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Conserved domains on  [gi|388454162|ref|NP_001252540|]
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mitogen-activated protein kinase-binding protein 1 isoform c [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
290-728 3.98e-40

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 3.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  290 GCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARypdtiALTFDPTNQWLSCVYNDHSIYVWDVRD 369
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  370 PKKVGKVYSalyHSSCVWSVEVYPevkDSNQaclppssFITCSSDNTIRLWNTEssgvhgstlhrnilssdlikiiyvdg 449
Cdd:COG2319   110 GLLLRTLTG---HTGAVRSVAFSP---DGKT-------LASGSADGTVRLWDLA-------------------------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  450 nTQALLDTeLPGGDKAdaslldprvgIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSkPDtG 529
Cdd:COG2319   151 -TGKLLRT-LTGHSGA----------VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PD-G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  530 lKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQkSGDGVQfTRTHHVVR 609
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLWDLA-TGELLR-TLTGHSGG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  610 KTTLydmdvepSW----KYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFS 685
Cdd:COG2319   291 VNSV-------AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLA 360

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 388454162  686 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 728
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
15-504 1.67e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   15 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 93
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   94 TALAFSPDGKYLVTGESGHmpAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 173
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  174 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGllgelrnnlftdvacgrgkkadstfci 251
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSG--------------------------- 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  252 tssgllcefsdrrlldkWVelrttvaHCISVSQD--YIFCGCADGTVRLFNpsnlhfLSTLPRPHALGTDIASVTeasrl 329
Cdd:COG2319   248 -----------------SV-------RSVAFSPDgrLLASGSADGTVRLWD------LATGELLRTLTGHSGGVN----- 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  330 fsgvanarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPevkDSNQaclppssFI 409
Cdd:COG2319   293 -------------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LA 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  410 TCSSDNTIRLWNTESSGvhgstlhrnilssdlikiiyvdgntqalLDTELPGGDKAdaslldprvgIRSVCVSPNGQHLA 489
Cdd:COG2319   347 SGSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLA 388

                         490
                  ....*....|....*
gi 388454162  490 SGDRMGTLRVHELQS 504
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 753-1081 2.32e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  753 PSSPQRASGPNRhqaPSMLSPGPALSSDSDKEGEDEGTEEelPALPVLAK-STKKALASVPSPALPRSLSHWEMSRAQES 831
Cdd:PHA03247 2561 PAAPDRSVPPPR---PAPRPSEPAVTSRARRPDAPPQSAR--PRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  832 VGFLDPAPAANPGPRRRGRWVQPG-VELSVRSMLDLRQLETLAPslqdpsqdslaiiPSGPRKHGQEALETSLTSQNEKP 910
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAPGrVSRPRRARRLGRAAQASSP-------------PQRPRRRAARPTVGSLTSLADPP 2702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  911 PRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVyPEPSDNPTMDTSEFQVQAPArGTLGRVYPGSRSSEKHSPD 990
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP-PAVPAGPATPGGPARPARPP-TTAGPPAPAPPAAPAAGPP 2780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  991 SACSVD-YSSSCLSSPEHPTEDSESTEPLSVDGISSDLeepaegDEEEEEEEGGMGPYGLQEGSPQTPDQEQflkQHFET 1069
Cdd:PHA03247 2781 RRLTRPaVASLSESRESLPSPWDPADPPAAVLAPAAAL------PPAASPAGPLPPPTSAQPTAPPPPPGPP---PPSLP 2851

                         330
                  ....*....|..
gi 388454162 1070 LASGAAPGAPVQ 1081
Cdd:PHA03247 2852 LGGSVAPGGDVR 2863
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
290-728 3.98e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 3.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  290 GCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARypdtiALTFDPTNQWLSCVYNDHSIYVWDVRD 369
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  370 PKKVGKVYSalyHSSCVWSVEVYPevkDSNQaclppssFITCSSDNTIRLWNTEssgvhgstlhrnilssdlikiiyvdg 449
Cdd:COG2319   110 GLLLRTLTG---HTGAVRSVAFSP---DGKT-------LASGSADGTVRLWDLA-------------------------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  450 nTQALLDTeLPGGDKAdaslldprvgIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSkPDtG 529
Cdd:COG2319   151 -TGKLLRT-LTGHSGA----------VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PD-G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  530 lKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQkSGDGVQfTRTHHVVR 609
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLWDLA-TGELLR-TLTGHSGG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  610 KTTLydmdvepSW----KYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFS 685
Cdd:COG2319   291 VNSV-------AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLA 360

