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Conserved domains on  [gi|386767144|ref|NP_001246147|]
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tetratricopeptide repeat domain 7, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TTC7_N super family cl44857
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 7-409 4.38e-134

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


The actual alignment was detected with superfamily member pfam19440:

Pssm-ID: 466084  Cd Length: 386  Bit Score: 404.93  E-value: 4.38e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144    7 RNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNFGRAKSGLAEARRFLH 86
Cdd:pfam19440   6 SFSGYRLETEIERCRSECQWDKVPELVEQLKAKRIANDDMANLLLGEGKLEQYLKENPPILENSTEKNQPKLSEAKKHLT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144   87 LALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKF 166
Cdd:pfam19440  86 SALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAYAIKGLCLEKQAVSSSSRV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  167 KKAEKDTEMISCFERASDLGLLYLQEYDlvsgssgssnnstagstlNVNASTvqpssssfaiSSTIPASGPSGLEMnrRM 246
Cdd:pfam19440 166 RLAEREEEMITCYEKAGDIALLYLQELE------------------RINSNT----------QNRSPKPGPPSQEQ--EL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  247 GAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGKSGGGTL--- 323
Cdd:pfam19440 216 GFFLETALQRAYVLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLLdep 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  324 RGGSSKKLW----KPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVR 399
Cdd:pfam19440 296 LKGTNTKNYtpsrKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGR 375

                         410
                  ....*....|
gi 386767144  400 WGLVQLLNES 409
Cdd:pfam19440 376 RGQYEMLSEC 385
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
702-837 3.85e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 84.67  E-value: 3.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 702 QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAH 781
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 386767144 782 LVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPS 837
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 474-631 4.56e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 4.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 474 QGLDYAQQALKREVKGLRPSRSQLFVGIGHQQLAIQSNLKSERDACHKL---------ALDALERAVQFDGNDHLAEYYL 544
Cdd:COG3914   39 AALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLlqalgryeeALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 545 SLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAET 624
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198


                 ....*..
gi 386767144 625 ALGTVQH 631
Cdd:COG3914  199 AIAAYRR 205
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 408-486 3.33e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386767144 408 ESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLcYESLETVKQGLDYAQQALKRE 486
Cdd:COG4783   59 VLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA-YRALGRPDEAIAALEKALELD 136
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 7-409 4.38e-134

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 404.93  E-value: 4.38e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144    7 RNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNFGRAKSGLAEARRFLH 86
Cdd:pfam19440   6 SFSGYRLETEIERCRSECQWDKVPELVEQLKAKRIANDDMANLLLGEGKLEQYLKENPPILENSTEKNQPKLSEAKKHLT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144   87 LALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKF 166
Cdd:pfam19440  86 SALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAYAIKGLCLEKQAVSSSSRV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  167 KKAEKDTEMISCFERASDLGLLYLQEYDlvsgssgssnnstagstlNVNASTvqpssssfaiSSTIPASGPSGLEMnrRM 246
Cdd:pfam19440 166 RLAEREEEMITCYEKAGDIALLYLQELE------------------RINSNT----------QNRSPKPGPPSQEQ--EL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  247 GAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGKSGGGTL--- 323
Cdd:pfam19440 216 GFFLETALQRAYVLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLLdep 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  324 RGGSSKKLW----KPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVR 399
Cdd:pfam19440 296 LKGTNTKNYtpsrKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGR 375

                         410
                  ....*....|
gi 386767144  400 WGLVQLLNES 409
Cdd:pfam19440 376 RGQYEMLSEC 385
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
702-837 3.85e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 84.67  E-value: 3.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 702 QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAH 781
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 386767144 782 LVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPS 837
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 474-631 4.56e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 4.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 474 QGLDYAQQALKREVKGLRPSRSQLFVGIGHQQLAIQSNLKSERDACHKL---------ALDALERAVQFDGNDHLAEYYL 544
Cdd:COG3914   39 AALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLlqalgryeeALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 545 SLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAET 624
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198


                 ....*..
gi 386767144 625 ALGTVQH 631
Cdd:COG3914  199 AIAAYRR 205
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 522-840 5.80e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.18  E-value: 5.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  522 LALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALAL-RMEHAPCLHLFALLLtSSRRPREALGVVEDALH 600
Cdd:TIGR02917 517 DAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELnPQEIEPALALAQYYL-GKGQLKKALAILNEAAD 595

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  601 EFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDVYEAQLAgeeekhsdtksgvhLAHSSQ-MSDKDSISRVeqal 679
Cdd:TIGR02917 596 AAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLL--------------LADAYAvMKNYAKAITS---- 657

