|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
299-654 |
7.56e-29 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 121.19 E-value: 7.56e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 299 TLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELfaeqakiiQEVYLQNNSISVLnPQLFSNLDQLQA 378
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNL--------ESLDLSGNQLTDL-PEELANLTNLKE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 379 LDLSMNQITStwIDKNtFVGLIRLVLLNLSHNKLTKLePEIFSDLYTLQILNLRHNQLENIaADTFAPMNNLHTLLLSHN 458
Cdd:COG4886 141 LDLSNNQLTD--LPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 459 KLKYLDAyALNGLYVLSLLSLDNNALIGVhpDAFRNCSALQDLNLNGNQLKTVPlALRNMRHLRTVDLGENMITVMEDSA 538
Cdd:COG4886 216 QLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKE 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 539 FKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNR-IAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLL 617
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKgLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
|
330 340 350
....*....|....*....|....*....|....*..
gi 386771139 618 WLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNR 654
Cdd:COG4886 372 LGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
202-691 |
3.06e-27 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 120.72 E-value: 3.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 202 LERLDLSSNNI-WSLPDNIFCTLSELSALNMSENRLQDVNELGFrdrskeptngsteststtesakkssssstscSLDLE 280
Cdd:PLN00113 95 IQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS-------------------------------IPNLE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 281 YLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVA-LPTELfaEQAKIIQEVYLQN 359
Cdd:PLN00113 144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPREL--GQMKSLKWIYLGY 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 360 NSIS------------------VLN------PQLFSNLDQLQALDLSMNQITSTwIDKNTFvGLIRLVLLNLSHNKLTKL 415
Cdd:PLN00113 222 NNLSgeipyeiggltslnhldlVYNnltgpiPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGE 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 416 EPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNC 495
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSS 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 496 SALQDLNLNGNQLKT-VPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNL 574
Cdd:PLN00113 380 GNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSL 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 575 ARNRIAVVEPGAFemtSSIQAVRLDGNElNDINGL----FSNMPSLLWLNISDNRLEsfdyGHVPSTLQW------LDLH 644
Cdd:PLN00113 460 ARNKFFGGLPDSF---GSKRLENLDLSR-NQFSGAvprkLGSLSELMQLKLSENKLS----GEIPDELSSckklvsLDLS 531
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 386771139 645 KNRLS-SLSNRFgldSELK-LQTLDVSFNQLQRIGPSSIPNSIELLFLN 691
Cdd:PLN00113 532 HNQLSgQIPASF---SEMPvLSQLDLSQNQLSGEIPKNLGNVESLVQVN 577
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
1114-1247 |
1.92e-21 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 92.00 E-value: 1.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1114 DAYFAYSlQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALH 1193
Cdd:smart00255 3 DVFISYS-GKEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAALE 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1194 E-LVKRRKRVVFILYGDLPQ--RDIDMDMRHYLRTsTCIEWDDKK---FWQKLRLALPLP 1247
Cdd:smart00255 82 NaLEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKK-NYLKWPEDEkeqFWKKALYAVPSK 140
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
300-506 |
9.73e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.90 E-value: 9.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 300 LRRLRVLSVNNNGISMIADkaLSGLKNLQILNLSSNKIVALPTELFAEQakiIQEVYLQNNSISVLNPqlFSNLDQLQAL 379
Cdd:cd21340 1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEFLTN---LTHLYLQNNQIEKIEN--LENLVNLKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 380 DLSMNQITstwidkntfV-----GLIRLVLLNLSHNKL---TKLEPEIFSDLY---TLQILNLRHNQLENIAAdtFAPMN 448
Cdd:cd21340 74 YLGGNRIS---------VvegleNLTNLEELHIENQRLppgEKLTFDPRSLAAlsnSLRVLNISGNNIDSLEP--LAPLR 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 386771139 449 NLHTLLLSHNKLKYLDAyalnglyVLSLLSldnnaligvhpdafrNCSALQDLNLNGN 506
Cdd:cd21340 143 NLEQLDASNNQISDLEE-------LLDLLS---------------SWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
401-460 |
5.22e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.16 E-value: 5.22e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 401 RLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKL 460
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
1124-1212 |
8.57e-11 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 62.00 E-value: 8.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1124 EHFVNQILAQTLENdiGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVV 1203
Cdd:pfam01582 14 EWFVSHLLKELKQK--GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILECALDLGQKVI 91
|
....*....
gi 386771139 1204 FILYGDLPQ 1212
Cdd:pfam01582 92 PIFYEVDPS 100
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
863-990 |
1.28e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.34 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 863 ELYIDGNNFVELagHSFLGR-KNLAVLYANNSNVAHIyNTTFSGLKRLLILHLEDNHIISLeGNEFHNLENLRELYLQSN 941
Cdd:COG4886 140 ELDLSNNQLTDL--PEPLGNlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 386771139 942 KIASIANgSFQMLRKLEVLRLDGNRLMHFEvwQLSANPYLVEISLADNQ 990
Cdd:COG4886 216 QLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQ 261
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
864-967 |
1.03e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 60.18 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 864 LYIDGNNFVELAGHSFLgrKNLAVLYANNSNVAHIYNttFSGLKRLLILHLEDNHIISLEGneFHNLENLRELYLQSNKI 943
Cdd:cd21340 7 LYLNDKNITKIDNLSLC--KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
|
90 100
....*....|....*....|....
