|
Name |
Accession |
Description |
Interval |
E-value |
| NHL super family |
cl18310 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1231-1589 |
1.80e-26 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
The actual alignment was detected with superfamily member cd14953:
Pssm-ID: 302697 [Multi-domain] Cd Length: 323 Bit Score: 113.01 E-value: 1.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1231 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1298
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1299 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1357
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1358 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1432
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1433 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1510
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392895375 1511 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1589
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2689-2761 |
1.54e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
:
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.54e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392895375 2689 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2761
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1458-2444 |
2.43e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
:
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 63.24 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1458 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1537
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1538 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1617
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1618 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1697
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1698 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1777
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1778 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1856
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1857 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1936
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1937 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 2016
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2017 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 2096
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2097 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 2176
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2177 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 2255
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2256 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2328
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2329 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2408
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 392895375 2409 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2444
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
588-612 |
3.24e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.72 E-value: 3.24e-05
10 20
....*....|....*....|....*.
gi 392895375 588 DCNGRGRCDT-DGRCRCNPGWTGEAC 612
Cdd:pfam07974 1 ICSGRGTCVNqCGKCVCDSGYQGATC 26
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
839-856 |
9.65e-05 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
:
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 9.65e-05
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
524-546 |
3.19e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.19e-04
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
520-628 |
1.39e-03 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 41.67 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 520 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 596
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 392895375 597 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 628
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
617-645 |
2.60e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 37.66 E-value: 2.60e-03
10 20
....*....|....*....|....*....
gi 392895375 617 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 645
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1231-1589 |
1.80e-26 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 113.01 E-value: 1.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1231 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1298
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1299 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1357
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1358 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1432
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1433 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1510
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392895375 1511 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1589
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2689-2761 |
1.54e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.54e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392895375 2689 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2761
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1458-2444 |
2.43e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 63.24 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1458 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1537
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1538 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1617
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1618 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1697
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1698 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1777
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1778 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1856
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1857 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1936
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1937 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 2016
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2017 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 2096
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2097 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 2176
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2177 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 2255
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2256 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2328
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2329 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2408
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 392895375 2409 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2444
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1260-1589 |
5.09e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1260 RPTTVVYAQDGSLIIGD--HNMIRRVS-QDGQVSTILtlgLADTSHSYYIAVSPvDGTIAISLPLHKQVWRISslePQDs 1336
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTEYP---LGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRID---PKT- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1337 rNNYDVLAGDGTVCAsavdscgdgalaqnaqlifPKGISFDKMGNLYLADSR--RIRVIDT-TGHIRSIGETTPDQHPir 1413
Cdd:COG4257 90 -GEITTFALPGGGSN-------------------PHGIAFDPDGNLWFTDQGgnRIGRLDPaTGEVTEFPLPTGGAGP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1414 tcaqitklvdlqmewpTSLTIDPiTGSVLVLD--TNVVYEIDVVHDVVTIALGsPTTcdlanatssasaksldhrrhlIQ 1491
Cdd:COG4257 148 ----------------YGIAVDP-DGNLWVTDfgANAIGRIDPDTGTLTEYAL-PTP---------------------GA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1492 NARDITVGTDGAIYVVESDGrrlNQVRKLSSDrstfsilTGgkspcscdvaacgcddavSLRDVAASQAhLSSPYAVCVS 1571
Cdd:COG4257 189 GPRGLAVDPDGNLWVADTGS---GRIGRFDPK-------TG------------------TVTEYPLPGG-GARPYGVAVD 239
|
330
....*....|....*...
gi 392895375 1572 PSGDVIIADSGNSKIKKV 1589
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
588-612 |
3.24e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.72 E-value: 3.24e-05
10 20
....*....|....*....|....*.
gi 392895375 588 DCNGRGRCDT-DGRCRCNPGWTGEAC 612
Cdd:pfam07974 1 ICSGRGTCVNqCGKCVCDSGYQGATC 26
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
839-856 |
9.65e-05 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 9.65e-05
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
524-546 |
3.19e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.19e-04
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
520-628 |
1.39e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 41.67 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 520 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 596
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 392895375 597 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 628
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
617-645 |
2.60e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.66 E-value: 2.60e-03
10 20
....*....|....*....|....*....
gi 392895375 617 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 645
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
523-548 |
4.48e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 37.33 E-value: 4.48e-03
10 20 30
....*....|....*....|....*....|..