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 388454162  686 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 728
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
15-504 1.67e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   15 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 93
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   94 TALAFSPDGKYLVTGESGHmpAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 173
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  174 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGllgelrnnlftdvacgrgkkadstfci 251
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSG--------------------------- 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  252 tssgllcefsdrrlldkWVelrttvaHCISVSQD--YIFCGCADGTVRLFNpsnlhfLSTLPRPHALGTDIASVTeasrl 329
Cdd:COG2319   248 -----------------SV-------RSVAFSPDgrLLASGSADGTVRLWD------LATGELLRTLTGHSGGVN----- 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  330 fsgvanarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPevkDSNQaclppssFI 409
Cdd:COG2319   293 -------------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LA 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  410 TCSSDNTIRLWNTESSGvhgstlhrnilssdlikiiyvdgntqalLDTELPGGDKAdaslldprvgIRSVCVSPNGQHLA 489
Cdd:COG2319   347 SGSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLA 388

                         490
                  ....*....|....*
gi 388454162  490 SGDRMGTLRVHELQS 504
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-421 1.53e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.53e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   83 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 162
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  163 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 240
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  241 RGKKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-----CISVSQDY--IFCGCADGTVRLFNPSNLHFLST 309
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  310 LpRPHalgtdIASVTeasrlfsgvanarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 389
Cdd:cd00200   215 L-RGH-----ENGVN------------------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 388454162  390 EVYPEVKDsnqaclppssFITCSSDNTIRLWN 421
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 343-725 1.73e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  343 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPevkDSNQaclppssFITCSSDNTIRLWN 421
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  422 TESSGVHgSTLHrnilssdlikiiyvdgntqalldtelpgGDKADaslldprvgIRSVCVSPNGQHLASGDRMGTLRVHE 501
Cdd:cd00200    80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  502 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 581
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  582 GADKSIyfrtaqksgdgvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 661
Cdd:cd00200   196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 388454162  662 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 725
Cdd:cd00200   226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 686-724 3.04e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 3.04e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 388454162    686 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 724
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
687-724 8.15e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 8.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 388454162   687 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 724
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 116-206 2.46e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  116 VRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 195
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                          90
                  ....*....|.
gi 388454162  196 GNRHIKFWYLD 206
Cdd:PLN00181  636 GSADHKVYYYD 646
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-120 4.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 388454162     79 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 120
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 753-1081 2.32e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  753 PSSPQRASGPNRhqaPSMLSPGPALSSDSDKEGEDEGTEEelPALPVLAK-STKKALASVPSPALPRSLSHWEMSRAQES 831
Cdd:PHA03247 2561 PAAPDRSVPPPR---PAPRPSEPAVTSRARRPDAPPQSAR--PRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  832 VGFLDPAPAANPGPRRRGRWVQPG-VELSVRSMLDLRQLETLAPslqdpsqdslaiiPSGPRKHGQEALETSLTSQNEKP 910
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAPGrVSRPRRARRLGRAAQASSP-------------PQRPRRRAARPTVGSLTSLADPP 2702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  911 PRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVyPEPSDNPTMDTSEFQVQAPArGTLGRVYPGSRSSEKHSPD 990
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP-PAVPAGPATPGGPARPARPP-TTAGPPAPAPPAAPAAGPP 2780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  991 SACSVD-YSSSCLSSPEHPTEDSESTEPLSVDGISSDLeepaegDEEEEEEEGGMGPYGLQEGSPQTPDQEQflkQHFET 1069
Cdd:PHA03247 2781 RRLTRPaVASLSESRESLPSPWDPADPPAAVLAPAAAL------PPAASPAGPLPPPTSAQPTAPPPPPGPP---PPSLP 2851

                         330
                  ....*....|..
gi 388454162 1070 LASGAAPGAPVQ 1081
Cdd:PHA03247 2852 LGGSVAPGGDVR 2863
WD40 pfam00400
WD domain, G-beta repeat;
81-120 2.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454162    81 KQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 120
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGT--VKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
290-728 3.98e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 3.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  290 GCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARypdtiALTFDPTNQWLSCVYNDHSIYVWDVRD 369
Cdd:COG2319    35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL-----SVAFSPDGRLLASASADGTVRLWDLAT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  370 PKKVGKVYSalyHSSCVWSVEVYPevkDSNQaclppssFITCSSDNTIRLWNTEssgvhgstlhrnilssdlikiiyvdg 449
Cdd:COG2319   110 GLLLRTLTG---HTGAVRSVAFSP---DGKT-------LASGSADGTVRLWDLA-------------------------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  450 nTQALLDTeLPGGDKAdaslldprvgIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSkPDtG 529
Cdd:COG2319   151 -TGKLLRT-LTGHSGA----------VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PD-G 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  530 lKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQkSGDGVQfTRTHHVVR 609
Cdd:COG2319   217 -KLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLWDLA-TGELLR-TLTGHSGG 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  610 KTTLydmdvepSW----KYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFS 685
Cdd:COG2319   291 VNSV-------AFspdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLA 360

