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Conserved domains on  [gi|386768610|ref|NP_001246506|]
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Na,K-ATPase interacting, isoform K [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NKAIN super family cl05290
Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of ...
 6-199 1.07e-91

Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.


The actual alignment was detected with superfamily member pfam05640:

Pssm-ID: 461699  Cd Length: 206  Bit Score: 282.84  E-value: 1.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768610    6 CTRRHFLLSICFLQVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFY 85
Cdd:pfam05640   4 CSGRCTLIFFCFLQLLAVLERQVFDFLGYQWAPILVNFFHIIFVILGLFGTIQYRPRYLVVYAVWLVLWVGWNIFIICFY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768610   86 LNVGQLNRDSDLLNLGTG-SVSWFEANGYGCKPTYNMA-ADDTFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILG 163
Cdd:pfam05640  84 LEVGILSRDSDLLTFNTSqHRSWWMENGPGCRVTPPTItSEDAPEDHRYISVSGCLLDYQYIEVVHSAIQILLALVGFIY 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 386768610  164 AILISCIFLDEDDRFDFMNG-DA------KSPQHTVVHPMYVS 199
Cdd:pfam05640 164 ACYVVKTFLEEEDSFDFIGGfDSygyqapQKTSHLQLQPMYVS 206
 
Name Accession Description Interval E-value
NKAIN pfam05640
Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of ...
 6-199 1.07e-91

Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.


Pssm-ID: 461699  Cd Length: 206  Bit Score: 282.84  E-value: 1.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768610    6 CTRRHFLLSICFLQVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFY 85
Cdd:pfam05640   4 CSGRCTLIFFCFLQLLAVLERQVFDFLGYQWAPILVNFFHIIFVILGLFGTIQYRPRYLVVYAVWLVLWVGWNIFIICFY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768610   86 LNVGQLNRDSDLLNLGTG-SVSWFEANGYGCKPTYNMA-ADDTFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILG 163
Cdd:pfam05640  84 LEVGILSRDSDLLTFNTSqHRSWWMENGPGCRVTPPTItSEDAPEDHRYISVSGCLLDYQYIEVVHSAIQILLALVGFIY 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 386768610  164 AILISCIFLDEDDRFDFMNG-DA------KSPQHTVVHPMYVS 199
Cdd:pfam05640 164 ACYVVKTFLEEEDSFDFIGGfDSygyqapQKTSHLQLQPMYVS 206
 
Name Accession Description Interval E-value
NKAIN pfam05640
Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of ...
 6-199 1.07e-91

Na,K-Atpase Interacting protein; NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localize to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterized domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer.


Pssm-ID: 461699  Cd Length: 206  Bit Score: 282.84  E-value: 1.07e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768610    6 CTRRHFLLSICFLQVITIIERQVFDFLGYMWAPILVNFFHILFIIFGFYGAYHFRVKYIITYLIWNFLWIGWNTFLICFY 85
Cdd:pfam05640   4 CSGRCTLIFFCFLQLLAVLERQVFDFLGYQWAPILVNFFHIIFVILGLFGTIQYRPRYLVVYAVWLVLWVGWNIFIICFY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768610   86 LNVGQLNRDSDLLNLGTG-SVSWFEANGYGCKPTYNMA-ADDTFRPQRPERVEGCLLDYPLVEITHSGVQCALALLGILG 163
Cdd:pfam05640  84 LEVGILSRDSDLLTFNTSqHRSWWMENGPGCRVTPPTItSEDAPEDHRYISVSGCLLDYQYIEVVHSAIQILLALVGFIY 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 386768610  164 AILISCIFLDEDDRFDFMNG-DA------KSPQHTVVHPMYVS 199
Cdd:pfam05640 164 ACYVVKTFLEEEDSFDFIGGfDSygyqapQKTSHLQLQPMYVS 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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