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Conserved domains on  [gi|391224459|ref|NP_001254645|]
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zinc finger protein 728 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.90e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.90e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 391224459     4 LTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAPKPDLIIFLEQGKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-606 2.39e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 310 KPYKCEECGKAFNRSSNLMEHKRIHTGEKPCKC--EECGKAFGNFSTLTKHKVIHTGEKPYKCE-ECGKAFSWPSSLTEH 386
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 387 KRIHAGDKPYKCEECGKTFKWSSTLTK--HKIIHTGEKPYK---------------------CEECGKAFTTFSSLTKHK 443
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 444 VIHTGEKHYKCEECGKVFSWSSSLTTHKAIHAgEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKCEECGKAFSKVANL 523
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 524 TKHKVIHTGE-------KQYKCEECGKAFIWSSRLSEHKR--IHTGE--KPYKCEE--CGKAFSWVSVLNKHKKIHAGKK 590
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330
                 ....*....|....*...
gi 391224459 591 FYKC--EECGKDFNQSSH 606
Cdd:COG5048  351 PAKEklLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-360 1.04e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 185 LSHLSQHKRIYTRENSYKSEEHGKAFNWSSALTYKRIHTGE--KPCKCEE--CGKAFSKFSILTKHKVIHTGEKHYKC-- 258
Cdd:COG5048  277 ESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkl 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 259 EECGKAFTRSS-----SLIEHKRSHAGEKPYKCE--ECGKAFSKASTLTAHKTIHAGEKP--YKCEECGKAFNRSSNLME 329
Cdd:COG5048  357 LNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                        170       180       190
                 ....*....|....*....|....*....|.
gi 391224459 330 HKRIHTGEKPCKCEECGKAFGNFSTLTKHKV 360
Cdd:COG5048  437 HKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.90e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.90e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 391224459     4 LTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAPKPDLIIFLEQGKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.17e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 4.17e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 391224459    3 SLTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.67e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.67e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 391224459   4 LTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-606 2.39e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 310 KPYKCEECGKAFNRSSNLMEHKRIHTGEKPCKC--EECGKAFGNFSTLTKHKVIHTGEKPYKCE-ECGKAFSWPSSLTEH 386
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 387 KRIHAGDKPYKCEECGKTFKWSSTLTK--HKIIHTGEKPYK---------------------CEECGKAFTTFSSLTKHK 443
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 444 VIHTGEKHYKCEECGKVFSWSSSLTTHKAIHAgEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKCEECGKAFSKVANL 523
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 524 TKHKVIHTGE-------KQYKCEECGKAFIWSSRLSEHKR--IHTGE--KPYKCEE--CGKAFSWVSVLNKHKKIHAGKK 590
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330
                 ....*....|....*...
gi 391224459 591 FYKC--EECGKDFNQSSH 606
Cdd:COG5048  351 PAKEklLNSSSKFSPLLN 368
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-519 7.31e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.31e-05
                          10        20
                  ....*....|....*....|....*.
gi 391224459  494 NLMEHKRIHTGEKPYKCEECGKAFSK 519
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-360 1.04e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 185 LSHLSQHKRIYTRENSYKSEEHGKAFNWSSALTYKRIHTGE--KPCKCEE--CGKAFSKFSILTKHKVIHTGEKHYKC-- 258
Cdd:COG5048  277 ESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkl 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 259 EECGKAFTRSS-----SLIEHKRSHAGEKPYKCE--ECGKAFSKASTLTAHKTIHAGEKP--YKCEECGKAFNRSSNLME 329
Cdd:COG5048  357 LNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                        170       180       190
                 ....*....|....*....|....*....|.
gi 391224459 330 HKRIHTGEKPCKCEECGKAFGNFSTLTKHKV 360
Cdd:COG5048  437 HKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 5.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 391224459  270 SLIEHKRSHAGEKPYKCEECGKAFSK 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.90e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.90e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 391224459     4 LTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAAPKPDLIIFLEQGKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.17e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 4.17e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 391224459    3 SLTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.67e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.67e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 391224459   4 LTFRDVAIQFSLEEWQCLDTAQQNLYRNVMLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-606 2.39e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 310 KPYKCEECGKAFNRSSNLMEHKRIHTGEKPCKC--EECGKAFGNFSTLTKHKVIHTGEKPYKCE-ECGKAFSWPSSLTEH 386
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 387 KRIHAGDKPYKCEECGKTFKWSSTLTK--HKIIHTGEKPYK---------------------CEECGKAFTTFSSLTKHK 443
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 444 VIHTGEKHYKCEECGKVFSWSSSLTTHKAIHAgEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKCEECGKAFSKVANL 523
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 524 TKHKVIHTGE-------KQYKCEECGKAFIWSSRLSEHKR--IHTGE--KPYKCEE--CGKAFSWVSVLNKHKKIHAGKK 590
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330
                 ....*....|....*...
gi 391224459 591 FYKC--EECGKDFNQSSH 606
Cdd:COG5048  351 PAKEklLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
229-612 3.71e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 3.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 229 KCEECGKAFSKFSILTKHKVIHTGEKHYKC--EECGKAFTRSSSLIEHKRSHAGEKPYKCE-ECGKAFSKASTLTAHKTI 305
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 306 HAGEKPYKCEECGKAFNRSSNLMEHKRIHTGEKPCKCEECGKAFGNFSTLTKHKVIHTGEkpykcEECGKAFSWPSSLTE 385
Cdd:COG5048  115 SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 386 HKRIHAGDKPYKCEECGKTFKWSSTLTKHKIIHTgEKPYKCEECGKAF----------TTFSSLTKHKVIhtgeKHYKCE 455
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllsqspsSLSSSDSSSSAS----ESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 456 ECGKVFSWSSSLTTHKAIHAGEKL-YKCEECGKAFKWSSNLMEHKR--IHTGE--KPYKCEE--CGKAFSKVANLTKHKV 528
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 529 IHTGEKQYKCeecgkafIWSSRLSEHKRIHTGEKPykceecgkafswvSVLNKHKKIHAGKKFY-----KCEECGKDFNQ 603
Cdd:COG5048  345 LHTSISPAKE-------KLLNSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNL 404


                 ....*....
gi 391224459 604 SSHLTTHKR 612
Cdd:COG5048  405 SLHIITHLS 413
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-583 2.45e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 186 SHLSQHKRIYTRENSYKSEEHGKAFNWSSALTY-KRIHTGEKPCKC--EECGKAFSKFSILTKHKVIHTGEKHYKCE--E 260
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRhIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSksL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 261 CGKAFTRSSSLIEHKRSHaGEKPYKCEECGKAFSKASTLT--AHKTIHAGEKPYkceecgKAFNRSSNLMEH--KRIHTG 336
Cdd:COG5048   99 PLSNSKASSSSLSSSSSN-SNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPL------PGNNSSSVNTPQsnSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 337 EKPCKCEEcgkAFGNFSTLTKHKVIHTGEKPYKCEECGKAFSWPSSLTEHKRIHA------------------------- 391
Cdd:COG5048  172 PANSLSKD---PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSssslplttnsqlspksllsqspssl 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 392 --GDKPYKCEECGKTFKWSSTLTKHKIIHTGE-------KPYKCEECGKAFTTFSSLTKHK--VIHTGEKHYKCEE---- 456
Cdd:COG5048  249 ssSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpysl 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 457 CGKVFSWSSSLTTHKAIHAGEKLYKC--EECGKAFKWSSN-----LMEHKRIHTGEKPYKCE--ECGKAFSKVANLTKHK 527
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHI 408

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 391224459 528 VIHT--GEKQYKCEECGKAFIWSSRLSEHKRIHTGEKPYKCEECGKAFSWVSVLNKHK 583
Cdd:COG5048  409 ITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-519 7.31e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.31e-05
                          10        20
                  ....*....|....*....|....*.
gi 391224459  494 NLMEHKRIHTGEKPYKCEECGKAFSK 519
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
185-360 1.04e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 185 LSHLSQHKRIYTRENSYKSEEHGKAFNWSSALTYKRIHTGE--KPCKCEE--CGKAFSKFSILTKHKVIHTGEKHYKC-- 258
Cdd:COG5048  277 ESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkl 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 259 EECGKAFTRSS-----SLIEHKRSHAGEKPYKCE--ECGKAFSKASTLTAHKTIHAGEKP--YKCEECGKAFNRSSNLME 329
Cdd:COG5048  357 LNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                        170       180       190
                 ....*....|....*....|....*....|.
gi 391224459 330 HKRIHTGEKPCKCEECGKAFGNFSTLTKHKV 360
Cdd:COG5048  437 HKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 364-452 4.09e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 364 GEKPYKCE--ECGKAFSWPSSLTEHkRIHAgdkpykceECGKTFKWSSTLTKHKIIHTGEKPYKCEECGKAFTTFSSLTK 441
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                         90
                 ....*....|.
gi 391224459 442 HKvihtgeKHY 452
Cdd:COG5189  417 HR------KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
550-574 4.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.91e-04
                          10        20
                  ....*....|....*....|....*
gi 391224459  550 RLSEHKRIHTGEKPYKCEECGKAFS 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 420-499 7.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 420 GEKPYKCE--ECGKAFTTFSSLTKHKVihtgEKHykceeCGKVFSWSSSLTTHKAIHAGEKLYKCEECGKAFKWSSNLME 497
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGH-----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 391224459 498 HK 499
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
464-531 8.03e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 8.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 464 SSSLTTHKAIHAGEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKC--EECGKAFSKVANLTKHKVIHT 531
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-435 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....*
gi 391224459  411 LTKHKIIHTGEKPYKCEECGKAFTT 435
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 308-393 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 391224459 308 GEKPYKCE--ECGKAFnRSSNLMEHKRIHTGEKPCKCEECGKafgnfstlTKHKVIHTGEKPYKCEECGKAFSWPSSLTE 385
Cdd:COG5189  346 DGKPYKCPveGCNKKY-KNQNGLKYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*...
gi 391224459 386 HkRIHAGD 393
Cdd:COG5189  417 H-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
355-378 4.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.13e-03
                          10        20
                  ....*....|....*....|....
gi 391224459  355 LTKHKVIHTGEKPYKCEECGKAFS 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-349 4.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.56e-03
                          10        20
                  ....*....|....*....|....
gi 391224459  326 NLMEHKRIHTGEKPCKCEECGKAF 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-406 5.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.03e-03
                          10        20
                  ....*....|....*....|....*
gi 391224459  382 SLTEHKRIHAGDKPYKCEECGKTFK 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 5.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|....*.
gi 391224459  270 SLIEHKRSHAGEKPYKCEECGKAFSK 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
522-545 6.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.62e-03
                          10        20
                  ....*....|....*....|....
gi 391224459  522 NLTKHKVIHTGEKQYKCEECGKAF 545
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-267 8.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.47e-03
                          10        20
                  ....*....|....*....|....*
gi 391224459  243 LTKHKVIHTGEKHYKCEECGKAFTR 267
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 312-334 9.38e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.38e-03
                          10        20
                  ....*....|....*....|...
gi 391224459  312 YKCEECGKAFNRSSNLMEHKRIH 334
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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