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Conserved domains on  [gi|392891901|ref|NP_001254314|]
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N-acetyltransferase domain-containing protein [Caenorhabditis elegans]

Protein Classification

GIY-YIG nuclease family protein( domain architecture ID 10179954)

GIY-YIG nuclease family protein is involved in many cellular processes, including DNA repair and recombination, transfer of mobile genetic elements, and restriction of incoming foreign DNA

CATH:  3.40.1440.10
Gene Ontology:  GO:0004518
PubMed:  16646971
SCOP:  3000597

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GIY-YIG_COG3680_Meta cd10454
GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally ...
 76-162 7.76e-40

GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.


:

Pssm-ID: 198401  Cd Length: 114  Bit Score: 132.81  E-value: 7.76e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891901  76 DVKFDNFVSYIFYVGKGTGFRSLHHFIEALQKENDP---YIDSKCGSIVSIWNSGQEIGCVKIFVGVSSTVAQIKEAAMI 152
Cdd:cd10454   25 IETFQTFVSSIFYVGKGKRSRPYAHFYEALKQHNDKdkkKGSRKLRRILDIWNSGLGVVSLHCFQNVIPVEAYTREAAMI 104

                         90
                 ....*....|
gi 392891901 153 KALSKHDLTN 162
Cdd:cd10454  105 EALGLSNLTN 114
 
Name Accession Description Interval E-value
GIY-YIG_COG3680_Meta cd10454
GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally ...
 76-162 7.76e-40

GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.


Pssm-ID: 198401  Cd Length: 114  Bit Score: 132.81  E-value: 7.76e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891901  76 DVKFDNFVSYIFYVGKGTGFRSLHHFIEALQKENDP---YIDSKCGSIVSIWNSGQEIGCVKIFVGVSSTVAQIKEAAMI 152
Cdd:cd10454   25 IETFQTFVSSIFYVGKGKRSRPYAHFYEALKQHNDKdkkKGSRKLRRILDIWNSGLGVVSLHCFQNVIPVEAYTREAAMI 104

                         90
                 ....*....|
gi 392891901 153 KALSKHDLTN 162
Cdd:cd10454  105 EALGLSNLTN 114
COG3680 COG3680
Uncharacterized protein, contains GIY-YIG domain [Function unknown];
86-167 5.01e-07

Uncharacterized protein, contains GIY-YIG domain [Function unknown];


Pssm-ID: 442896  Cd Length: 253  Bit Score: 48.96  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891901  86 IFYVGKGTGFRSLHHFIEALQKENDpyIDSKCGSIVSIWNSGQEIGCVKIFVGVSSTVAQIKEAAMIKALSKHD--LTNK 163
Cdd:COG3680   28 PFYIGKGKGNRVFAHLREAIASNES--ESAKLERIREIKKAGLDVEHYILRHGLDEKTAFEVEAALIDLLGIVEakLTNI 105


                 ....
gi 392891901 164 IEGS 167
Cdd:COG3680  106 VRGH 109
 
Name Accession Description Interval E-value
GIY-YIG_COG3680_Meta cd10454
GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally ...
 76-162 7.76e-40

GIY-YIG domain of hypothetical proteins from Metazoa; Members of this family are functionally uncharacterized hypothetical proteins from Metazoa. They have bacterial homologs that display sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. However, unlike their bacterial relatives, these Metazoan proteins contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of them do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domains composition suggests members in this subfamily might participate in interactions with multiple partners and imply some important cellular functions.


Pssm-ID: 198401  Cd Length: 114  Bit Score: 132.81  E-value: 7.76e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891901  76 DVKFDNFVSYIFYVGKGTGFRSLHHFIEALQKENDP---YIDSKCGSIVSIWNSGQEIGCVKIFVGVSSTVAQIKEAAMI 152
Cdd:cd10454   25 IETFQTFVSSIFYVGKGKRSRPYAHFYEALKQHNDKdkkKGSRKLRRILDIWNSGLGVVSLHCFQNVIPVEAYTREAAMI 104

                         90
                 ....*....|
gi 392891901 153 KALSKHDLTN 162
Cdd:cd10454  105 EALGLSNLTN 114
GIY-YIG_COG3680 cd10440
GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; This ...
 86-162 8.70e-11

GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; This family includes a group of functionally uncharacterized proteins from bacteria and their eukaryotic homologs which are present only in metazoa. These proteins might have nuclease activities and possibly be engaged in DNA repair or recombination, since they share sequence homology with the catalytic GIY-YIG domain of bacterial UvrC DNA repair proteins. Distinct from their prokaryotic relatives, the eukaryotic homologs contain an N-terminal extension that includes the region of approximately 3-4 ankyrin repeats, unique motifs mediating protein-protein interactions. Some of eukaryotic homologs do have an additional LEM domain located between ankyrin repeats region and GIY-YIG domain. The LEM domain, found in inner nuclear membrane proteins, may be involved in protein- or DNA-binding. The different domain composition of the eukaryotic homologs suggests that they might participate in interactions with multiple partners and implies important cellular function.


Pssm-ID: 198387 [Multi-domain]  Cd Length: 94  Bit Score: 56.62  E-value: 8.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891901  86 IFYVGKGTGFRSLHHFIEAL--QKENDPYIDSKCGSIVSIWNSGQEIGCVKIFVGVSSTVAQIKEAAMIKALSKHD--LT 161
Cdd:cd10440   14 VFYVGKGKGNRVFSHVKEALgeYENIKEKLSAKLQRIREILSAGLEVEHYILRHGLDEVEAFEVEAALIDALGLTLpgLT 93


                 .
gi 392891901 162 N 162
Cdd:cd10440   94 N 94
COG3680 COG3680
Uncharacterized protein, contains GIY-YIG domain [Function unknown];
86-167 5.01e-07

Uncharacterized protein, contains GIY-YIG domain [Function unknown];


Pssm-ID: 442896  Cd Length: 253  Bit Score: 48.96  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891901  86 IFYVGKGTGFRSLHHFIEALQKENDpyIDSKCGSIVSIWNSGQEIGCVKIFVGVSSTVAQIKEAAMIKALSKHD--LTNK 163
Cdd:COG3680   28 PFYIGKGKGNRVFAHLREAIASNES--ESAKLERIREIKKAGLDVEHYILRHGLDEKTAFEVEAALIDLLGIVEakLTNI 105


                 ....
gi 392891901 164 IEGS 167
Cdd:COG3680  106 VRGH 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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