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Conserved domains on  [gi|386768414|ref|NP_001246455|]
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uncharacterized protein Dmel_CG13502, isoform D [Drosophila melanogaster]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-134 7.18e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 7.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG0457   58 YEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                         90       100
                 ....*....|....*....|....*...
gi 386768414 114 RARPEL--ALFRLGV-----QKTQEAIE 134
Cdd:COG0457  138 ELDPDDadALYNLGIaleklGRYEEALE 165
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-134 7.18e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 7.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG0457   58 YEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                         90       100
                 ....*....|....*....|....*...
gi 386768414 114 RARPEL--ALFRLGV-----QKTQEAIE 134
Cdd:COG0457  138 ELDPDDadALYNLGIaleklGRYEEALE 165
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 32-109 1.67e-04

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 39.54  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386768414   32 RAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETAlGEDKNNIRAIYQKAESLYYLGQFEQSLMFF 109
Cdd:pfam12895   3 HQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKA-KLNGSSLGCRYLFAQCLLKLKKYDEALDAL 79
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 34-182 3.35e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 41.31  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:PLN03088  18 FALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGA 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386768414 114 RARPELALFRLGVQKTQEAIENTIGskpGPPGPTASVPKSgkSRKSGEDTPKSQAAGATGTSARTR----QKP 182
Cdd:PLN03088  98 SLAPGDSRFTKLIKECDEKIAEEEK---DLVQPVPSDLPS--SVTAPPVEEADATPVVPPSKPKYRhefyQKP 165
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 18-126 5.04e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414   18 IKLLCDQSNNHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLY 97
Cdd:TIGR02917 125 AELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLL 204

                          90       100       110
                  ....*....|....*....|....*....|.
gi 386768414   98 YLGQFEQSLMFFHRGLRARPE--LALFRLGV 126
Cdd:TIGR02917 205 SLGNIELALAAYRKAIALRPNniAVLLALAT 235
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-134 7.18e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.79  E-value: 7.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG0457   58 YEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                         90       100
                 ....*....|....*....|....*...
gi 386768414 114 RARPEL--ALFRLGV-----QKTQEAIE 134
Cdd:COG0457  138 ELDPDDadALYNLGIaleklGRYEEALE 165
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-134 8.87e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.41  E-value: 8.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG0457   24 YEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKAL 103

                         90       100       110
                 ....*....|....*....|....*....|
gi 386768414 114 RARPE---------LALFRLGvqKTQEAIE 134
Cdd:COG0457  104 ELDPDdaealynlgLALLELG--RYDEAIE 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-134 5.15e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.09  E-value: 5.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG0457   92 YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLE 171

                         90       100
                 ....*....|....*....|.
gi 386768414 114 RARPELALFRLGVQKTQEAIE 134
Cdd:COG0457  172 AAALAALLAAALGEAALALAA 192
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 28-124 4.17e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.47  E-value: 4.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  28 HMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLM 107
Cdd:COG4235   27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106

                         90
                 ....*....|....*..
gi 386768414 108 FFHRGLRARPELALFRL 124
Cdd:COG4235  107 AWQKLLALLPADAPARL 123
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 23-134 6.45e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 6.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  23 DQSNNHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQF 102
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386768414 103 EQSLMFFHRGLRARPE--LALFRLG-----VQKTQEAIE 134
Cdd:COG4783   89 DEALALLEKALKLDPEhpEAYLRLArayraLGRPDEAIA 127
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 34-117 7.37e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.43  E-value: 7.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG5010   70 FEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRAL 149


                 ....
gi 386768414 114 RARP 117
Cdd:COG5010  150 GTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
45-134 8.80e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 8.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  45 LELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGLRARPEL--ALF 122
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDaeALN 80

                         90
                 ....*....|....*..
gi 386768414 123 RLGV-----QKTQEAIE 134
Cdd:COG0457   81 NLGLalqalGRYEEALE 97
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
28-119 2.51e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.55  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  28 HMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQdAETALGEDKNNIRAIYQKAESLYYLGQFEQSLM 107
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|..
gi 386768414 108 FFHRGLRARPEL 119
Cdd:COG3063   81 YLERALELDPSA 92
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 17-134 5.51e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.46  E-value: 5.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  17 NIKLLCDQSNNHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESL 96
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAL 156

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 386768414  97 YYLGQFEQSLMFFHRGLRARPEL--ALFRLGV-----QKTQEAIE 134
Cdd:COG3914  157 RRLGRLEEAIAALRRALELDPDNaeALNNLGNalqdlGRLEEAIA 201
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 11-125 9.16e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 9.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  11 LEEIETNIKLLCDQSNNHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIY 90
Cdd:COG2956  103 LELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALL 182

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 386768414  91 QKAESLYYLGQFEQSLMFFHRGLRARPEL--ALFRLG 125
Cdd:COG2956  183 LLAELYLEQGDYEEAIAALERALEQDPDYlpALPRLA 219
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 36-134 9.35e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 9.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  36 KALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGLRA 115
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100
                 ....*....|....*....|....*.
gi 386768414 116 RPE--LALFRLGV-----QKTQEAIE 134
Cdd:COG4235   81 DPDnpEALYLLGLaafqqGDYAEAIA 106
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 28-134 1.02e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  28 HMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLM 107
Cdd:COG2956   86 YLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIE 165