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  680 seaasslssfTQRPGPRRPWMLqiEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQC 759
Cdd:TIGR02917 658 ----------LKRALELKPDNT--EAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQA 725

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  760 FLNAVAANPNHTEALRaLGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCP 839
Cdd:TIGR02917 726 YRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNA 804


                  .
gi 386767144  840 V 840
Cdd:TIGR02917 805 V 805
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 523-801 1.32e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG2956   61 AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 603 PDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVwrdvyeaqlageeekhsdtksgvhlahssqmsDKDSisrveqalsea 682
Cdd:COG2956  141 PENAHAYCELAELYLEQGDYDEAIEALEKALKL--------------------------------DPDC----------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 683 asslssftqrpgprrpwmlqIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLN 762
Cdd:COG2956  178 --------------------ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRK 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 386767144 763 AVAANPNHTEALrALGEAHLVLGEPRLAEKMLKDAAKLD 801
Cdd:COG2956  238 ALELDPSDDLLL-ALADLLERKEGLEAALALLERQLRRH 275
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 756-803 2.76e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 43.77  E-value: 2.76e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 386767144 756 AKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPS 803
Cdd:cd24142   19 ALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPD 66
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-626 1.79e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  428 GLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLcYESLETVKQGLDYAQQALKREvKGLRPSRsqlfvgIGHQQLA 507
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADA-YAVMKNYAKAITSLKRALELK-PDNTEAQ------IGLAQLL 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  508 IQSNLKSE---------------------------RDACHKLALDALERAVQFDGNDHLAeYYLSLQYALLGQLAEALVH 560
Cdd:TIGR02917 680 LAAKRTESakkiakslqkqhpkaalgfelegdlylRQKDYPAAIQAYRKALKRAPSSQNA-IKLHRALLASGNTAEAVKT 758

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767144  561 IRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLED------AETAL 626
Cdd:TIGR02917 759 LEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDpraleyAERAL 830
TPR_14 pfam13428
Tetratricopeptide repeat;
772-814 2.61e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 36.25  E-value: 2.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386767144  772 EALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKV 814
Cdd:pfam13428   2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 408-486 3.33e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386767144 408 ESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLcYESLETVKQGLDYAQQALKRE 486
Cdd:COG4783   59 VLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA-YRALGRPDEAIAALEKALELD 136
YPP1 cd23270
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called ...
 499-733 4.41e-03

cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called alpha-synuclein protective protein 1), which is essential in Saccharomyces cerevisiae. It has also been shown to perform fundamental functions in human and mouse. YPP1 is a cargo-transport protein involved in endocytosis. It interacts with genes involved in protein sorting and secretion, and plays a role in the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane. It has been found to suppress the toxicity of alpha-synuclein (alpha-syn) mutant (A30P) that is associated with early onset of Parkinson's disease (PD) in humans, but not wild-type or the A53T mutant (also associated with early onset PD).


Pssm-ID: 438014 [Multi-domain]  Cd Length: 740  Bit Score: 40.72  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 499 VGIGHQQLAIQSNLKSERDACHKLALDALERA--VQFDGNDHLAeYYLSLQYALLGQLAEALVHIRFALALRM-EHAPCL 575
Cdd:cd23270  400 LYEYYSYLLIYTSNESELELNSNDLLSYLKNSliVNPTGNSDLL-FQYAYTLAQQREIEPAIKLLKFILLKKNpESFKSW 478

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 576 HLFALLLTSSRRPREALGVVEDAL-------HEFPDNL------QLLHVKahL-QLHLedAETALGtVQHMLAVWRDVYE 641
Cdd:cd23270  479 HLLALCLSIQEDKEESFKIINSVLnamgeylEKNRVKLtiedkwQIIQLK--LtQLAL--IEEIFG-VEDALEMLPEVFE 553

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 642 --AQLAGEEEKHSDTKSGVHLA----------HSSQMSD-----------KDSISRVEQALSEaasslssftqrpgprrp 698
Cdd:cd23270  554 lyNELFPDSEESPDSGPESNQSkeyllqsiwsFRPSLYDpssesdhlenaKEAIKEASKVSSI----------------- 616

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 386767144 699 wmLQiEIWLLLADVYLRIDQPNEALNCIHEASQIY 733
Cdd:cd23270  617 --LQ-NLWLWTASGYLKLGLGEEAEQAIVEAETVL 648
 
Name Accession Description Interval E-value
TTC7_N pfam19440
Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a ...
 7-409 4.38e-134

Tetratricopeptide repeat protein 7 N-terminal; This is the N-terminal domain of TTC7, a protein that forms the regulatory subunit of the PI4KIIIalpha complex (also known as PI4KA). This complex is composed of PI4KIIIalpha, TTC7 and FAM126A and catalyzes the first step in plasma membrane phosphoinositide synthesis. This TTC7 N-terminal domain contains basic residues suitable for interaction with the acidic inner leaflet of the plasma membrane and is required for localising the active site near its substrate. TTC7 acts as a bridge between PI4KA and EFR3B-FAM126A, via direct interactions. ERF3B is not part of the complex but contributes to its recruitment to the membrane.