gi 386771139 944 ASIANgsFQMLRKLEVLRLDGNRL 967
Cdd:cd21340 81 SVVEG--LENLTNLEELHIENQRL 102
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
908-967 |
4.57e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.68 E-value: 4.57e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 908 RLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRL 967
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
662-719 |
4.40e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.59 E-value: 4.40e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 662 KLQTLDVSFNQLQRIGPSSIPN--SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQI 719
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGlsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
200-246 |
2.17e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 2.17e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 386771139 200 RRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRD 246
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
135-242 |
4.06e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 135 SRLEaqSFAHLVRLQQLSIQYCKLgrlgrQVLDGLEQLRNLT-LR-THNILWPALNFEIEADA-FSVTRRLERLDLSSNN 211
Cdd:cd21340 59 EKIE--NLENLVNLKKLYLGGNRI-----SVVEGLENLTNLEeLHiENQRLPPGEKLTFDPRSlAALSNSLRVLNISGNN 131
|
90 100 110
....*....|....*....|....*....|.
gi 386771139 212 IWSLPDniFCTLSELSALNMSENRLQDVNEL 242
Cdd:cd21340 132 IDSLEP--LAPLRNLEQLDASNNQISDLEEL 160
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
299-654 |
7.56e-29 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 121.19 E-value: 7.56e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 299 TLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELfaeqakiiQEVYLQNNSISVLnPQLFSNLDQLQA 378
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNL--------ESLDLSGNQLTDL-PEELANLTNLKE 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 379 LDLSMNQITStwIDKNtFVGLIRLVLLNLSHNKLTKLePEIFSDLYTLQILNLRHNQLENIaADTFAPMNNLHTLLLSHN 458
Cdd:COG4886 141 LDLSNNQLTD--LPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 459 KLKYLDAyALNGLYVLSLLSLDNNALIGVhpDAFRNCSALQDLNLNGNQLKTVPlALRNMRHLRTVDLGENMITVMEDSA 538
Cdd:COG4886 216 QLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKE 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 539 FKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNR-IAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLL 617
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKgLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
|
330 340 350
....*....|....*....|....*....|....*..
gi 386771139 618 WLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNR 654
Cdd:COG4886 372 LGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
326-698 |
6.20e-28 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 118.50 E-value: 6.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 326 NLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNqitstwidkNTFVGLIRLVLL 405
Cdd:COG4886 48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 406 NLSHNKLTKLePEIFSDLYTLQILNLRHNQLENIAADtFAPMNNLHTLLLSHNKLKYLDAyALNGLYVLSLLSLDNNALI 485
Cdd:COG4886 119 DLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQIT 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 486 GVhPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDsaFKGLGNLYGLRLIGNYLENITmhTFRD 565
Cdd:COG4886 196 DL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLAN 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 566 LPNLQILNLARNRIAVVEPgafemtSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHK 645
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKL------KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 386771139 646 NRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTV 698
Cdd:COG4886 345 SLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
329-741 |
2.48e-27 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 116.57 E-value: 2.48e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLS 408
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 409 HNKLTKLEPEIFSDLYTLQILNLRHNqleniaaDTFAPMNNLHTLLLSHNKLKYLdayalnglyvlsllsldnnaligvh 488
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL------------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 489 PDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMeDSAFKGLGNLYGLRLIGNYLENITmHTFRDLPN 568
Cdd:COG4886 129 PEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTN 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 569 LQILNLARNRIAVVePGAFEMTSSIQAVRLDGNELNDINGLfSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRL 648
Cdd:COG4886 207 LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 649 SSLS-NRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSL 727
Cdd:COG4886 285 TDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364
|
410
....*....|....
gi 386771139 728 RILPVWEHRALPEF 741
Cdd:COG4886 365 LLLTLGLLGLLEAT 378
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
202-691 |
3.06e-27 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 120.72 E-value: 3.06e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 202 LERLDLSSNNI-WSLPDNIFCTLSELSALNMSENRLQDVNELGFrdrskeptngsteststtesakkssssstscSLDLE 280
Cdd:PLN00113 95 IQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS-------------------------------IPNLE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 281 YLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVA-LPTELfaEQAKIIQEVYLQN 359
Cdd:PLN00113 144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPREL--GQMKSLKWIYLGY 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 360 NSIS------------------VLN------PQLFSNLDQLQALDLSMNQITSTwIDKNTFvGLIRLVLLNLSHNKLTKL 415
Cdd:PLN00113 222 NNLSgeipyeiggltslnhldlVYNnltgpiPSSLGNLKNLQYLFLYQNKLSGP-IPPSIF-SLQKLISLDLSDNSLSGE 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 416 EPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNC 495
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSS 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 496 SALQDLNLNGNQLKT-VPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNL 574
Cdd:PLN00113 380 GNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSL 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 575 ARNRIAVVEPGAFemtSSIQAVRLDGNElNDINGL----FSNMPSLLWLNISDNRLEsfdyGHVPSTLQW------LDLH 644
Cdd:PLN00113 460 ARNKFFGGLPDSF---GSKRLENLDLSR-NQFSGAvprkLGSLSELMQLKLSENKLS----GEIPDELSSckklvsLDLS 531
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 386771139 645 KNRLS-SLSNRFgldSELK-LQTLDVSFNQLQRIGPSSIPNSIELLFLN 691
Cdd:PLN00113 532 HNQLSgQIPASF---SEMPvLSQLDLSQNQLSGEIPKNLGNVESLVQVN 577
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
378-801 |
2.84e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 107.33 E-value: 2.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 378 ALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLS- 456
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 457 HNKLKYLDAYALNGLYVLSLLSLDNNALIGvhpdafrNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMeD 536
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL-P 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 537 SAFKGLGNLYGLRLIGNYLENITMHtFRDLPNLQILNLARNRIAVVePGAFEMTSSIQAVRLDGNELNDINGLFSNMPSL 616
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 617 LWLNISDNRLESFDYghvpstlqwldlhknrLSSLSNrfgldselkLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLIT 696
Cdd:COG4886 231 ETLDLSNNQLTDLPE----------------LGNLTN---------LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 697 TVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLET 776
