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Conserved domains on  [gi|442622037|ref|NP_001247385|]
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uncharacterized protein Dmel_CG12054, isoform E [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger family protein( domain architecture ID 705934)

Cys2His2 (C2H2)-type zinc finger family protein may be involved in transcriptional regulation

Gene Ontology:  GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 123-231 2.95e-14

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 74.75  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622037 123 SEMDEDEMVVTESEDSNDSWTTEEFS--SEFIMRYGSRhsgggsNGTPGNEKPFACPVPGCKKRYKNVNGIKYHSKNGH- 199
Cdd:COG5189  303 GGISTGEMIDVRKLPCTNSSSNGKLAhgGERNIDTPSR------MLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMLHGHq 376

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442622037 200 -----------KKDGRV--RKGYKCH-CGKSYKTAQGLKNHALHTH 231
Cdd:COG5189  377 nqklhenpspeKMNIFSakDKPYRCEvCDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 123-231 2.95e-14

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 74.75  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622037 123 SEMDEDEMVVTESEDSNDSWTTEEFS--SEFIMRYGSRhsgggsNGTPGNEKPFACPVPGCKKRYKNVNGIKYHSKNGH- 199
Cdd:COG5189  303 GGISTGEMIDVRKLPCTNSSSNGKLAhgGERNIDTPSR------MLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMLHGHq 376

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442622037 200 -----------KKDGRV--RKGYKCH-CGKSYKTAQGLKNHALHTH 231
Cdd:COG5189  377 nqklhenpspeKMNIFSakDKPYRCEvCDKRYKNLNGLKYHRKHSH 422
zf-C2H2_aberr pfam17017
Aberrant zinc-finger; This is a family of largely microsporidia-specific proteins with an ...
 166-197 5.66e-04

Aberrant zinc-finger; This is a family of largely microsporidia-specific proteins with an aberrant zinc-finger motif of Cx(4)C2H repeated.


Pssm-ID: 374942  Cd Length: 165  Bit Score: 40.62  E-value: 5.66e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442622037  166 GTPGNEKPFACPVPGCKKRYKNVNGIKYHSKN 197
Cdd:pfam17017 122 IDIDNFQLIYCRIPGCGKQFKSLMAYKYHCGN 153
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 181-241 1.50e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442622037 181 CKKRYKNVNGIKYHSKNGHkkdgrvrkgYKCH-CGKSYKTAQGLKNHALHTHNSQPDSVLNA 241
Cdd:cd20908    7 CDREFDDEKILIQHQKAKH---------FKCHiCHKKLYTAGGLAVHCLQVHKETLTKVPNA 59
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 123-231 2.95e-14

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 74.75  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622037 123 SEMDEDEMVVTESEDSNDSWTTEEFS--SEFIMRYGSRhsgggsNGTPGNEKPFACPVPGCKKRYKNVNGIKYHSKNGH- 199
Cdd:COG5189  303 GGISTGEMIDVRKLPCTNSSSNGKLAhgGERNIDTPSR------MLKVKDGKPYKCPVEGCNKKYKNQNGLKYHMLHGHq 376

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442622037 200 -----------KKDGRV--RKGYKCH-CGKSYKTAQGLKNHALHTH 231
Cdd:COG5189  377 nqklhenpspeKMNIFSakDKPYRCEvCDKRYKNLNGLKYHRKHSH 422
zf-C2H2_aberr pfam17017
Aberrant zinc-finger; This is a family of largely microsporidia-specific proteins with an ...
 166-197 5.66e-04

Aberrant zinc-finger; This is a family of largely microsporidia-specific proteins with an aberrant zinc-finger motif of Cx(4)C2H repeated.


Pssm-ID: 374942  Cd Length: 165  Bit Score: 40.62  E-value: 5.66e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442622037  166 GTPGNEKPFACPVPGCKKRYKNVNGIKYHSKN 197
Cdd:pfam17017 122 IDIDNFQLIYCRIPGCGKQFKSLMAYKYHCGN 153
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 181-241 1.50e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 1.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442622037 181 CKKRYKNVNGIKYHSKNGHkkdgrvrkgYKCH-CGKSYKTAQGLKNHALHTHNSQPDSVLNA 241
Cdd:cd20908    7 CDREFDDEKILIQHQKAKH---------FKCHiCHKKLYTAGGLAVHCLQVHKETLTKVPNA 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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