Pssm-ID: 466084  Cd Length: 386  Bit Score: 404.93  E-value: 4.38e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144    7 RNTTTKVEALIESCRSEGKWHRVIELTDELKTGSPHNECLANFLVGEARLESYLEENALASDSNFGRAKSGLAEARRFLH 86
Cdd:pfam19440   6 SFSGYRLETEIERCRSECQWDKVPELVEQLKAKRIANDDMANLLLGEGKLEQYLKENPPILENSTEKNQPKLSEAKKHLT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144   87 LALGESGQKAGIALDAYLLLAKLCFACGEYEQSLDNFVKAELNTLAEKELTLRSLKILAESYAIKGLCLEQQTTKPSSKF 166
Cdd:pfam19440  86 SALDRGNLKPEFLQEAHLLLAKLNYVEGDYREALNMYARAGLDDLTLKELPVYRLRLLAEAYAIKGLCLEKQAVSSSSRV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  167 KKAEKDTEMISCFERASDLGLLYLQEYDlvsgssgssnnstagstlNVNASTvqpssssfaiSSTIPASGPSGLEMnrRM 246
Cdd:pfam19440 166 RLAEREEEMITCYEKAGDIALLYLQELE------------------RINSNT----------QNRSPKPGPPSQEQ--EL 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  247 GAILETALQRAPIVLIKTEKLQEAVERYRIMLNAIETRATQSLRLTLARQLAEVLLRGVSGTIYSPPFTGKSGGGTL--- 323
Cdd:pfam19440 216 GFFLETALQRAYVLYFKKGNLARGVGRYREILRAVETRTTQNLRMTIARQLAEVLLRGVCEQSYWNPLEDPPPQSLLdep 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  324 RGGSSKKLW----KPRKYAARQQFNPRNQQEEVILLLLIAEALAVRDTVLSQSPEFRQARQHAMGNVTAVYDLLTLATVR 399
Cdd:pfam19440 296 LKGTNTKNYtpsrKPRVYSGENIFCPQDNVEEALLLLLISESMANRDAVLSRSPEHREARIISLQNATAVYDLLTIAMGR 375

                         410
                  ....*....|
gi 386767144  400 WGLVQLLNES 409
Cdd:pfam19440 376 RGQYEMLSEC 385
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
702-837 3.85e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 84.67  E-value: 3.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 702 QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAH 781
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 386767144 782 LVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPS 837
Cdd:COG0457   87 QALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 700-841 8.70e-17

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 85.04  E-value: 8.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 700 MLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGE 779
Cdd:COG3914   75 LLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGE 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767144 780 AHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVL 841
Cdd:COG3914  155 ALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 702-836 1.03e-16

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 77.54  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 702 QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAH 781
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 386767144 782 LVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEP 836
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
704-828 2.91e-14

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.50  E-value: 2.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 704 EIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLV 783
Cdd:COG0457   43 EALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLE 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 386767144 784 LGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCF 828
Cdd:COG0457  123 LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELL 167
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 721-836 3.43e-13

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 67.34  E-value: 3.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 721 EALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKL 800
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 386767144 801 DPSCPKIWFALGKVMEILGDFHASADCFATSLQLEP 836
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
731-839 1.54e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 1.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 731 QIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFA 810
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100
                 ....*....|....*....|....*....
gi 386767144 811 LGKVMEILGDFHASADCFATSLQLEPSCP 839
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDA 110
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 706-841 1.68e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.60  E-value: 1.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 706 WLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLG 785
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 386767144 786 EPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVL 841
Cdd:COG2956   91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 702-839 3.36e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.83  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 702 QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAH 781
Cdd:COG2956   41 TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIY 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 386767144 782 LVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCP 839
Cdd:COG2956  121 EQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA 178
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 523-833 4.82e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 4.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG2956   27 AIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 603 PDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDvyeaqlageeekhsdtksgvhlahssqmsdkdsisrveqalsea 682
Cdd:COG2956  107 PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE-------------------------------------------- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 683 asslssftqrpgprrpwmlQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLN 762
Cdd:COG2956  143 -------------------NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALER 203

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386767144 763 AVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPkIWFALGKVMEILGDFHASADCFATSLQ 833
Cdd:COG2956  204 ALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDD-LLLALADLLERKEGLEAALALLERQLR 273
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 703-841 1.01e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 66.29  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 703 IEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHL 782
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 386767144 783 VLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCPVL 841
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 703-802 1.52e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 62.33  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 703 IEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHL 782
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAF 96