Cdd:COG4886 286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365
|
410 420
....*....|....*....|....*
gi 386771139 777 IYCKLLNNRERAYIPLIEAEPKHFL 801
Cdd:COG4886 366 LLTLGLLGLLEATLLTLALLLLTLL 390
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
1114-1247 |
1.92e-21 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 92.00 E-value: 1.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1114 DAYFAYSlQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALH 1193
Cdd:smart00255 3 DVFISYS-GKEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAALE 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1194 E-LVKRRKRVVFILYGDLPQ--RDIDMDMRHYLRTsTCIEWDDKK---FWQKLRLALPLP 1247
Cdd:smart00255 82 NaLEEGGLRVIPIFYEVIPSdvRKQPGKFRKVFKK-NYLKWPEDEkeqFWKKALYAVPSK 140
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
86-481 |
1.55e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 93.07 E-value: 1.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 86 AAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLgrlgrqv 165
Cdd:COG4886 36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 166 LDGLEQLRNLTLRTHNILwpALNFEIEAdafsvTRRLERLDLSSNNIWSLPDNIFcTLSELSALNMSENRLQDVNElGFR 245
Cdd:COG4886 109 LSNLTNLESLDLSGNQLT--DLPEELAN-----LTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPE-ELG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 246 DRSKeptngsteststtesakkssssstscsldLEYLDVSHNDFVVLPAnGFGTLRRLRVLSVNNNGISMIaDKALSGLK 325
Cdd:COG4886 180 NLTN-----------------------------LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 326 NLQILNLSSNKIVALPtELfaEQAKIIQEVYLQNNSISVLNPqlFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLL 405
Cdd:COG4886 229 NLETLDLSNNQLTDLP-EL--GNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386771139 406 NLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDN 481
Cdd:COG4886 304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
140-494 |
2.63e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 86.14 E-value: 2.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 140 QSFAHLVRLQQLSIQYCKLGRLGRQvLDGLEQLRNLTLRtHNilwpalNFEIEADAFSVTRRLERLDLSSNNIWSLPDNI 219
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLS-NN------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 220 FcTLSELSALNMSENRLQDV-NELGfrdrskEPTNgsteststtesakkssssstscsldLEYLDVSHNDFVVLPANgFG 298
Cdd:COG4886 179 G-NLTNLKELDLSNNQITDLpEPLG------NLTN-------------------------LEELDLSGNQLTDLPEP-LA 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 299 TLRRLRVLSVNNNGISMIADkaLSGLKNLQILNLSSNKIVALPTELfaeQAKIIQEVYLQNNSISVLnpqlfsNLDQLQA 378
Cdd:COG4886 226 NLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDL------KLKELEL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 379 LDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN 458
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374
|
330 340 350
....*....|....*....|....*....|....*.
gi 386771139 459 KLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRN 494
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
371-727 |
6.22e-16 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 83.74 E-value: 6.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 371 SNLDQLQALDLSMNQItSTWIDKNTFvGLIRLVLLNLSHNKLT-KLEPEIFSDLYTLQILNLRHNQLENIAADTFAPmnN 449
Cdd:PLN00113 66 NNSSRVVSIDLSGKNI-SGKISSAIF-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--N 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 450 LHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQL-KTVPLALRNMRHLRTVDLGE 528
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGY 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 529 NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIA-VVEPGAFEMTSsiqavrldgnelndin 607
Cdd:PLN00113 222 NNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQK---------------- 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 608 glfsnmpsLLWLNISDNRLEsfdyGHVPS------TLQWLDLHKNRLSSLSNRfGLDSELKLQTLDVSFNQLQRIGPSSI 681
Cdd:PLN00113 286 --------LISLDLSDNSLS----GEIPElviqlqNLEILHLFSNNFTGKIPV-ALTSLPRLQVLQLWSNKFSGEIPKNL 352
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 386771139 682 --PNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSL 727
Cdd:PLN00113 353 gkHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSL 400
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
300-506 |
9.73e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.90 E-value: 9.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 300 LRRLRVLSVNNNGISMIADkaLSGLKNLQILNLSSNKIVALPTELFAEQakiIQEVYLQNNSISVLNPqlFSNLDQLQAL 379
Cdd:cd21340 1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEFLTN---LTHLYLQNNQIEKIEN--LENLVNLKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 380 DLSMNQITstwidkntfV-----GLIRLVLLNLSHNKL---TKLEPEIFSDLY---TLQILNLRHNQLENIAAdtFAPMN 448
Cdd:cd21340 74 YLGGNRIS---------VvegleNLTNLEELHIENQRLppgEKLTFDPRSLAAlsnSLRVLNISGNNIDSLEP--LAPLR 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 386771139 449 NLHTLLLSHNKLKYLDAyalnglyVLSLLSldnnaligvhpdafrNCSALQDLNLNGN 506
Cdd:cd21340 143 NLEQLDASNNQISDLEE-------LLDLLS---------------SWPSLRELDLTGN 178
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
278-508 |
4.76e-12 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 71.03 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 278 DLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSN-----------------KIVAL 340
Cdd:PLN00113 309 NLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNnltgeipeglcssgnlfKLILF 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 341 PTELFAE------QAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQI-----TSTW---------IDKNTFVGLI 400
Cdd:PLN00113 389 SNSLEGEipkslgACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqgrinSRKWdmpslqmlsLARNKFFGGL 468
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 401 -------RLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYV 473
Cdd:PLN00113 469 pdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPV 548
|
250 260 270
....*....|....*....|....*....|....*
gi 386771139 474 LSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQL 508
Cdd:PLN00113 549 LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
401-460 |
5.22e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.16 E-value: 5.22e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 401 RLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKL 460
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
141-463 |
2.03e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 2.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 141 SFAHLVRLQQLSIQYCKLGRLGRqVLDGLEQLRNLTLRTHNIlwpalnFEIEADAFSVTRrLERLDLSSNNIWSLPDNIf 220
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQL------TDLPEELGNLTN-LKELDLSNNQITDLPEPL- 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 221 CTLSELSALNMSENRLQDVNElGFRDRSKeptngsteststtesakkssssstscsldLEYLDVSHNDFVVLPAngFGTL 300
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLPE-PLANLTN-----------------------------LETLDLSNNQLTDLPE--LGNL 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 301 RRLRVLSVNNNGISMIadKALSGLKNLQILNLSSNKIVALP-TELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQAL 379
Cdd:COG4886 250 TNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 380 DLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNK 459
Cdd:COG4886 328 LLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
|
....