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 388454162  686 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 728
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
24-547 8.57e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 8.57e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   24 RRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 103
Cdd:COG2319    12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  104 YLVTGesGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHdmIVNVWAWKKNIVVAS-NKVSSRVTA 182
Cdd:COG2319    92 LLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGAVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  183 VSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftdvacgrgkkadstfcitssgllcefs 261
Cdd:COG2319   168 VAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTGHTG------------------------------------- 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  262 drrlldkWVelrttvaHCISVSQD--YIFCGCADGTVRLFNpsnlhfLSTLPRPHALGTDIASVTeasrlfsgvanaryp 339
Cdd:COG2319   206 -------AV-------RSVAFSPDgkLLASGSADGTVRLWD------LATGKLLRTLTGHSGSVR--------------- 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  340 dtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVYPevkDSNQaclppssFITCSSDNTIRL 419
Cdd:COG2319   251 ---SVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSP---DGKL-------LASGSDDGTVRL 314

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  420 WNTESsgvhGSTLHrnilssdlikiiyvdgntqalldtelpggdkadaSLLDPRVGIRSVCVSPNGQHLASGDRMGTLRV 499
Cdd:COG2319   315 WDLAT----GKLLR----------------------------------TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 388454162  500 HELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDA 547
Cdd:COG2319   357 WDLATGELLRTLTGHTGAVTSVAFS-PDG--RTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
15-504 1.67e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   15 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 93
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   94 TALAFSPDGKYLVTGESGHmpAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 173
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  174 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGllgelrnnlftdvacgrgkkadstfci 251
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSG--------------------------- 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  252 tssgllcefsdrrlldkWVelrttvaHCISVSQD--YIFCGCADGTVRLFNpsnlhfLSTLPRPHALGTDIASVTeasrl 329
Cdd:COG2319   248 -----------------SV-------RSVAFSPDgrLLASGSADGTVRLWD------LATGELLRTLTGHSGGVN----- 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  330 fsgvanarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPevkDSNQaclppssFI 409
Cdd:COG2319   293 -------------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LA 346

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  410 TCSSDNTIRLWNTESSGvhgstlhrnilssdlikiiyvdgntqalLDTELPGGDKAdaslldprvgIRSVCVSPNGQHLA 489
Cdd:COG2319   347 SGSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLA 388

                         490
                  ....*....|....*
gi 388454162  490 SGDRMGTLRVHELQS 504
Cdd:COG2319   389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 83-421 1.53e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.53e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   83 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 162
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  163 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 240
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  241 RGKKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-----CISVSQDY--IFCGCADGTVRLFNPSNLHFLST 309
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  310 LpRPHalgtdIASVTeasrlfsgvanarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 389
Cdd:cd00200   215 L-RGH-----ENGVN------------------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 388454162  390 EVYPEVKDsnqaclppssFITCSSDNTIRLWN 421
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 343-725 1.73e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.73e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  343 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPevkDSNQaclppssFITCSSDNTIRLWN 421
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  422 TESSGVHgSTLHrnilssdlikiiyvdgntqalldtelpgGDKADaslldprvgIRSVCVSPNGQHLASGDRMGTLRVHE 501
Cdd:cd00200    80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  502 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 581
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  582 GADKSIyfrtaqksgdgvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 661
Cdd:cd00200   196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 388454162  662 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 725
Cdd:cd00200   226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 475-729 9.07e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 9.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  475 GIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREYSLQ 554
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADG--TYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  555 qTLDEHSSSITAVKFAASDgqvRMI-SCGADKSIY---FRTAQKsgdgvQFTRTHHvvrKTTLYDMDVEPSWKYTAIGCQ 630
Cdd:cd00200    88 -TLTGHTSYVSSVAFSPDG---RILsSSSRDKTIKvwdVETGKC-----LTTLRGH---TDWVNSVAFSPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  631 DRNIRIFNISSGKQKKLFKGSQGEdgtLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCK 710
Cdd:cd00200   156 DGTIKLWDLRTGKCVATLTGHTGE---VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY 232

                         250
                  ....*....|....*....
gi 388454162  711 HLISVSGDSCIFVWRLSSE 729
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 514-732 1.83e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 1.83e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  514 HDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAASDGQvrMISCGADKSIYFRTAQ 593
Cdd:cd00200     8 HTGGVTCVAFS-PDG--KLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  594 KSgdgvQFTRTHHVVRKTtLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGedgTLIKVQTDPSGIYIATS 673
Cdd:cd00200    82 TG----ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVASS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 388454162  674 CSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTI 732
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-587 1.62e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.19  E-value: 1.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  279 CISVSQDYIFCGCADGTVRLFNPSNLHFLSTLpRPHALG-TDIASVTEASRLFSG----------VANARYPDTI----- 342
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPvRDVAASADGTYLASGssdktirlwdLETGECVRTLtghts 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  343 ---ALTFDPTNQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVypevkdsnqacLPPSSFITCSS-DNTIR 418
Cdd:cd00200    95 yvsSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTLRGHTDWVNSVAF-----------SPDGTFVASSSqDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  419 LWNTESsgvhGSTLHRnilssdlikiiyvdgntqalldtelpggdkadasLLDPRVGIRSVCVSPNGQHLASGDRMGTLR 498
Cdd:cd00200   161 LWDLRT----GKCVAT----------------------------------LTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  499 VHELQSLSEMLKVEAHDSEILCLEYSKPDtglKLLASASRDRLIHVLDaGREYSLQQTLDEHSSSITAVKFAAsDGQvRM 578
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDG---YLLASGSEDGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSP-DGK-RL 276