                         90       100
                 ....*....|....*....|
gi 386767144 783 VLGEPRLAEKMLKDAAKLDP 802
Cdd:COG4235   97 QQGDYAEAIAAWQKLLALLP 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 704-811 1.82e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.71  E-value: 1.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 704 EIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLV 783
Cdd:COG3914  113 EALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQD 192

                         90       100
                 ....*....|....*....|....*...
gi 386767144 784 LGEPRLAEKMLKDAAKLDPSCPKIWFAL 811
Cdd:COG3914  193 LGRLEEAIAAYRRALELDPDNADAHSNL 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 702-836 4.50e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.37  E-value: 4.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 702 QIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAH 781
Cdd:COG2956   75 RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELY 154

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 386767144 782 LVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEP 836
Cdd:COG2956  155 LEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDP 209
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 474-631 4.56e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 4.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 474 QGLDYAQQALKREVKGLRPSRSQLFVGIGHQQLAIQSNLKSERDACHKL---------ALDALERAVQFDGNDHLAEYYL 544
Cdd:COG3914   39 AALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLlqalgryeeALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 545 SLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAET 624
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198


                 ....*..
gi 386767144 625 ALGTVQH 631
Cdd:COG3914  199 AIAAYRR 205
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 699-839 8.84e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.40  E-value: 8.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 699 WMLQIEIWLLLADVYLRIDQPNE-ALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRAL 777
Cdd:COG3914   39 AALGLALLLLAALAEAAAAALLAlAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNL 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767144 778 GEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCP 839
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 738-839 9.34e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.59  E-value: 9.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 738 QIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEI 817
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90       100
                 ....*....|....*....|..
gi 386767144 818 LGDFHASADCFATSLQLEPSCP 839
Cdd:COG4783   85 AGDYDEALALLEKALKLDPEHP 106
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 522-840 5.80e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.18  E-value: 5.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  522 LALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALAL-RMEHAPCLHLFALLLtSSRRPREALGVVEDALH 600
Cdd:TIGR02917 517 DAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELnPQEIEPALALAQYYL-GKGQLKKALAILNEAAD 595

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  601 EFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDVYEAQLAgeeekhsdtksgvhLAHSSQ-MSDKDSISRVeqal 679
Cdd:TIGR02917 596 AAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLL--------------LADAYAvMKNYAKAITS---- 657

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  680 seaasslssfTQRPGPRRPWMLqiEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQC 759
Cdd:TIGR02917 658 ----------LKRALELKPDNT--EAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQA 725

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  760 FLNAVAANPNHTEALRaLGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPSCP 839
Cdd:TIGR02917 726 YRKALKRAPSSQNAIK-LHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNA 804


                  .
gi 386767144  840 V 840
Cdd:TIGR02917 805 V 805
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 746-836 1.01e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 746 VHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASA 825
Cdd:COG5010   63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAK 142

                         90
                 ....*....|.
gi 386767144 826 DCFATSLQLEP 836
Cdd:COG5010  143 AALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
727-839 1.26e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 1.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 727 HEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPK 806
Cdd:COG4785   63 IDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142

                         90       100       110
                 ....*....|....*....|....*....|...
gi 386767144 807 IWFALGKVMEILGDFHASADCFATSLQLEPSCP 839
Cdd:COG4785  143 AYLNRGIALYYLGRYELAIADLEKALELDPNDP 175
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 755-839 1.30e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.24  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 755 DAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQL 834
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                 ....*
gi 386767144 835 EPSCP 839
Cdd:COG4235   81 DPDNP 85
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 523-801 1.32e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG2956   61 AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 603 PDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVwrdvyeaqlageeekhsdtksgvhlahssqmsDKDSisrveqalsea 682
Cdd:COG2956  141 PENAHAYCELAELYLEQGDYDEAIEALEKALKL--------------------------------DPDC----------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 683 asslssftqrpgprrpwmlqIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLN 762
Cdd:COG2956  178 --------------------ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRK 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 386767144 763 AVAANPNHTEALrALGEAHLVLGEPRLAEKMLKDAAKLD 801
Cdd:COG2956  238 ALELDPSDDLLL-ALADLLERKEGLEAALALLERQLRRH 275
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
746-837 1.51e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.87  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 746 VHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKmLKDAAKLDPSCPKIWFALGKVMEILGDFHASA 825
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|..
gi 386767144 826 DCFATSLQLEPS 837
Cdd:COG3063   80 AYLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
423-649 1.97e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 423 VWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLP-CLLAsrLCYESLETVKQGLDYAQQALKrevkgLRPSRSQLFVGI 501
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEAlYNLG--LAYLRLGRYEEALADYEQALE-----LDPDDAEALNNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 502 GHQQLAIQSnlkserdacHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALL 581
Cdd:COG0457   83 GLALQALGR---------YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386767144 582 LTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDVYEAQLAGEEE 649
Cdd:COG0457  154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 408-634 2.25e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.28  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 408 ESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPlPCLLASRLCYESLETVKQGLDYAQQALKrev 487
Cdd:COG2956   63 RIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDA-EALRLLAEIYEQEGDWEKAIEVLERLLK--- 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 488 kgLRPSRSQLFVGIGHQQLAiQSNLKSerdachklALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALAL 567
Cdd:COG2956  139 --LGPENAHAYCELAELYLE-QGDYDE--------AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386767144 568 RMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVkAHLQLHLEDAETALGTVQHMLA 634
Cdd:COG2956  208 DPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALALLERQLR 273
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 692-802 2.96e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.81  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 692 RPGPRRPWMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHT 771
Cdd:COG5010   43 AAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP 122