gi 386771139 460 LKYL 463
Cdd:COG4886 408 LDAV 411
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
1124-1212 |
8.57e-11 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 62.00 E-value: 8.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1124 EHFVNQILAQTLENdiGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVV 1203
Cdd:pfam01582 14 EWFVSHLLKELKQK--GIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILECALDLGQKVI 91
|
....*....
gi 386771139 1204 FILYGDLPQ 1212
Cdd:pfam01582 92 PIFYEVDPS 100
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
863-990 |
1.28e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.34 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 863 ELYIDGNNFVELagHSFLGR-KNLAVLYANNSNVAHIyNTTFSGLKRLLILHLEDNHIISLeGNEFHNLENLRELYLQSN 941
Cdd:COG4886 140 ELDLSNNQLTDL--PEPLGNlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 386771139 942 KIASIANgSFQMLRKLEVLRLDGNRLMHFEvwQLSANPYLVEISLADNQ 990
Cdd:COG4886 216 QLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQ 261
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
353-412 |
4.46e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.76 E-value: 4.46e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 353 QEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITStwIDKNTFVGLIRLVLLNLSHNKL 412
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
519-579 |
6.03e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 6.03e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386771139 519 RHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRI 579
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
501-697 |
6.62e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 60.96 E-value: 6.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 501 LNLNGNQLKTVPlALRNMRHLRTVDLGENMITVMEDsaFKGLGNLYGLRLIGNYLENITMhtFRDLPNLQILNLARNRIA 580
Cdd:cd21340 7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 581 VVEpgafemtssiqavrldgnelndinGLfSNMPSLLWLNISDNRLES-----FDYGHVPS---TLQWLDLHKNRLSSLS 652
Cdd:cd21340 82 VVE------------------------GL-ENLTNLEELHIENQRLPPgekltFDPRSLAAlsnSLRVLNISGNNIDSLE 136
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 386771139 653 NRFGLDSelkLQTLDVSFNQLQRIGPSSIP----NSIELLFLNDNLITT 697
Cdd:cd21340 137 PLAPLRN---LEQLDASNNQISDLEELLDLlsswPSLRELDLTGNPVCK 182
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
375-436 |
7.63e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 7.63e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386771139 375 QLQALDLSMNQITStwIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQL 436
Cdd:pfam13855 2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
864-967 |
1.03e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 60.18 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 864 LYIDGNNFVELAGHSFLgrKNLAVLYANNSNVAHIYNttFSGLKRLLILHLEDNHIISLEGneFHNLENLRELYLQSNKI 943
Cdd:cd21340 7 LYLNDKNITKIDNLSLC--KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
|
90 100
....*....|....*....|....
gi 386771139 944 ASIANgsFQMLRKLEVLRLDGNRL 967
Cdd:cd21340 81 SVVEG--LENLTNLEELHIENQRL 102
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
298-489 |
1.19e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 63.33 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 298 GTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIiQEVYLQNNSISVLNPQLFSNlDQLQ 377
Cdd:PLN00113 401 GACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSL-QMLSLARNKFFGGLPDSFGS-KRLE 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 378 ALDLSMNQITSTWidKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSH 457
Cdd:PLN00113 479 NLDLSRNQFSGAV--PRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556
|
170 180 190
....*....|....*....|....*....|..
gi 386771139 458 NKLKYLDAYALNGLYVLSLLSLDNNALIGVHP 489
Cdd:PLN00113 557 NQLSGEIPKNLGNVESLVQVNISHNHLHGSLP 588
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
449-508 |
1.20e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.61 E-value: 1.20e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 449 NLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQL 508
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
883-967 |
1.75e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.41 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 883 KNLAVLYANNSNVAHIYNttFSGLKRLLILHLEDNHIISLEGneFHNLENLRELYLQSNKIASIANgsFQMLRKLEVLRL 962
Cdd:cd21340 2 KRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYL 75
|
....*
gi 386771139 963 DGNRL 967
Cdd:cd21340 76 GGNRI 80
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
301-386 |
1.88e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.84 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 301 RRLRVLSVNNNGISMIADKALSGLKNLQILNLSsnkivalptelfaeqakiiqevylqNNSISVLNPQLFSNLDQLQALD 380
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLS-------------------------NNLLTTLSPGAFSGLPSLRYLD 55
|
....*.