                  ....*....
gi 388454162  579 ISCGADKSI 587
Cdd:cd00200   277 ASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-300 6.95e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 6.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   74 LFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTgeSGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVG 153
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS--SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  154 YqhDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSED-CSYFVTAGNRHIKFWYLDDSKTSKVnatvpllgrsgLLGElrN 231
Cdd:cd00200   155 Q--DGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLSTGKCLGT-----------LRGH--E 219

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 388454162  232 NLFTDVACGRgkkaDSTFCITSS--GLLCEFSdrrlLDKWVELRTTVAH-----CISVSQD--YIFCGCADGTVRLFN 300
Cdd:cd00200   220 NGVNSVAFSP----DGYLLASGSedGTIRVWD----LRTGECVQTLSGHtnsvtSLAWSPDgkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-218 1.97e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 1.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162   72 VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVS 151
Cdd:cd00200   117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  152 VGyqHDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSEDcSYFVTAG--NRHIKFWyldDSKTSKVNATVP 218
Cdd:cd00200   195 SS--SDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLASGseDGTIRVW---DLRTGECVQTLS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 686-724 3.04e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 3.04e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 388454162    686 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 724
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
687-724 8.15e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 8.15e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 388454162   687 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 724
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 116-206 2.46e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  116 VRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 195
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                          90
                  ....*....|.
gi 388454162  196 GNRHIKFWYLD 206
Cdd:PLN00181  636 GSADHKVYYYD 646
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-120 4.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.39e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 388454162     79 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 120
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 63-120 5.61e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 5.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 388454162   63 LVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 120
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-163 9.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 9.09e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 388454162    125 SQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 163
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 689-729 1.04e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 388454162  689 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 729
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 93-149 1.09e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.49  E-value: 1.09e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 388454162   93 ITALAFSPDGKYLVTGESG--HMPAVRVWDVAEHSQVaELQEHKYGVACVAFSPSAKYI 149
Cdd:COG4946   434 ISDLAWSPDSKWLAYSKPGpnQLSQIFLYDVETGKTV-QLTDGRYDDGSPAFSPDGKYL 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 753-1081 2.32e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  753 PSSPQRASGPNRhqaPSMLSPGPALSSDSDKEGEDEGTEEelPALPVLAK-STKKALASVPSPALPRSLSHWEMSRAQES 831
Cdd:PHA03247 2561 PAAPDRSVPPPR---PAPRPSEPAVTSRARRPDAPPQSAR--PRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  832 VGFLDPAPAANPGPRRRGRWVQPG-VELSVRSMLDLRQLETLAPslqdpsqdslaiiPSGPRKHGQEALETSLTSQNEKP 910
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAPGrVSRPRRARRLGRAAQASSP-------------PQRPRRRAARPTVGSLTSLADPP 2702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  911 PRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVyPEPSDNPTMDTSEFQVQAPArGTLGRVYPGSRSSEKHSPD 990
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP-PAVPAGPATPGGPARPARPP-TTAGPPAPAPPAAPAAGPP 2780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162  991 SACSVD-YSSSCLSSPEHPTEDSESTEPLSVDGISSDLeepaegDEEEEEEEGGMGPYGLQEGSPQTPDQEQflkQHFET 1069
Cdd:PHA03247 2781 RRLTRPaVASLSESRESLPSPWDPADPPAAVLAPAAAL------PPAASPAGPLPPPTSAQPTAPPPPPGPP---PPSLP 2851

                         330
                  ....*....|..
gi 388454162 1070 LASGAAPGAPVQ 1081
Cdd:PHA03247 2852 LGGSVAPGGDVR 2863
WD40 pfam00400
WD domain, G-beta repeat;
81-120 2.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 2.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454162    81 KQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 120
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGT--VKVWD 39
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 72-150 2.89e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.33  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454162    72 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAEHSQVAElQEHKYGVACvAFSPSAKYIV 150
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
WD40 pfam00400
WD domain, G-beta repeat;
125-163 7.96e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 7.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 388454162   125 SQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 163
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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