                         90       100       110
                 ....*....|....*....|....*....|.
gi 386767144 772 EALRALGEAHLVLGEPRLAEKMLKDAAKLDP 802
Cdd:COG5010  123 NAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
464-650 4.35e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.01  E-value: 4.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 464 LCYESLETVKQGLDYAQQALKrevkgLRPSRSQLFVGIGhqqlaiQSNLKSERdacHKLALDALERAVQFDGNDHLAEYY 543
Cdd:COG0457   16 LAYRRLGRYEEAIEDYEKALE-----LDPDDAEALYNLG------LAYLRLGR---YEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 544 LSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAE 623
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE 161

                        170       180
                 ....*....|....*....|....*..
gi 386767144 624 TALGTVQHMLAVWRDVYEAQLAGEEEK 650
Cdd:COG0457  162 EALELLEKLEAAALAALLAAALGEAAL 188
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 523-638 6.16e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.54  E-value: 6.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG3914  131 ALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 386767144 603 PDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRD 638
Cdd:COG3914  211 PDNADAHSNLLFALRQACDWEVYDRFEELLAALARG 246
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
712-803 6.72e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.94  E-value: 6.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 712 VYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQcFLNAVAANPNHTEALRALGEAHLVLGEPRLAE 791
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|..
gi 386767144 792 KMLKDAAKLDPS 803
Cdd:COG3063   80 AYLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
703-801 6.83e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.24  E-value: 6.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 703 IEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHL 782
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                         90
                 ....*....|....*....
gi 386767144 783 VLGEPRLAEKMLKDAAKLD 801
Cdd:COG0457  156 KLGRYEEALELLEKLEAAA 174
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
408-637 4.53e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 4.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 408 ESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPlPCLLASRLCYESLETVKQGLDYAQQALKrev 487
Cdd:COG0457   29 EDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA-EALNNLGLALQALGRYEEALEDYDKALE--- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 488 kgLRPSRSQLFVGIGhqqlaiQSNLKSERdacHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALAL 567
Cdd:COG0457  105 --LDPDDAEALYNLG------LALLELGR---YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAA 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 568 RMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWR 637
Cdd:COG0457  174 ALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQY 243
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 523-634 5.22e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.81  E-value: 5.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG4783   23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                         90       100       110
                 ....*....|....*....|....*....|..
gi 386767144 603 PDNLQLLHVKAHLQLHLEDAETALGTVQHMLA 634
Cdd:COG4783  103 PEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 474-644 7.07e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.07  E-value: 7.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 474 QGLDYAQQALKREVKGLRPSRSQLFVGIGHQQLAIQSNLKSERDACHKLALDALERAVQFDGNDHLAEYYLSLQYALLGQ 553
Cdd:COG3914   14 AAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 554 LAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHML 633
Cdd:COG3914   94 YEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL 173

                        170
                 ....*....|.
gi 386767144 634 AVWRDVYEAQL 644
Cdd:COG3914  174 ELDPDNAEALN 184
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
764-836 1.02e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 1.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386767144 764 VAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEP 836
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDP 73
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 523-635 1.17e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.46  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 386767144 603 PDNLQLLHVKAHLQLHLEDAETALGTVQHMLAV 635
Cdd:COG4235   82 PDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 523-605 2.45e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG4783   57 AIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136