gi 386771139 381 LSMNQI 386
Cdd:pfam13855 56 LSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
864-989 |
2.35e-09 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.03 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 864 LYIDGNNFVELAGHSFLgrKNLAVLYANNSNVAHIYNttFSGLKRLLILHLEDNHIISLEGneFHNLENLRELYLQ---- 939
Cdd:cd21340 29 LYLYDNKITKIENLEFL--TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIEnqrl 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386771139 940 --------------------------SNKIASIAngSFQMLRKLEVLRLDGNRLMHFE--VWQLSANPYLVEISLADN 989
Cdd:cd21340 103 ppgekltfdprslaalsnslrvlnisGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
1119-1209 |
4.08e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 55.78 E-value: 4.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 1119 YSLQDEHFVNQIlAQTLENDiGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALhELVKR 1198
Cdd:pfam13676 5 YAGEDRAWAEWL-ADALEAA-GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAAL-ADPEG 81
|
90
....*....|.
gi 386771139 1199 RKRVVFILYGD 1209
Cdd:pfam13676 82 RKRLIPVRLEC 92
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
908-967 |
4.57e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.68 E-value: 4.57e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 908 RLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRL 967
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
884-943 |
9.91e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 9.91e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 884 NLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKI 943
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
279-337 |
2.30e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 2.30e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 386771139 279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKI 337
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
296-462 |
2.72e-08 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 55.95 E-value: 2.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 296 GFGTLRRLRVLSVNNNGISMIADkaLSGLKNLQILNLSsnkivalptelfaeqakiiqevylqNNSISVLNPqlFSNLDQ 375
Cdd:cd21340 41 NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG-------------------------GNRISVVEG--LENLTN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 376 LQALDLSMNQI---TSTWIDKNTFVGLIR-LVLLNLSHNKLTKLEPeiFSDLYTLQILNLRHNQLENIA--ADTFAPMNN 449
Cdd:cd21340 92 LEELHIENQRLppgEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPS 169
|
170
....*....|....*..
gi 386771139 450 LHTLLLSHN----KLKY 462
Cdd:cd21340 170 LRELDLTGNpvckKPKY 186
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
425-484 |
6.89e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 6.89e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 425 TLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNAL 484
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
567-626 |
7.98e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.22 E-value: 7.98e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386771139 567 PNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDIN-GLFSNMPSLLWLNISDNRL 626
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
197-463 |
9.31e-08 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 57.01 E-value: 9.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 197 SVTRRLERLDLSSNNIWSLPDNIFCTLSELSAlnmSENRLQDVNElgfrdrsKEPTNgsteststtesakkssssstscs 276
Cdd:PRK15370 196 CIPEQITTLILDNNELKSLPENLQGNIKTLYA---NSNQLTSIPA-------TLPDT----------------------- 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 277 ldLEYLDVSHNDFVVLPANgfgTLRRLRVLSVNNNGISMIADKALSGlknLQILNLSSNKIVALPTELFAEqakiIQEVY 356
Cdd:PRK15370 243 --IQEMELSINRITELPER---LPSALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSG----ITHLN 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 357 LQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKntfvglirLVLLNLSHNKLTKLePEIFSDlyTLQILNLRHNQL 436
Cdd:PRK15370 311 VQSNSLTALPETLPPGLKTLEAGENALTSLPASLPPE--------LQVLDVSKNQITVL-PETLPP--TITTLDVSRNAL 379
|
250 260
....*....|....*....|....*..
gi 386771139 437 ENIAADTFAPMNNLHTlllSHNKLKYL 463
Cdd:PRK15370 380 TNLPENLPAALQIMQA---SRNNLVRL 403
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
863-990 |
1.35e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 55.71 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 863 ELYIDGNNFVELaGHSFLGRKNLAVLYANNSNVAHIyNTTFSGLKRLLILHLEDNHIISLEgnEFHNLENLRELYLQSNK 942
Cdd:COG4886 186 ELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQ 261
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 386771139 943 IASIANGSFqmLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQ 990
Cdd:COG4886 262 LTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
341-683 |
1.56e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 56.24 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 341 PTELFAEQAKIIQEVY--LQNNSISVlnpqlfsNLDQLQALDLSM---NQITSTWIDKNTFVGL-----IRLVLLNLSHN 410
Cdd:PRK15370 158 PAKEAANREEAVQRMRdcLKNNKTEL-------RLKILGLTTIPAcipEQITTLILDNNELKSLpenlqGNIKTLYANSN 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 411 KLTKLePEIFSDlyTLQILNLRHNQLENIAADTfaPmNNLHTLLLSHNKLKYLDAYALNGLYVLSLlsLDNNalIGVHPD 490
Cdd:PRK15370 231 QLTSI-PATLPD--TIQEMELSINRITELPERL--P-SALQSLDLFHNKISCLPENLPEELRYLSV--YDNS--IRTLPA 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 491 AFRncSALQDLNLNGNQLKTVPLALRnmRHLRTVDLGENMITVMEDSAfkglgnlyglrlignylenitmhtfrdLPNLQ 570
Cdd:PRK15370 301 HLP--SGITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASL---------------------------PPELQ 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 571 ILNLARNRIAVvepgafemtssiqavrldgnelndinglfsnMPSLLwlnisdnrlesfdyghvPSTLQWLDLHKNRLSS 650
Cdd:PRK15370 350 VLDVSKNQITV-------------------------------LPETL-----------------PPTITTLDVSRNALTN 381
|
330 340 350
....*....|....*....|....*....|...