gi 392895375 523 NCNQRG----EC--VHGKCHCAPGFTGRTCDE 548
Cdd:cd00055 3 DCNGHGslsgQCdpGTGQCECKPNTTGRRCDR 34
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
555-572 |
4.88e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.70 E-value: 4.88e-03
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
523-578 |
5.50e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 5.50e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392895375 523 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKGKECE 578
Cdd:smart00180 2 DCDPGGsasgTCdpDTGQCECKPNVTGRRCDR-------------------CAPGYYGDGPP 44
|
|
| DSL |
smart00051 |
delta serrate ligand; |
567-612 |
6.56e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 37.31 E-value: 6.56e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 392895375 567 VCKSGFKGKECEmrhNWC-EVADCNGRGRCDTDGRCRCNPGWTGEAC 612
Cdd:smart00051 20 TCDENYYGEGCN---KFCrPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1231-1589 |
1.80e-26 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 113.01 E-value: 1.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1231 VSTFAG--LDGVKRDVEclkcegkvDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLA-------- 1298
Cdd:cd14953 1 VSTVAGsgTAGFSGGGG--------TAARFNSPSGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAgfadggga 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1299 ------------DTSHSYYIA---------VSPvDGTIAislplhkqvwrisslepqdsrnnydVLAGDGTVcasavdSC 1357
Cdd:cd14953 73 aaqfntpsgvavDAAGNLYVAdtgnhrirkITP-DGVVS-------------------------TLAGTGTA------GF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1358 GDGALAQNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGHIRSI---GETTPDQHPIRTCAQITklvdlqmeWPTSL 1432
Cdd:cd14953 121 SDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRIRKITPDGVVTTVagtGGAGYAGDGPATAAQFN--------NPTGV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1433 TIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTcdLANATSSASAKSLdhrrhliQNARDITVGTDGAIYVVESD 1510
Cdd:cd14953 193 AVDA-AGNLYVADRgnHRIRKITPDGVVTTVA-GTGTA--GFSGDGGATAAQL-------NNPTGVAVDAAGNLYVADSG 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392895375 1511 GRRlnqVRKLSSDrSTFSILTGGKSpcscdvaacgcddAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKV 1589
Cdd:cd14953 262 NHR---IRKITPA-GVVTTVAGGGA-------------GFSGDGGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2689-2761 |
1.54e-21 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 90.75 E-value: 1.54e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392895375 2689 KKIVEELKTRENIAVWRAERKRAEAGEKTWRQWSDRETRELTSKGSVSGYDIEMK-PAHQ-SGLLASVHSWKFRK 2761
Cdd:pfam15636 4 KRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIhPVEQyPELADDPSNIRFRK 78
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1342-1591 |
2.30e-19 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 91.82 E-value: 2.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1342 VLAGDGTVCASavdscGDGALAqnAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTGHIRSIGET-----TPDQHPIrt 1414
Cdd:cd14953 3 TVAGSGTAGFS-----GGGGTA--ARFNSPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTgtagfADGGGAA-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1415 cAQITKlvdlqmewPTSLTIDPiTGSVLVLDT--NVVYEIDVVHDVVTIAlGSPTTCDLANATssASAKSLDhrrhliqN 1492
Cdd:cd14953 74 -AQFNT--------PSGVAVDA-AGNLYVADTgnHRIRKITPDGVVSTLA-GTGTAGFSDDGG--ATAAQFN-------Y 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1493 ARDITVGTDGAIYVVESDGRRlnqVRKLSSDR--STFSiltggkspcscdvaacGCDDAVSLRDVAASQAHLSSPYAVCV 1570
Cdd:cd14953 134 PTGVAVDAAGNLYVADTGNHR---IRKITPDGvvTTVA----------------GTGGAGYAGDGPATAAQFNNPTGVAV 194
|
250 260
....*....|....*....|.