                 ...
gi 386767144 603 PDN 605
Cdd:COG4783  137 PDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 440-802 4.62e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.47  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  440 ALRVLQESMKLTPSDPLPCLLASRLcYESLETVKQGLDYAQQALKREVKglrpsrsqlfVGIGHQQLAIqSNLKSERdac 519
Cdd:TIGR02917 348 AIATLSPALGLDPDDPAALSLLGEA-YLALGDFEKAAEYLAKATELDPE----------NAAARTQLGI-SKLSQGD--- 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  520 HKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDAL 599
Cdd:TIGR02917 413 PSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKAL 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  600 HEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRDVYEA--QLAGEEEKHSDTKSGVHLAHSSQMSDKDSISrveq 677
Cdd:TIGR02917 493 SIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAilALAGLYLRTGNEEEAVAWLEKAAELNPQEIE---- 568

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  678 alseaasslssftqrpgPRrpwmlqieiwLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAK 757
Cdd:TIGR02917 569 -----------------PA----------LALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAV 621

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 386767144  758 QCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDP 802
Cdd:TIGR02917 622 SSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKP 666
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 536-811 7.58e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 7.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  536 NDHLAEY--YLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKA 613
Cdd:TIGR02917 121 DEGAAELlaLRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKG 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  614 HLQLHLEDAETALGTV-QHMLAVWRDV-YEAQLAG---------EEEKHSDT-------KSGVH----LAHSSQMSDKDS 671
Cdd:TIGR02917 201 DLLLSLGNIELALAAYrKAIALRPNNIaVLLALATilieagefeEAEKHADAllkkapnSPLAHylkaLVDFQKKNYEDA 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  672 ISRVE-------------QALSEAASSLSSFTQRPGPRRPWMLQIE----IWLLLADVYLRIDQPNEALNCIHEASQIYP 734
Cdd:TIGR02917 281 RETLQdalksapeylpalLLAGASEYQLGNLEQAYQYLNQILKYAPnshqARRLLASIQLRLGRVDEAIATLSPALGLDP 360

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386767144  735 LSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFAL 811
Cdd:TIGR02917 361 DDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLL 437
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 523-616 9.05e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.77  E-value: 9.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEF 602
Cdd:COG4235   36 ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALL 115

                         90
                 ....*....|....
gi 386767144 603 PDNLQLLHVKAHLQ 616
Cdd:COG4235  116 PADAPARLLEASIA 129
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 520-603 2.17e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 520 HKLALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDAL 599
Cdd:COG5010   70 FEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRAL 149


                 ....
gi 386767144 600 HEFP 603
Cdd:COG5010  150 GTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
699-805 2.60e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.45  E-value: 2.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 699 WMLQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEALRALG 778
Cdd:COG4785   69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                         90       100
                 ....*....|....*....|....*..
gi 386767144 779 EAHLVLGEPRLAEKMLKDAAKLDPSCP 805
Cdd:COG4785  149 IALYYLGRYELAIADLEKALELDPNDP 175
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 523-836 9.58e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 9.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  523 ALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALAlrmeHAPCLHLFALLLTSSR----RPREALGVVEDA 598
Cdd:TIGR02917 280 ARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILK----YAPNSHQARRLLASIQlrlgRVDEAIATLSPA 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  599 LHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMLAVWRD--VYEAQLAGEEEKHSDTKSGV-HLAHSSQMSDKDSISRV 675
Cdd:TIGR02917 356 LGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPEnaAARTQLGISKLSQGDPSEAIaDLETAAQLDPELGRADL 435

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  676 ---------EQALSEAASSLSSFTQRPGprrpwmlQIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQV 746
Cdd:TIGR02917 436 llilsylrsGQFDKALAAAKKLEKKQPD-------NASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARI 508

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  747 HVYLEQWFDAKQCFLNAVAANPNHTEALRA----------------------------------LGEAHLVLGEPRLAEK 792
Cdd:TIGR02917 509 DIQEGNPDDAIQRFEKVLTIDPKNLRAILAlaglylrtgneeeavawlekaaelnpqeiepalaLAQYYLGKGQLKKALA 588

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 386767144  793 MLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEP 836
Cdd:TIGR02917 589 ILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQP 632
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
548-641 1.08e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.69  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 548 YALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALgVVEDALHEFPDNLQLLHVKAHLQLHLEDAETALG 627
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|....
gi 386767144 628 TVQHMLAVWRDVYE 641
Cdd:COG3063   81 YLERALELDPSALR 94
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 521-841 1.72e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.46  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  521 KLALDALERAVqfDGNDHLAEYYLSLQYALL--GQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDA 598
Cdd:TIGR02917 584 KKALAILNEAA--DAAPDSPEAWLMLGRAQLaaGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRA 661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  599 LHEFPDNLQLLHVKAHLQLHLEDAETALGTVQHMlavwrdvyeaqlageEEKHSDTKSGVHLAHSSQMSDKDsisrveqa 678
Cdd:TIGR02917 662 LELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSL---------------QKQHPKAALGFELEGDLYLRQKD-------- 718