gi 386771139 651 LSNRFgldsELKLQTLDVSFNQLQRIgPSSIPN 683
Cdd:PRK15370 382 LPENL----PAALQIMQASRNNLVRL-PESLPH 409
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
474-531 |
6.75e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 6.75e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 386771139 474 LSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTV-PLALRNMRHLRTVDLGENMI 531
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
899-992 |
1.13e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.01 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 899 YNTTFSGLKRLLILHLEDNHIISLeGNEFHNLENLRELYLQSNKIASIANgSFQMLRKLEVLRLDGNRLMHFEVWqLSAN 978
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNL 181
|
90
....*....|....
gi 386771139 979 PYLVEISLADNQWS 992
Cdd:COG4886 182 TNLKELDLSNNQIT 195
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
863-919 |
4.27e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.59 E-value: 4.27e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 386771139 863 ELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHI 919
Cdd:pfam13855 5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
662-719 |
4.40e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.59 E-value: 4.40e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 662 KLQTLDVSFNQLQRIGPSSIPN--SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQI 719
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGlsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
401-626 |
5.32e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 50.05 E-value: 5.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 401 RLVLLNLSHNKLTKLEPEIFSDL---YTLQILNLRHNQLENIAADTFA-----PMNNLHTLLLSHNKLKYLDAYALNGly 472
Cdd:cd00116 82 GLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLEGASCEALAK-- 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 473 vlsllsldnnaligvhpdAFRNCSALQDLNLNGNQL-----KTVPLALRNMRHLRTVDLGENMITVMEDSAFKglgnlyg 547
Cdd:cd00116 160 ------------------ALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTDEGASALA------- 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 548 lrlignylenitmHTFRDLPNLQILNLARNRI-----AVVEPGAFEMTSSIQAVRLDGNELNDINGL-----FSNMPSLL 617
Cdd:cd00116 215 -------------ETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKdlaevLAEKESLL 281
|
....*....
gi 386771139 618 WLNISDNRL 626
Cdd:cd00116 282 ELDLRGNKF 290
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
593-722 |
2.35e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 48.92 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 593 IQAVRLDGNELNDI-NGLFSNMPSLlwlNISDNRLESFDyGHVPSTLQWLDLHKNRLSSLSNRfgLDSelKLQTLDVSFN 671
Cdd:PRK15370 201 ITTLILDNNELKSLpENLQGNIKTL---YANSNQLTSIP-ATLPDTIQEMELSINRITELPER--LPS--ALQSLDLFHN 272
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 386771139 672 QLQRIgPSSIPNSIELLFLNDNLITTVdPDTFmhKTNLTRVDLYANQITTL 722
Cdd:PRK15370 273 KISCL-PENLPEELRYLSVYDNSIRTL-PAHL--PSGITHLNVQSNSLTAL 319
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
472-728 |
2.46e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 49.01 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 472 YVLSLLSLDNN--ALIGVHPDafrncsaLQDLNLNGNQLKTVPLALRNMRHLrtvDLGENMITVMEdSAFKGLGNLYglr 549
Cdd:PRK15387 223 HITTLVIPDNNltSLPALPPE-------LRTLEVSGNQLTSLPVLPPGLLEL---SIFSNPLTHLP-ALPSGLCKLW--- 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 550 LIGNYLENITMHTfrdlPNLQILNLARNRIAVVEPGAFEMT----------------SSIQAVRLDGNELNDINGLFSNM 613
Cdd:PRK15387 289 IFGNQLTSLPVLP----PGLQELSVSDNQLASLPALPSELCklwaynnqltslptlpSGLQELSVSDNQLASLPTLPSEL 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 614 PSLLWLNisdNRLESFDygHVPSTLQWLDLHKNRLSSLSNrfgLDSELKlqTLDVSFNQLQRIgpSSIPNSIELLFLNDN 693
Cdd:PRK15387 365 YKLWAYN---NRLTSLP--ALPSGLKELIVSGNRLTSLPV---LPSELK--ELMVSGNRLTSL--PMLPSGLLSLSVYRN 432
|
250 260 270
....*....|....*....|....*....|....*
gi 386771139 694 LITTVdPDTFMHKTNLTRVDLYANQITTLDIKSLR 728
Cdd:PRK15387 433 QLTRL-PESLIHLSSETTVNLEGNPLSERTLQALR 466
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
319-538 |
2.79e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 48.25 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 319 KALSGLKNLQILNLSSNKIVALPTELFAEqakiiqevYLQNNsisvlnpqlfsnlDQLQALDLSMNQITSTwidkntfvG 398
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAE--------ALKNN-------------TTVETLYLSGNQIGAE--------G 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 399 LIRLVLLnLSHNKltklepeifsdlyTLQILNLRHNQLENIAADTFAPM----NNLHTLLLSHNKL-----KYLdAYALN 469
Cdd:COG5238 281 AIALAKA-LQGNT-------------TLTSLDLSVNRIGDEGAIALAEGlqgnKTLHTLNLAYNGIgaqgaIAL-AKALQ 345
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386771139 470 GLYVLSLLSLDNNAlIGVH-----PDAFRNCSALQDLNLNGNQLKTVP----LALRNMRHLRTVDLGENMITVMEDSA 538
Cdd:COG5238 346 ENTTLHSLDLSDNQ-IGDEgaialAKYLEGNTTLRELNLGKNNIGKQGaealIDALQTNRLHTLILDGNLIGAEAQQR 422
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
906-967 |