gi 392895375 1571 SPSGDVIIADSGNSKIKKVSA 1591
Cdd:cd14953 195 DAAGNLYVADRGNHRIRKITP 215
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1365-1591 |
4.12e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.99 E-value: 4.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1365 NAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTIDPiTGSV 1441
Cdd:cd05819 4 PGELNNPQGIAVDSSGNIYVADTGnnRIQVFDPDGnFITSFGSFGSG--------------DGQFNEPAGVAVDS-DGNL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1442 LVLDTN----VVYEIDVVHDVVTIALGSPTTCDlanatssasaksldhrrhliQNARDITVGTDGAIYVVESDGRRlnqV 1517
Cdd:cd05819 69 YVADTGnhriQKFDPDGNFLASFGGSGDGDGEF--------------------NGPRGIAVDSSGNIYVADTGNHR---I 125
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392895375 1518 RKLSSDRS-TFSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1591
Cdd:cd05819 126 QKFDPDGEfLTTFGSGGSGP-----------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVFDP 177
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1258-1589 |
3.90e-16 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 81.21 E-value: 3.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1258 LFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQ-VSTILTLGLADTSHSY--YIAVSPvDGTIAISlplhkqvwrissle 1332
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADtgNNRIQVFDPDGNfITSFGSFGSGDGQFNEpaGVAVDS-DGNLYVA-------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1333 pqDSRNN-YDVLAGDGTVCASAVDScGDGalaqNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGH-IRSIGETTpd 1408
Cdd:cd05819 72 --DTGNHrIQKFDPDGNFLASFGGS-GDG----DGEFNGPRGIAVDSSGNIYVADTGnhRIQKFDPDGEfLTTFGSGG-- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1409 qhpirtcaqitkLVDLQMEWPTSLTIDPiTGSVLVLDT--NVVYEIDvvhdvvtialgspttcdlANATSSASAKSLDHR 1486
Cdd:cd05819 143 ------------SGPGQFNGPTGVAVDS-DGNIYVADTgnHRIQVFD------------------PDGNFLTTFGSTGTG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1487 RHLIQNARDITVGTDGAIYVVESDGRRlnqVRKLssDRSTFSILTGGKspcscdvaacgcddavslrdVAASQAHLSSPY 1566
Cdd:cd05819 192 PGQFNYPTGIAVDSDGNIYVADSGNNR---VQVF--DPDGAGFGGNGN--------------------FLGSDGQFNRPS 246
|
330 340
....*....|....*....|...
gi 392895375 1567 AVCVSPSGDVIIADSGNSKIKKV 1589
Cdd:cd05819 247 GLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1335-1587 |
2.00e-10 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 64.21 E-value: 2.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1335 DSRNNYDVLAGDGTVCASAVDSCGDGalaqNAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTG-HIRSIGETTpdqhp 1411
Cdd:cd14957 35 DTGNNRIQVFTSSGVYSYSIGSGGTG----SGQFNSPYGIAVDSNGNIYVADTdnNRIQVFNSSGvYQYSIGTGG----- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1412 irtcaqitkLVDLQMEWPTSLTIDPiTGSVLVLDTN----VVYEIDvvhDVVTIALGSPTTCDLAnatssasaksldhrr 1487
Cdd:cd14957 106 ---------SGDGQFNGPYGIAVDS-NGNIYVADTGnhriQVFTSS---GTFSYSIGSGGTGPGQ--------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1488 hlIQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDRST-FSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPY 1566
Cdd:cd14957 158 --FNGPQGIAVDSDGNIYVADTGNHR---IQVFTSSGTFqYTFGSSGSGP-----------------------GQFSDPY 209
|
250 260
....*....|....*....|.
gi 392895375 1567 AVCVSPSGDVIIADSGNSKIK 1587
Cdd:cd14957 210 GIAVDSDGNIYVADTGNHRIQ 230
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1230-1393 |
1.64e-09 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 62.16 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1230 RVSTFAGLDGVKRDVEclkceGKVDSISLFRPTTVVYAQDGSLIIGD--HNMIRRVSQDGQVSTILTLGLADTS------ 1301
Cdd:cd14953 163 VVTTVAGTGGAGYAGD-----GPATAAQFNNPTGVAVDAAGNLYVADrgNHRIRKITPDGVVTTVAGTGTAGFSgdggat 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1302 -----HSYYIAVSPvDGTIAISLPLHKQVWRISSLEpqdsrnNYDVLAGDGTvcasavDSCGDGALAQNAQLIFPKGISF 1376
Cdd:cd14953 238 aaqlnNPTGVAVDA-AGNLYVADSGNHRIRKITPAG------VVTTVAGGGA------GFSGDGGPATSAQFNNPTGVAV 304
|
170
....*....|....*....
