:pfam01290   8 VESFDKSKLKKTETQEKNPLPTKEDIEQEK 37
WH2_BetaT cd22059
Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in beta-Thymosin, and similar ...
 15-48 1.77e-04

Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in beta-Thymosin, and similar proteins; This family contains beta-thymosin (betaT; also called thymosin beta or Tbeta) domain which is similar to the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2). Proteins in the beta-thymosin family are small peptides that act as actin monomer (G-actin) sequestering factors. They bind to G-actin into a 1:1 complex, rendering G-actin resistant to polymerization into filaments (F-actin). Thymosin beta 4 (Tbeta4 or TB4) and beta10 (Tbeta10) are minor variants of betaT that bind skeletal muscle actin and inhibit actin polymerization. Thymosin beta4 can also bind to polymerized F-actin. The roles of beta-thymosins also appear to extend beyond G-actin sequestration. Thymosin beta4 has also been linked to a number of additional biological events, including angiogenesis, wound healing, inflammation, and intracellular signaling through kinase activation. Research on thymosin beta10 in breast cancer cells has suggested a relationship with actin cytoskeletal remodeling and cell motility. In addition, thymosins beta4, beta10, and beta15 are highly expressed in several tumor cells, and these have been associated with a higher metastatic potential, possibly due to their function in cell proliferation.


Pssm-ID: 409202  Cd Length: 34  Bit Score: 36.56  E-value: 1.77e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 386763786  15 AENLKSQLEGFNQDKLKNASTQEKIILPTAEDVA 48
Cdd:cd22059    1 AENLKSQLEGFDKSKLKKTETQEKNPLPSKETIE 34
THY smart00152
Thymosin beta actin-binding motif;
95-129 2.33e-04

Thymosin beta actin-binding motif;


Pssm-ID: 128457  Cd Length: 37  Bit Score: 36.42  E-value: 2.33e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 386763786    95 IAGIENFDAKKLKHTETNEKNVLPTKEVIEAEKQA 129
Cdd:smart00152   1 IDEIEHFDSENLKKTETIEKNVLPSKEDIEQEKQH 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH