alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.; The alpha-crystallin-Hsps_p23-like superfamily includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12-43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this superfamily is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770894  106 PQPHMCIRTTTEAGEELFINVLSWTRIVIPQEPSDPIPLYGGM----RVP--PGSPR-------SPPIVFAVMANPEVLK 172
Cdd:pfam08190  30 PEPGFVVKTFVDGGGKCFINVCQHELIGKPEEEPGTDGDNGTTglswRIPysLGQPRfdkdkkgKPCKVYDVVFHPDTLH 109

                          90       100
                  ....*....|....*....|....
gi 386770894  173 dsgRHSKDPEERRAMVELMCDFVE 196
Cdd:pfam08190 110 ---LATKNHNFRKFVIDTALEAIE 130

PIH1 N-terminal domain; This domain is involved in pre-rRNA processing. It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770894  106 PQPHMCIRTTTEAGEELFINVLSWTRIVIPQEPSDPIPLYGGM----RVP--PGSPR-------SPPIVFAVMANPEVLK 172
Cdd:pfam08190  30 PEPGFVVKTFVDGGGKCFINVCQHELIGKPEEEPGTDGDNGTTglswRIPysLGQPRfdkdkkgKPCKVYDVVFHPDTLH 109

                          90       100
                  ....*....|....*....|....
gi 386770894  173 dsgRHSKDPEERRAMVELMCDFVE 196
Cdd:pfam08190 110 ---LATKNHNFRKFVIDTALEAIE 130

PIH1 N-terminal domain; This domain is involved in pre-rRNA processing. It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770894  106 PQPHMCIRTTTEAGEELFINVLSWTRIVIPQEPSDPIPLYGGM----RVP--PGSPR-------SPPIVFAVMANPEVLK 172
Cdd:pfam08190  30 PEPGFVVKTFVDGGGKCFINVCQHELIGKPEEEPGTDGDNGTTglswRIPysLGQPRfdkdkkgKPCKVYDVVFHPDTLH 109

                          90       100
                  ....*....|....*....|....
gi 386770894  173 dsgRHSKDPEERRAMVELMCDFVE 196
Cdd:pfam08190 110 ---LATKNHNFRKFVIDTALEAIE 130