gi 392895375 1377 DKMGNLYLADSR--RIRVI 1393
Cdd:cd14953 305 DAAGNLYVADTGnnRIRKI 323
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1458-2444 |
2.43e-09 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 63.24 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1458 VVTIALGSPTTCDLANATSSASAKSLDHRRHLIQNARDITVGTDGAIYVVESDGRRLNQVRKLSSDRSTFSILTGGKSPC 1537
Cdd:COG3209 7 VGGTTGASSTLLAATNAGGGTAVTNAGSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1538 SCDVAACGCDDAVSLRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMAKYDGRSRTYEVTDAERQEKYTFN 1617
Cdd:COG3209 87 SAAGGGYVGGAAAGGGATLTGLAAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1618 RHGQHSSTVSLITGRTFFNFSYQVDSPISMISEIRAASGVVLRVLKRNDSLFDLETTLGQRTTLTMSAYDGTLEQVSKRD 1697
Cdd:COG3209 167 SAYGLTLGGAAAGPATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1698 SATSRDATKLFYKKGLLTSRIDVATAVGFEYDEYGRAIGLKRDREYWRLGEETISMGSVNTEVLLNGQRFQQVRLGEGNL 1777
Cdd:COG3209 247 GAGAAVATAATTLGGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1778 AVHSTNGATTRLISLRNEGYSLASPLGTSTLYDKSSSIPDSN-GEPLISRRRTKVPAIGNPQRRELTTRWDWRHVARRGD 1856
Cdd:COG3209 327 SGAADAGTTTTTGTGTGGTTTTVGGGGSLTLGGYGAAGGLTTsVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAG 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1857 DSDGSLGRRKVAEINGVNMFSMEYDVKSNQDTLRLGSTTDDAQALLFIDYTSSGRIRRISAPEDSQMAEMNITWDGAGRK 1936
Cdd:COG3209 407 TTTTSTTGGDGGPATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTL 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1937 SEVTWGSWKIRLTYDNSNRLTEHAIDGARVpikmSYAGASRRPNEIQHDGAKWNIQYDNYDRIKEVISKSQEATSFSSIA 2016
Cdd:COG3209 487 TSGSAGATTLGTDTTLDDTLGGTTTTTAGA----RGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGT 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2017 LGGDEWVLKRRTSLNSKPSLVRLSREGKVLESTTPDENHyWLERKDPITGRTTEILNDEETTVVTCWSPEGAPmcSRSRN 2096
Cdd:COG3209 563 GGTGTVTTTGDGTGGASTTTGTTGGTATTTTVTTTTTTS-TAGTTTTTTSGYTRAGLTLTLGTGTASGLERAT--ASTGS 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2097 LQENTTMQGHLVARKSVTIMTPTSSEPSITSSFTYEYDDMLRVTTIQPVIEQSVLESIQLSYDERRGHVAAINGFKWARD 2176
Cdd:COG3209 640 TTGGTTGTGVTTTGTTTTRATGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRL 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2177 ASTSRCQGHGLMYETSKANDHRQVVERKLIFGDARAS-IKIIRDKAGRASESHLeiSSSGTQRNQKITRTFDAAGRVASV 2255
Cdd:COG3209 720 GTTTTGGGGGTTTDGTGTGGTTGTLTTTSTTTTTTAGaLTYTYDALGRLTSETT--PGGVTQGTYTTRYTYDALGRLTSV 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2256 EQNDQEPVRIIWNSDARVEKindrvVEWNRGGALKTFQDISYQVDSIGWVVKRDN-------TTVFGYDGKGRLVSARSS 2328
Cdd:COG3209 798 TYPDGETVTYTYDALGRLTS-----VITVGSGGGTDLQDRTYTYDAAGNITSITDalragtlTQTYTYDALGRLTSATDP 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 2329 QLRINIFYDREDRVVQIQNSKDfIHFYYGYIDTPKLVSHfsKNGKISTLFYDDDSvpfamqsddgtryalLTDETSTIKA 2408
Cdd:COG3209 873 GTTESYTYDANGNLTSRTDGGT-TTYTYDALGRLVSVTK--PDGTTTTYTYDALG---------------HTDHLGSVRA 934
|
970 980 990
....*....|....*....|....*....|....*..