8.13e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 8.13e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386771139 906 LKRLLILHLEDNHIISLEgnEFHNLENLRELYLQSNKIASIANGSFqmLRKLEVLRLDGNRL 967
Cdd:cd21340 1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQI 58
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
604-740 |
8.40e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 47.38 E-value: 8.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 604 NDINGLFSNMP-SLLWLNISDNRLESFDYgHVPSTLQWLDLHKNRLSSLSNRfgLDSElkLQTLDVSFNQLQRIgPSSIP 682
Cdd:PRK15370 230 NQLTSIPATLPdTIQEMELSINRITELPE-RLPSALQSLDLFHNKISCLPEN--LPEE--LRYLSVYDNSIRTL-PAHLP 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386771139 683 NSIELLFLNDNLITTVdPDTFmhKTNLTRVDLYANQITTLDIK---SLRILPVWEHR--ALPE 740
Cdd:PRK15370 304 SGITHLNVQSNSLTAL-PETL--PPGLKTLEAGENALTSLPASlppELQVLDVSKNQitVLPE 363
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
470-555 |
1.38e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 46.35 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 470 GLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK-TVPLALRNMRHLRTVDLGENMITvmeDSAFKGLGNLYGL 548
Cdd:PLN03150 416 GKWFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN---GSIPESLGQLTSL 492
|
90
....*....|
gi 386771139 549 R---LIGNYL 555
Cdd:PLN03150 493 RilnLNGNSL 502
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
200-246 |
2.17e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 2.17e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 386771139 200 RRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRD 246
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
351-436 |
3.71e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 45.19 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 351 IIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWidKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILN 430
Cdd:PLN03150 419 FIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI--PPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILN 496
|
....*.
gi 386771139 431 LRHNQL 436
Cdd:PLN03150 497 LNGNSL 502
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
346-720 |
4.52e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 4.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 346 AEQAKIIQEVYLQNNSIsvLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLtkLEPEIFSDLYT 425
Cdd:COG5238 106 AETATAVATPPPDLRRI--MAKTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAA--ISMAKALQNNS 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 426 LQILNLRHNQLENIAADTFAPM----NNLHTLLLSHNKLKYLDAY----ALNGLYVLSLLSLDNNAL--IGVHP--DAFR 493
Cdd:COG5238 182 VETVYLGCNQIGDEGIEELAEAltqnTTVTTLWLKRNPIGDEGAEilaeALKGNKSLTTLDLSNNQIgdEGVIAlaEALK 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 494 NCSALQDLNLNGNQL-----KTVPLALRNMRHLRTVDLGENMITvmeDSAFKGLGNlyGLRlignylENITMHTfrdlpn 568
Cdd:COG5238 262 NNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSLDLSVNRIG---DEGAIALAE--GLQ------GNKTLHT------ 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 569 lqiLNLARNRIavvepGAFEMTSSIQAvrldgnelndinglfsnmpsllwlnisdnrlesfdyghvpstlqwldLHKNRl 648
Cdd:COG5238 325 ---LNLAYNGI-----GAQGAIALAKA-----------------------------------------------LQENT- 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 649 sslsnrfgldselKLQTLDVSFNQLQRIGPSSIPNSIE----LLFLN--DNLITTVDPDTF---MHKTNLTRVDLYANQI 719
Cdd:COG5238 349 -------------TLHSLDLSDNQIGDEGAIALAKYLEgnttLRELNlgKNNIGKQGAEALidaLQTNRLHTLILDGNLI 415
|
.
gi 386771139 720 T 720
Cdd:COG5238 416 G 416
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
278-468 |
1.22e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 42.73 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 278 DLEYLDVSHN------DFVVLPANGFGTLRRLRVLSVNNNGIS---MIADKALSGLKNLQILNLSSNKIVALPTELFAEQ 348
Cdd:cd00116 52 SLKELCLSLNetgripRGLQSLLQGLTKGCGLQELDLSDNALGpdgCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 349 AKIIQ----EVYLQNNSISVLN----PQLFSNLDQLQALDLSMNQITSTWIDKnTFVGL---IRLVLLNLSHNKLTKLE- 416
Cdd:cd00116 132 LKDLPpaleKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRA-LAEGLkanCNLEVLDLNNNGLTDEGa 210
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 417 ---PEIFSDLYTLQILNLRHNQLENIAADTFAPMN-----NLHTLLLSHNKLKYLDAYAL 468
Cdd:cd00116 211 salAETLASLKSLEVLNLGDNNLTDAGAAALASALlspniSLLTLSLSCNDITDDGAKDL 270
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
405-491 |
1.24e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.27 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 405 LNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNAL 484
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
|
....*..
gi 386771139 485 IGVHPDA 491
Cdd:PLN03150 503 SGRVPAA 509
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
898-990 |
1.26e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.00 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 898 IYNTTFSGLKRLLILHLEDNhiislegNEFHNLENLRELYLQSNKIASIANgSFQMLRKLEVLRLDGNRLMHFEVWqLSA 977
Cdd:COG4886 87 LGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGN 157
|
90
....*....|...