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  679 lseAASSLSSFTQRpgprrpwmLQIE----IWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWF 754
Cdd:TIGR02917 719 ---YPAAIQAYRKA--------LKRApssqNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYD 787

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  755 DAKQCFLNAVAANPNHTEALRALGEAHLVLGEPRlAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQL 834
Cdd:TIGR02917 788 KAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDPR-ALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNI 866


                  ....*..
gi 386767144  835 EPSCPVL 841
Cdd:TIGR02917 867 APEAAAI 873
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 522-634 2.10e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.64  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 522 LALDALERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHE 601
Cdd:COG5010   38 KEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALAL 117

                         90       100       110
                 ....*....|....*....|....*....|...
gi 386767144 602 FPDNLQLLHVKAHLQLHLEDAETALGTVQHMLA 634
Cdd:COG5010  118 SPDNPNAYSNLAALLLSLGQDDEAKAALQRALG 150
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 756-803 2.76e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 43.77  E-value: 2.76e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 386767144 756 AKQCFLNAVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPS 803
Cdd:cd24142   19 ALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPD 66
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 763-836 3.31e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 43.75  E-value: 3.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386767144 763 AVAANPNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPScPKIWFALGKVMEILGDFHASADCFATSLQLEP 836
Cdd:COG3071  250 WLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPS-AEAYAELARLLEQLGDPEEAAEHYRKALALAL 322
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 527-824 3.93e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  527 LERAVQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDA-LHEFPDN 605
Cdd:TIGR02917  45 LKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKFQQVLDELPGKtLLDDEGA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  606 LQLLHVKAHLQLHLEDAETAlgtvqhmlavwRDVYEAQLAgEEEKHSDTKSGvhLAHSsQMSDKDsISRVEQALSEAass 685
Cdd:TIGR02917 125 AELLALRGLAYLGLGQLELA-----------QKSYEQALA-IDPRSLYAKLG--LAQL-ALAENR-FDEARALIDEV--- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  686 lssFTQRPGPrrpwmlqIEIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQwFDAKQCFLNAVA 765
Cdd:TIGR02917 186 ---LTADPGN-------VDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGE-FEEAEKHADALL 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  766 AN-PNHTEALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHAS 824
Cdd:TIGR02917 255 KKaPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQA 314
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 713-803 4.86e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.36  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 713 YLRIDQPNEALNCIHEASQIYP---LSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHT---EALRALGEAHLVLGE 786
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPnspLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKLGLSYLELGD 82

                         90
                 ....*....|....*..
gi 386767144 787 PRLAEKMLKDAAKLDPS 803
Cdd:COG1729   83 YDKARATLEELIKKYPD 99
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 752-837 8.37e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 8.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 752 QWFDAKQCFLNAVAANPNHT---EALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKI---WFALGKVMEILGDFHASA 825
Cdd:COG1729    8 DYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLELGDYDKAR 87

                         90
                 ....*....|..
gi 386767144 826 DCFATSLQLEPS 837
Cdd:COG1729   88 ATLEELIKKYPD 99
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 428-626 1.79e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  428 GLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLcYESLETVKQGLDYAQQALKREvKGLRPSRsqlfvgIGHQQLA 507
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADA-YAVMKNYAKAITSLKRALELK-PDNTEAQ------IGLAQLL 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144  508 IQSNLKSE---------------------------RDACHKLALDALERAVQFDGNDHLAeYYLSLQYALLGQLAEALVH 560
Cdd:TIGR02917 680 LAAKRTESakkiakslqkqhpkaalgfelegdlylRQKDYPAAIQAYRKALKRAPSSQNA-IKLHRALLASGNTAEAVKT 758

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767144  561 IRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHLED------AETAL 626
Cdd:TIGR02917 759 LEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDpraleyAERAL 830
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
531-801 2.20e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 531 VQFDGNDHLAEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLH 610
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 611 VKAHLQLHLEDAETALGTVQHMLAVWRDVYEAqlageeekhsdtksgvhlahssqmsdkdsisrveqalseaasslssft 690
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPDDAEA------------------------------------------------ 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 691 qrpgprrpwmlqieiWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNH 770
Cdd:COG0457  113 ---------------LYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAA 177