gi 392895375 2409 IIGDS-NVLRIIDRSVFGALLPSSSSSHPFlPIGYLG 2444
Cdd:COG3209 935 LTDASgQVVWRYDYDPFGNLLAETSGAAAN-PLRFTG 970
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1260-1589 |
5.09e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.03 E-value: 5.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1260 RPTTVVYAQDGSLIIGD--HNMIRRVS-QDGQVSTILtlgLADTSHSYYIAVSPvDGTIAISLPLHKQVWRISslePQDs 1336
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTEYP---LGGGSGPHGIAVDP-DGNLWFTDNGNNRIGRID---PKT- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1337 rNNYDVLAGDGTVCAsavdscgdgalaqnaqlifPKGISFDKMGNLYLADSR--RIRVIDT-TGHIRSIGETTPDQHPir 1413
Cdd:COG4257 90 -GEITTFALPGGGSN-------------------PHGIAFDPDGNLWFTDQGgnRIGRLDPaTGEVTEFPLPTGGAGP-- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1414 tcaqitklvdlqmewpTSLTIDPiTGSVLVLD--TNVVYEIDVVHDVVTIALGsPTTcdlanatssasaksldhrrhlIQ 1491
Cdd:COG4257 148 ----------------YGIAVDP-DGNLWVTDfgANAIGRIDPDTGTLTEYAL-PTP---------------------GA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1492 NARDITVGTDGAIYVVESDGrrlNQVRKLSSDrstfsilTGgkspcscdvaacgcddavSLRDVAASQAhLSSPYAVCVS 1571
Cdd:COG4257 189 GPRGLAVDPDGNLWVADTGS---GRIGRFDPK-------TG------------------TVTEYPLPGG-GARPYGVAVD 239
|
330
....*....|....*...
gi 392895375 1572 PSGDVIIADSGNSKIKKV 1589
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1368-1591 |
5.39e-08 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 56.45 E-value: 5.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1368 LIFPKGISFDKMGNLYLADSRRIRVIDTTGhirsiGETTPDQHPIRTCAQitklvdlqmewPTSLTIDPiTGSVLVLDTn 1447
Cdd:cd14952 9 LDGPGGVAVDAAGNVYVADSGNNRVLKLAA-----GSTTQTVLPFTGLYQ-----------PQGVAVDA-AGTVYVTDF- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1448 vvyeidVVHDVVTIALGSPTTCDLANAtssasakSLDhrrhliqNARDITVGTDGAIYVVESDGrrlNQVRKLSSDRSTF 1527
Cdd:cd14952 71 ------GNNRVLKLAAGSTTQTVLPFT-------GLN-------DPTGVAVDAAGNVYVADTGN---NRVLKLAAGSNTQ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1528 SIL--TGGKSPCscDVAAcgcDDA-------------VSLRDVAASQ-----AHLSSPYAVCVSPSGDVIIADSGNSKIK 1587
Cdd:cd14952 128 TVLpfTGLSNPD--GVAV---DGAgnvyvtdtgnnrvLKLAAGSTTQtvlpfTGLNSPSGVAVDTAGNVYVTDHGNNRVL 202
|
....
gi 392895375 1588 KVSA 1591
Cdd:cd14952 203 KLAA 206
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1364-1591 |
2.01e-06 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 52.27 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1364 QNAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTG-HIRSIGE--TTPDQhpirtcaqitklvdlqMEWPTSLTIDPiT 1438
Cdd:cd14957 13 GNGQFNTPRGIAVDSAGNIYVADTgnNRIQVFTSSGvYSYSIGSggTGSGQ----------------FNSPYGIAVDS-N 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1439 GSVLVLDTNVvYEIDVvhdvvtiaLGSPTTCDLANATSSASAKSLDhrrhliqNARDITVGTDGAIYVVESDGRRlnqVR 1518
Cdd:cd14957 76 GNIYVADTDN-NRIQV--------FNSSGVYQYSIGTGGSGDGQFN-------GPYGIAVDSNGNIYVADTGNHR---IQ 136
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392895375 1519 KLSSDRST-FSILTGGKSPcscdvaacgcddavslrdvaasqAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1591
Cdd:cd14957 137 VFTSSGTFsYSIGSGGTGP-----------------------GQFNGPQGIAVDSDGNIYVADTGNHRIQVFTS 187
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1352-1513 |
6.58e-06 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 50.36 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1352 SAVDSCGD-GALAQnaQLIFPKGISFDKMGNLYLADSR--RIRVIDTTGH-IRSIGE--TTPDqhpirtcaqitklvdlQ 1425
Cdd:cd14956 138 SFLRQWGGtGIEPG--SFNYPRGVAVDPDGTLYVADTYndRIQVFDNDGAfLRKWGGrgTGPG----------------Q 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1426 MEWPTSLTIDPiTGSVLVLDTN----VVYEIDVvhdVVTIALGSPTtcdlanatssasaksldHRRHLIQNARDITVGTD 1501
Cdd:cd14956 200 FNYPYGIAIDP-DGNVFVADFGnnriQKFTADG---TFLTSWGSPG-----------------TGPGQFKNPWGVVVDAD 258
|
170
....*....|..