gi 386771139 978 NPYLVEISLADNQ 990
Cdd:COG4886 158 LTNLKSLDLSNNQ 170
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
863-967 |
1.47e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.00 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 863 ELYIDGNNFVELaGHSFLGRKNLAVLYANNSNVAHIYNttFSGLKRLLILHLEDNHIISLEgnEFHNLENLRELYLQSNK 942
Cdd:COG4886 209 ELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQ 283
|
90 100
....*....|....*....|....*
gi 386771139 943 IASIANGSFQMLRKLEVLRLDGNRL 967
Cdd:COG4886 284 LTDLKLKELELLLGLNSLLLLLLLL 308
|
|
| LRR_9 |
pfam14580 |
Leucine-rich repeat; |
282-340 |
2.08e-03 |
|
Leucine-rich repeat;
Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 40.90 E-value: 2.08e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 386771139 282 LDVSHNDFVVLpaNGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVAL 340
Cdd:pfam14580 47 IDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
932-990 |
2.54e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.50 E-value: 2.54e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 386771139 932 NLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQ 990
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
171-236 |
2.74e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.50 E-value: 2.74e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386771139 171 QLRNLTLRtHNILWpalnfEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRL 236
Cdd:pfam13855 2 NLRSLDLS-NNRLT-----SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
401-624 |
3.54e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 401 RLVLLNLSHNKLTKLEpeIFSDLYTLQILNLRHNQLENIAADTFAPmnNLHTLLLSHNKLKyldayalnglyvlsllSLD 480
Cdd:cd21340 3 RITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIENLEFLT--NLTHLYLQNNQIE----------------KIE 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 481 NnaligvhpdaFRNCSALQDLNLNGNQlktvplalrnmrhlrtvdlgenmITVMEdsafkGLGNLYGLR-LignYLEN-- 557
Cdd:cd21340 63 N----------LENLVNLKKLYLGGNR-----------------------ISVVE-----GLENLTNLEeL---HIENqr 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 558 -----------ITMHTFRdlPNLQILNLARNRIAVVEPgaFEMTSSIQAVRLDGNELNDIN---GLFSNMPSLLWLNISD 623
Cdd:cd21340 102 lppgekltfdpRSLAALS--NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTG 177
|
.
gi 386771139 624 N 624
Cdd:cd21340 178 N 178
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
135-242 |
4.06e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 135 SRLEaqSFAHLVRLQQLSIQYCKLgrlgrQVLDGLEQLRNLT-LR-THNILWPALNFEIEADA-FSVTRRLERLDLSSNN 211
Cdd:cd21340 59 EKIE--NLENLVNLKKLYLGGNRI-----SVVEGLENLTNLEeLHiENQRLPPGEKLTFDPRSlAALSNSLRVLNISGNN 131
|
90 100 110
....*....|....*....|....*....|.
gi 386771139 212 IWSLPDniFCTLSELSALNMSENRLQDVNEL 242
Cdd:cd21340 132 IDSLEP--LAPLRNLEQLDASNNQISDLEEL 160
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
299-472 |
5.16e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 41.31 E-value: 5.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 299 TLRRLRvLSVNN---NGISMIAdKALSGLKNLQILNLSSNKI-----VALPTELfaEQAKIIQEVYLQNNSISVLNPQ-L 369
Cdd:COG5238 265 TVETLY-LSGNQigaEGAIALA-KALQGNTTLTSLDLSVNRIgdegaIALAEGL--QGNKTLHTLNLAYNGIGAQGAIaL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 370 FSNLD---QLQALDLSMNQITstwiDKNTfVGLIRLVLLNlshnkltklepeifsdlYTLQILNLRHNQLENIAADTFAP 446
Cdd:COG5238 341 AKALQentTLHSLDLSDNQIG----DEGA-IALAKYLEGN-----------------TTLRELNLGKNNIGKQGAEALID 398
|
170 180
....*....|....*....|....*....
gi 386771139 447 M---NNLHTLLLSHNKLKYLDAYALNGLY 472
Cdd:COG5238 399 AlqtNRLHTLILDGNLIGAEAQQRLEQLL 427
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
302-338 |
8.53e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 8.53e-03
10 20 30
....*....|....*....|....*....|....*..
gi 386771139 302 RLRVLSVNNNGISMIadKALSGLKNLQILNLSSNKIV 338
Cdd:pfam12799 2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKI 36
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
498-741 |
9.15e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.03 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 498 LQDLNLNGNQLKTVPLALRNMRHLRTVDLGEN---MITVMEDSAFKGLGNLYGLR---LIGNYLENITMHTFRDL---PN 568
Cdd:cd00116 30 LEGNTLGEEAAKALASALRPQPSLKELCLSLNetgRIPRGLQSLLQGLTKGCGLQeldLSDNALGPDGCGVLESLlrsSS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 569 LQILNLARNRIAvvepgafemtssIQAVRLDgnelndINGLFSNMPSLLWLNISDNRLE---SFDYGHV---PSTLQWLD 642
Cdd:cd00116 110 LQELKLNNNGLG------------DRGLRLL------AKGLKDLPPALEKLVLGRNRLEgasCEALAKAlraNRDLKELN 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771139 643 LHKNRLSSLSNRF---GLDSELKLQTLDVSFNQLQRIGPSSI------PNSIELLFLNDNLIT-----TVDPDTFMHKTN 708
Cdd:cd00116 172 LANNGIGDAGIRAlaeGLKANCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGDNNLTdagaaALASALLSPNIS 251
|
250 260 270
....*....|....*....|....*....|...
gi 386771139 709 LTRVDLYANQITTLDIKSLRilpvwehRALPEF 741
Cdd:cd00116 252 LLTLSLSCNDITDDGAKDLA-------EVLAEK 277
|
|
| |
