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Conserved domains on  [gi|389885064|ref|NP_001254515|]
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F-box/WD repeat-containing protein 10 isoform 2 [Homo sapiens]

Protein Classification

F-box/WD repeat-containing protein( domain architecture ID 17778652)

F-box/WD repeat-containing protein functions as the substrate-recognition component of a SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50|2.130.10.10
Gene Ontology:  GO:0019005|GO:0005515|GO:0016567|GO:0006511
PubMed:  31898225|11178263|30069656|29026209
SCOP:  4001927|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-601 1.24e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.24e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 418 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 498 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Cdd:cd00200   96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                        170       180       190
                 ....*....|....*....|....*....|.
gi 389885064 573 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
Cdd:cd00200  176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDL 206
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 277-316 9.38e-18

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438908  Cd Length: 40  Bit Score: 77.28  E-value: 9.38e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 389885064 277 FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVK 316
Cdd:cd22136    1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTEEVK 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-601 1.24e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.24e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 418 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 498 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Cdd:cd00200   96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                        170       180       190
                 ....*....|....*....|....*....|.
gi 389885064 573 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
Cdd:cd00200  176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
423-600 3.64e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 3.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 423 GDLIAVSS-NRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319  174 GKLLASGSdDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319  253 AFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        170       180
                 ....*....|....*....|....*.
gi 389885064 577 VKCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:COG2319  333 VRSVAFspDGKTLASGSDDGTVRLWD 358
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 277-316 9.38e-18

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 77.28  E-value: 9.38e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 389885064 277 FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVK 316
Cdd:cd22136    1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTEEVK 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 484-521 7.40e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 7.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 389885064   484 SGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWD 521
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
485-521 4.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 389885064  485 GVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 521
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-601 1.24e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.86  E-value: 1.24e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 418 IHYSGGDLIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGT 497
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 498 ITCMDLCKNR--LVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572
Cdd:cd00200   96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFspDGTFVASSSQDGTIKLWDLRTGKCVATLTG 175

                        170       180       190
                 ....*....|....*....|....*....|.
gi 389885064 573 HEGAVKCLFF--DQWHLLSGSTDGLVMAWSM 601
Cdd:cd00200  176 HTGEVNSVAFspDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 418-600 2.67e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 2.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 418 IHYSGGDLIAVSSNR--KIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQ 495
Cdd:cd00200   99 VAFSPDGRILSSSSRdkTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHT 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 496 GTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRIN-DTYIVSSC-ERGLVKVWHIAMAQLVKTL 570
Cdd:cd00200  178 GEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSpDGYLLASGsEDGTIRVWDLRTGECVQTL 257

                        170       180       190
                 ....*....|....*....|....*....|..
gi 389885064 571 SGHEGAVKCLFFDQW--HLLSGSTDGLVMAWS 600
Cdd:cd00200  258 SGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-621 5.47e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.38  E-value: 5.47e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLC--KNRLVSGGRDCQVKVWDVDTG 525
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 526 KCLKTFR-HKDPILATRIN-DTYIVSSCER-GLVKVWHIAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:cd00200   84 ECVRTLTgHTSYVSSVAFSpDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWD 163

                        170       180
                 ....*....|....*....|.
gi 389885064 601 MvgKYERCLMAFKHPKMVVNT 621
Cdd:cd00200  164 L--RTGKCVATLTGHTGEVNS 182
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 425-613 1.49e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 1.49e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 425 LIAVSSNRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITC--MD 502
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSvaFS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 503 LCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTY--IVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKC 579
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 389885064 580 LFFDQWHLL--SGSTDGLVMAWSMVGKyeRCLMAFK 613
Cdd:cd00200  225 VAFSPDGYLlaSGSEDGTIRVWDLRTG--ECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
423-600 3.64e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 3.64e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 423 GDLIAVSS-NRKIHLLDIIQVKAIPVeFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319  174 GKLLASGSdDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319  253 AFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        170       180
                 ....*....|....*....|....*.
gi 389885064 577 VKCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:COG2319  333 VRSVAFspDGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
423-601 6.49e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 6.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 423 GDLIAVSS-NRKIHLLDIIQVKAIpVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319  216 GKLLASGSaDGTVRLWDLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGA 576
Cdd:COG2319  295 AFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                        170       180
                 ....*....|....*....|....*..
gi 389885064 577 VKCLFFDQW--HLLSGSTDGLVMAWSM 601
Cdd:COG2319  375 VTSVAFSPDgrTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
406-620 6.54e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 6.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 406 RILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSG 485
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 486 VCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWH 560
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFspDGKLLASGSDDGTVRLWD 190