gi 392895375 1502 GAIYVVESDGRR 1513
Cdd:cd14956 259 GTVYVADSNNNR 270
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
588-612 |
3.24e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.72 E-value: 3.24e-05
10 20
....*....|....*....|....*.
gi 392895375 588 DCNGRGRCDT-DGRCRCNPGWTGEAC 612
Cdd:pfam07974 1 ICSGRGTCVNqCGKCVCDSGYQGATC 26
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1370-1605 |
3.27e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 48.09 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1370 FPKGISFDKMGNLYLADSR--RIRVID-TTGhirsigettpdqhpirtcaQITKLVDLQMEWPTSLTIDPiTGSVLVLDT 1446
Cdd:COG4257 18 GPRDVAVDPDGAVWFTDQGggRIGRLDpATG-------------------EFTEYPLGGGSGPHGIAVDP-DGNLWFTDN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1447 --NVVYEIDVV-HDVVTIALGSPttcdlanatssasaksldhrrhlIQNARDITVGTDGAIYVVESDGrrlNQVRKLSSD 1523
Cdd:COG4257 78 gnNRIGRIDPKtGEITTFALPGG-----------------------GSNPHGIAFDPDGNLWFTDQGG---NRIGRLDPA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1524 RSTFSILTGGKSPcscdvaacgcddavslrdvaasqahlSSPYAVCVSPSGDVIIADSGNSKIKKVSARmakyDGRSRTY 1603
Cdd:COG4257 132 TGEVTEFPLPTGG--------------------------AGPYGIAVDPDGNLWVTDFGANAIGRIDPD----TGTLTEY 181
|
..
gi 392895375 1604 EV 1605
Cdd:COG4257 182 AL 183
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1368-1590 |
4.32e-05 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.59 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1368 LIFPKGISFDKMGNLYLADSRRIRVIDTTGhirsiGETTPdqhpirtcaqiTKLVDLQMEWPTSLTIDPiTGSVLVLDTn 1447
Cdd:cd14952 51 LYQPQGVAVDAAGTVYVTDFGNNRVLKLAA-----GSTTQ-----------TVLPFTGLNDPTGVAVDA-AGNVYVADT- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1448 vvyeidVVHDVVTIALGS--PTTCDLAnatssasaksldhrrHLIqNARDITVGTDGAIYVVESDGrrlNQVRKLSSDRS 1525
Cdd:cd14952 113 ------GNNRVLKLAAGSntQTVLPFT---------------GLS-NPDGVAVDGAGNVYVTDTGN---NRVLKLAAGST 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1526 TFSIL--TGGKSPCSCDVAACGC--------DDAVSLRDVAASQA-----HLSSPYAVCVSPSGDVIIADSGNSKIKKVS 1590
Cdd:cd14952 168 TQTVLpfTGLNSPSGVAVDTAGNvyvtdhgnNRVLKLAAGSTTPTvlpftGLNGPLGVAVDAAGNVYVADRGNDRVVKLP 247
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1458-1591 |
5.36e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.91 E-value: 5.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1458 VVTIAlGSPTTCDLANATSSASaksldhrrhlIQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDrSTFSILTGGKSPC 1537
Cdd:cd14953 1 VSTVA-GSGTAGFSGGGGTAAR----------FNSPSGVAVDAAGNLYVADRGNHR---IRKITPD-GVVTTVAGTGTAG 65
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 392895375 1538 ScdvaacgcddavslRDVAASQAHLSSPYAVCVSPSGDVIIADSGNSKIKKVSA 1591
Cdd:cd14953 66 F--------------ADGGGAAAQFNTPSGVAVDAAGNLYVADTGNHRIRKITP 105
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
839-856 |
9.65e-05 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 41.35 E-value: 9.65e-05
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
568-613 |
1.00e-04 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 41.84 E-value: 1.00e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 392895375 568 CKSGFKGKECEmrhNWCEV-ADCNGRGRCDTDGRCRCNPGWTGEACE 613
Cdd:pfam01414 1 CDENYYGSTCS---KFCRPrDDKFGHYTCDANGNKVCLPGWTGPYCD 44
|
|
| NHL_like_4 |
cd14955 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1356-1588 |
1.26e-04 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 46.42 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1356 SCGDGalaqNAQLIFPKGISFDKMGNLYLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSL 1432
Cdd:cd14955 101 SSGSG----DGQFNSPSGIAVDSAGNVYVTDSGnnRIQKFDSSGtFITKWGSFGSG--------------DGQFNSPTGI 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1433 TIDPiTGSVLVLDTNvvyeidvVHDVVTIalgSPTTCDLANATSSASAKSldhrrhliQ--NARDITVGTDGAIYVVESD 1510
Cdd:cd14955 163 AVDS-AGNVYVADTG-------NNRIQKF---TSTGTFLTKWGSEGSGDG--------QfnAPYGIAVDSAGNVYVADTG 223
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392895375 1511 GRRlnqVRKLSSDrSTFsILTGGKSpcscdvaacGCDDavslrdvaaSQahLSSPYAVCVSPSGDVIIADSGNSKIKK 1588
Cdd:cd14955 224 NNR---IQKFDSS-GTF-ITKWGSE---------GSGD---------GQ--FNSPSGIAVDSAGNVYVADSGNNRIQK 276
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1496-1589 |
1.93e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 46.42 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1496 ITVGTDGAIYVVESDGrrlNQVRKLSsdrstfsiLTGGKspcscdVAACGCDDAVSL-------RDVAASQAHLSSPYAV 1568
Cdd:cd14951 139 LSLAGWGELFVADSES---SAIRAVS--------LKDGG------VKTLVGGTRVGTglfdfgdRDGPGAEALLQHPLGV 201
|
90 100
....*....|....*....|.
