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Conserved domains on  [gi|386764175|ref|NP_001245615|]
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uncharacterized protein Dmel_CG2889, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 2-79 7.55e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 214871  Cd Length: 73  Bit Score: 55.21  E-value: 7.55e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386764175     2 ICRLCLRCLSPGSAVFLFETDDTLAEtrlvkMIAKFLQLEILPDDGISTSVCTECCEHLEDFNGFWQLVEQKQCSLKK 79
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSEASLAE-----KIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 301-353 2.65e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 386764175 301 YYikcCGKVFTRASKLMDHIR-KHinpklFTCTICKKSLNSQDYLATHIETVHN 353
Cdd:cd20908    5 YY---CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVHCLQVHK 50
BNR_2 super family cl48157
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 214-290 6.08e-03

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


The actual alignment was detected with superfamily member pfam13088:

Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 38.84  E-value: 6.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386764175  214 ELADLLDDGGKRRRRKAPDQRTTtesqeSELQAVLERKPKGCSRAqLAKSYEKAIasYMSASCDLCE-FSAPYLSELK 290
Cdd:pfam13088 138 AHLELSDDGGVTWRKGRPDNAIS-----GELQPSVLVLADGRLVM-LFRSQEGAI--LASESTDGGLtWSPPEPTNLP 207
 
Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 2-79 7.55e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 55.21  E-value: 7.55e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386764175     2 ICRLCLRCLSPGSAVFLFETDDTLAEtrlvkMIAKFLQLEILPDDGISTSVCTECCEHLEDFNGFWQLVEQKQCSLKK 79
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSEASLAE-----KIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 2-80 3.53e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 50.53  E-value: 3.53e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386764175    2 ICRLCLRCLSPGSAVFlfetDDTLAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLEDFNGFWQLVEQKQCSLKKE 80
Cdd:pfam07776   1 VCRLCLDESDELIPIF----DPSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 301-353 2.65e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 386764175 301 YYikcCGKVFTRASKLMDHIR-KHinpklFTCTICKKSLNSQDYLATHIETVHN 353
Cdd:cd20908    5 YY---CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVHCLQVHK 50
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 214-290 6.08e-03

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 38.84  E-value: 6.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386764175  214 ELADLLDDGGKRRRRKAPDQRTTtesqeSELQAVLERKPKGCSRAqLAKSYEKAIasYMSASCDLCE-FSAPYLSELK 290
Cdd:pfam13088 138 AHLELSDDGGVTWRKGRPDNAIS-----GELQPSVLVLADGRLVM-LFRSQEGAI--LASESTDGGLtWSPPEPTNLP 207
 
Name Accession Description Interval E-value
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 2-79 7.55e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 55.21  E-value: 7.55e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386764175     2 ICRLCLRCLSPGSAVFLFETDDTLAEtrlvkMIAKFLQLEILPDDGISTSVCTECCEHLEDFNGFWQLVEQKQCSLKK 79
Cdd:smart00868   1 VCRLCLSESENLVSIFDESSEASLAE-----KIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 2-80 3.53e-08

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 50.53  E-value: 3.53e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386764175    2 ICRLCLRCLSPGSAVFlfetDDTLAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLEDFNGFWQLVEQKQCSLKKE 80
Cdd:pfam07776   1 VCRLCLDESDELIPIF----DPSDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 301-353 2.65e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 386764175 301 YYikcCGKVFTRASKLMDHIR-KHinpklFTCTICKKSLNSQDYLATHIETVHN 353
Cdd:cd20908    5 YY---CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVHCLQVHK 50
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
 214-290 6.08e-03

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 38.84  E-value: 6.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386764175  214 ELADLLDDGGKRRRRKAPDQRTTtesqeSELQAVLERKPKGCSRAqLAKSYEKAIasYMSASCDLCE-FSAPYLSELK 290
Cdd:pfam13088 138 AHLELSDDGGVTWRKGRPDNAIS-----GELQPSVLVLADGRLVM-LFRSQEGAI--LASESTDGGLtWSPPEPTNLP 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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