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 389885064 561 IAMAQLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWSMVGKyeRCLMAFKHPKMVVN 620
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVR 250
WD40 COG2319
WD40 repeat [General function prediction only];
423-562 8.05e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 8.05e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 423 GDLIAVSS-NRKIHLLDIiQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319  258 GRLLASGSaDGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 389885064 502 DLCKN--RLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPI--LATRINDTYIVSSCERGLVKVWHIA 562
Cdd:COG2319  337 AFSPDgkTLASGSDDGTVRLWDLATGELLRTLTgHTGAVtsVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 487-621 1.17e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 1.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 487 CTRIFGGHQGTITCMDL--CKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHI 561
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 389885064 562 AMAQLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGLVMAWSMvgKYERCLMAFKHPKMVVNT 621
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNS 140
WD40 COG2319
WD40 repeat [General function prediction only];
423-600 7.25e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 7.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 423 GDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM- 501
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVa 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 502 -DLCKNRLVSGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRI--NDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAV 577
Cdd:COG2319   86 fSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                        170       180
                 ....*....|....*....|....*
gi 389885064 578 KCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:COG2319  166 TSVAFspDGKLLASGSDDGTVRLWD 190
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 277-316 9.38e-18

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 77.28  E-value: 9.38e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 389885064 277 FIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVK 316
Cdd:cd22136    1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRALTEEVK 40
WD40 COG2319
WD40 repeat [General function prediction only];
423-524 4.45e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 4.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389885064 423 GDLIAVSSN-RKIHLLDIiQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCM 501
Cdd:COG2319  300 GKLLASGSDdGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                         90       100
                 ....*....|....*....|....*
gi 389885064 502 DLCKN--RLVSGGRDCQVKVWDVDT 524
Cdd:COG2319  379 AFSPDgrTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 484-521 7.40e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 7.40e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 389885064   484 SGVCTRIFGGHQGTITCMDLCKN--RLVSGGRDCQVKVWD 521
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
F-box_FBXW2 cd22131
F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, ...
 276-312 1.03e-06

F-box domain found in F-box/WD repeat-containing protein 2 (FBXW2) and similar proteins; FBXW2, also called F-box and WD-40 domain-containing protein 2, or protein MD6, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a tumor suppressor by promoting SKP2 degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438903  Cd Length: 40  Bit Score: 46.17  E-value: 1.03e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 389885064 276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMA 312
Cdd:cd22131    1 DFLKLLPLELSFYLLSFLDPESLLTCCLVSKQWNKVI 37
WD40 pfam00400
WD domain, G-beta repeat;
485-521 4.70e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.70e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 389885064  485 GVCTRIFGGHQGTITCMDLCKNR--LVSGGRDCQVKVWD 521
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
F-box_ECT2L cd22173
F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and ...
 276-314 4.90e-05

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438944  Cd Length: 52  Bit Score: 41.63  E-value: 4.90e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 389885064 276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQ 314
Cdd:cd22173    1 DFTTVLPRFLSLYIFSFLDPRSLCRAAQVSWHWKFLAEQ 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 565-600 9.17e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 9.17e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 389885064   565 QLVKTLSGHEGAVKCLFF--DQWHLLSGSTDGLVMAWS 600
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 448-481 3.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 3.13e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 389885064   448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
448-481 4.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 389885064  448 EFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWD 481
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
F-box_FBXO16 cd22172
F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called ...
 276-308 5.50e-04

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438943  Cd Length: 55  Bit Score: 38.80  E-value: 5.50e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 389885064 276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHW 308
Cdd:cd22172    4 DFTRVLPRVLSLYIFSFLDPRSLCRCAQVCWYW 36
WD40 pfam00400
WD domain, G-beta repeat;
565-600 1.45e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.45e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 389885064  565 QLVKTLSGHEGAVKCLFFDQWH--LLSGSTDGLVMAWS 600
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
F-box_FBXO16-like cd22094
F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 ...
 276-314 1.69e-03

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438866  Cd Length: 49  Bit Score: 37.43  E-value: 1.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 389885064 276 DFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQ 314
Cdd:cd22094    1 DFTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCES 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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