gi 392895375 1569 CVSPSGDVIIADSGNSKIKKV 1589
Cdd:cd14951 202 AALPDGSVYVADTYNHKIKRV 222
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
524-546 |
3.19e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.02 E-value: 3.19e-04
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1490-1594 |
1.17e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 43.35 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1490 IQNARDITVGTDGAIYVVESDGRRlnqVRKLSSDRSTFSIL--TGGKSPCSCDVAACG---CDDAVSLRDV-----AASQ 1559
Cdd:cd14952 9 LDGPGGVAVDAAGNVYVADSGNNR---VLKLAAGSTTQTVLpfTGLYQPQGVAVDAAGtvyVTDFGNNRVLklaagSTTQ 85
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 392895375 1560 -----AHLSSPYAVCVSPSGDVIIADSGNSKIKKVSARMA 1594
Cdd:cd14952 86 tvlpfTGLNDPTGVAVDAAGNVYVADTGNNRVLKLAAGSN 125
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
520-628 |
1.39e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 41.67 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 520 CESNCNQRGECVHGKCHCAPGFT--GRTC-DEAVCPVVCSGNGVFSGGICVCKSGFkgkecemrhnwCEVADCNGRGRCd 596
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACvDTASDPAHCGACGAACAPGQVCEGGA-----------CREACSEGLTRC- 112
|
90 100 110
....*....|....*....|....*....|....*...
gi 392895375 597 tDGRC------RCNPGWTGEACElracPHASCHDrGVC 628
Cdd:NF041328 113 -GGACvdlatdPLHCGACGVACD----PGESCRG-GAC 144
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
523-574 |
1.55e-03 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 38.49 E-value: 1.55e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 392895375 523 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKG 574
Cdd:pfam00053 2 DCNPHGslsdTCdpETGQCLCKPGVTGRHCDR-------------------CKPGYYG 40
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
617-645 |
2.60e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.66 E-value: 2.60e-03
10 20
....*....|....*....|....*....
gi 392895375 617 CPhASCHDRGVCVNGTCYCMDGWRGNDCS 645
Cdd:pfam18720 2 CP-LGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| NHL_TRIM71_like |
cd14954 |
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ... |
1304-1445 |
2.85e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 42.15 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1304 YYIAVSPvDGTIAISlplhkqvwrisslepqDSRNN-YDVLAGDGTVcASAVDSCGDGalaqNAQLIFPKGISFDKMGNL 1382
Cdd:cd14954 168 RGVAVNP-DGNIVVS----------------DFNNHrLQVFDPDGQF-LRFFGSEGSG----NGQFKRPRGVAVDDEGNI 225
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392895375 1383 YLADSR--RIRVIDTTG-HIRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTIDPiTGSVLVLD 1445
Cdd:cd14954 226 IVADSGnhRVQVFSPDGeFLCSFGTEGNG--------------EGQFDRPSGVAVTP-DGRIVVVD 276
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1359-1446 |
3.51e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 41.89 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1359 DGALAQNAQLIFPKGISFDKMGNLYLAD--SRRIRVIDTTGH-IRSIGETTPDqhpirtcaqitklvDLQMEWPTSLTID 1435
Cdd:cd14963 185 NGSPDGKSGFVNPRGIAVDPDGNLYVVDnlSHRVYVFDEQGKeLFTFGGRGKD--------------DGQFNLPNGLFID 250
|
90
....*....|.