                        250       260       270
                 ....*....|....*....|....*....|.
gi 386767144 771 TEALRALGEAHLVLGEPRLAEKMLKDAAKLD 801
Cdd:COG0457  178 LLAAALGEAALALAAAEVLLALLLALEQALR 208
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 523-802 2.32e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.05  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 523 ALDALERAVQFDGNDHLAEYYLSLQYAL-LGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVE----- 596
Cdd:COG3071   69 RDEYLAQALELAPEAELAVLLTRAELLLdQGQAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPalrkh 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 597 DALHefPDNLQLLHVKAHLQLHLEDAETALGtvqhMLAVWRDVyeaqlaGEEEKHSDTksgVHLAHSSQMSDKDSISRVE 676
Cdd:COG3071  149 KALS--AEEAQALERRAYLGLLRQAARDAEA----LKALWKAL------PRAERRDPE---LAAAYARALIALGDHDEAE 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 677 QALseaasslssftqRPGPRRPWmlQIEIWLLLADvyLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDA 756
Cdd:COG3071  214 RLL------------REALKRQW--DPRLVRLYGR--LQGGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKA 277

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 386767144 757 KQCFLNAVAANPNhTEALRALGEAHLVLGEPRLAEKMLKDAAKLDP 802
Cdd:COG3071  278 REYLEAALALRPS-AEAYAELARLLEQLGDPEEAAEHYRKALALAL 322
TPR_14 pfam13428
Tetratricopeptide repeat;
772-814 2.61e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 36.25  E-value: 2.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386767144  772 EALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKV 814
Cdd:pfam13428   2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 540-634 3.08e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 540 AEYYLSLQYALLGQLAEALVHIRFALALRMEHAPCLHLFALLLTSSRRPREALGVVEDALHEFPDNLQLLHVKAHLQLHL 619
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                         90
                 ....*....|....*
gi 386767144 620 EDAETALGTVQHMLA 634
Cdd:COG4783   86 GDYDEALALLEKALK 100
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 408-486 3.33e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 3.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386767144 408 ESFEKALKFSFGEQHVWRQYGLSLMAAEKHSHALRVLQESMKLTPSDPLPCLLASRLcYESLETVKQGLDYAQQALKRE 486
Cdd:COG4783   59 VLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA-YRALGRPDEAIAALEKALELD 136
YPP1 cd23270
cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called ...
 499-733 4.41e-03

cargo-transport protein YPP1; This family includes YGR198w (named YPP1, also called alpha-synuclein protective protein 1), which is essential in Saccharomyces cerevisiae. It has also been shown to perform fundamental functions in human and mouse. YPP1 is a cargo-transport protein involved in endocytosis. It interacts with genes involved in protein sorting and secretion, and plays a role in the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane. It has been found to suppress the toxicity of alpha-synuclein (alpha-syn) mutant (A30P) that is associated with early onset of Parkinson's disease (PD) in humans, but not wild-type or the A53T mutant (also associated with early onset PD).


Pssm-ID: 438014 [Multi-domain]  Cd Length: 740  Bit Score: 40.72  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 499 VGIGHQQLAIQSNLKSERDACHKLALDALERA--VQFDGNDHLAeYYLSLQYALLGQLAEALVHIRFALALRM-EHAPCL 575
Cdd:cd23270  400 LYEYYSYLLIYTSNESELELNSNDLLSYLKNSliVNPTGNSDLL-FQYAYTLAQQREIEPAIKLLKFILLKKNpESFKSW 478

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 576 HLFALLLTSSRRPREALGVVEDAL-------HEFPDNL------QLLHVKahL-QLHLedAETALGtVQHMLAVWRDVYE 641
Cdd:cd23270  479 HLLALCLSIQEDKEESFKIINSVLnamgeylEKNRVKLtiedkwQIIQLK--LtQLAL--IEEIFG-VEDALEMLPEVFE 553

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 642 --AQLAGEEEKHSDTKSGVHLA----------HSSQMSD-----------KDSISRVEQALSEaasslssftqrpgprrp 698
Cdd:cd23270  554 lyNELFPDSEESPDSGPESNQSkeyllqsiwsFRPSLYDpssesdhlenaKEAIKEASKVSSI----------------- 616

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 386767144 699 wmLQiEIWLLLADVYLRIDQPNEALNCIHEASQIY 733
Cdd:cd23270  617 --LQ-NLWLWTASGYLKLGLGEEAEQAIVEAETVL 648
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 704-773 5.71e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.68  E-value: 5.71e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767144 704 EIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNHTEA 773
Cdd:COG4235   52 DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 704-770 7.69e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 7.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386767144 704 EIWLLLADVYLRIDQPNEALNCIHEASQIYPLSHQIMFMRGQVHVYLEQWFDAKQCFLNAVAANPNH 770
Cdd:COG4783   73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 772-837 8.93e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.15  E-value: 8.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386767144 772 EALRALGEAHLVLGEPRLAEKMLKDAAKLDPSCPKIWFALGKVMEILGDFHASADCFATSLQLEPS 837
Cdd:cd24142    1 DELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPD 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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