                         90       100       110
                 ....*....|....*....|....*....|....
gi 386768414 108 FFHRGLRARPE-------LALFRLGVQKTQEAIE 134
Cdd:COG2956  166 ALEKALKLDPDcaralllLAELYLEQGDYEEAIA 199
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 34-118 6.35e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 6.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG4783   54 LDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133


                 ....*
gi 386768414 114 RARPE 118
Cdd:COG4783  134 ELDPD 138
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 11-121 1.08e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  11 LEEIETNIKLLCDQSNNHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIY 90
Cdd:COG2956  137 LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216

                         90       100       110
                 ....*....|....*....|....*....|.
gi 386768414  91 QKAESLYYLGQFEQSLMFFHRGLRARPELAL 121
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKALELDPSDDL 247
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 49-126 1.26e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.72  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  49 STDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGLRARPE--LALFRLGV 126
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDepEARLNLGL 80
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
34-104 1.47e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.99  E-value: 1.47e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQ 104
Cdd:COG4785   89 YDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYEL 159
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 34-124 4.11e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 4.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG2956   58 YDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLL 137

                         90
                 ....*....|.
gi 386768414 114 RARPELALFRL 124
Cdd:COG2956  138 KLGPENAHAYC 148
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 32-109 1.67e-04

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 39.54  E-value: 1.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386768414   32 RAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETAlGEDKNNIRAIYQKAESLYYLGQFEQSLMFF 109
Cdd:pfam12895   3 HQYKNAIFLAERLLAAEPESPEDAYLLAQCLFLNGQYKRAYELLRKA-KLNGSSLGCRYLFAQCLLKLKKYDEALDAL 79
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 27-134 1.87e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  27 NHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSL 106
Cdd:COG2956   17 NYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 386768414 107 MFFHRGLRARP--ELALFRLG-----VQKTQEAIE 134
Cdd:COG2956   97 ELLEKLLELDPddAEALRLLAeiyeqEGDWEKAIE 131
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 34-182 3.35e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 41.31  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:PLN03088  18 FALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKAALEKGA 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386768414 114 RARPELALFRLGVQKTQEAIENTIGskpGPPGPTASVPKSgkSRKSGEDTPKSQAAGATGTSARTR----QKP 182
Cdd:PLN03088  98 SLAPGDSRFTKLIKECDEKIAEEEK---DLVQPVPSDLPS--SVTAPPVEEADATPVVPPSKPKYRhefyQKP 165
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 18-126 5.04e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414   18 IKLLCDQSNNHMKVRAYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLY 97
Cdd:TIGR02917 125 AELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLL 204

                          90       100       110
                  ....*....|....*....|....*....|.
gi 386768414   98 YLGQFEQSLMFFHRGLRARPE--LALFRLGV 126
Cdd:TIGR02917 205 SLGNIELALAAYRKAIALRPNniAVLLALAT 235
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 41-118 8.68e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 40.35  E-value: 8.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386768414   41 YNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGLRARPE 118
Cdd:TIGR00990 388 FDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGVTQYKEGSIASSMATFRRCKKNFPE 465
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 34-118 8.83e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 8.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414   34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:TIGR02917 209 IELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDAL 288


                  ....*
gi 386768414  114 RARPE 118
Cdd:TIGR02917 289 KSAPE 293
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 21-107 2.50e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 39.20  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414   21 LCDQSNNHMKVRAYEKALFGYNQALELNStDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLG 100
Cdd:TIGR00990 130 LKEKGNKAYRNKDFNKAIKLYSKAIECKP-DPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLG 208


                  ....*..
gi 386768414  101 QFEQSLM 107
Cdd:TIGR00990 209 KYADALL 215
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
34-127 3.28e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.06  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  34 YEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGL 113
Cdd:COG0457  126 YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQ 205

                         90
                 ....*....|....
gi 386768414 114 RARPELALFRLGVQ 127
Cdd:COG0457  206 ALRKKLAILTLAAL 219
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
61-125 3.90e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 3.90e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386768414  61 CYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMfFHRGLRARPELALFRLG 125
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLN 64
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
54-134 9.30e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 36.43  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  54 ALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRGLRARPE---------LALFRL 124
Cdd:COG4785   75 LYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDyayaylnrgIALYYL 154

                         90
                 ....*....|
gi 386768414 125 GvqKTQEAIE 134
Cdd:COG4785  155 G--RYELAIA 162
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 33-134 9.41e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.09  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768414  33 AYEKALFGYNQALELNSTDINALISRSKCYLLLGEASKALQDAETALGEDKNNIRAIYQKAESLYYLGQFEQSLMFFHRG 112
Cdd:COG5010   35 NNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKA 114

                         90       100
                 ....*....|....*....|....*....
gi 386768414 113 LRARPE-------LALFRLGVQKTQEAIE 134
Cdd:COG5010  115 LALSPDnpnaysnLAALLLSLGQDDEAKA 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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