gi 392895375 1436 PiTGSVLVLDT 1446
Cdd:cd14963 251 D-DGRLYVTDR 260
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
622-644 |
3.53e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.53e-03
|
| NHL_TRIM32_like |
cd14961 |
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ... |
1365-1586 |
3.57e-03 |
|
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271331 [Multi-domain] Cd Length: 273 Bit Score: 41.88 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1365 NAQLIFPKGISFDKMGNLYLADS--RRIRVIDTTGH-IRSIGETTPDQHPIRTcaqitklvdlqmewPTSLTIDPI---- 1437
Cdd:cd14961 7 PGTLNNPTGVAVTPTGRVVVADDgnKRIQVFDSDGNcLQQFGPKGDAGQDIRY--------------PLDVAVTPDghiv 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1438 -----TGSVLVLDTN-----VVYE-----IDVV-----HDVVTIALGSPTTCdlanATSSASAKSLDHRRHLIQNA---R 1494
Cdd:cd14961 73 vtdagDRSVKVFSFDgrlklFVRKsfslpWGVAvnpsgEILVTDSEAGKLFV----LTVDFKLGILKKGQKLCSQLcrpR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1495 DITVGTDGAIYVVEsdgrRLNQVRKLSSDRST---FSILTGGkspcscdvaacGCDDAVSLRDVAASQAHLSspyAVCVS 1571
Cdd:cd14961 149 FVAVSRLGAVAVTE----HLFANGTRSSSTRVkvfSSGGQLL-----------GQIDSFGLNLVFPSLICAS---GVAFD 210
|
250
....*....|....*
gi 392895375 1572 PSGDVIIADSGNSKI 1586
Cdd:cd14961 211 SEGNVIVADTGSGAI 225
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
523-548 |
4.48e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 37.33 E-value: 4.48e-03
10 20 30
....*....|....*....|....*....|..
gi 392895375 523 NCNQRG----EC--VHGKCHCAPGFTGRTCDE 548
Cdd:cd00055 3 DCNGHGslsgQCdpGTGQCECKPNTTGRRCDR 34
|
|
| I-EGF_1 |
pfam18372 |
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ... |
555-572 |
4.88e-03 |
|
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.
Pssm-ID: 465729 Cd Length: 29 Bit Score: 36.70 E-value: 4.88e-03
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
523-578 |
5.50e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 36.91 E-value: 5.50e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392895375 523 NCNQRG----EC--VHGKCHCAPGFTGRTCDEavcpvvcsgngvfsggicvCKSGFKGKECE 578
Cdd:smart00180 2 DCDPGGsasgTCdpDTGQCECKPNVTGRRCDR-------------------CAPGYYGDGPP 44
|
|
| NHL_PAL_like |
cd14958 |
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ... |
1496-1591 |
5.51e-03 |
|
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271328 [Multi-domain] Cd Length: 300 Bit Score: 41.48 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895375 1496 ITVGTDGAIYVVESDgrrLNQVRKLSSDRSTFSILTGGKspcscdvaacgcddavslRDVA-ASQAHLSSPYAVCVSPSG 1574
Cdd:cd14958 81 LTIDPDGNIWVTDVG---LHQVFKFDPEGKLLPLLTLGE------------------RGEPgSDQTHFCKPTDVAVAPDG 139
|
90
....*....|....*...
gi 392895375 1575 DVIIADS-GNSKIKKVSA 1591
Cdd:cd14958 140 DIFVADGyCNSRIVKFSP 157
|
|
| DSL |
smart00051 |
delta serrate ligand; |
567-612 |
6.56e-03 |
|
delta serrate ligand;
Pssm-ID: 128366 Cd Length: 63 Bit Score: 37.31 E-value: 6.56e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 392895375 567 VCKSGFKGKECEmrhNWC-EVADCNGRGRCDTDGRCRCNPGWTGEAC 612
Cdd:smart00051 20 TCDENYYGEGCN---KFCrPRDDFFGHYTCDENGNKGCLEGWMGPYC 63
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
520-546 |
9.72e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.08 E-value: 9.72e-03
10 20 30
....*....|....*....|....*....|...
gi 392895375 520 CESN--CNQRGECVHG----KCHCAPGFTGRTC 546
Cdd:cd00054 5 CASGnpCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
|
|
| |
